CO6220857A2 - Derivados de azabicicloalcano su preparacion y su aplicacion terapeutica - Google Patents
Derivados de azabicicloalcano su preparacion y su aplicacion terapeuticaInfo
- Publication number
- CO6220857A2 CO6220857A2 CO09081875A CO09081875A CO6220857A2 CO 6220857 A2 CO6220857 A2 CO 6220857A2 CO 09081875 A CO09081875 A CO 09081875A CO 09081875 A CO09081875 A CO 09081875A CO 6220857 A2 CO6220857 A2 CO 6220857A2
- Authority
- CO
- Colombia
- Prior art keywords
- cycloalkyl
- azabicyclo
- heptane
- alkylene
- aryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
1.- Compuesto que responde a la fórmula (I)en la que R representa bien un átomo de hidrógeno o de halógeno; bien un grupo hidroxi, alcoxi(C1-C6), cicloalquilo(C3-C7)-O- o cicloalquilo(C3-C7)-alquileno(C1-C3)-O-; bien un grupo heterocicloalquilo, arilo o heteroarilo; pudiendo estar este grupo sustituido opcionalmente con uno o varios grupos elegidos entre los átomos de halógenos, los grupos alquilo(C1-C6), cicloalquilo(C3-C7), cicloalquilo(C3-C7)-alquileno(C1-C3), alcoxi(C1-C6), cicloalquilo(C3-C7)-O-, cicloalquilo(C3-C7)-alquileno(C1-C3)-O-, fluoroalquilo(C1-C6), fluoroalcoxi(C1-C6), nitro, ciano, hidroxi, amino, alquilamino(C1-C6) o dialquilamino(C1-C6), heterocicloalquilo, arilo, arilo-alquileno-(C1-C6), heteroarilo, heteroarilo-alquileno(C1-C6), arilo-O-, -C(O)-alquilo(C1-C6), estando el grupo heterocicloalquilo sustituido opcionalmente con -C(O)O(CH3)3; n representa 1 ó 2; m representa 1 ó 2; o representa 1 ó 2; en el estado de base o de sal de adición a un ácido, así como en el estado de hidrato o de solvato;estando excluido el caso en el que n y o =1 y m = 2;estando excluido los compuestos siguientes:-4-(6-fiuoropiridin-3-il)-1-azabiciclo[2.2.1]heptano;-4-(6-cloropiridin-3-il)-1-azabiciclo[2.2.1]heptano;-4-(6-bromopiridin-3-il)-1-azabiciclo[2.2.1]heptano;-4-(piridin-3-il)-1-azabiciclo[2.2.1]heptano.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0700940A FR2912404B1 (fr) | 2007-02-09 | 2007-02-09 | Derives d'azabicycloalkane,leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6220857A2 true CO6220857A2 (es) | 2010-11-19 |
Family
ID=38523491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09081875A CO6220857A2 (es) | 2007-02-09 | 2009-08-05 | Derivados de azabicicloalcano su preparacion y su aplicacion terapeutica |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US8173669B2 (es) |
| EP (1) | EP2118104B1 (es) |
| JP (1) | JP5356257B2 (es) |
| KR (1) | KR101517629B1 (es) |
| CN (1) | CN101605793B (es) |
| AR (1) | AR065248A1 (es) |
| AU (1) | AU2008224785B2 (es) |
| BR (1) | BRPI0806969A2 (es) |
| CA (1) | CA2677713C (es) |
| CL (1) | CL2008000394A1 (es) |
| CO (1) | CO6220857A2 (es) |
| CR (1) | CR10969A (es) |
| CY (1) | CY1113896T1 (es) |
| DK (1) | DK2118104T3 (es) |
| DO (1) | DOP2009000186A (es) |
| EA (1) | EA017802B1 (es) |
| EC (1) | ECSP099568A (es) |
| ES (1) | ES2402328T3 (es) |
| FR (1) | FR2912404B1 (es) |
| GT (1) | GT200900206A (es) |
| HK (1) | HK1139671A1 (es) |
| HN (1) | HN2009001484A (es) |
| HR (1) | HRP20130279T1 (es) |
| IL (1) | IL199966A (es) |
| MA (1) | MA31233B1 (es) |
| MX (1) | MX2009008492A (es) |
| MY (1) | MY161067A (es) |
| NI (1) | NI200900157A (es) |
| NZ (1) | NZ578673A (es) |
| PE (1) | PE20081664A1 (es) |
| PL (1) | PL2118104T3 (es) |
| PT (1) | PT2118104E (es) |
| SI (1) | SI2118104T1 (es) |
| SV (1) | SV2009003347A (es) |
| TN (1) | TN2009000314A1 (es) |
| TW (1) | TWI395585B (es) |
| UA (1) | UA97833C2 (es) |
| UY (1) | UY30908A1 (es) |
| WO (1) | WO2008110699A2 (es) |
| ZA (1) | ZA200905511B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2007002866A1 (es) * | 2006-10-04 | 2008-07-04 | Pharmacopeia Inc | Compuestos derivados de 6-sustituidos-2-(bencimidazolil) purina y purinona; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades autoinmunes, enfermedad inflamatoria, enfermedad mediada por m |
| RU2537390C1 (ru) * | 2013-07-02 | 2015-01-10 | Федеральное государственное унитарное предприятие "Государственный завод медицинских препаратов" | Способ получения 2-экзо-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана |
| WO2016015333A1 (en) * | 2014-08-01 | 2016-02-04 | F.Hoffmann-La Roche Ag | 2-oxa-5-azabicyclo [2.2.1] heptan-3-yl derivatives |
| CN111777593B (zh) * | 2019-04-03 | 2024-07-23 | 南京天印健华医药科技有限公司 | 作为转染期间重排激酶抑制剂的新的化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8610130D0 (en) * | 1986-04-25 | 1986-05-29 | Wellcome Found | Pesticidal compounds |
| WO1995003306A1 (en) * | 1993-07-22 | 1995-02-02 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
| FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
| RU2337908C2 (ru) | 2003-06-12 | 2008-11-10 | Ново Нордиск А/С | Пиридинилкарбаматы в качестве ингибиторов гормон-чувствительной липазы |
| FR2889701B1 (fr) * | 2005-08-12 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique. |
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2007
- 2007-02-09 FR FR0700940A patent/FR2912404B1/fr not_active Expired - Fee Related
-
2008
- 2008-01-24 TW TW097102652A patent/TWI395585B/zh not_active IP Right Cessation
- 2008-02-04 CN CN2008800045359A patent/CN101605793B/zh not_active Expired - Fee Related
- 2008-02-04 SI SI200830925T patent/SI2118104T1/sl unknown
- 2008-02-04 PL PL08761840T patent/PL2118104T3/pl unknown
- 2008-02-04 WO PCT/FR2008/000137 patent/WO2008110699A2/fr active Application Filing
- 2008-02-04 KR KR1020097016530A patent/KR101517629B1/ko not_active IP Right Cessation
- 2008-02-04 NZ NZ578673A patent/NZ578673A/en not_active IP Right Cessation
- 2008-02-04 MX MX2009008492A patent/MX2009008492A/es active IP Right Grant
- 2008-02-04 CA CA2677713A patent/CA2677713C/fr not_active Expired - Fee Related
- 2008-02-04 PT PT87618401T patent/PT2118104E/pt unknown
- 2008-02-04 EA EA200970745A patent/EA017802B1/ru not_active IP Right Cessation
- 2008-02-04 ES ES08761840T patent/ES2402328T3/es active Active
- 2008-02-04 ZA ZA200905511A patent/ZA200905511B/xx unknown
- 2008-02-04 AU AU2008224785A patent/AU2008224785B2/en not_active Ceased
- 2008-02-04 MY MYPI20093204A patent/MY161067A/en unknown
- 2008-02-04 JP JP2009548712A patent/JP5356257B2/ja not_active Expired - Fee Related
- 2008-02-04 EP EP08761840A patent/EP2118104B1/fr active Active
- 2008-02-04 DK DK08761840.1T patent/DK2118104T3/da active
- 2008-02-04 BR BRPI0806969-7A2A patent/BRPI0806969A2/pt not_active IP Right Cessation
- 2008-02-07 PE PE2008000275A patent/PE20081664A1/es not_active Application Discontinuation
- 2008-02-07 AR ARP080100527A patent/AR065248A1/es unknown
- 2008-02-07 CL CL200800394A patent/CL2008000394A1/es unknown
- 2008-02-08 UY UY30908A patent/UY30908A1/es not_active Application Discontinuation
- 2008-04-02 UA UAA200909264A patent/UA97833C2/ru unknown
-
2009
- 2009-07-20 IL IL199966A patent/IL199966A/en not_active IP Right Cessation
- 2009-07-21 GT GT200900206A patent/GT200900206A/es unknown
- 2009-07-22 DO DO2009000186A patent/DOP2009000186A/es unknown
- 2009-07-30 TN TNP2009000314A patent/TN2009000314A1/fr unknown
- 2009-07-31 SV SV2009003347A patent/SV2009003347A/es unknown
- 2009-08-04 US US12/535,156 patent/US8173669B2/en not_active Expired - Fee Related
- 2009-08-05 CO CO09081875A patent/CO6220857A2/es active IP Right Grant
- 2009-08-06 CR CR10969A patent/CR10969A/es unknown
- 2009-08-07 EC EC2009009568A patent/ECSP099568A/es unknown
- 2009-08-07 NI NI200900157A patent/NI200900157A/es unknown
- 2009-08-07 HN HN2009001484A patent/HN2009001484A/es unknown
- 2009-09-01 MA MA32196A patent/MA31233B1/fr unknown
-
2010
- 2010-06-09 HK HK10105729.5A patent/HK1139671A1/xx not_active IP Right Cessation
-
2012
- 2012-03-16 US US13/422,296 patent/US8759343B2/en not_active Expired - Fee Related
-
2013
- 2013-03-27 HR HRP20130279AT patent/HRP20130279T1/hr unknown
- 2013-04-02 CY CY20131100273T patent/CY1113896T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |