EE02950B1 - Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon - Google Patents
Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioonInfo
- Publication number
- EE02950B1 EE02950B1 EE9400299A EE9400299A EE02950B1 EE 02950 B1 EE02950 B1 EE 02950B1 EE 9400299 A EE9400299 A EE 9400299A EE 9400299 A EE9400299 A EE 9400299A EE 02950 B1 EE02950 B1 EE 02950B1
- Authority
- EE
- Estonia
- Prior art keywords
- pct
- groups
- group
- independently
- formula
- Prior art date
Links
- MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical compound OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- -1 methylenebisphosphonic acid ester amide Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/44—Amides thereof
- C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4423—Amides of poly (thio)phosphonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Paints Or Removers (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI906296A FI89365C (fi) | 1990-12-20 | 1990-12-20 | Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE02950B1 true EE02950B1 (et) | 1996-12-16 |
Family
ID=8531621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9400299A EE02950B1 (et) | 1990-12-20 | 1994-11-14 | Metüleenbisfosfoonhappe esteramiidderivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5442101A (cs) |
| EP (1) | EP0570380B1 (cs) |
| JP (1) | JPH06504770A (cs) |
| KR (1) | KR930703336A (cs) |
| CN (1) | CN1028866C (cs) |
| AT (1) | ATE171182T1 (cs) |
| AU (1) | AU663268B2 (cs) |
| CA (1) | CA2098734A1 (cs) |
| CZ (1) | CZ119593A3 (cs) |
| DE (1) | DE69130231T2 (cs) |
| DK (1) | DK0570380T3 (cs) |
| EE (1) | EE02950B1 (cs) |
| ES (1) | ES2121003T3 (cs) |
| FI (1) | FI89365C (cs) |
| HU (1) | HUT64547A (cs) |
| IE (1) | IE914390A1 (cs) |
| IL (1) | IL100336A (cs) |
| NO (1) | NO303121B1 (cs) |
| NZ (1) | NZ241039A (cs) |
| PL (1) | PL169728B1 (cs) |
| RU (1) | RU2100364C1 (cs) |
| SK (1) | SK63093A3 (cs) |
| TW (1) | TW203053B (cs) |
| WO (1) | WO1992011268A1 (cs) |
| ZA (1) | ZA9110007B (cs) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1469003A3 (en) * | 1996-10-09 | 2004-11-24 | Pharmasset, Ltd. | Tetraphosphonate bicyclic trisanhydrides |
| EP0934325B1 (en) | 1996-10-09 | 2004-07-14 | Pharmasset, Ltd. | Mycophenolic bisphosphonate compounds |
| US20040181078A1 (en) * | 1997-10-10 | 2004-09-16 | Pharmasset, Ltd. | Tetraphosphonate bicyclic trisanhydrides |
| FI104901B (fi) * | 1997-10-20 | 2000-04-28 | Leiras Oy | Uudet metyleenibisfosfonihappojohdannaiset |
| US5998390A (en) * | 1998-09-28 | 1999-12-07 | The Research Foundation Of State University Of New York | Combination of bisphosphonate and tetracycline |
| RU2213959C2 (ru) * | 2001-01-15 | 2003-10-10 | Войсковая часть 61469 МО РФ | Способ количественного определения о-алкиловых эфиров метилфосфоновой кислоты в водных матрицах методом реакционной газовой хроматографии с атомно-эмиссионным детектированием |
| WO2005090370A1 (en) | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| US8642577B2 (en) | 2005-04-08 | 2014-02-04 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| US20070003608A1 (en) * | 2005-04-08 | 2007-01-04 | Almond Merrick R | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| US7862552B2 (en) | 2005-05-09 | 2011-01-04 | Boston Scientific Scimed, Inc. | Medical devices for treating urological and uterine conditions |
| US8993542B2 (en) * | 2008-01-25 | 2015-03-31 | Chimerix Inc. | Methods of treating viral infections |
| WO2011011519A1 (en) | 2009-07-21 | 2011-01-27 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| JP2013501056A (ja) | 2009-08-03 | 2013-01-10 | キメリクス，インコーポレイテッド | ウイルス感染およびウイルス誘発腫瘍を治療する組成物および方法 |
| AU2011216243B2 (en) | 2010-02-12 | 2015-07-09 | Chimerix, Inc. | Nucleoside phosphonate salts |
| CN102190684A (zh) * | 2010-03-15 | 2011-09-21 | 南通波锐生物医药有限公司 | 一种具有药物应用的含磷化合物及其制备和用途 |
| EP2563367A4 (en) | 2010-04-26 | 2013-12-04 | Chimerix Inc | Methods of treating retroviral infections and related dosage regimes |
| CN102453050B (zh) | 2010-11-03 | 2015-01-07 | 成都云克药业有限责任公司 | 一种二膦酸化合物及其制备方法 |
| EP3984540A3 (en) * | 2016-06-28 | 2022-07-06 | Aequor, Inc. | Antimicrobial compounds and methods of use |
| RU2630226C1 (ru) * | 2016-12-20 | 2017-09-06 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный университет" | Новая ионная жидкость производная бис-(N,N-диметиламида) метилфосфоновой кислоты с высокими термическими свойствами |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4293505A (en) * | 1967-04-06 | 1981-10-06 | Randall David I | Preparation of β-haloethylphosphonic acids and half esters thereof |
| US3524846A (en) * | 1967-06-02 | 1970-08-18 | Syntex Corp | Process for the didealkylation of phosphonate esters |
| US3808265A (en) * | 1971-03-26 | 1974-04-30 | Gaf Corp | Preparation of 2-haloethylphosphonic acid |
| IT1187828B (it) * | 1985-05-24 | 1987-12-23 | Gentili Ist Spa | Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi |
| US5212164A (en) * | 1988-08-29 | 1993-05-18 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors |
| EP0356866A3 (en) * | 1988-08-29 | 1991-03-27 | E.R. SQUIBB & SONS, INC. | Phosphorus-containing squalene synthetase inhibitors and method |
| US5273969A (en) * | 1988-08-29 | 1993-12-28 | E. R. Squibb & Sons, Inc. | Phosphorus-containing squalene synthetase inhibitors and method |
| FI89366C (fi) * | 1990-12-20 | 1993-09-27 | Leiras Oy | Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
-
1990
- 1990-12-20 FI FI906296A patent/FI89365C/fi not_active IP Right Cessation
-
1991
- 1991-12-11 IL IL10033691A patent/IL100336A/en not_active IP Right Cessation
- 1991-12-17 IE IE439091A patent/IE914390A1/en not_active Application Discontinuation
- 1991-12-18 CZ CS931195A patent/CZ119593A3/cs unknown
- 1991-12-18 DE DE69130231T patent/DE69130231T2/de not_active Expired - Fee Related
- 1991-12-18 RU RU9393050805A patent/RU2100364C1/ru active
- 1991-12-18 ES ES92901217T patent/ES2121003T3/es not_active Expired - Lifetime
- 1991-12-18 KR KR1019930701879A patent/KR930703336A/ko not_active Abandoned
- 1991-12-18 WO PCT/FI1991/000396 patent/WO1992011268A1/en not_active Application Discontinuation
- 1991-12-18 SK SK630-93A patent/SK63093A3/sk unknown
- 1991-12-18 NZ NZ241039A patent/NZ241039A/en unknown
- 1991-12-18 PL PL91299980A patent/PL169728B1/pl unknown
- 1991-12-18 AT AT92901217T patent/ATE171182T1/de not_active IP Right Cessation
- 1991-12-18 HU HU9301780A patent/HUT64547A/hu unknown
- 1991-12-18 AU AU90800/91A patent/AU663268B2/en not_active Ceased
- 1991-12-18 EP EP92901217A patent/EP0570380B1/en not_active Expired - Lifetime
- 1991-12-18 US US08/078,155 patent/US5442101A/en not_active Expired - Fee Related
- 1991-12-18 JP JP4502098A patent/JPH06504770A/ja active Pending
- 1991-12-18 DK DK92901217T patent/DK0570380T3/da active
- 1991-12-18 CA CA002098734A patent/CA2098734A1/en not_active Abandoned
- 1991-12-19 ZA ZA9110007A patent/ZA9110007B/xx unknown
- 1991-12-20 CN CN91111881A patent/CN1028866C/zh not_active Expired - Fee Related
- 1991-12-31 TW TW081100320A patent/TW203053B/zh active
-
1993
- 1993-06-18 NO NO932256A patent/NO303121B1/no unknown
-
1994
- 1994-11-14 EE EE9400299A patent/EE02950B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NZ241039A (en) | 1993-05-26 |
| CN1062533A (zh) | 1992-07-08 |
| ATE171182T1 (de) | 1998-10-15 |
| AU9080091A (en) | 1992-07-22 |
| HUT64547A (en) | 1994-01-28 |
| ZA9110007B (en) | 1992-09-30 |
| ES2121003T3 (es) | 1998-11-16 |
| WO1992011268A1 (en) | 1992-07-09 |
| SK63093A3 (en) | 1993-12-08 |
| NO932256D0 (no) | 1993-06-18 |
| CZ119593A3 (en) | 1994-02-16 |
| KR930703336A (ko) | 1993-11-29 |
| DK0570380T3 (da) | 1999-02-08 |
| FI89365C (fi) | 1993-09-27 |
| EP0570380B1 (en) | 1998-09-16 |
| IE914390A1 (en) | 1992-07-01 |
| CN1028866C (zh) | 1995-06-14 |
| EP0570380A1 (en) | 1993-11-24 |
| FI89365B (fi) | 1993-06-15 |
| TW203053B (cs) | 1993-04-01 |
| DE69130231T2 (de) | 1999-03-25 |
| RU2100364C1 (ru) | 1997-12-27 |
| FI906296A7 (fi) | 1992-06-21 |
| US5442101A (en) | 1995-08-15 |
| FI906296A0 (fi) | 1990-12-20 |
| NO303121B1 (no) | 1998-06-02 |
| CA2098734A1 (en) | 1992-06-21 |
| DE69130231D1 (de) | 1998-10-22 |
| IL100336A (en) | 1998-07-15 |
| HU9301780D0 (en) | 1993-09-28 |
| PL169728B1 (pl) | 1996-08-30 |
| IL100336A0 (en) | 1992-09-06 |
| JPH06504770A (ja) | 1994-06-02 |
| NO932256L (no) | 1993-08-20 |
| AU663268B2 (en) | 1995-09-28 |
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