UA97833C2 - Азабициклоалкановые производные, их получение и применение в терапии - Google Patents

Азабициклоалкановые производные, их получение и применение в терапии

Info

Publication number
UA97833C2
UA97833C2 UAA200909264A UAA200909264A UA97833C2 UA 97833 C2 UA97833 C2 UA 97833C2 UA A200909264 A UAA200909264 A UA A200909264A UA A200909264 A UAA200909264 A UA A200909264A UA 97833 C2 UA97833 C2 UA 97833C2
Authority
UA
Ukraine
Prior art keywords
cycloalkyl
alkylene
aryl
group
heterocycloalkyl
Prior art date
Application number
UAA200909264A
Other languages
English (en)
Ukrainian (uk)
Inventor
Аяд Омар Бен
Одиль Леклерк
Алистер Локхед
Мурад Саади
Франк Словински
Жюльен Ваше
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38523491&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA97833(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of UA97833C2 publication Critical patent/UA97833C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
UAA200909264A 2007-02-09 2008-04-02 Азабициклоалкановые производные, их получение и применение в терапии UA97833C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0700940A FR2912404B1 (fr) 2007-02-09 2007-02-09 Derives d'azabicycloalkane,leur preparation et leur application en therapeutique.
PCT/FR2008/000137 WO2008110699A2 (fr) 2007-02-09 2008-02-04 Dérivés d'azabicycloalkane, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
UA97833C2 true UA97833C2 (ru) 2012-03-26

Family

ID=38523491

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200909264A UA97833C2 (ru) 2007-02-09 2008-04-02 Азабициклоалкановые производные, их получение и применение в терапии

Country Status (40)

Country Link
US (2) US8173669B2 (ru)
EP (1) EP2118104B1 (ru)
JP (1) JP5356257B2 (ru)
KR (1) KR101517629B1 (ru)
CN (1) CN101605793B (ru)
AR (1) AR065248A1 (ru)
AU (1) AU2008224785B2 (ru)
BR (1) BRPI0806969A2 (ru)
CA (1) CA2677713C (ru)
CL (1) CL2008000394A1 (ru)
CO (1) CO6220857A2 (ru)
CR (1) CR10969A (ru)
CY (1) CY1113896T1 (ru)
DK (1) DK2118104T3 (ru)
DO (1) DOP2009000186A (ru)
EA (1) EA017802B1 (ru)
EC (1) ECSP099568A (ru)
ES (1) ES2402328T3 (ru)
FR (1) FR2912404B1 (ru)
GT (1) GT200900206A (ru)
HK (1) HK1139671A1 (ru)
HN (1) HN2009001484A (ru)
HR (1) HRP20130279T1 (ru)
IL (1) IL199966A (ru)
MA (1) MA31233B1 (ru)
MX (1) MX2009008492A (ru)
MY (1) MY161067A (ru)
NI (1) NI200900157A (ru)
NZ (1) NZ578673A (ru)
PE (1) PE20081664A1 (ru)
PL (1) PL2118104T3 (ru)
PT (1) PT2118104E (ru)
SI (1) SI2118104T1 (ru)
SV (1) SV2009003347A (ru)
TN (1) TN2009000314A1 (ru)
TW (1) TWI395585B (ru)
UA (1) UA97833C2 (ru)
UY (1) UY30908A1 (ru)
WO (1) WO2008110699A2 (ru)
ZA (1) ZA200905511B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008043031A1 (en) * 2006-10-04 2008-04-10 Pharmacopeia, Inc. 6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
RU2537390C1 (ru) * 2013-07-02 2015-01-10 Федеральное государственное унитарное предприятие "Государственный завод медицинских препаратов" Способ получения 2-экзо-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана
WO2016015333A1 (en) * 2014-08-01 2016-02-04 F.Hoffmann-La Roche Ag 2-oxa-5-azabicyclo [2.2.1] heptan-3-yl derivatives
CN111777593A (zh) * 2019-04-03 2020-10-16 南京天印健华医药科技有限公司 作为转染期间重排激酶抑制剂的新的化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610130D0 (en) * 1986-04-25 1986-05-29 Wellcome Found Pesticidal compounds
AU7474794A (en) * 1993-07-22 1995-02-20 E.I. Du Pont De Nemours And Company Arthropodicidal azacyclic heterocycles
FR2834511B1 (fr) * 2002-01-07 2004-02-13 Sanofi Synthelabo Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique
MXPA05013224A (es) 2003-06-12 2006-03-09 Novo Nordisk As Piridinilcarbamatos como inhibidores de lipasa sensible a hormonas.
FR2889701B1 (fr) * 2005-08-12 2007-10-05 Sanofi Aventis Sa Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique.

Also Published As

Publication number Publication date
KR101517629B1 (ko) 2015-05-04
UY30908A1 (es) 2008-09-30
DOP2009000186A (es) 2009-09-15
WO2008110699A2 (fr) 2008-09-18
PL2118104T3 (pl) 2013-05-31
ES2402328T3 (es) 2013-04-30
FR2912404A1 (fr) 2008-08-15
CL2008000394A1 (es) 2008-06-13
EA017802B1 (ru) 2013-03-29
MY161067A (en) 2017-04-14
IL199966A0 (en) 2010-04-15
NI200900157A (es) 2010-07-15
GT200900206A (es) 2011-08-18
WO2008110699A3 (fr) 2009-01-15
CY1113896T1 (el) 2016-07-27
CO6220857A2 (es) 2010-11-19
CN101605793A (zh) 2009-12-16
MA31233B1 (fr) 2010-03-01
SV2009003347A (es) 2010-02-01
ECSP099568A (es) 2009-09-29
HN2009001484A (es) 2012-01-16
AU2008224785B2 (en) 2013-03-14
MX2009008492A (es) 2009-09-28
TWI395585B (zh) 2013-05-11
NZ578673A (en) 2011-12-22
CN101605793B (zh) 2013-04-24
HK1139671A1 (en) 2010-09-24
US20120202807A1 (en) 2012-08-09
KR20090106600A (ko) 2009-10-09
HRP20130279T1 (hr) 2013-04-30
AR065248A1 (es) 2009-05-27
US8173669B2 (en) 2012-05-08
BRPI0806969A2 (pt) 2014-04-08
US8759343B2 (en) 2014-06-24
EP2118104A2 (fr) 2009-11-18
CR10969A (es) 2009-10-23
TN2009000314A1 (fr) 2010-12-31
US20100035916A1 (en) 2010-02-11
TW200838519A (en) 2008-10-01
ZA200905511B (en) 2010-10-27
PE20081664A1 (es) 2008-12-14
PT2118104E (pt) 2013-03-25
JP5356257B2 (ja) 2013-12-04
JP2010518053A (ja) 2010-05-27
CA2677713C (fr) 2015-11-24
EA200970745A1 (ru) 2010-02-26
FR2912404B1 (fr) 2009-04-10
DK2118104T3 (da) 2013-04-08
CA2677713A1 (fr) 2008-09-18
EP2118104B1 (fr) 2013-01-02
AU2008224785A1 (en) 2008-09-18
SI2118104T1 (sl) 2013-05-31
IL199966A (en) 2014-11-30

Similar Documents

Publication Publication Date Title
MY150289A (en) Derivatives of indole-2-carboxamides and of azaindole-2-carboxamides substituted with a silanyl group, preparation thereof and therapeutic use thereof
AU2006325931A8 (en) Amine compound and use thereof for medical purposes
MX2012002217A (es) Compuestos heterociclicos como inhibidores de cinasa janus.
RU2012112824A (ru) Производные бис-бензимидазола
PH12015502675A1 (en) Cycloaklane derivative
UA95976C2 (en) 2-ARYL-6-PHENYLIMIDAZO[1,2-b]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
MX2012006994A (es) Agente antiplaquetas novedoso.
UA109883C2 (uk) Спосіб отримання сполук для застосування як інгібіторів sglt2
JP2012082227A5 (ru)
NO331165B1 (no) Derivater av dioksan-2-alkylkarbamater, fremgangsmate for fremstilling derav og anvendelse av de samme for fremstilling av medikamenter
NO20080955L (no) Kinolinderivater som antibakterielle midler
UA99637C2 (ru) Производные пиридина, замещенные гетероциклическим кольцом и фосфоноксиметильной группой, и содержащее их противогрибковое средство
EA201171328A1 (ru) Производное замещенного изохинолина
EA201071113A1 (ru) ПОЛИЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ 2-ГЕТЕРОАРИЛ-6-ФЕНИЛИМИДАЗО[1,2-α] ПИРИДИНОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ
WO2010089510A3 (fr) Dérivés d'azaspiranyl-alkylcarbamates d'hétérocycles à 5 chaînons, leur préparation et leur application en thérapeutique
MX2011009146A (es) Sales de adicion de aminas que contienen grupos hidroxilo y/o carboxilicos con derivados de acido aminonicotinico como inhibidores de dhodh.
MX2012001420A (es) Derivados de pirrolo[1,2-b]piridazina como inhibidores de cinasa janus.
MX2012015100A (es) Compuestos y composiciones de heteroarilo como inhibidores de cinasa de proteina.
HK1142604A1 (en) Quinolines and their therapeutic use
UA97833C2 (ru) Азабициклоалкановые производные, их получение и применение в терапии
TW200708506A (en) Derivatives of triazines, their preparation and their application in therapeutics
GEP20074256B (en) Novel benzothiadiazine, process for their preparation and pharmaceutical compositions containing
BRPI1009497A2 (pt) Derivados de n-[(6-aza-biciclo[3.2.1] oct-5-il)-aril- metil]-heterobenzamida, o respectivo preparo e a respectiva aplicação em terapêutica
WO2010076524A3 (fr) Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif
ME01157B (me) DERlVATI 6-HETEROCIKLIČNOG-IMIDAZO[1,2-a]PIRIDIN-2 -KARBOKSAMIDA, NJIHOVA PRIPREMA I NJIHOVA PRIMJENA U LIJEČENJU