DOP2009000186A - Derivados de azabicicloalcano, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de azabicicloalcano, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- DOP2009000186A DOP2009000186A DO2009000186A DO2009000186A DOP2009000186A DO P2009000186 A DOP2009000186 A DO P2009000186A DO 2009000186 A DO2009000186 A DO 2009000186A DO 2009000186 A DO2009000186 A DO 2009000186A DO P2009000186 A DOP2009000186 A DO P2009000186A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- alkyl
- cycloalkyl
- alkylene
- aryl
- heterocycloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención se refiere a los compuestos de formula general (I) en la R representa bien un átomo de hidrogeno o de halógeno; bien un grupo hidroxi, alcoxi (C1-C6), ciclo alquilo (C3-C7) -O-o ciclo alquilo (C3-C7) - alquileno (C1-C3)-O-; bien un grupo heterocicloalquilo, arilo o heteroarilo; pudiendo estar este grupo sustituido opcionalmente con uno o varios grupos elegidos entres los átomos de halógenos, los grupos alquilo (C1-C6), cicloalquilo(C3-C7) cicloalquilo(C3-C7) alquileno (C1-C3), alcoxi (C1-C6), cicloaluilo (C3-C7)-O-, cicloalquilo(C3-C7)-alquileno(C1-C3)-O-, fluoroalquilo (C1-C6), fluoroalcoxi (C1-C6), nitro, ciano, hidroxi, amino, alquilamino (C1-C6) o dialquilamino (C1-C6), heterocicloalquilo, arilo, arilo-alquileno(C1-C6), heteroarilo, heteroarilo-alquileno (C1-C6), arilo-O-, -C(O)-alquilo (C1-C6), estando el grupo heterocicloalquilo sustituido opcionalmente con -C(O)O(CH3)3; n representa 1 ó 2; m representa 1 ó 2; en el estado de base o de sal de adición a un acido, así como en el estado de hidrato o de solvato. Procedimiento de preparación y aplicación en terapéutica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0700940A FR2912404B1 (fr) | 2007-02-09 | 2007-02-09 | Derives d'azabicycloalkane,leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DOP2009000186A true DOP2009000186A (es) | 2009-09-15 |
Family
ID=38523491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DO2009000186A DOP2009000186A (es) | 2007-02-09 | 2009-07-22 | Derivados de azabicicloalcano, su preparacion y su aplicacion en terapeutica |
Country Status (40)
| Country | Link |
|---|---|
| US (2) | US8173669B2 (es) |
| EP (1) | EP2118104B1 (es) |
| JP (1) | JP5356257B2 (es) |
| KR (1) | KR101517629B1 (es) |
| CN (1) | CN101605793B (es) |
| AR (1) | AR065248A1 (es) |
| AU (1) | AU2008224785B2 (es) |
| BR (1) | BRPI0806969A2 (es) |
| CA (1) | CA2677713C (es) |
| CL (1) | CL2008000394A1 (es) |
| CO (1) | CO6220857A2 (es) |
| CR (1) | CR10969A (es) |
| CY (1) | CY1113896T1 (es) |
| DK (1) | DK2118104T3 (es) |
| DO (1) | DOP2009000186A (es) |
| EA (1) | EA017802B1 (es) |
| EC (1) | ECSP099568A (es) |
| ES (1) | ES2402328T3 (es) |
| FR (1) | FR2912404B1 (es) |
| GT (1) | GT200900206A (es) |
| HK (1) | HK1139671A1 (es) |
| HN (1) | HN2009001484A (es) |
| HR (1) | HRP20130279T1 (es) |
| IL (1) | IL199966A (es) |
| MA (1) | MA31233B1 (es) |
| MX (1) | MX2009008492A (es) |
| MY (1) | MY161067A (es) |
| NI (1) | NI200900157A (es) |
| NZ (1) | NZ578673A (es) |
| PE (1) | PE20081664A1 (es) |
| PL (1) | PL2118104T3 (es) |
| PT (1) | PT2118104E (es) |
| SI (1) | SI2118104T1 (es) |
| SV (1) | SV2009003347A (es) |
| TN (1) | TN2009000314A1 (es) |
| TW (1) | TWI395585B (es) |
| UA (1) | UA97833C2 (es) |
| UY (1) | UY30908A1 (es) |
| WO (1) | WO2008110699A2 (es) |
| ZA (1) | ZA200905511B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2007002866A1 (es) * | 2006-10-04 | 2008-07-04 | Pharmacopeia Inc | Compuestos derivados de 6-sustituidos-2-(bencimidazolil) purina y purinona; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento de enfermedades autoinmunes, enfermedad inflamatoria, enfermedad mediada por m |
| RU2537390C1 (ru) * | 2013-07-02 | 2015-01-10 | Федеральное государственное унитарное предприятие "Государственный завод медицинских препаратов" | Способ получения 2-экзо-[3'-(6'-хлорпиридил)]-7-азабицикло[2.2.1]-гептана |
| WO2016015333A1 (en) * | 2014-08-01 | 2016-02-04 | F.Hoffmann-La Roche Ag | 2-oxa-5-azabicyclo [2.2.1] heptan-3-yl derivatives |
| CN111777593A (zh) * | 2019-04-03 | 2020-10-16 | 南京天印健华医药科技有限公司 | 作为转染期间重排激酶抑制剂的新的化合物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8610130D0 (en) * | 1986-04-25 | 1986-05-29 | Wellcome Found | Pesticidal compounds |
| AU7474794A (en) * | 1993-07-22 | 1995-02-20 | E.I. Du Pont De Nemours And Company | Arthropodicidal azacyclic heterocycles |
| FR2834511B1 (fr) * | 2002-01-07 | 2004-02-13 | Sanofi Synthelabo | Derives de 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, leur preparation et leur application en therapeutique |
| CA2526204A1 (en) | 2003-06-12 | 2004-12-23 | Novo Nordisk A/S | Pyridinyl carbamates as hormone-sensitive lipase inhibitors |
| FR2889701B1 (fr) * | 2005-08-12 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridinyl-1-azabicyclo[3.2.1]octane, leur preparation en therapeutique. |
-
2007
- 2007-02-09 FR FR0700940A patent/FR2912404B1/fr not_active Expired - Fee Related
-
2008
- 2008-01-24 TW TW097102652A patent/TWI395585B/zh not_active IP Right Cessation
- 2008-02-04 DK DK08761840.1T patent/DK2118104T3/da active
- 2008-02-04 ZA ZA200905511A patent/ZA200905511B/xx unknown
- 2008-02-04 PL PL08761840T patent/PL2118104T3/pl unknown
- 2008-02-04 EA EA200970745A patent/EA017802B1/ru not_active IP Right Cessation
- 2008-02-04 WO PCT/FR2008/000137 patent/WO2008110699A2/fr active Application Filing
- 2008-02-04 AU AU2008224785A patent/AU2008224785B2/en not_active Ceased
- 2008-02-04 MY MYPI20093204A patent/MY161067A/en unknown
- 2008-02-04 CA CA2677713A patent/CA2677713C/fr not_active Expired - Fee Related
- 2008-02-04 CN CN2008800045359A patent/CN101605793B/zh not_active Expired - Fee Related
- 2008-02-04 KR KR1020097016530A patent/KR101517629B1/ko not_active IP Right Cessation
- 2008-02-04 PT PT87618401T patent/PT2118104E/pt unknown
- 2008-02-04 BR BRPI0806969-7A2A patent/BRPI0806969A2/pt not_active IP Right Cessation
- 2008-02-04 MX MX2009008492A patent/MX2009008492A/es active IP Right Grant
- 2008-02-04 SI SI200830925T patent/SI2118104T1/sl unknown
- 2008-02-04 EP EP08761840A patent/EP2118104B1/fr active Active
- 2008-02-04 JP JP2009548712A patent/JP5356257B2/ja not_active Expired - Fee Related
- 2008-02-04 NZ NZ578673A patent/NZ578673A/en not_active IP Right Cessation
- 2008-02-04 ES ES08761840T patent/ES2402328T3/es active Active
- 2008-02-07 PE PE2008000275A patent/PE20081664A1/es not_active Application Discontinuation
- 2008-02-07 AR ARP080100527A patent/AR065248A1/es unknown
- 2008-02-07 CL CL200800394A patent/CL2008000394A1/es unknown
- 2008-02-08 UY UY30908A patent/UY30908A1/es not_active Application Discontinuation
- 2008-04-02 UA UAA200909264A patent/UA97833C2/ru unknown
-
2009
- 2009-07-20 IL IL199966A patent/IL199966A/en not_active IP Right Cessation
- 2009-07-21 GT GT200900206A patent/GT200900206A/es unknown
- 2009-07-22 DO DO2009000186A patent/DOP2009000186A/es unknown
- 2009-07-30 TN TNP2009000314A patent/TN2009000314A1/fr unknown
- 2009-07-31 SV SV2009003347A patent/SV2009003347A/es unknown
- 2009-08-04 US US12/535,156 patent/US8173669B2/en not_active Expired - Fee Related
- 2009-08-05 CO CO09081875A patent/CO6220857A2/es active IP Right Grant
- 2009-08-06 CR CR10969A patent/CR10969A/es unknown
- 2009-08-07 HN HN2009001484A patent/HN2009001484A/es unknown
- 2009-08-07 EC EC2009009568A patent/ECSP099568A/es unknown
- 2009-08-07 NI NI200900157A patent/NI200900157A/es unknown
- 2009-09-01 MA MA32196A patent/MA31233B1/fr unknown
-
2010
- 2010-06-09 HK HK10105729.5A patent/HK1139671A1/xx not_active IP Right Cessation
-
2012
- 2012-03-16 US US13/422,296 patent/US8759343B2/en not_active Expired - Fee Related
-
2013
- 2013-03-27 HR HRP20130279AT patent/HRP20130279T1/hr unknown
- 2013-04-02 CY CY20131100273T patent/CY1113896T1/el unknown
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