UA104302C2 - Производные морфин-6-глюкуронида, их получение и их применение в терапии - Google Patents

Производные морфин-6-глюкуронида, их получение и их применение в терапии

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Publication number
UA104302C2
UA104302C2 UAA201108592A UAA201108592A UA104302C2 UA 104302 C2 UA104302 C2 UA 104302C2 UA A201108592 A UAA201108592 A UA A201108592A UA A201108592 A UAA201108592 A UA A201108592A UA 104302 C2 UA104302 C2 UA 104302C2
Authority
UA
Ukraine
Prior art keywords
alkyl
glucuronide
morphine
derivatives
halo
Prior art date
Application number
UAA201108592A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ален Длюбала
Изабелль Рипош
Клер Трекан
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of UA104302C2 publication Critical patent/UA104302C2/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Данное изобретение касается производных морфин-6-глюкуронида следующей формулы (I), (I)в которой: R1 означает 5-членную гетероароматическую группу, необязательно замещенную одним или несколькими заместителями, выбранными из атомов галогена и (С-С)алкила, галогена, гидроксила, оксо, гало(С-С)алкила, гало(С-С)алкилокси, (С-С)алкилокси, арил(С-С)алкила и арила, причем указанная арильная группа необязательно замещена одной или несколькими группами, выбранными из групп: (С-С)алкила, гало(С-С)алкила, гидроксила и (С-С)алкилокси, в виде основания или соли присоединения с кислотой, а также в виде гидрата или сольвата.Данное изобретение также касается способа получения указанных соединений и их применение в терапии.
UAA201108592A 2008-12-10 2009-12-08 Производные морфин-6-глюкуронида, их получение и их применение в терапии UA104302C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0806949A FR2939437B1 (fr) 2008-12-10 2008-12-10 Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
PCT/FR2009/052448 WO2010067010A2 (fr) 2008-12-10 2009-12-08 Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
UA104302C2 true UA104302C2 (ru) 2014-01-27

Family

ID=41031604

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201108592A UA104302C2 (ru) 2008-12-10 2009-12-08 Производные морфин-6-глюкуронида, их получение и их применение в терапии

Country Status (30)

Country Link
US (1) US8461122B2 (ru)
EP (1) EP2376512B1 (ru)
JP (1) JP5616356B2 (ru)
KR (1) KR20110104486A (ru)
CN (1) CN102317301B (ru)
AR (1) AR074514A1 (ru)
AU (1) AU2009326909B2 (ru)
BR (1) BRPI0922733A2 (ru)
CA (1) CA2746429A1 (ru)
CL (1) CL2011001399A1 (ru)
CR (1) CR20110306A (ru)
EA (1) EA019053B1 (ru)
EC (1) ECSP11011110A (ru)
ES (1) ES2468990T3 (ru)
FR (1) FR2939437B1 (ru)
HK (1) HK1163110A1 (ru)
HN (1) HN2011001601A (ru)
IL (1) IL213381A (ru)
MA (1) MA32952B1 (ru)
MX (1) MX2011006252A (ru)
MY (1) MY152978A (ru)
NI (1) NI201100115A (ru)
NZ (1) NZ593344A (ru)
PE (1) PE20120260A1 (ru)
SG (1) SG172068A1 (ru)
TN (1) TN2011000266A1 (ru)
TW (1) TW201026312A (ru)
UA (1) UA104302C2 (ru)
WO (1) WO2010067010A2 (ru)
ZA (1) ZA201104305B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103421063B (zh) * 2012-05-23 2016-04-06 宜昌人福药业有限责任公司 一种合成吗啡-6-β-D-葡萄糖醛酸苷的方法
CN111346104B (zh) * 2018-12-21 2022-06-10 宜昌人福药业有限责任公司 一种吗啡-6-葡萄糖醛酸苷透皮给药的药物组合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
AU723859B2 (en) * 1997-04-14 2000-09-07 Ufc Limited Morphine derivatives
CA2332974C (en) 1998-06-06 2009-03-10 Cenes Limited Morphine-6-glucuronide synthesis
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
FR2864082B1 (fr) * 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
US8481501B2 (en) * 2004-05-28 2013-07-09 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
FR2907121B1 (fr) * 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques

Also Published As

Publication number Publication date
HN2011001601A (es) 2013-09-16
JP2012511553A (ja) 2012-05-24
HK1163110A1 (en) 2012-09-07
CR20110306A (es) 2011-09-21
ES2468990T3 (es) 2014-06-17
ECSP11011110A (es) 2011-07-29
KR20110104486A (ko) 2011-09-22
AU2009326909A1 (en) 2011-06-30
MA32952B1 (fr) 2012-01-02
EA019053B1 (ru) 2013-12-30
EA201170792A1 (ru) 2012-01-30
CL2011001399A1 (es) 2011-10-28
NZ593344A (en) 2013-08-30
MX2011006252A (es) 2011-11-04
AR074514A1 (es) 2011-01-19
CN102317301A (zh) 2012-01-11
WO2010067010A3 (fr) 2011-06-30
US8461122B2 (en) 2013-06-11
CN102317301B (zh) 2015-08-26
IL213381A0 (en) 2011-07-31
NI201100115A (es) 2011-12-14
SG172068A1 (en) 2011-07-28
CA2746429A1 (fr) 2010-06-17
IL213381A (en) 2014-02-27
MY152978A (en) 2014-12-15
WO2010067010A2 (fr) 2010-06-17
TW201026312A (en) 2010-07-16
TN2011000266A1 (fr) 2012-12-17
PE20120260A1 (es) 2012-04-13
FR2939437B1 (fr) 2010-12-17
AU2009326909B2 (en) 2016-05-26
US20110301107A1 (en) 2011-12-08
FR2939437A1 (fr) 2010-06-11
BRPI0922733A2 (pt) 2016-01-05
EP2376512B1 (fr) 2014-02-26
EP2376512A2 (fr) 2011-10-19
JP5616356B2 (ja) 2014-10-29
ZA201104305B (en) 2012-10-31

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