NI201100113A - Derivados bicíclicos de morfina - 6 - glucuronido, su preparación y su aplicación en terapeutica. - Google Patents
Derivados bicíclicos de morfina - 6 - glucuronido, su preparación y su aplicación en terapeutica.Info
- Publication number
- NI201100113A NI201100113A NI201100113A NI201100113A NI201100113A NI 201100113 A NI201100113 A NI 201100113A NI 201100113 A NI201100113 A NI 201100113A NI 201100113 A NI201100113 A NI 201100113A NI 201100113 A NI201100113 A NI 201100113A
- Authority
- NI
- Nicaragua
- Prior art keywords
- therapeutics
- application
- group
- glucuronide
- morphine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
La presente invención tiene por objeto los compuestos que responden a la fórmula (I) en la que: R 1 representa un átomo de hidrógeno o un grupo alquilo(C1-C4), R2 representa un grupo hidroxilo, un grupo tiol, un grupo alquiloxi(C1-C4) o un grupo tioalquilo(C1 -C4), y n es un número entero igual a 1 ó 2, en el estado de base o de sal de adición a un ácido así como en el estado de hidrato o de solvato. La presente invención pretende igualmente su procedimiento de preparación y su aplicación en terapéutica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0806974A FR2939796B1 (fr) | 2008-12-11 | 2008-12-11 | Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
NI201100113A true NI201100113A (es) | 2011-12-15 |
Family
ID=41037668
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NI201100113A NI201100113A (es) | 2008-12-11 | 2011-06-08 | Derivados bicíclicos de morfina - 6 - glucuronido, su preparación y su aplicación en terapeutica. |
Country Status (33)
Country | Link |
---|---|
US (1) | US8440634B2 (es) |
EP (1) | EP2376511B1 (es) |
JP (1) | JP5616355B2 (es) |
KR (1) | KR20110091536A (es) |
CN (1) | CN102317302B (es) |
AR (1) | AR074578A1 (es) |
AU (1) | AU2009326907B2 (es) |
BR (1) | BRPI0923368A2 (es) |
CA (1) | CA2746701A1 (es) |
CL (1) | CL2011001401A1 (es) |
CO (1) | CO6382159A2 (es) |
CR (1) | CR20110317A (es) |
EA (1) | EA201170791A1 (es) |
EC (1) | ECSP11011107A (es) |
ES (1) | ES2470684T3 (es) |
FR (1) | FR2939796B1 (es) |
HK (1) | HK1163109A1 (es) |
HN (1) | HN2011001614A (es) |
IL (1) | IL213380A (es) |
MA (1) | MA32954B1 (es) |
ME (1) | ME01147B (es) |
MX (1) | MX2011006251A (es) |
MY (1) | MY153779A (es) |
NI (1) | NI201100113A (es) |
NZ (1) | NZ593340A (es) |
PE (1) | PE20120231A1 (es) |
SG (1) | SG172070A1 (es) |
SV (1) | SV2011003937A (es) |
TN (1) | TN2011000277A1 (es) |
TW (1) | TW201026313A (es) |
UA (1) | UA104445C2 (es) |
WO (1) | WO2010067008A2 (es) |
ZA (1) | ZA201104389B (es) |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3766188A (en) | 1971-06-28 | 1973-10-16 | Yamanouchi Pharma Co Ltd | Carbonyldioxymorphinan derivatives |
GB9116909D0 (en) | 1991-08-06 | 1991-09-18 | Salford Ultrafine Chem & Res | Morphine derivatives |
GB2282758A (en) | 1993-08-23 | 1995-04-19 | Euro Celtique Sa | Oral morphine-6-glucuronide compositions |
WO1998046618A1 (en) * | 1997-04-14 | 1998-10-22 | Salford Ultrafine Chemicals And Research Ltd. | Morphine derivatives |
HUP0100841A3 (en) * | 1998-02-02 | 2003-03-28 | Cenes Ltd Cambridge | Glycosidation of 4,5-epoxymorphinan-6-ols |
IL139773A0 (en) | 1998-06-06 | 2002-02-10 | Cenes Ltd | Morphine-6-glucuronide synthesis |
DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
DE10229842A1 (de) * | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
GB0218811D0 (en) * | 2002-08-14 | 2002-09-18 | Cenes Ltd | Salts of morphine-6-glucuronide |
FR2864082B1 (fr) * | 2003-12-22 | 2006-03-10 | Synt Em | Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur |
US8481501B2 (en) * | 2004-05-28 | 2013-07-09 | Human Biomolecular Research Institute | Synthesis of metabolically stable analgesics, pain medications and other agents |
FR2907121B1 (fr) * | 2006-10-12 | 2012-05-04 | Neorphys | Nouveaux derives morphiniques |
-
2008
- 2008-12-11 FR FR0806974A patent/FR2939796B1/fr not_active Expired - Fee Related
-
2009
- 2009-12-08 PE PE2011001206A patent/PE20120231A1/es not_active Application Discontinuation
- 2009-12-08 NZ NZ593340A patent/NZ593340A/xx not_active IP Right Cessation
- 2009-12-08 BR BRPI0923368A patent/BRPI0923368A2/pt not_active IP Right Cessation
- 2009-12-08 WO PCT/FR2009/052446 patent/WO2010067008A2/fr active Application Filing
- 2009-12-08 KR KR1020117013251A patent/KR20110091536A/ko active IP Right Grant
- 2009-12-08 JP JP2011540162A patent/JP5616355B2/ja not_active Expired - Fee Related
- 2009-12-08 SG SG2011042330A patent/SG172070A1/en unknown
- 2009-12-08 CN CN200980156458.3A patent/CN102317302B/zh not_active Expired - Fee Related
- 2009-12-08 EA EA201170791A patent/EA201170791A1/ru unknown
- 2009-12-08 MY MYPI2011002645A patent/MY153779A/en unknown
- 2009-12-08 MX MX2011006251A patent/MX2011006251A/es active IP Right Grant
- 2009-12-08 EP EP09801747.8A patent/EP2376511B1/fr active Active
- 2009-12-08 ES ES09801747.8T patent/ES2470684T3/es active Active
- 2009-12-08 AU AU2009326907A patent/AU2009326907B2/en not_active Ceased
- 2009-12-08 CA CA2746701A patent/CA2746701A1/fr not_active Abandoned
- 2009-12-08 UA UAA201108555A patent/UA104445C2/uk unknown
- 2009-12-08 ME MEP-2011-104A patent/ME01147B/me unknown
- 2009-12-08 MA MA34001A patent/MA32954B1/fr unknown
- 2009-12-10 AR ARP090104785A patent/AR074578A1/es unknown
- 2009-12-11 TW TW098142583A patent/TW201026313A/zh unknown
-
2011
- 2011-05-30 TN TN2011000277A patent/TN2011000277A1/fr unknown
- 2011-06-03 EC EC2011011107A patent/ECSP11011107A/es unknown
- 2011-06-05 IL IL213380A patent/IL213380A/en not_active IP Right Cessation
- 2011-06-07 CR CR20110317A patent/CR20110317A/es unknown
- 2011-06-08 SV SV2011003937A patent/SV2011003937A/es unknown
- 2011-06-08 US US13/155,727 patent/US8440634B2/en not_active Expired - Fee Related
- 2011-06-08 NI NI201100113A patent/NI201100113A/es unknown
- 2011-06-09 CL CL2011001401A patent/CL2011001401A1/es unknown
- 2011-06-10 HN HN2011001614A patent/HN2011001614A/es unknown
- 2011-06-10 CO CO11072131A patent/CO6382159A2/es not_active Application Discontinuation
- 2011-06-13 ZA ZA2011/04389A patent/ZA201104389B/en unknown
-
2012
- 2012-04-18 HK HK12103828.8A patent/HK1163109A1/xx not_active IP Right Cessation
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