EE02949B1 - Metüleenbisfosfoonhappe derivaadid, meetod nende valmistamiseks ja farmatsutiline kompositsioon - Google Patents

Metüleenbisfosfoonhappe derivaadid, meetod nende valmistamiseks ja farmatsutiline kompositsioon

Info

Publication number
EE02949B1
EE02949B1 EE9400298A EE9400298A EE02949B1 EE 02949 B1 EE02949 B1 EE 02949B1 EE 9400298 A EE9400298 A EE 9400298A EE 9400298 A EE9400298 A EE 9400298A EE 02949 B1 EE02949 B1 EE 02949B1
Authority
EE
Estonia
Prior art keywords
opt
preparation
pharmaceutical composition
acid derivatives
alkyl
Prior art date
Application number
EE9400298A
Other languages
English (en)
Estonian (et)
Inventor
Pohjala Esko
Heikkil�-Hoikka Marjaana
Nikander Hannu
Hanhij�rvi Hannu
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of EE02949B1 publication Critical patent/EE02949B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Detergent Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Luminescent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
EE9400298A 1990-12-20 1994-11-14 Metüleenbisfosfoonhappe derivaadid, meetod nende valmistamiseks ja farmatsutiline kompositsioon EE02949B1 (et)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI906295A FI89366C (fi) 1990-12-20 1990-12-20 Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Publications (1)

Publication Number Publication Date
EE02949B1 true EE02949B1 (et) 1996-12-16

Family

ID=8531620

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400298A EE02949B1 (et) 1990-12-20 1994-11-14 Metüleenbisfosfoonhappe derivaadid, meetod nende valmistamiseks ja farmatsutiline kompositsioon

Country Status (25)

Country Link
US (1) US5393748A (xx)
EP (1) EP0563107B1 (xx)
JP (1) JP3224817B2 (xx)
KR (1) KR100220157B1 (xx)
CN (1) CN1030253C (xx)
AT (1) ATE192452T1 (xx)
AU (1) AU664541B2 (xx)
CA (1) CA2098735C (xx)
CZ (1) CZ288084B6 (xx)
DE (1) DE69132164T2 (xx)
DK (1) DK0563107T3 (xx)
EE (1) EE02949B1 (xx)
ES (1) ES2147726T3 (xx)
FI (1) FI89366C (xx)
HU (1) HUT64549A (xx)
IE (1) IE914389A1 (xx)
IL (1) IL100337A (xx)
NO (1) NO302074B1 (xx)
NZ (1) NZ241040A (xx)
PL (1) PL169796B1 (xx)
RU (1) RU2086556C1 (xx)
SK (1) SK279601B6 (xx)
TW (1) TW201752B (xx)
WO (1) WO1992011269A1 (xx)
ZA (1) ZA9110008B (xx)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI89365C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
US5157027A (en) * 1991-05-13 1992-10-20 E. R. Squibb & Sons, Inc. Bisphosphonate squalene synthetase inhibitors and method
SK279589B6 (sk) * 1991-11-22 1999-01-11 Procter And Gamble Pharmaceuticals Farmaceutický prípravok s retardovaným uvoľňovaním
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US6444656B1 (en) 1992-12-23 2002-09-03 Biochem Pharma, Inc. Antiviral phosphonate nucleotides
US6005107A (en) 1992-12-23 1999-12-21 Biochem Pharma, Inc. Antiviral compounds
GB9226879D0 (en) * 1992-12-23 1993-02-17 Iaf Biochem Int Anti-viral compounds
US20010007863A1 (en) 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
DE4435496A1 (de) * 1994-10-04 1996-04-11 Hoechst Ag Imidobisphosphorsäuren, Verfahren zu ihrer Herstellung und Verwendung derselben
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
AU761267C (en) 1998-09-09 2007-08-09 Metabasis Therapeutics, Inc. Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
SE9903345D0 (sv) 1999-09-17 1999-09-17 Astra Pharma Prod Novel process
US7563774B2 (en) 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US20040014726A1 (en) * 2000-10-27 2004-01-22 Thua Osterman Method for the preparation of a pharmaceutical composition, and its use
FR2837490B1 (fr) * 2002-03-21 2009-04-17 Univ Paris 13 Nouveaux derives de bisphosphonates, leurs preparations et utilisations
US20030036537A1 (en) * 2001-07-16 2003-02-20 Marc Lecouvey Bisphosphonate derivatives, their preparations and uses
ATE455121T1 (de) * 2001-07-16 2010-01-15 Univ Paris 13 Herstellungsverfahren von derivate von bisphosphonaten
EP1482897A2 (en) * 2002-02-19 2004-12-08 Ilex Products, Inc. Aminodiphosphonate apolipoprotein e modulators
US7862552B2 (en) * 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
EP2310398A2 (en) * 2008-07-11 2011-04-20 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
CN102630227B (zh) * 2009-10-26 2016-03-23 沃纳奇尔科特有限责任公司 用于治疗骨代谢紊乱的双膦酸盐化合物
TWI730039B (zh) * 2016-01-29 2021-06-11 日商富士藥品股份有限公司 新穎雙膦酸化合物
CN108218918A (zh) * 2018-03-01 2018-06-29 四川大学 芳基偕二磷酸衍生物制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3303139A (en) * 1962-01-27 1967-02-07 Henkel & Cie Gmbh Aminophosphonic acids and their derivatives as complex formers for metal ions
DE1617118C3 (de) * 1966-08-26 1975-04-03 Henkel & Cie Gmbh, 4000 Duesseldorf Verfahren zur Reinigung von etikettierten starren Gegenständen
US3957858A (en) * 1970-04-13 1976-05-18 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US3962318A (en) * 1970-04-13 1976-06-08 Monsanto Company Substituted ethane diphosphonic acids and salts and esters thereof
US4447256A (en) * 1977-07-20 1984-05-08 Nissan Chemical Industries, Ltd. N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
GB8530603D0 (en) * 1985-12-12 1986-01-22 Leo Pharm Prod Ltd Chemical compounds
HU199151B (en) * 1987-03-10 1990-01-29 Yamanouchi Pharma Co Ltd Process for producing bis-phosphonic acid derivatives
EP0356866A3 (en) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphorus-containing squalene synthetase inhibitors and method

Also Published As

Publication number Publication date
JPH06504769A (ja) 1994-06-02
CN1030253C (zh) 1995-11-15
HU9301781D0 (en) 1993-09-28
NO302074B1 (no) 1998-01-19
ZA9110008B (en) 1992-09-30
NO932255L (no) 1993-08-20
DE69132164T2 (de) 2001-01-11
KR100220157B1 (ko) 1999-10-01
IL100337A (en) 2000-12-06
FI906295A0 (fi) 1990-12-20
EP0563107A1 (en) 1993-10-06
AU9068291A (en) 1992-07-22
IL100337A0 (en) 1992-09-06
DE69132164D1 (de) 2000-06-08
FI906295A (fi) 1992-06-21
ATE192452T1 (de) 2000-05-15
JP3224817B2 (ja) 2001-11-05
FI89366C (fi) 1993-09-27
FI89366B (fi) 1993-06-15
HUT64549A (en) 1994-01-28
CZ121793A3 (en) 1994-10-19
US5393748A (en) 1995-02-28
KR930703335A (ko) 1993-11-29
EP0563107B1 (en) 2000-05-03
ES2147726T3 (es) 2000-10-01
CZ288084B6 (cs) 2001-04-11
PL169796B1 (pl) 1996-08-30
WO1992011269A1 (en) 1992-07-09
SK279601B6 (sk) 1999-01-11
CA2098735A1 (en) 1992-06-21
DK0563107T3 (da) 2000-09-25
NZ241040A (en) 1994-07-26
CA2098735C (en) 2002-03-05
NO932255D0 (no) 1993-06-18
CN1062534A (zh) 1992-07-08
AU664541B2 (en) 1995-11-23
SK63493A3 (en) 1994-09-07
TW201752B (xx) 1993-03-11
IE914389A1 (en) 1992-07-01
RU2086556C1 (ru) 1997-08-10

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20021231

KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

MM4A Lapsed by not paying the annual fees

Effective date: 20041114