EA021356B1 - Гуманизированные антитела против il-22ra человека - Google Patents
Гуманизированные антитела против il-22ra человека Download PDFInfo
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- EA021356B1 EA021356B1 EA201290360A EA201290360A EA021356B1 EA 021356 B1 EA021356 B1 EA 021356B1 EA 201290360 A EA201290360 A EA 201290360A EA 201290360 A EA201290360 A EA 201290360A EA 021356 B1 EA021356 B1 EA 021356B1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
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- Molecular Biology (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09176525 | 2009-11-19 | ||
| US26299809P | 2009-11-20 | 2009-11-20 | |
| PCT/EP2010/067332 WO2011061119A1 (en) | 2009-11-19 | 2010-11-12 | Humanized antibodies against human il-22ra |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201290360A1 EA201290360A1 (ru) | 2012-11-30 |
| EA021356B1 true EA021356B1 (ru) | 2015-05-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201290360A EA021356B1 (ru) | 2009-11-19 | 2010-11-12 | Гуманизированные антитела против il-22ra человека |
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| Country | Link |
|---|---|
| US (1) | US8545844B2 (enExample) |
| EP (1) | EP2512511B1 (enExample) |
| JP (1) | JP5818804B2 (enExample) |
| KR (1) | KR20120098783A (enExample) |
| CN (1) | CN102665759B (enExample) |
| AU (1) | AU2010321047B2 (enExample) |
| BR (1) | BR112012012003A2 (enExample) |
| CA (1) | CA2778864C (enExample) |
| EA (1) | EA021356B1 (enExample) |
| EC (1) | ECSP12011980A (enExample) |
| ES (1) | ES2531996T3 (enExample) |
| IL (1) | IL219740A0 (enExample) |
| IN (1) | IN2012DN03362A (enExample) |
| MX (1) | MX2012005791A (enExample) |
| NZ (1) | NZ599438A (enExample) |
| PE (1) | PE20121560A1 (enExample) |
| PH (1) | PH12012500924A1 (enExample) |
| UA (1) | UA105405C2 (enExample) |
| WO (1) | WO2011061119A1 (enExample) |
| ZA (1) | ZA201202793B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007004770A (es) * | 2004-10-22 | 2007-11-22 | Zymogenetics Inc | Anticuerpos anti-il-22ra y moleculas y metodos para usarlos en inflamacion. |
| HUE039849T2 (hu) | 2011-03-16 | 2019-02-28 | Argenx Bvba | CD70 elleni ellenanyagok |
| CN107318267B (zh) | 2013-08-12 | 2021-08-17 | 豪夫迈·罗氏有限公司 | 用于治疗补体相关的病症的组合物和方法 |
| PE20161440A1 (es) * | 2014-05-01 | 2017-01-26 | Genentech Inc | Variantes del anticuerpo anti-factor d y sus usos |
| US10391168B1 (en) | 2014-08-22 | 2019-08-27 | University Of Bern | Anti-CD70 combination therapy |
| WO2017075173A2 (en) | 2015-10-30 | 2017-05-04 | Genentech, Inc. | Anti-factor d antibodies and conjugates |
| JP2018536650A (ja) | 2015-10-30 | 2018-12-13 | ジェネンテック， インコーポレイテッド | 抗ｄ因子抗体変異体コンジュゲート及びその使用 |
| ES2966133T3 (es) * | 2016-03-18 | 2024-04-18 | Staidson Beijing Biopharmaceuticals Co Ltd | Proteína de fusión que comprende el factor de crecimiento nervioso y método de preparación y uso de la misma |
| GB201612337D0 (en) | 2016-07-15 | 2016-08-31 | Argen-X N V | Ant-il-22r antibodies |
| EP3630182A4 (en) * | 2017-05-24 | 2021-02-24 | Development Center for Biotechnology | HUMANIZED ANTIBODIES TO GLOBO H AND THEIR USE IN CANCER TREATMENT |
| KR102611853B1 (ko) | 2017-06-30 | 2023-12-08 | 자임워크스 비씨 인코포레이티드 | 안정화된 키메라 fabs |
| GB201800649D0 (en) | 2018-01-16 | 2018-02-28 | Argenx Bvba | CD70 Combination Therapy |
| WO2023232789A1 (en) * | 2022-06-03 | 2023-12-07 | Leo Pharma A/S | Liquid formulation of il-22r antibody |
| WO2024184333A1 (en) | 2023-03-08 | 2024-09-12 | Leo Pharma A/S | Il-22r antibody for use in treating atopic dermatitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006047249A1 (en) * | 2004-10-22 | 2006-05-04 | Zymogenetics, Inc. | Anti-il-22ra antibodies and binding partners and methods of using in inflammation |
| WO2006100582A1 (en) * | 2005-03-25 | 2006-09-28 | Glycart Biotechnology Ag | Antigen binding molecules directed to mcsp and having increased fc receptor binding affinity and effector function |
| WO2007126439A2 (en) * | 2005-12-02 | 2007-11-08 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US5965704A (en) | 1997-08-05 | 1999-10-12 | Zymogenetics, Inc. | Class two cytokine receptor-11 |
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- 2012-06-18 EC ECSP12011980 patent/ECSP12011980A/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006047249A1 (en) * | 2004-10-22 | 2006-05-04 | Zymogenetics, Inc. | Anti-il-22ra antibodies and binding partners and methods of using in inflammation |
| WO2006100582A1 (en) * | 2005-03-25 | 2006-09-28 | Glycart Biotechnology Ag | Antigen binding molecules directed to mcsp and having increased fc receptor binding affinity and effector function |
| WO2007126439A2 (en) * | 2005-12-02 | 2007-11-08 | Genentech, Inc. | Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling involving antibodies that bind to il-22 and il-22r |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012012003A2 (pt) | 2016-11-29 |
| ES2531996T3 (es) | 2015-03-23 |
| EP2512511B1 (en) | 2015-01-07 |
| CA2778864A1 (en) | 2011-05-26 |
| ECSP12011980A (es) | 2012-07-31 |
| CN102665759B (zh) | 2015-09-30 |
| MX2012005791A (es) | 2012-07-03 |
| ZA201202793B (en) | 2013-06-26 |
| IN2012DN03362A (enExample) | 2015-10-23 |
| CA2778864C (en) | 2017-06-27 |
| AU2010321047A1 (en) | 2012-05-24 |
| WO2011061119A1 (en) | 2011-05-26 |
| PE20121560A1 (es) | 2012-12-05 |
| AU2010321047B2 (en) | 2016-06-09 |
| NZ599438A (en) | 2013-12-20 |
| PH12012500924A1 (en) | 2012-11-26 |
| EA201290360A1 (ru) | 2012-11-30 |
| CN102665759A (zh) | 2012-09-12 |
| JP2013511267A (ja) | 2013-04-04 |
| US20120230990A1 (en) | 2012-09-13 |
| KR20120098783A (ko) | 2012-09-05 |
| UA105405C2 (ru) | 2014-05-12 |
| US8545844B2 (en) | 2013-10-01 |
| IL219740A0 (en) | 2012-07-31 |
| JP5818804B2 (ja) | 2015-11-18 |
| EP2512511A1 (en) | 2012-10-24 |
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