EE03124B1 - Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamine - Google Patents
Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamineInfo
- Publication number
- EE03124B1 EE03124B1 EE9400336A EE9400336A EE03124B1 EE 03124 B1 EE03124 B1 EE 03124B1 EE 9400336 A EE9400336 A EE 9400336A EE 9400336 A EE9400336 A EE 9400336A EE 03124 B1 EE03124 B1 EE 03124B1
- Authority
- EE
- Estonia
- Prior art keywords
- deacetylbaccatin iii
- obtaining
- yew
- deacetylbaccatin
- iii
- Prior art date
Links
- YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 2
- 241001116500 Taxus Species 0.000 abstract 3
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000010956 selective crystallization Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epoxy Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Extraction Or Liquid Replacement (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9211745A FR2696462B1 (fr) | 1992-10-05 | 1992-10-05 | Procédé d'obtention de la désacétyl-10 baccatine III. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE03124B1 true EE03124B1 (et) | 1998-10-15 |
Family
ID=9434123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9400336A EE03124B1 (et) | 1992-10-05 | 1994-11-18 | Meetod 10-desatsetüülbakatiin III saamiseks ja 10-desatsetüülbakatiin III kasutamine |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US5393896A (pl) |
| EP (1) | EP0663909B1 (pl) |
| JP (1) | JP3299753B2 (pl) |
| KR (1) | KR100301238B1 (pl) |
| CN (1) | CN1041310C (pl) |
| AT (1) | ATE147381T1 (pl) |
| AU (1) | AU680440B2 (pl) |
| CA (2) | CA2146248C (pl) |
| CZ (2) | CZ286452B6 (pl) |
| DE (1) | DE69307333T2 (pl) |
| DK (1) | DK0663909T3 (pl) |
| EE (1) | EE03124B1 (pl) |
| ES (1) | ES2095672T3 (pl) |
| FI (1) | FI109797B (pl) |
| FR (1) | FR2696462B1 (pl) |
| GE (1) | GEP19981433B (pl) |
| GR (1) | GR3022229T3 (pl) |
| HU (1) | HU225969B1 (pl) |
| LT (1) | LT3465B (pl) |
| LV (1) | LV10620B (pl) |
| MX (1) | MX9305770A (pl) |
| NO (1) | NO310414B1 (pl) |
| NZ (1) | NZ256449A (pl) |
| PL (1) | PL173993B1 (pl) |
| RU (1) | RU2108330C1 (pl) |
| SK (1) | SK280335B6 (pl) |
| TW (1) | TW404944B (pl) |
| UA (1) | UA40601C2 (pl) |
| WO (1) | WO1994007881A1 (pl) |
| ZA (1) | ZA937312B (pl) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ268326A (en) | 1993-07-19 | 1997-12-19 | Angiogenesis Tech Inc | Stent with a coating comprising an anti-angiogenic compound, such as taxol, and a polymeric carrier |
| FR2714053B1 (fr) * | 1993-12-22 | 1996-03-08 | Pf Medicament | Procédé d'extraction et d'isolement de la 10-désacétylbaccatine III. |
| CN1112433A (zh) * | 1994-05-24 | 1995-11-29 | 郭明 | 红豆杉属植物提取物及其应用 |
| CA2178541C (en) | 1995-06-07 | 2009-11-24 | Neal E. Fearnot | Implantable medical device |
| FR2736355B1 (fr) * | 1995-07-07 | 1997-11-07 | Pf Medicament | Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii |
| US5965752A (en) * | 1996-08-23 | 1999-10-12 | Institut National De La Recherche Scientifique | Preparative scale isolation and purification of taxanes |
| DE69812395T2 (de) | 1997-08-21 | 2004-02-05 | Florida State University, Tallahassee | Verfahren zur synthese von taxanen |
| US6066748A (en) * | 1997-12-17 | 2000-05-23 | Han; Man Woo | Process of extracting TAXOL® from taxus cuspidata |
| CA2317728A1 (en) * | 1998-01-14 | 1999-07-22 | Bristol-Myers Squibb Company | Novel crystalline complexes of baccatin iii with imidazole, 2-methylimidazole or isopropanol |
| US6136989A (en) * | 1998-12-30 | 2000-10-24 | Phytogen Life Sciences, Incorporated | Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material |
| US5969165A (en) * | 1999-01-07 | 1999-10-19 | 508037 (Nb) Inc. | Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column |
| US6495705B2 (en) | 2000-03-16 | 2002-12-17 | Napro Biotherapeutics, Inc. | Efficient process for the production of 10-DAB III by selective hydrazinolysis of various taxanes |
| US6281368B1 (en) | 2000-03-16 | 2001-08-28 | Napro Biotherapeutics, Inc. | Simple and efficient hydrazinolysis of C-10 and C-13 ester functionalities of taxanes to obtain 10-DAB III |
| CA2307393A1 (en) | 2000-05-01 | 2001-11-01 | The University Of British Columbia | Ginsenoside chemotherapy |
| IT1320107B1 (it) * | 2000-11-28 | 2003-11-18 | Indena Spa | Procedimento per la preparazione di derivati tassanici. |
| CA2440935A1 (en) | 2001-03-13 | 2002-09-19 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
| US20030157170A1 (en) * | 2001-03-13 | 2003-08-21 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
| EP1392254B1 (en) * | 2001-04-20 | 2007-06-06 | The University of British Columbia | Micellar drug delivery systems for hydrophobic drugs |
| US7351542B2 (en) | 2002-05-20 | 2008-04-01 | The Regents Of The University Of California | Methods of modulating tubulin deacetylase activity |
| JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
| EP1594668A4 (en) * | 2002-12-31 | 2006-06-07 | Natural Pharmaceuticals Inc | PELLETIZATION OF EIBENBIOMASSE FOR THE EXTRACTION OF TAXANES AND OTHER NATURAL PRODUCTS |
| US20070172446A1 (en) | 2003-05-16 | 2007-07-26 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
| US8770459B2 (en) * | 2003-10-17 | 2014-07-08 | Covidien Lp | Surgical stapling device with independent tip rotation |
| US7407973B2 (en) | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| US20060127510A1 (en) * | 2003-12-30 | 2006-06-15 | Natural Pharmaceuticals, Inc. | Harvesting and pelletizing yew biomass for extraction of taxanes and other natural products |
| US8003122B2 (en) | 2004-03-31 | 2011-08-23 | Cordis Corporation | Device for local and/or regional delivery employing liquid formulations of therapeutic agents |
| US7846940B2 (en) | 2004-03-31 | 2010-12-07 | Cordis Corporation | Solution formulations of sirolimus and its analogs for CAD treatment |
| US7989490B2 (en) | 2004-06-02 | 2011-08-02 | Cordis Corporation | Injectable formulations of taxanes for cad treatment |
| US20050250954A1 (en) * | 2004-05-04 | 2005-11-10 | Phytogen Life Sciences Inc. | Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes |
| US20050240036A1 (en) * | 2004-04-23 | 2005-10-27 | Phytogen Life Sciences Inc. | Semi-synthesis of taxane intermediates from a mixture of taxanes |
| US20050272807A1 (en) * | 2004-06-04 | 2005-12-08 | Phytogen Life Sciences Inc. | Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel |
| ATE421959T1 (de) * | 2004-07-02 | 2009-02-15 | Ivax Pharmaceuticals Sro | Verfahren zur trennung von paclitaxel und cephalomannin |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| US20060188508A1 (en) | 2005-02-17 | 2006-08-24 | Cohen Stanley N | Methods and compositions for modulating angiogenesis |
| WO2007045093A1 (en) * | 2005-10-21 | 2007-04-26 | Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Natural Resources Canada, Canadian Forest Service | Preparation of taxanes |
| CA2646156C (en) | 2006-03-22 | 2016-05-24 | Medigene Ag | Treatment of triple receptor negative breast cancer |
| EP2380606B1 (en) | 2006-06-30 | 2018-03-21 | Cook Medical Technologies LLC | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
| CN100404520C (zh) * | 2006-08-15 | 2008-07-23 | 北京诺瑞医药技术有限公司 | 从欧洲红豆杉枝叶中提取分离10-去乙酰基巴卡汀ⅲ的方法 |
| CN101230053B (zh) * | 2007-12-04 | 2010-06-02 | 北京诺瑞医药技术有限公司 | 从红豆杉枝叶中超声提取分离10-去乙酰基巴卡汀ⅲ的方法 |
| US8420110B2 (en) | 2008-03-31 | 2013-04-16 | Cordis Corporation | Drug coated expandable devices |
| US8409601B2 (en) | 2008-03-31 | 2013-04-02 | Cordis Corporation | Rapamycin coated expandable devices |
| US8273404B2 (en) | 2008-05-19 | 2012-09-25 | Cordis Corporation | Extraction of solvents from drug containing polymer reservoirs |
| CA2724550C (en) | 2008-05-22 | 2017-01-03 | Kereos, Inc. | Combination antitumor therapy |
| WO2010005850A1 (en) | 2008-07-08 | 2010-01-14 | The J. David Gladstone Institutes | Methods and compositions for modulating angiogenesis |
| US8642063B2 (en) | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
| US20120303115A1 (en) | 2011-05-25 | 2012-11-29 | Dadino Ronald C | Expandable devices coated with a rapamycin composition |
| US20120302954A1 (en) | 2011-05-25 | 2012-11-29 | Zhao Jonathon Z | Expandable devices coated with a paclitaxel composition |
| PL2760848T3 (pl) | 2011-09-26 | 2019-07-31 | Fresenius Kabi Oncology Limited | Sposoby otrzymywania kabazytakselu powiązane z sililowaniem c(7)-oh i c(13)-oh lub z sililowaniem tylko c(7)-oh |
| US9956385B2 (en) | 2012-06-28 | 2018-05-01 | The Spectranetics Corporation | Post-processing of a medical device to control morphology and mechanical properties |
| JP6578206B2 (ja) | 2012-07-19 | 2019-09-18 | レッドウッド バイオサイエンス, インコーポレイテッド | Cd22に特異的な抗体およびその使用方法 |
| WO2014074218A1 (en) | 2012-11-12 | 2014-05-15 | Redwood Bioscience, Inc. | Compounds and methods for producing a conjugate |
| JP6450690B2 (ja) | 2013-02-15 | 2019-01-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | キメラ抗原受容体及びその使用方法 |
| KR20150135332A (ko) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 미토콘드리아 알데히드 탈수소효소-2 조절인자들 및 이들의 사용 방법 |
| CN103508984B (zh) * | 2013-10-22 | 2017-03-08 | 北京诺瑞医药技术有限公司 | 连续浸漉吸附富集法从红豆杉中提取10-dab的方法 |
| WO2015081282A1 (en) | 2013-11-27 | 2015-06-04 | Redwood Bioscience, Inc. | Hydrazinyl-pyrrolo compounds and methods for producing a conjugate |
| PL3107899T3 (pl) | 2014-02-19 | 2021-01-25 | Aviv Therapeutics, Inc. | Policykliczne amidy wiążące mitochondrialną dehydrogenazę aldehydową-2 (aldh2) i ich zastosowanie w leczeniu nowotworów |
| EP3352796B1 (en) | 2015-09-25 | 2025-03-05 | U.S. Tianyou Capital Corp | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
| WO2017083637A1 (en) | 2015-11-12 | 2017-05-18 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-penetrating, guanidinium-rich oligophosphotriesters for drug and probe delivery |
| HUP1500603A2 (en) * | 2015-12-11 | 2017-06-28 | Rotachrom Tech Kft | Process for the separation of 10-deacetyl baccatin iii |
| TWI760319B (zh) | 2015-12-30 | 2022-04-11 | 杏國新藥股份有限公司 | 乳癌治療 |
| CA3019398A1 (en) | 2016-04-26 | 2017-11-02 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| HUE057856T2 (hu) | 2016-06-01 | 2022-06-28 | Servier Ip Uk Ltd | Polialkilén-oxid-aszparagináz készítményei és eljárás ezek elõállítására és alkalmazására |
| CN106397371A (zh) * | 2016-08-31 | 2017-02-15 | 重庆市碚圣医药科技股份有限公司 | 一种用曼地亚红豆杉高产10‑dabⅲ的方法 |
| TWI852903B (zh) | 2017-01-05 | 2024-08-21 | 杏國新藥股份有限公司 | 胰臟癌治療 |
| US12187801B2 (en) | 2017-01-18 | 2025-01-07 | Exuma Biotech Corp. | Chimeric antigen receptors against AXL or ROR2 and methods of use thereof |
| EP3388082A1 (en) | 2017-04-13 | 2018-10-17 | Galera Labs, LLC | Combination cancer immunotherapy with pentaaza macrocyclic ring complex |
| CN111065623B9 (zh) | 2017-05-24 | 2024-10-25 | 德克萨斯州大学系统董事会 | 用于抗体药物缀合物的接头 |
| US20210338686A1 (en) | 2018-01-31 | 2021-11-04 | Galera Labs, Llc | Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent |
| US12144826B2 (en) | 2018-04-06 | 2024-11-19 | The Regents Of The University Of California | Methods of treating EGFRvIII expressing glioblastomas |
| WO2019195596A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating glioblastomas |
| AU2019252676A1 (en) | 2018-04-11 | 2020-11-26 | Ohio State Innovation Foundation | Methods and compositions for sustained release microparticles for ocular drug delivery |
| EP3823674A4 (en) | 2018-07-18 | 2022-12-28 | Manzanita Pharmaceuticals, Inc. | CONJUGATES FOR DELIVERING AN ANTI-CANCER AGENT TO NERVE CELLS, METHODS OF USE AND METHODS OF PRODUCTION THEREOF |
| WO2020148612A1 (en) | 2019-01-14 | 2020-07-23 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
| CA3129883A1 (en) | 2019-02-14 | 2020-08-20 | Ignite Immunotherapy, Inc. | Recombinant vaccinia virus and methods of use thereof |
| EP3946626A1 (en) | 2019-04-02 | 2022-02-09 | Kenjockety Biotechnology, Inc. | Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
| AU2020402303A1 (en) | 2019-12-12 | 2022-06-09 | Ignite Immunotherapy, Inc. | Variant oncolytic vaccinia virus and methods of use thereof |
| AU2021214370A1 (en) | 2020-01-29 | 2022-08-18 | William Robert ARATHOON | Anti-MDR1 antibodies and uses thereof |
| CA3182969A1 (en) | 2020-06-04 | 2021-12-09 | Kenjockety Biotechnology, Inc. | Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
| US20230212305A1 (en) | 2020-06-04 | 2023-07-06 | Kenjockety Biotechnology, Inc. | Anti-abcg2 antibodies and uses thereof |
| BR112023000650A2 (pt) | 2020-07-14 | 2023-01-31 | Pfizer | Vírus vaccinia recombinante |
| CA3193588A1 (en) | 2020-09-02 | 2022-03-10 | Kenjockety Biotechnology, Inc. | Anti-abcc1 antibodies and uses thereof |
| CA3203652A1 (en) | 2020-11-13 | 2022-05-19 | William Robert ARATHOON | Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof |
| MX2023005979A (es) | 2020-11-20 | 2023-08-11 | Scherer Technologies Llc R P | Enlazadores de escisión doble de glicósido para conjugados de anticuerpo y fármaco. |
| CN112694458A (zh) * | 2020-12-29 | 2021-04-23 | 重庆臻源红豆杉发展有限公司 | 一种10-去乙酰基巴卡亭ⅲ提取纯化方法 |
| EP4448007A1 (en) | 2021-12-13 | 2024-10-23 | William Robert Arathoon Living Trust Dated August 29, 2016 | Anti-abcb1 antibodies |
| WO2023159220A1 (en) | 2022-02-18 | 2023-08-24 | Kenjockety Biotechnology, Inc. | Anti-cd47 antibodies |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2601676B1 (fr) | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
| FR2629818B1 (fr) * | 1988-04-06 | 1990-11-16 | Centre Nat Rech Scient | Procede de preparation du taxol |
| FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
| US5019504A (en) * | 1989-03-23 | 1991-05-28 | The United States Of America As Represented By The Secretary Of Agriculture | Production of taxol or taxol-like compounds in cell culture |
| US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
| US5380916A (en) | 1990-11-02 | 1995-01-10 | University Of Florida | Method for the isolation and purification of taxane derivatives |
| MX9102128A (es) | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US5279953A (en) * | 1992-06-24 | 1994-01-18 | Esca Genetics Corporation | In vivo production of taxanes |
| FR2696463B1 (fr) * | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
| FR2703049B1 (fr) * | 1993-03-22 | 1995-04-21 | Rhone Poulenc Rorer Sa | Procédé de purification des taxoïdes. |
-
1992
- 1992-10-05 FR FR9211745A patent/FR2696462B1/fr not_active Expired - Lifetime
-
1993
- 1993-01-27 US US08/010,084 patent/US5393896A/en not_active Expired - Lifetime
- 1993-04-21 CN CN93104617A patent/CN1041310C/zh not_active Expired - Lifetime
- 1993-09-21 MX MX9305770A patent/MX9305770A/es unknown
- 1993-10-01 ZA ZA937312A patent/ZA937312B/xx unknown
- 1993-10-02 TW TW082108097A patent/TW404944B/zh not_active IP Right Cessation
- 1993-10-04 PL PL93308243A patent/PL173993B1/pl unknown
- 1993-10-04 KR KR1019950701305A patent/KR100301238B1/ko not_active Expired - Lifetime
- 1993-10-04 CA CA002146248A patent/CA2146248C/fr not_active Expired - Lifetime
- 1993-10-04 AU AU51154/93A patent/AU680440B2/en not_active Expired
- 1993-10-04 WO PCT/FR1993/000971 patent/WO1994007881A1/fr not_active Ceased
- 1993-10-04 DE DE69307333T patent/DE69307333T2/de not_active Expired - Lifetime
- 1993-10-04 SK SK431-95A patent/SK280335B6/sk not_active IP Right Cessation
- 1993-10-04 CA CA002470124A patent/CA2470124C/fr not_active Expired - Lifetime
- 1993-10-04 UA UA95038243A patent/UA40601C2/uk unknown
- 1993-10-04 NZ NZ256449A patent/NZ256449A/en not_active IP Right Cessation
- 1993-10-04 LT LTIP1398A patent/LT3465B/lt not_active IP Right Cessation
- 1993-10-04 HU HU9500969A patent/HU225969B1/hu unknown
- 1993-10-04 AT AT93921986T patent/ATE147381T1/de active
- 1993-10-04 DK DK93921986.1T patent/DK0663909T3/da active
- 1993-10-04 EP EP93921986A patent/EP0663909B1/fr not_active Expired - Lifetime
- 1993-10-04 JP JP50879194A patent/JP3299753B2/ja not_active Expired - Lifetime
- 1993-10-04 LV LVP-93-1119A patent/LV10620B/xx unknown
- 1993-10-04 ES ES93921986T patent/ES2095672T3/es not_active Expired - Lifetime
- 1993-10-04 CZ CZ1995844A patent/CZ286452B6/cs not_active IP Right Cessation
- 1993-10-04 GE GEAP19932496A patent/GEP19981433B/en unknown
- 1993-10-04 RU RU95110662/04A patent/RU2108330C1/ru active
-
1994
- 1994-11-18 EE EE9400336A patent/EE03124B1/xx unknown
-
1995
- 1995-04-03 NO NO19951281A patent/NO310414B1/no not_active IP Right Cessation
- 1995-04-04 FI FI951590A patent/FI109797B/fi not_active IP Right Cessation
- 1995-06-07 US US08/481,208 patent/US5736366A/en not_active Expired - Lifetime
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1997
- 1997-01-09 GR GR960402652T patent/GR3022229T3/el unknown
- 1997-12-15 CZ CZ19974038A patent/CZ286593B6/cs not_active IP Right Cessation
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