CO6420344A2 - Derivados de triazolopiridina como inhibidores de proteínas cinasas activadas por mitogeno p38 (map) - Google Patents

Derivados de triazolopiridina como inhibidores de proteínas cinasas activadas por mitogeno p38 (map)

Info

Publication number
CO6420344A2
CO6420344A2 CO11103685A CO11103685A CO6420344A2 CO 6420344 A2 CO6420344 A2 CO 6420344A2 CO 11103685 A CO11103685 A CO 11103685A CO 11103685 A CO11103685 A CO 11103685A CO 6420344 A2 CO6420344 A2 CO 6420344A2
Authority
CO
Colombia
Prior art keywords
radical
optionally substituted
map
inhibitors
triazolopiridine
Prior art date
Application number
CO11103685A
Other languages
English (en)
Inventor
Harry Finch
John Montana
Bohdan Waszkowycz
Jamie Knight
Chi-Kit Woo
Niel Monique Bodil Van
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42232647&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6420344(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0902651A external-priority patent/GB0902651D0/en
Priority claimed from GB0908069A external-priority patent/GB0908069D0/en
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of CO6420344A2 publication Critical patent/CO6420344A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I) que son inhibidores de cinasa p38 MAP, útiles como agentes anti-inflamatorios en el tratamiento de, entre otros, enfermedades del tracto respiratorio en donde; R1 es alquilo C1-C4, cicloalquilo C3-C6, fenilo el cual es opcionalmente sustituido, heteroarilo monocíclico de 5 o 6 elementos el cual es opcionalmente sustituido, o un radical de fórmula (II) en donde n es 1 o 2, y R3 y R4 son independientemente H o alquilo C1-C4, o R3 y R4 tomados junto con el nitrógeno al cual están unidos forman un anillo heterociclico de 6 elementos opcionalmente que contiene un heteroátomo adicional seleccionado de N y O; Y es -O- o - S(O)p- en donde p es 0, 1 o 2; A es un radical arileno divalente opcionalmente sustituido, o un radical heteroarileno mono- o bicíclico, o un radical cicloalquileno nt divalente C3-C6 que tiene 5 o 6 átomos de anillo, o un radical piperidinileno en donde el nitrógeno del anillo se enlaza a R2NHC(=O)W-; W es un enlace, -NH- o -C(RA) (RB), en donde RA y RB son independientemente H, metilo, etilo, amino, hidroxilo o halo; y R2 es un radical como se define en las reivindicaciones.
CO11103685A 2009-02-17 2011-08-16 Derivados de triazolopiridina como inhibidores de proteínas cinasas activadas por mitogeno p38 (map) CO6420344A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0902651A GB0902651D0 (en) 2009-02-17 2009-02-17 Pharmaceutical compounds and compositions
GB0908069A GB0908069D0 (en) 2009-05-11 2009-05-11 Pharmaceutical compounds and compositions

Publications (1)

Publication Number Publication Date
CO6420344A2 true CO6420344A2 (es) 2012-04-16

Family

ID=42232647

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11103685A CO6420344A2 (es) 2009-02-17 2011-08-16 Derivados de triazolopiridina como inhibidores de proteínas cinasas activadas por mitogeno p38 (map)

Country Status (19)

Country Link
US (1) US8557797B2 (es)
EP (1) EP2398798A1 (es)
JP (1) JP2012517992A (es)
KR (1) KR20110116030A (es)
CN (2) CN102395586A (es)
AU (1) AU2010215261A1 (es)
BR (1) BRPI1005327A2 (es)
CA (1) CA2752693A1 (es)
CL (1) CL2011001977A1 (es)
CO (1) CO6420344A2 (es)
EA (1) EA201190119A1 (es)
IL (1) IL214658A0 (es)
MA (1) MA33128B1 (es)
MX (1) MX2011008496A (es)
PE (1) PE20120655A1 (es)
SG (1) SG174134A1 (es)
TN (1) TN2011000380A1 (es)
WO (1) WO2010094956A1 (es)
ZA (1) ZA201105993B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
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RU2010120671A (ru) * 2007-10-24 2011-11-27 Мерк Шарп Энд Домэ Корп. (Us) Гетероциклические фениламидные антагонисты кальциевых каналов т-типа
GB201009731D0 (en) 2010-06-10 2010-07-21 Pulmagen Therapeutics Inflamma Kinase inhibitors
MX2014000963A (es) 2011-07-26 2014-03-27 Gruenenthal Gmbh Derivados de carboxamida y urea aromaticos biciclicos sustituidos como ligandos del receptor de vanilloide.
CN103974953B (zh) * 2011-12-09 2016-06-29 奇斯药制品公司 激酶抑制剂
HUE029826T2 (en) * 2011-12-09 2017-04-28 Chiesi Farm Spa Kinase Inhibitors
KR20140103925A (ko) 2011-12-09 2014-08-27 키에시 파르마슈티시 엣스. 피. 에이. 4-히드록시-1,2,3,4-테트라히드로나프탈렌-1-일 우레아 및 호흡기 질환의 치료에서의 이들의 용도
CA2879431A1 (en) 2012-07-17 2014-01-23 Washington University Anti-mucus drugs and uses therefor
WO2014195400A1 (en) * 2013-06-06 2014-12-11 Chiesi Farmaceutici S.P.A. Kinase inhibitors
BR112015029970A2 (pt) 2013-06-06 2017-07-25 Chiesi Farm Spa inibidores de cinase
US9573949B2 (en) * 2013-06-06 2017-02-21 Chiesi Farmaceutici S.P.A. Derivatives of [1, 2, 4] triazolo [4, 3-a] pyridine as P38—MAP kinase inhibitors
GB201321742D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
JP2017538678A (ja) 2014-11-05 2017-12-28 フレクサス・バイオサイエンシーズ・インコーポレイテッドＦｌｅｘｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 免疫調節剤
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
CA3077499C (en) 2017-10-05 2021-09-21 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd

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AU650953B2 (en) 1991-03-21 1994-07-07 Novartis Ag Inhaler
JPH11508583A (ja) 1995-07-06 1999-07-27 ゼネカ・リミテッド ペプチド系のフィブロネクチン阻害薬
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YU25500A (sh) 1999-05-11 2003-08-29 Pfizer Products Inc. Postupak za sintezu analoga nukleozida
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JP2006517580A (ja) * 2003-02-14 2006-07-27 ファイザー・プロダクツ・インク 抗炎症化合物としてのトリアゾロピリジン
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EP1609789A1 (en) 2004-06-23 2005-12-28 Eli Lilly And Company Ureido-pyrazole derivatives and their use as kinase inhibitors
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GB0902648D0 (en) 2009-02-17 2009-04-01 Argenta Discovery Ltd Pharmaceutical compounds and compositions

Also Published As

Publication number Publication date
AU2010215261A1 (en) 2011-09-08
US20120088763A1 (en) 2012-04-12
PE20120655A1 (es) 2012-06-07
BRPI1005327A2 (pt) 2019-09-24
SG174134A1 (en) 2011-10-28
KR20110116030A (ko) 2011-10-24
ZA201105993B (en) 2012-10-31
MA33128B1 (fr) 2012-03-01
EA201190119A1 (ru) 2012-05-30
MX2011008496A (es) 2011-11-18
CN103483338A (zh) 2014-01-01
CL2011001977A1 (es) 2011-11-18
EP2398798A1 (en) 2011-12-28
US8557797B2 (en) 2013-10-15
CN102395586A (zh) 2012-03-28
TN2011000380A1 (en) 2013-03-27
IL214658A0 (en) 2011-09-27
JP2012517992A (ja) 2012-08-09
WO2010094956A1 (en) 2010-08-26
CA2752693A1 (en) 2010-08-26

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