EE03527B1 - Tsükloalkaanindool- ja -asaindoolderivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks, nimetatud derivaate sisaldavad ravimid ning karboksüülhapped kui vaheühendid nimetatud tsükloalkaanindool- ja -asaindoolderivaatide valmistamise - Google Patents

Tsükloalkaanindool- ja -asaindoolderivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks, nimetatud derivaate sisaldavad ravimid ning karboksüülhapped kui vaheühendid nimetatud tsükloalkaanindool- ja -asaindoolderivaatide valmistamise

Info

Publication number
EE03527B1
EE03527B1 EE9500071A EE9500071A EE03527B1 EE 03527 B1 EE03527 B1 EE 03527B1 EE 9500071 A EE9500071 A EE 9500071A EE 9500071 A EE9500071 A EE 9500071A EE 03527 B1 EE03527 B1 EE 03527B1
Authority
EE
Estonia
Prior art keywords
indole
opt
derivatives
substd
alkyl
Prior art date
Application number
EE9500071A
Other languages
English (en)
Estonian (et)
Other versions
EE9500071A (et
Inventor
M�ller Ulrich
Connell Richard
Goldmann Siegfried
Gr�tzmann Rudi
Beuck Martin
Bischoff Hilmar
Denzer Dirk
Domdey-Bette Anke
Wohlfeil Stefan
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of EE9500071A publication Critical patent/EE9500071A/xx
Publication of EE03527B1 publication Critical patent/EE03527B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EE9500071A 1994-10-04 1995-10-03 Tsükloalkaanindool- ja -asaindoolderivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks, nimetatud derivaate sisaldavad ravimid ning karboksüülhapped kui vaheühendid nimetatud tsükloalkaanindool- ja -asaindoolderivaatide valmistamise EE03527B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4435477A DE4435477A1 (de) 1994-10-04 1994-10-04 Cycloalkano-indol- und -azaindol-derivate

Publications (2)

Publication Number Publication Date
EE9500071A EE9500071A (et) 1996-04-15
EE03527B1 true EE03527B1 (et) 2001-10-15

Family

ID=6529939

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9500071A EE03527B1 (et) 1994-10-04 1995-10-03 Tsükloalkaanindool- ja -asaindoolderivaadid, nende valmistamismeetod, kasutamine ravimite valmistamiseks, nimetatud derivaate sisaldavad ravimid ning karboksüülhapped kui vaheühendid nimetatud tsükloalkaanindool- ja -asaindoolderivaatide valmistamise

Country Status (36)

Country Link
US (6) US5684014A (ja)
EP (1) EP0705831B1 (ja)
JP (1) JP3901234B2 (ja)
KR (1) KR100355986B1 (ja)
CN (2) CN1050605C (ja)
AT (1) ATE255580T1 (ja)
AU (1) AU700609B2 (ja)
CA (1) CA2159546C (ja)
CZ (1) CZ291348B6 (ja)
DE (2) DE4435477A1 (ja)
DK (1) DK0705831T3 (ja)
DZ (1) DZ1934A1 (ja)
EE (1) EE03527B1 (ja)
ES (1) ES2211890T3 (ja)
FI (2) FI113048B (ja)
HK (1) HK1005139A1 (ja)
HN (1) HN1995009160A (ja)
HR (1) HRP950505B1 (ja)
HU (1) HU225052B1 (ja)
IL (3) IL129641A0 (ja)
MA (1) MA23683A1 (ja)
MY (1) MY117282A (ja)
NO (1) NO305365B1 (ja)
NZ (1) NZ280130A (ja)
PH (1) PH31400A (ja)
PL (1) PL183154B1 (ja)
PT (1) PT705831E (ja)
RU (1) RU2157803C2 (ja)
SG (1) SG63528A1 (ja)
SI (1) SI0705831T1 (ja)
SK (1) SK284260B6 (ja)
SV (1) SV1995000062A (ja)
TN (1) TNSN95098A1 (ja)
TW (1) TW448175B (ja)
UA (1) UA44700C2 (ja)
ZA (1) ZA958297B (ja)

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DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19525028A1 (de) * 1995-07-10 1997-01-16 Bayer Ag Amide und Sulfonamide von heterocyclisch substituierten Benzylaminen
US6774236B1 (en) 1996-04-04 2004-08-10 Bayer Aktiengesellschaft Process for the preparation of enantiomerically pure cycloalkano-indol -and azaindol -and pyrimido [1,2A]indolcarbocyclic acids and their activated derivatives
DE19613549A1 (de) * 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
DE19615119A1 (de) 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide
DE19615265A1 (de) * 1996-04-18 1997-12-04 Bayer Ag Neue Pyridazino-, Pyrimido-, Pyrazino- und Triazino-indole
IL139203A0 (en) * 1998-05-01 2001-11-25 Lilly Co Eli Spla2 inhibitor ester
ES2213984T3 (es) 1998-10-30 2004-09-01 Eli Lilly And Company Derivados de azaindol y su uso como agentes antitrombicos.
WO2000071502A1 (fr) * 1999-05-25 2000-11-30 Yamanouchi Pharmaceutical Co., Ltd. Derives d'hydrazide
DE19929065A1 (de) * 1999-06-25 2000-12-28 Bayer Ag Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
DE19934610A1 (de) * 1999-07-23 2001-01-25 Bayer Ag Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen
EP1134221A1 (en) * 2000-03-15 2001-09-19 Aventis Pharma Deutschland GmbH Substituted beta-carbolines as lkB kinase inhibitors
PL357284A1 (en) * 2000-03-15 2004-07-26 Aventis Pharma Deutschland Gmbh Substituted beta-carbolines with ikb-kinase inhibiting activity
WO2001074817A1 (fr) * 2000-03-30 2001-10-11 Yamanouchi Pharmaceutical Co., Ltd. Derives d'hydrazide
DE10030375A1 (de) * 2000-06-21 2002-01-03 Bayer Ag Verwendung von MTP-Inhibitoren zur Senkung von ppTRL
IL157102A0 (en) * 2001-01-31 2004-02-08 Synaptic Pharma Corp Use of gal3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
IL161134A0 (en) * 2002-02-28 2004-08-31 Japan Tobacco Inc Ester compound and medical use thereof
US20050239780A1 (en) * 2002-05-31 2005-10-27 Akira Suga Tetrahydropyran derivative
WO2004063156A1 (en) * 2003-01-08 2004-07-29 Biovitrum Ab Novel indole derivates as fabp-4 inhibitors
WO2005051382A1 (ja) * 2003-11-28 2005-06-09 Astellas Pharma Inc. 脂質低下作用増強剤
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
SI1725234T1 (sl) 2004-03-05 2013-04-30 The Trustees Of The University Of Pennsylvania Postopki zdravljenja nepravilnosti ali bolezni povezanih s hiperlipidemijo in hiperholesterolemijo z minimiziranjem stranskih uäśinkov
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
EP1737460A2 (en) * 2004-04-09 2007-01-03 Janssen Pharmaceutica N.V. Intermittent dosing regimen for the treatment of overweight with mtp-inhibitors
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
US20060030623A1 (en) * 2004-07-16 2006-02-09 Noboru Furukawa Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis
FR2873694B1 (fr) * 2004-07-27 2006-12-08 Merck Sante Soc Par Actions Si Nouveaux aza-indoles inhibiteurs de la mtp et apob
US8101774B2 (en) * 2004-10-18 2012-01-24 Japan Tobacco Inc. Ester derivatives and medicinal use thereof
KR20070072888A (ko) * 2004-10-25 2007-07-06 니뽄 다바코 산교 가부시키가이샤 용해성 및 안정성이 개선된 고형 제제 및 그의 제조 방법
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
WO2006129193A2 (en) * 2005-05-27 2006-12-07 Pfizer Products Inc. Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss
WO2007015162A1 (en) * 2005-08-04 2007-02-08 Pfizer Limited Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
WO2007047724A2 (en) * 2005-10-18 2007-04-26 Aegerion Pharmaceuticals Compositions for lowering serum cholesterol and/or triglycerides
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
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US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
CA2652751A1 (en) * 2006-05-18 2007-11-29 Bayer Healthcare Ag Pharmaceutical compositions and methods of using same
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JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
US20080161279A1 (en) * 2006-12-21 2008-07-03 Wisler Gerald L Methods of Treating Obesity
RU2338745C1 (ru) * 2007-03-21 2008-11-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
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CN108218862B (zh) * 2018-02-07 2020-06-23 贵州医科大学 α-卡波林类衍生物在制备抗心肌缺氧复氧损伤药物中的应用
CN110467560A (zh) 2018-05-09 2019-11-19 深圳微芯生物科技股份有限公司 一种苯基氨基丙酸钠衍生物、其制备方法和应用
CN113166058A (zh) 2018-08-14 2021-07-23 奥斯特克有限公司 氟β-咔啉化合物
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IL81325A (en) * 1986-01-23 1990-11-29 Merck Frosst Canada Inc Tetrahydrocarbazole 1-alkanoic acids and pharmaceutical compositions containing them
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GB9101375D0 (en) * 1991-01-22 1991-03-06 Erba Carlo Spa N-imidazolyl derivatives of substituted tetrahydrocarbazole and cyclohepht(b)indole
DE4112533A1 (de) * 1991-04-17 1992-10-22 Bayer Ag Verfahren zur herstellung von enantiomerenreinen substituierten (chinolin-2-yl-methoxy)phenyl-essigsaeuren
DE4200954A1 (de) 1991-04-26 1992-10-29 Bayer Ag Heterocyclisch substituierte phenylessigsaeurederivate
DE4308788A1 (de) * 1993-03-18 1994-09-22 Bayer Ag Hetero-tricyclisch-substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4435477A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
DE19613549A1 (de) 1996-04-04 1997-10-09 Bayer Ag Verfahren zur Herstellung von enantiomerenreinen Cycloalkano-indol- und azaindol-carbonsäuren und deren aktivierte Derivate
DE19615119A1 (de) * 1996-04-17 1997-10-23 Bayer Ag Neue Arylessigsäureamide

Also Published As

Publication number Publication date
MA23683A1 (fr) 1996-07-01
CZ291348B6 (cs) 2003-02-12
US20030149073A1 (en) 2003-08-07
DE4435477A1 (de) 1996-04-11
FI954681A (fi) 1996-04-05
HUT73240A (en) 1996-07-29
HU9502891D0 (en) 1995-11-28
PH31400A (en) 1998-10-29
DE59510839D1 (de) 2004-01-15
AU700609B2 (en) 1999-01-07
TNSN95098A1 (fr) 1996-02-06
CN1183111C (zh) 2005-01-05
NZ280130A (en) 1996-05-28
SK123995A3 (en) 1996-06-05
JPH08225526A (ja) 1996-09-03
RU2157803C2 (ru) 2000-10-20
CZ256795A3 (en) 1996-04-17
NO953930L (no) 1996-04-09
EP0705831A2 (de) 1996-04-10
EE9500071A (et) 1996-04-15
MY117282A (en) 2004-06-30
SI0705831T1 (en) 2004-02-29
JP3901234B2 (ja) 2007-04-04
US6245775B1 (en) 2001-06-12
SK284260B6 (sk) 2004-12-01
CN1224715A (zh) 1999-08-04
HRP950505A2 (en) 1997-08-31
AU3292095A (en) 1996-04-18
ZA958297B (en) 1996-05-06
US20020147209A1 (en) 2002-10-10
SG63528A1 (en) 1999-03-30
HRP950505B1 (en) 2002-04-30
UA44700C2 (uk) 2002-03-15
SV1995000062A (es) 1996-07-10
DK0705831T3 (da) 2004-04-05
CA2159546A1 (en) 1996-04-05
US20020055635A1 (en) 2002-05-09
IL115493A (en) 1999-10-28
ATE255580T1 (de) 2003-12-15
TW448175B (en) 2001-08-01
HU225052B1 (en) 2006-05-29
PT705831E (pt) 2004-04-30
IL129641A0 (en) 2000-02-29
KR960014126A (ko) 1996-05-22
ES2211890T3 (es) 2004-07-16
PL310756A1 (en) 1996-04-15
CA2159546C (en) 2010-12-14
IL115493A0 (en) 1996-01-19
CN1130631A (zh) 1996-09-11
CN1050605C (zh) 2000-03-22
NO305365B1 (no) 1999-05-18
FI20002693A (fi) 2000-12-08
US5684014A (en) 1997-11-04
DZ1934A1 (fr) 2002-02-17
HN1995009160A (es) 2000-04-24
FI108791B (fi) 2002-03-28
HK1005139A1 (en) 1998-12-24
EP0705831A3 (de) 1997-01-22
US6479503B2 (en) 2002-11-12
US6858622B2 (en) 2005-02-22
FI954681A0 (fi) 1995-10-02
PL183154B1 (pl) 2002-05-31
US6265431B1 (en) 2001-07-24
FI113048B (fi) 2004-02-27
NO953930D0 (no) 1995-10-03
KR100355986B1 (ko) 2003-01-06
EP0705831B1 (de) 2003-12-03
IL129641A (en) 2000-08-31

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