ECSP17038999A - 4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139 - Google Patents

4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139

Info

Publication number
ECSP17038999A
ECSP17038999A ECIEPI201738999A ECPI201738999A ECSP17038999A EC SP17038999 A ECSP17038999 A EC SP17038999A EC IEPI201738999 A ECIEPI201738999 A EC IEPI201738999A EC PI201738999 A ECPI201738999 A EC PI201738999A EC SP17038999 A ECSP17038999 A EC SP17038999A
Authority
EC
Ecuador
Prior art keywords
gpr139
benzotriazines
modulators
dihydro
oxo
Prior art date
Application number
ECIEPI201738999A
Other languages
English (en)
Spanish (es)
Inventor
Holly Reichard
Stephen Hitchcock
Betty Lam
Holger Monenschein
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of ECSP17038999A publication Critical patent/ECSP17038999A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ECIEPI201738999A 2014-11-20 2017-06-20 4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139 ECSP17038999A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462082539P 2014-11-20 2014-11-20
US201562184729P 2015-06-25 2015-06-25

Publications (1)

Publication Number Publication Date
ECSP17038999A true ECSP17038999A (es) 2017-10-31

Family

ID=55022667

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201738999A ECSP17038999A (es) 2014-11-20 2017-06-20 4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139

Country Status (40)

Country Link
US (5) US9556130B2 (enrdf_load_stackoverflow)
EP (2) EP3536324B1 (enrdf_load_stackoverflow)
JP (2) JP6637501B2 (enrdf_load_stackoverflow)
KR (1) KR102582021B1 (enrdf_load_stackoverflow)
CN (2) CN112062730B (enrdf_load_stackoverflow)
AU (1) AU2015349866B2 (enrdf_load_stackoverflow)
CA (1) CA2968242C (enrdf_load_stackoverflow)
CL (1) CL2017001292A1 (enrdf_load_stackoverflow)
CO (1) CO2017005959A2 (enrdf_load_stackoverflow)
CR (1) CR20170275A (enrdf_load_stackoverflow)
CY (2) CY1122613T1 (enrdf_load_stackoverflow)
DK (2) DK3536324T3 (enrdf_load_stackoverflow)
DO (1) DOP2017000120A (enrdf_load_stackoverflow)
EA (1) EA033728B1 (enrdf_load_stackoverflow)
EC (1) ECSP17038999A (enrdf_load_stackoverflow)
ES (2) ES2897545T3 (enrdf_load_stackoverflow)
GE (1) GEP20196961B (enrdf_load_stackoverflow)
HR (2) HRP20191003T1 (enrdf_load_stackoverflow)
HU (2) HUE057451T2 (enrdf_load_stackoverflow)
IL (1) IL252311B (enrdf_load_stackoverflow)
JO (1) JO3719B1 (enrdf_load_stackoverflow)
LT (2) LT3221298T (enrdf_load_stackoverflow)
MA (1) MA40993B1 (enrdf_load_stackoverflow)
MD (1) MD3221298T2 (enrdf_load_stackoverflow)
MX (1) MX378158B (enrdf_load_stackoverflow)
MY (1) MY187423A (enrdf_load_stackoverflow)
NZ (1) NZ732208A (enrdf_load_stackoverflow)
PE (1) PE20170899A1 (enrdf_load_stackoverflow)
PH (1) PH12017500920A1 (enrdf_load_stackoverflow)
PL (2) PL3536324T3 (enrdf_load_stackoverflow)
PT (2) PT3221298T (enrdf_load_stackoverflow)
RS (2) RS59078B1 (enrdf_load_stackoverflow)
SG (1) SG11201704002UA (enrdf_load_stackoverflow)
SI (2) SI3221298T1 (enrdf_load_stackoverflow)
SM (2) SMT202200142T1 (enrdf_load_stackoverflow)
TN (1) TN2017000196A1 (enrdf_load_stackoverflow)
TW (1) TWI684590B (enrdf_load_stackoverflow)
UA (1) UA120375C2 (enrdf_load_stackoverflow)
UY (1) UY36406A (enrdf_load_stackoverflow)
WO (1) WO2016081736A1 (enrdf_load_stackoverflow)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3719B1 (ar) * 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139
CA3121108A1 (en) 2018-10-16 2020-04-23 The Scripps Research Institute Methods related to opioid therapeutics
WO2020097609A1 (en) 2018-11-09 2020-05-14 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
EP4031552B1 (en) * 2019-09-16 2024-11-06 Takeda Pharmaceutical Company Limited Azole-fused pyridazin-3(2h)-one derivatives
WO2021127459A1 (en) * 2019-12-20 2021-06-24 Blackthorn Therapeutics, Inc. Gpr139 receptor modulators
WO2021224680A1 (en) * 2020-05-08 2021-11-11 Takeda Pharmaceutical Company Limited Substituted benzotriazinone metabolites of a gpr139 agonist
US20230310441A1 (en) * 2020-09-21 2023-10-05 Takeda Pharmaceutical Company Treatment for schizophrenia
US11760788B2 (en) 2021-03-02 2023-09-19 Pathways Neuro Pharma, Inc. Neuroreceptor compositions and methods of use
CN116693545A (zh) * 2022-03-01 2023-09-05 上海科技大学 噻吩并含氮杂环类化合物、含其的药物组合物、其制备方法及其应用
CN116693536A (zh) * 2022-03-01 2023-09-05 上海科技大学 吡咯并三嗪酮类化合物、含其的药物组合物、其制备方法及其应用
CN117986183A (zh) * 2022-10-28 2024-05-07 浙江友宁生物医药科技有限公司 一种gpr139受体激动剂、其制备方法及其应用
WO2024102802A1 (en) * 2022-11-11 2024-05-16 Takeda Pharmaceutical Company Limited Zelatriazin for the treatment of depression

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794726A (en) * 1972-08-21 1974-02-26 Uniroyal Inc Inhibiting aggressive behavior with 1,2,3-benzotriazin-(3h)-one
WO1987004928A1 (en) 1986-02-24 1987-08-27 Mitsui Petrochemical Industries, Ltd. Agents for treating neurophathy
EP0315390B1 (en) * 1987-11-04 1994-07-20 Beecham Group Plc Novel 4-oxobenzotriazines and 4-oxoquinazolines
PE20050630A1 (es) 2003-06-09 2005-09-22 Boehringer Ingelheim Int Compuestos heterociclicos como inhibidores del papiloma virus
US7253164B2 (en) 2003-07-31 2007-08-07 Irm Llc Bicyclic compounds and compositions as PDF inhibitors
FR2875805B1 (fr) 2004-09-27 2006-12-29 Genfit S A Composes derives de n-(benzyl) phenylacetamide substitues, preparation et utilisations
AR058705A1 (es) 2005-12-23 2008-02-20 Astrazeneca Ab Compuestos de bencimidazol como inhibidores del receptor vaniloide 1 (vr1)
TWI433839B (zh) 2006-08-11 2014-04-11 Neomed Inst 新穎的苯并咪唑衍生物290
CA2680775A1 (en) * 2007-03-23 2008-10-02 F. Hoffmann-La Roche Ag Aza-pyridopyrimidinone derivatives
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2011138265A2 (en) 2010-05-03 2011-11-10 Evotec Ag Indole and indazole derivatives as orexin receptor antagonists
WO2014152917A2 (en) * 2013-03-14 2014-09-25 Janssen Pharmaceutica Nv Physiological ligands for gpr139
JO3719B1 (ar) * 2014-11-20 2021-01-31 Takeda Pharmaceuticals Co 4- أوكسو-4،3- داي هيدرو-3،2،1- بنزوترايازينات كمواد ضابطة لأجل gpr139

Also Published As

Publication number Publication date
US20160145218A1 (en) 2016-05-26
PT3221298T (pt) 2019-06-28
US10561662B2 (en) 2020-02-18
IL252311A0 (en) 2017-07-31
CY1122613T1 (el) 2021-05-05
ES2734735T3 (es) 2019-12-11
HUE057451T2 (hu) 2022-05-28
JP6918088B2 (ja) 2021-08-11
IL252311B (en) 2020-07-30
US20170095480A1 (en) 2017-04-06
HUE044145T2 (hu) 2019-09-30
SI3221298T1 (sl) 2019-10-30
JP6637501B2 (ja) 2020-01-29
US9556130B2 (en) 2017-01-31
US10159677B2 (en) 2018-12-25
EA033728B1 (ru) 2019-11-20
EP3221298B1 (en) 2019-04-03
CR20170275A (es) 2017-10-30
KR102582021B1 (ko) 2023-09-22
SI3536324T1 (sl) 2021-12-31
SG11201704002UA (en) 2017-06-29
US20170348319A1 (en) 2017-12-07
RS62563B1 (sr) 2021-12-31
DOP2017000120A (es) 2017-06-15
MX2017006448A (es) 2017-09-12
JP2017535559A (ja) 2017-11-30
DK3536324T3 (da) 2021-10-25
TWI684590B (zh) 2020-02-11
US20200129518A1 (en) 2020-04-30
CO2017005959A2 (es) 2017-10-20
EP3536324B1 (en) 2021-10-06
KR20170084324A (ko) 2017-07-19
RS59078B1 (sr) 2019-09-30
HRP20191003T1 (hr) 2019-08-23
DK3221298T3 (da) 2019-06-24
JP2020063285A (ja) 2020-04-23
CN107108531B (zh) 2020-10-20
SMT201900355T1 (it) 2019-07-11
UY36406A (es) 2016-06-30
LT3221298T (lt) 2019-08-12
CA2968242A1 (en) 2016-05-26
US20190070187A1 (en) 2019-03-07
AU2015349866A1 (en) 2017-06-15
LT3536324T (lt) 2021-12-10
AU2015349866B2 (en) 2020-12-03
NZ732208A (en) 2023-02-24
PT3536324T (pt) 2021-11-10
MX378158B (es) 2025-03-10
CN107108531A (zh) 2017-08-29
BR112017010311A2 (pt) 2017-12-26
PL3221298T3 (pl) 2019-10-31
MA40993B1 (fr) 2019-07-31
EP3221298A1 (en) 2017-09-27
CN112062730B (zh) 2023-09-29
MY187423A (en) 2021-09-22
PL3536324T3 (pl) 2022-02-07
EA201791096A1 (ru) 2017-11-30
GEP20196961B (en) 2019-03-25
UA120375C2 (uk) 2019-11-25
ES2897545T3 (es) 2022-03-01
CA2968242C (en) 2022-11-08
PH12017500920B1 (en) 2017-11-20
MD3221298T2 (ro) 2019-10-31
HRP20212009T1 (hr) 2022-04-01
PH12017500920A1 (en) 2017-11-20
JO3719B1 (ar) 2021-01-31
WO2016081736A1 (en) 2016-05-26
PE20170899A1 (es) 2017-07-12
CL2017001292A1 (es) 2018-02-16
MA40993A (fr) 2017-09-27
TN2017000196A1 (en) 2018-10-19
CN112062730A (zh) 2020-12-11
US11173161B2 (en) 2021-11-16
US9770450B2 (en) 2017-09-26
TW201625566A (zh) 2016-07-16
EP3536324A1 (en) 2019-09-11
SMT202200142T1 (it) 2022-05-12
CY1124929T1 (el) 2023-01-05

Similar Documents

Publication Publication Date Title
ECSP17038999A (es) 4-oxo-3,4-dihidro-1,2,3-benzotriazinas como moduladores de gpr139
CL2018001685A1 (es) Compuestos heterociclicos como inmuno moduladores.
SV2018005709A (es) 3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasa
CL2017001204A1 (es) Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa
CL2017003055A1 (es) Agonistas de receptor de apelina (apj) de 4-hidroxi-3-(heteroaril)piridin-2-ona para uso en el tratamiento de trastornos cardiovasculares.
UY37134A (es) Compuestos heteroarilos y composiciones que los contienen útiles como inhibidores de pad4
ECSP16061758A (es) Moduladores de tetrahidropiridopirazinas de gpr6
CL2017000054A1 (es) Indoles funcionalizados y sustituidos como agentes anti-cáncer
CL2017001046A1 (es) Inhibidoes del bromodominio
MX2017006283A (es) Peptidos macrociclicos utiles como inmunomoduladores.
MX2017014375A (es) Moduladores del ccr2.
CL2015002529A1 (es) Compuestos de tetrahidropirrolotiazina
UY37018A (es) Inhibidores bicíclicos de pad4
CL2018000375A1 (es) 2-amino-3-fluoro-3-(fluorometil)-6-meti-6-fenil-3,4,5,6-tetrahidropiridinas como inhibidores de bace1.
CR20190392A (es) Compuestos moduladores del receptor de hidrocarburos de arilo (ahr)
MX377534B (es) Compuestos para usarse en el tratamiento de hiperinsulinemia.
CR20190393A (es) Compuestos moduladores del receptor de hidrocarburos de arilo (ahr)
UY37017A (es) Inhibidores aza-bencimidazol de pad4
CL2016002615A1 (es) Heterociclil-sulfonas sustituidas con heteroarilo y su uso contra el dolor, accidente cerebrovascular, transtornos anímicos, epilepsia, esquizofrenia y trastornos neurodegenerativos.
CL2016003074A1 (es) Compuestos derivados de 2-oxi-2-fenil-n-5-pirrolidin-3-ilamino-1,3,4-tiadiazol-2-ilacetamida, inhibidores gls1 composición farmacéutica y su uso para tratar el cáncer.
ECSP16074207A (es) Pirazinas moduladoras de gpr6
BR112017013286A2 (pt) composto de isoxazolina, e, uso de um composto de isoxazolina.
MX391474B (es) Péptidos cíclicos derivados de cd44v6 para el tratamiento de enfermedades relacionadas con cánceres y angiogénesis
CL2016002515A1 (es) Quinazolin-thf-aminas halogenadas como inhibidores de pde1.
MX2017009514A (es) Moduladores de los receptores a3 de adenosina.