ECSP11011110A - Derivados de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica

Info

Publication number
ECSP11011110A
ECSP11011110A EC2011011110A ECSP11011110A ECSP11011110A EC SP11011110 A ECSP11011110 A EC SP11011110A EC 2011011110 A EC2011011110 A EC 2011011110A EC SP11011110 A ECSP11011110 A EC SP11011110A EC SP11011110 A ECSP11011110 A EC SP11011110A
Authority
EC
Ecuador
Prior art keywords
alkyl
alkyloxy
halo
therapeutics
application
Prior art date
Application number
EC2011011110A
Other languages
English (en)
Inventor
Alain Dlubala
Isabelle Ripoche
Claire Trecant
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ECSP11011110A publication Critical patent/ECSP11011110A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a derivados de morfina-6-glucurónido de fórmula (I) siguiente en la que R1 es un grupo heteroaromático de 5 eslabones eventualmente sustituido con uno o varios sustituyentes elegidos entre átomos de halógeno y los grupos alquilo(C1-C4), halógeno, hidroxilo, haloalquilo(C1-C4), haloalquiloxi(C1-C4), alquiloxi(C1-C4), aril-alquilo(C1-C4) y arilo, estando dicho grupo arilo eventualmente sustituido con uno o varios grupos elegidos entre los grupos alquilo(C1-C4), haloalquilo(C1-C4), hidroxilo y alquiloxi(C1-C4), en forma de base o de sal de adición a un ácido así como en el estado de hidrato o de solvato. La presente invención tiene también por objeto su procedimiento de preparación y su aplicación en terapéutica.
EC2011011110A 2008-12-10 2011-06-06 Derivados de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica ECSP11011110A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0806949A FR2939437B1 (fr) 2008-12-10 2008-12-10 Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
ECSP11011110A true ECSP11011110A (es) 2011-07-29

Family

ID=41031604

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011011110A ECSP11011110A (es) 2008-12-10 2011-06-06 Derivados de morfina-6-glucuronido, su preparacion y su aplicacion en terapeutica

Country Status (30)

Country Link
US (1) US8461122B2 (es)
EP (1) EP2376512B1 (es)
JP (1) JP5616356B2 (es)
KR (1) KR20110104486A (es)
CN (1) CN102317301B (es)
AR (1) AR074514A1 (es)
AU (1) AU2009326909B2 (es)
BR (1) BRPI0922733A2 (es)
CA (1) CA2746429A1 (es)
CL (1) CL2011001399A1 (es)
CR (1) CR20110306A (es)
EA (1) EA019053B1 (es)
EC (1) ECSP11011110A (es)
ES (1) ES2468990T3 (es)
FR (1) FR2939437B1 (es)
HK (1) HK1163110A1 (es)
HN (1) HN2011001601A (es)
IL (1) IL213381A (es)
MA (1) MA32952B1 (es)
MX (1) MX2011006252A (es)
MY (1) MY152978A (es)
NI (1) NI201100115A (es)
NZ (1) NZ593344A (es)
PE (1) PE20120260A1 (es)
SG (1) SG172068A1 (es)
TN (1) TN2011000266A1 (es)
TW (1) TW201026312A (es)
UA (1) UA104302C2 (es)
WO (1) WO2010067010A2 (es)
ZA (1) ZA201104305B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103421063B (zh) * 2012-05-23 2016-04-06 宜昌人福药业有限责任公司 一种合成吗啡-6-β-D-葡萄糖醛酸苷的方法
CN111346104B (zh) * 2018-12-21 2022-06-10 宜昌人福药业有限责任公司 一种吗啡-6-葡萄糖醛酸苷透皮给药的药物组合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
AU723859B2 (en) * 1997-04-14 2000-09-07 Ufc Limited Morphine derivatives
CA2332974C (en) 1998-06-06 2009-03-10 Cenes Limited Morphine-6-glucuronide synthesis
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
FR2864082B1 (fr) * 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
US8481501B2 (en) * 2004-05-28 2013-07-09 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
FR2907121B1 (fr) * 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques

Also Published As

Publication number Publication date
HN2011001601A (es) 2013-09-16
JP2012511553A (ja) 2012-05-24
HK1163110A1 (en) 2012-09-07
CR20110306A (es) 2011-09-21
ES2468990T3 (es) 2014-06-17
KR20110104486A (ko) 2011-09-22
AU2009326909A1 (en) 2011-06-30
MA32952B1 (fr) 2012-01-02
EA019053B1 (ru) 2013-12-30
EA201170792A1 (ru) 2012-01-30
CL2011001399A1 (es) 2011-10-28
NZ593344A (en) 2013-08-30
MX2011006252A (es) 2011-11-04
AR074514A1 (es) 2011-01-19
CN102317301A (zh) 2012-01-11
WO2010067010A3 (fr) 2011-06-30
US8461122B2 (en) 2013-06-11
CN102317301B (zh) 2015-08-26
IL213381A0 (en) 2011-07-31
NI201100115A (es) 2011-12-14
SG172068A1 (en) 2011-07-28
CA2746429A1 (fr) 2010-06-17
IL213381A (en) 2014-02-27
MY152978A (en) 2014-12-15
WO2010067010A2 (fr) 2010-06-17
TW201026312A (en) 2010-07-16
TN2011000266A1 (fr) 2012-12-17
PE20120260A1 (es) 2012-04-13
FR2939437B1 (fr) 2010-12-17
AU2009326909B2 (en) 2016-05-26
UA104302C2 (ru) 2014-01-27
US20110301107A1 (en) 2011-12-08
FR2939437A1 (fr) 2010-06-11
BRPI0922733A2 (pt) 2016-01-05
EP2376512B1 (fr) 2014-02-26
EP2376512A2 (fr) 2011-10-19
JP5616356B2 (ja) 2014-10-29
ZA201104305B (en) 2012-10-31

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