EE03698B1 - N-atsetüül-(L)-4-tsüanofenüülalaniini Ac-(L)-Phe (4-CN)-OH ja N-atsetüül- (L)-p-amidinofenüülalaniintsükloheksüülglütsiin-ß- (3-N-metüülpüridiinium)alaniini Ac-(L)-pAph-Chg-PalMe(3)-NH2 valmistamismeetod - Google Patents

N-atsetüül-(L)-4-tsüanofenüülalaniini Ac-(L)-Phe (4-CN)-OH ja N-atsetüül- (L)-p-amidinofenüülalaniintsükloheksüülglütsiin-ß- (3-N-metüülpüridiinium)alaniini Ac-(L)-pAph-Chg-PalMe(3)-NH2 valmistamismeetod

Info

Publication number
EE03698B1
EE03698B1 EE9800188A EE9800188A EE03698B1 EE 03698 B1 EE03698 B1 EE 03698B1 EE 9800188 A EE9800188 A EE 9800188A EE 9800188 A EE9800188 A EE 9800188A EE 03698 B1 EE03698 B1 EE 03698B1
Authority
EE
Estonia
Prior art keywords
acetyl
paph
amidinophenylalanine
palme
cyanophenylalanine
Prior art date
Application number
EE9800188A
Other languages
English (en)
Estonian (et)
Other versions
EE9800188A (et
Inventor
R. King Chi-Hsin
Original Assignee
Hoechst Marion Roussel, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel, Inc. filed Critical Hoechst Marion Roussel, Inc.
Publication of EE9800188A publication Critical patent/EE9800188A/xx
Publication of EE03698B1 publication Critical patent/EE03698B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
EE9800188A 1995-12-20 1996-11-25 N-atsetüül-(L)-4-tsüanofenüülalaniini Ac-(L)-Phe (4-CN)-OH ja N-atsetüül- (L)-p-amidinofenüülalaniintsükloheksüülglütsiin-ß- (3-N-metüülpüridiinium)alaniini Ac-(L)-pAph-Chg-PalMe(3)-NH2 valmistamismeetod EE03698B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57556995A 1995-12-20 1995-12-20
PCT/US1996/019005 WO1997022712A1 (en) 1995-12-20 1996-11-25 NOVEL PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE Ac-(L)-Phe(4-CN)-OH AND N-ACETYL-(L)-p-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYCINE-β-(3-N-METHYLPYRIDINIUM)-ALANINE Ac-(L)-pAph-Chg-PalMe(3)-NH¿2?

Publications (2)

Publication Number Publication Date
EE9800188A EE9800188A (et) 1998-12-15
EE03698B1 true EE03698B1 (et) 2002-04-15

Family

ID=24300839

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800188A EE03698B1 (et) 1995-12-20 1996-11-25 N-atsetüül-(L)-4-tsüanofenüülalaniini Ac-(L)-Phe (4-CN)-OH ja N-atsetüül- (L)-p-amidinofenüülalaniintsükloheksüülglütsiin-ß- (3-N-metüülpüridiinium)alaniini Ac-(L)-pAph-Chg-PalMe(3)-NH2 valmistamismeetod

Country Status (27)

Country Link
EP (1) EP0868526B1 (zh)
JP (1) JP4044614B2 (zh)
KR (1) KR100438879B1 (zh)
CN (1) CN1087349C (zh)
AR (1) AR005119A1 (zh)
AT (1) ATE222293T1 (zh)
AU (1) AU717995B2 (zh)
BR (1) BR9612059A (zh)
CA (1) CA2241210C (zh)
CZ (1) CZ295362B6 (zh)
DE (1) DE69623038T2 (zh)
DK (1) DK0868526T3 (zh)
EE (1) EE03698B1 (zh)
ES (1) ES2179957T3 (zh)
HK (1) HK1017384A1 (zh)
IL (1) IL125003A (zh)
MX (1) MX9804997A (zh)
NO (1) NO319678B1 (zh)
NZ (1) NZ324159A (zh)
PL (1) PL185541B1 (zh)
PT (1) PT868526E (zh)
RU (1) RU2170764C2 (zh)
SK (1) SK281432B6 (zh)
TR (1) TR199801107T2 (zh)
UA (1) UA48993C2 (zh)
WO (1) WO1997022712A1 (zh)
ZA (1) ZA9610600B (zh)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1016663A1 (en) * 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use and pharmaceutical compositions containing them (inhibition of factor Xa activity)
TR200101903T2 (tr) * 1999-01-02 2001-11-21 Aventis Pharma Deutschland Gmbh Yeni malonik asit türevleri, bunların preparasyon işlemleri.
MXPA02006762A (es) * 2000-01-28 2002-10-23 Aventis Pharma Gmbh Proceso para la preparacion de acetil-amidinoifenilalanil -ciclohexilglicil -piridinoalaninamidas.
EP1127884A1 (en) 2000-02-26 2001-08-29 Aventis Pharma Deutschland GmbH Novel malonic acid derivatives, processes for their preparation, their use as inhibitor of factor XA activity and pharmaceutical compositions containing them
PT1569912E (pt) 2002-12-03 2015-09-15 Pharmacyclics Llc Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia
GB0306267D0 (en) 2003-03-19 2003-04-23 Ineos Fluor Ltd Process
JP2008260755A (ja) * 2007-03-20 2008-10-30 Sumitomo Chemical Co Ltd Ｌ−ビフェニルアラニン化合物の塩の回収方法、およびそれを用いたビフェニルアラニンエステル化合物の回収方法
CN106946724B (zh) * 2017-04-07 2019-03-22 苏州汉德创宏生化科技有限公司 单胺基抑制剂类中间体2-乙酰氨基-2-苄基丙二酸单乙酯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981799A (en) * 1987-08-21 1991-01-01 Takeda Chemical Industries, Ltd. Acylamino acid racemase, production and use thereof
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
AU662522B2 (en) * 1991-05-13 1995-09-07 Fujisawa Pharmaceutical Co., Ltd. New peptide compound and a process for the preparation thereof
SK286094B6 (sk) * 1994-04-26 2008-03-05 Aventis Pharmaceuticals Inc. Zlúčenina špecificky inhibujúca aktivitu faktora Xa, farmaceutická kompozícia s jej obsahom a jej použitie

Also Published As

Publication number Publication date
NO319678B1 (no) 2005-09-05
WO1997022712A1 (en) 1997-06-26
SK281432B6 (sk) 2001-03-12
BR9612059A (pt) 1999-02-23
TR199801107T2 (xx) 1998-10-21
PL185541B1 (pl) 2003-05-30
CN1087349C (zh) 2002-07-10
JP2000501618A (ja) 2000-02-15
EP0868526A1 (en) 1998-10-07
SK85598A3 (en) 1998-12-02
NO982868D0 (no) 1998-06-19
DK0868526T3 (da) 2002-12-02
AU717995B2 (en) 2000-04-06
ES2179957T3 (es) 2003-02-01
CZ195698A3 (cs) 1999-01-13
RU2170764C2 (ru) 2001-07-20
UA48993C2 (uk) 2002-09-16
NO982868L (no) 1998-08-19
PT868526E (pt) 2002-12-31
JP4044614B2 (ja) 2008-02-06
CZ295362B6 (cs) 2005-07-13
IL125003A (en) 2001-12-23
IL125003A0 (en) 1999-01-26
AR005119A1 (es) 1999-04-14
KR100438879B1 (ko) 2004-07-16
DE69623038T2 (de) 2002-12-12
EE9800188A (et) 1998-12-15
KR20000064486A (ko) 2000-11-06
CA2241210C (en) 2002-05-14
CN1205742A (zh) 1999-01-20
PL327314A1 (en) 1998-12-07
ZA9610600B (en) 1997-06-20
HK1017384A1 (en) 1999-11-19
DE69623038D1 (de) 2002-09-19
MX9804997A (es) 1998-09-30
AU1125197A (en) 1997-07-14
ATE222293T1 (de) 2002-08-15
EP0868526B1 (en) 2002-08-14
NZ324159A (en) 1999-07-29
CA2241210A1 (en) 1997-06-26

Similar Documents

Publication Publication Date Title
EP0785276A4 (en) MODIFICATION OF A PEPTIDE AND A PROTEIN
HUP9901186A3 (en) Pharmaceutical composition for immunomodulation based on peptides and adjuvants
HK1096974A1 (en) Antibody against human parathormone related peptides
ZA969443B (en) Peptides which enhance transport across tissues and methods of identifying and using the same
ZA964733B (en) Ob protein compositions and methods
PL320824A1 (en) Aerodol form of a preparation of peptides and proteins
AU2526497A (en) Post-labeling stabilization of radiolabeled proteins and peptides
ZA955225B (en) Crucifer AFT proteins and uses thereof
ZA97283B (en) Isolated tyrosinase derived peptides and uses thereof
AU5297496A (en) Methods of preparation and use of recombinant adenoviral vectors
EE03698B1 (et) N-atsetüül-(L)-4-tsüanofenüülalaniini Ac-(L)-Phe (4-CN)-OH ja N-atsetüül- (L)-p-amidinofenüülalaniintsükloheksüülglütsiin-ß- (3-N-metüülpüridiinium)alaniini Ac-(L)-pAph-Chg-PalMe(3)-NH2 valmistamismeetod
EP0820295A4 (en) MODIFIED ARGININE OR LYSINE CONTAINING PROTEINS AND PEPTIDES
GB9504761D0 (en) Amphiphilic peptide and analogs thereof
NO990836D0 (no) Antitrombotiske azacykloalkylalkanoylpeptider og pseudopeptider
GB9516293D0 (en) Novel peptides and their use as vaccines
AU4236097A (en) Mhc peptides and methods of use
ZA96240B (en) Novel peptides their preparation and use
EP0537981A3 (en) Cleavage method for acyl thiohydantoins and use of the method in C-terminal peptide sequencing.
IL116658A0 (en) Peptides their preparation and use
GB2336844B (en) Anti-hiv peptides and proteins
ZA978220B (en) PTX-sensitive G proteins their preparation and use
IL118324A0 (en) Immunoregulatory polypeptide and its uses
SI0868526T1 (en) PROCESS FOR PREPARING N-ACETYL(L)-4-CYANOPHENYLALANINE Ac-(L)-Phe(4-CN)-OH AND N-ACETYL-(L)-p-AMIDINOPHENYLALANINE-CYCLOHEXYLGLYCINE-BETA-(3-N-METHYLPYRIDINIUM)-ALANINE Ac-(L)-pAph-Chg-PalMe(3)-NH2
AU2589497A (en) Constrained cd4 peptides and methods of using the same
HK1013918A1 (en) Liposomal human calcitonin gene-related peptide composition and preparation of the same

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

HC1A Change of owner name
KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20091231

KB4A Valid patent at the end of a year

Effective date: 20101231

MM4A Lapsed by not paying the annual fees

Effective date: 20111125