ECSP12011980A - Anticuerpos humanizados contra el receptor alfa de la interleucina 22 humana. - Google Patents

Anticuerpos humanizados contra el receptor alfa de la interleucina 22 humana.

Info

Publication number
ECSP12011980A
ECSP12011980A ECSP12011980A ECSP12011980A EC SP12011980 A ECSP12011980 A EC SP12011980A EC SP12011980 A ECSP12011980 A EC SP12011980A EC SP12011980 A ECSP12011980 A EC SP12011980A
Authority
EC
Ecuador
Prior art keywords
antibodies against
humanized antibodies
human
interleucine
alfa
Prior art date
Application number
Other languages
English (en)
Spanish (es)
Inventor
Roland Beckmann
Leger Caroline Johnson
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41565648&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011980(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of ECSP12011980A publication Critical patent/ECSP12011980A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
ECSP12011980 2009-11-19 2012-06-18 Anticuerpos humanizados contra el receptor alfa de la interleucina 22 humana. ECSP12011980A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09176525 2009-11-19
US26299809P 2009-11-20 2009-11-20

Publications (1)

Publication Number Publication Date
ECSP12011980A true ECSP12011980A (es) 2012-07-31

Family

ID=41565648

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011980 ECSP12011980A (es) 2009-11-19 2012-06-18 Anticuerpos humanizados contra el receptor alfa de la interleucina 22 humana.

Country Status (20)

Country Link
US (1) US8545844B2 (enExample)
EP (1) EP2512511B1 (enExample)
JP (1) JP5818804B2 (enExample)
KR (1) KR20120098783A (enExample)
CN (1) CN102665759B (enExample)
AU (1) AU2010321047B2 (enExample)
BR (1) BR112012012003A2 (enExample)
CA (1) CA2778864C (enExample)
EA (1) EA021356B1 (enExample)
EC (1) ECSP12011980A (enExample)
ES (1) ES2531996T3 (enExample)
IL (1) IL219740A0 (enExample)
IN (1) IN2012DN03362A (enExample)
MX (1) MX2012005791A (enExample)
NZ (1) NZ599438A (enExample)
PE (1) PE20121560A1 (enExample)
PH (1) PH12012500924A1 (enExample)
UA (1) UA105405C2 (enExample)
WO (1) WO2011061119A1 (enExample)
ZA (1) ZA201202793B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005299809B2 (en) * 2004-10-22 2010-12-02 Zymogenetics, Inc. Anti-IL-22RA antibodies and binding partners and methods of using in inflammation
EP2686347B1 (en) 2011-03-16 2018-05-02 argenx BVBA Antibodies to cd70
SG11201601044XA (en) 2013-08-12 2016-03-30 Genentech Inc Compositions and method for treating complement-associated conditions
AU2015253042A1 (en) * 2014-05-01 2016-10-20 Genentech, Inc. Anti-factor D antibody variants and uses thereof
US10391168B1 (en) 2014-08-22 2019-08-27 University Of Bern Anti-CD70 combination therapy
US10407510B2 (en) 2015-10-30 2019-09-10 Genentech, Inc. Anti-factor D antibodies and conjugates
EP3368090A1 (en) * 2015-10-30 2018-09-05 H. Hoffnabb-La Roche Ag Anti-factor d antibody variant conjugates and uses thereof
CN109153709B (zh) * 2016-03-18 2022-05-27 舒泰神（北京）生物制药股份有限公司 神经生长因子突变体
GB201612337D0 (en) 2016-07-15 2016-08-31 Argen-X N V Ant-il-22r antibodies
CN111032083B (zh) * 2017-05-24 2024-01-12 财团法人生物技术开发中心 抗globo h的人源化抗体及其在癌症治疗中的用途
KR102611853B1 (ko) 2017-06-30 2023-12-08 자임워크스 비씨 인코포레이티드 안정화된 키메라 fabs
GB201800649D0 (en) 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
JP2025520166A (ja) * 2022-06-03 2025-07-01 レオ ファーマ アクティーゼルスカブ Ｉｌ－２２ｒ抗体の液体製剤
EP4704974A1 (en) 2023-03-08 2026-03-11 LEO Pharma A/S Il-22r antibody for use in treating atopic dermatitis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965704A (en) 1997-08-05 1999-10-12 Zymogenetics, Inc. Class two cytokine receptor-11
AU2005299809B2 (en) * 2004-10-22 2010-12-02 Zymogenetics, Inc. Anti-IL-22RA antibodies and binding partners and methods of using in inflammation
WO2006100582A1 (en) * 2005-03-25 2006-09-28 Glycart Biotechnology Ag Antigen binding molecules directed to mcsp and having increased fc receptor binding affinity and effector function
BRPI0619118A2 (pt) * 2005-12-02 2011-09-13 Genentech Inc composições e métodos para o tratamento de doenças e desordens associadas com a sinalização de citocina

Also Published As

Publication number Publication date
CN102665759B (zh) 2015-09-30
EA021356B1 (ru) 2015-05-29
US20120230990A1 (en) 2012-09-13
CN102665759A (zh) 2012-09-12
IN2012DN03362A (enExample) 2015-10-23
ZA201202793B (en) 2013-06-26
EP2512511B1 (en) 2015-01-07
IL219740A0 (en) 2012-07-31
EA201290360A1 (ru) 2012-11-30
PH12012500924A1 (en) 2012-11-26
CA2778864C (en) 2017-06-27
MX2012005791A (es) 2012-07-03
EP2512511A1 (en) 2012-10-24
AU2010321047B2 (en) 2016-06-09
UA105405C2 (ru) 2014-05-12
ES2531996T3 (es) 2015-03-23
KR20120098783A (ko) 2012-09-05
US8545844B2 (en) 2013-10-01
JP5818804B2 (ja) 2015-11-18
AU2010321047A1 (en) 2012-05-24
BR112012012003A2 (pt) 2016-11-29
NZ599438A (en) 2013-12-20
JP2013511267A (ja) 2013-04-04
CA2778864A1 (en) 2011-05-26
PE20121560A1 (es) 2012-12-05
WO2011061119A1 (en) 2011-05-26

Similar Documents

Publication Publication Date Title
ECSP12011980A (es) Anticuerpos humanizados contra el receptor alfa de la interleucina 22 humana.
CR20110585A (es) Anticuerpos humanizados específicos de la forma protofibrilar del péptido beta-amiloide
MX389789B (es) Moléculas del receptor de envolvimiento quimérico.
CL2011000668A1 (es) Compuestos derivados de pirazolopiridina; proceso de preparacion; composicion farmaceutica y uso en el tratamiento de enfermedades tales como artritis reumatoide, psoriasis, esclerosis multiple, entre otras.
PH12015502565B1 (en) Anti-transferrin receptor antibodies and methods of use
CL2009000618A1 (es) Uso de anticuerpo monoclonal humanizado th1, que reconoce el dominio 1 del cd6 humano, para preparar un medicamento útil en el tratamiento de la diabetes tipo-1.
HK1212214A1 (en) Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
MY186066A (en) Anti-phf-tau antibodies and their uses
AR068354A1 (es) Anticuerpos contra el receptor del linfona de burkitt (anti- cxcr5) humanizados, derivados de los mismos y su uso
PH12013500055A1 (en) Ring-fused pyrimidines and triazines and use thereof for the treatment and/or prophylaxis of cardiovascular diseases
PH12013500315A1 (en) Antibodies that bind myostatin, compositions and methods
GT201200308A (es) Proteínas de unión a il-1
PH12017501522A1 (en) Antibodies to tau and uses thereof
GT200900016A (es) 2-fenilo-indoles como antagonistas del receptor de la prostaglandina d2
MX392780B (es) Polinucléotidos que condifican anticuerpos de oncostatina m humana
CL2011001427A1 (es) Compuestos derivados de 4-azetidinil-1-heteroaril-ciclohexanol; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como epoc, aterosclerosis, artritis reumatoide, entre otras.
PH12015502400A1 (en) Installation for the preparation of a solution of calcium hydrogen carbonate suitable for the remineralization of water
MX357166B (es) Anticuerpos que se unen a notum pectinacetilesterasa.
AU2012357747A8 (en) TRPM8 antagonists
EA201170220A1 (ru) Лечение ревматоидного артрита бета-дефенсинами млекопитающих
SG10201811475YA (en) Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
PA8827501A1 (es) Pirrolidin amidas sustituidas como moduladores del receptor histamina h3
MX372971B (es) Sintesis de trans-8-cloro-5-metil-1-[4-(piridin-2-iloxi)-ciclohexil]-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo[e]azuleno y formas cristalinas del mismo.
CL2012001309A1 (es) Anticuerpos humanizados contra el receptor alfa de la interleucina 22 (il-22ra) humana; polinucleotido que codifica tanto la cadena pesada como la cadena liviana de dicho anticuerpo; vector y celula hospedera que comprende dicho polinucleotido; composicion farmaceutica que comprende el anticuerpo; uso del anticuerpo para tratar soriasis, artritis soriatica o dermatitis atópica.
GT201100232A (es) Proteinas de union a il-17