BRPI0922733A2 - derivados de morfina-6-glicuronida, respectivo preparo e respectiva aplicação em terapêutica. - Google Patents

derivados de morfina-6-glicuronida, respectivo preparo e respectiva aplicação em terapêutica.

Info

Publication number
BRPI0922733A2
BRPI0922733A2 BRPI0922733A BRPI0922733A BRPI0922733A2 BR PI0922733 A2 BRPI0922733 A2 BR PI0922733A2 BR PI0922733 A BRPI0922733 A BR PI0922733A BR PI0922733 A BRPI0922733 A BR PI0922733A BR PI0922733 A2 BRPI0922733 A2 BR PI0922733A2
Authority
BR
Brazil
Prior art keywords
morphine
preparation
therapeutic application
glucuronide derivatives
glucuronide
Prior art date
Application number
BRPI0922733A
Other languages
English (en)
Inventor
Alain Dlubala
Claire Trecant
Isabelle Ripoche
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of BRPI0922733A2 publication Critical patent/BRPI0922733A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0922733A 2008-12-10 2009-12-08 derivados de morfina-6-glicuronida, respectivo preparo e respectiva aplicação em terapêutica. BRPI0922733A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0806949A FR2939437B1 (fr) 2008-12-10 2008-12-10 Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique
PCT/FR2009/052448 WO2010067010A2 (fr) 2008-12-10 2009-12-08 Derives de morphine-6-glucuronide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
BRPI0922733A2 true BRPI0922733A2 (pt) 2016-01-05

Family

ID=41031604

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0922733A BRPI0922733A2 (pt) 2008-12-10 2009-12-08 derivados de morfina-6-glicuronida, respectivo preparo e respectiva aplicação em terapêutica.

Country Status (30)

Country Link
US (1) US8461122B2 (pt)
EP (1) EP2376512B1 (pt)
JP (1) JP5616356B2 (pt)
KR (1) KR20110104486A (pt)
CN (1) CN102317301B (pt)
AR (1) AR074514A1 (pt)
AU (1) AU2009326909B2 (pt)
BR (1) BRPI0922733A2 (pt)
CA (1) CA2746429A1 (pt)
CL (1) CL2011001399A1 (pt)
CR (1) CR20110306A (pt)
EA (1) EA019053B1 (pt)
EC (1) ECSP11011110A (pt)
ES (1) ES2468990T3 (pt)
FR (1) FR2939437B1 (pt)
HK (1) HK1163110A1 (pt)
HN (1) HN2011001601A (pt)
IL (1) IL213381A (pt)
MA (1) MA32952B1 (pt)
MX (1) MX2011006252A (pt)
MY (1) MY152978A (pt)
NI (1) NI201100115A (pt)
NZ (1) NZ593344A (pt)
PE (1) PE20120260A1 (pt)
SG (1) SG172068A1 (pt)
TN (1) TN2011000266A1 (pt)
TW (1) TW201026312A (pt)
UA (1) UA104302C2 (pt)
WO (1) WO2010067010A2 (pt)
ZA (1) ZA201104305B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103421063B (zh) * 2012-05-23 2016-04-06 宜昌人福药业有限责任公司 一种合成吗啡-6-β-D-葡萄糖醛酸苷的方法
CN111346104B (zh) * 2018-12-21 2022-06-10 宜昌人福药业有限责任公司 一种吗啡-6-葡萄糖醛酸苷透皮给药的药物组合物及其制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
AU723859B2 (en) * 1997-04-14 2000-09-07 Ufc Limited Morphine derivatives
CA2332974C (en) 1998-06-06 2009-03-10 Cenes Limited Morphine-6-glucuronide synthesis
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
FR2864082B1 (fr) * 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
US8481501B2 (en) * 2004-05-28 2013-07-09 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
FR2907121B1 (fr) * 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques

Also Published As

Publication number Publication date
HN2011001601A (es) 2013-09-16
JP2012511553A (ja) 2012-05-24
HK1163110A1 (en) 2012-09-07
CR20110306A (es) 2011-09-21
ES2468990T3 (es) 2014-06-17
ECSP11011110A (es) 2011-07-29
KR20110104486A (ko) 2011-09-22
AU2009326909A1 (en) 2011-06-30
MA32952B1 (fr) 2012-01-02
EA019053B1 (ru) 2013-12-30
EA201170792A1 (ru) 2012-01-30
CL2011001399A1 (es) 2011-10-28
NZ593344A (en) 2013-08-30
MX2011006252A (es) 2011-11-04
AR074514A1 (es) 2011-01-19
CN102317301A (zh) 2012-01-11
WO2010067010A3 (fr) 2011-06-30
US8461122B2 (en) 2013-06-11
CN102317301B (zh) 2015-08-26
IL213381A0 (en) 2011-07-31
NI201100115A (es) 2011-12-14
SG172068A1 (en) 2011-07-28
CA2746429A1 (fr) 2010-06-17
IL213381A (en) 2014-02-27
MY152978A (en) 2014-12-15
WO2010067010A2 (fr) 2010-06-17
TW201026312A (en) 2010-07-16
TN2011000266A1 (fr) 2012-12-17
PE20120260A1 (es) 2012-04-13
FR2939437B1 (fr) 2010-12-17
AU2009326909B2 (en) 2016-05-26
UA104302C2 (ru) 2014-01-27
US20110301107A1 (en) 2011-12-08
FR2939437A1 (fr) 2010-06-11
EP2376512B1 (fr) 2014-02-26
EP2376512A2 (fr) 2011-10-19
JP5616356B2 (ja) 2014-10-29
ZA201104305B (en) 2012-10-31

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2494 DE 23-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.