CO6382159A2 - Derivados bicíclicos de morfina-6-glucurónido, su preparación y su aplicación en terapéuticaqq - Google Patents

Derivados bicíclicos de morfina-6-glucurónido, su preparación y su aplicación en terapéuticaqq

Info

Publication number
CO6382159A2
CO6382159A2 CO11072131A CO11072131A CO6382159A2 CO 6382159 A2 CO6382159 A2 CO 6382159A2 CO 11072131 A CO11072131 A CO 11072131A CO 11072131 A CO11072131 A CO 11072131A CO 6382159 A2 CO6382159 A2 CO 6382159A2
Authority
CO
Colombia
Prior art keywords
application
group
preparation
therapeuticsqq
glucurónido
Prior art date
Application number
CO11072131A
Other languages
English (en)
Inventor
Alain Dlubala
Isabelle Ripoche
Claire Trecant
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CO6382159A2 publication Critical patent/CO6382159A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

La presente invención tiene por objeto los compuestos que responden a la fórmula (I) en la que: R1 representa un átomo de hidrógeno o un grupo alquilo(C1-C4), R2 representa un grupo hidroxilo, un grupo tiol, un grupo alquiloxi(C1-C4) o un grupo tioalquilo(C1-C4), y n es un número entero igual a 1 ó 2, en el estado de base o de sal de adición a un ácido así como en el estado de hidrato o de solvato. La presente invención pretende igualmente su procedimiento de preparación y su aplicación en terapéutica.
CO11072131A 2008-12-11 2011-06-10 Derivados bicíclicos de morfina-6-glucurónido, su preparación y su aplicación en terapéuticaqq CO6382159A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0806974A FR2939796B1 (fr) 2008-12-11 2008-12-11 Derives bicycliques de morphine-6-glucuronide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CO6382159A2 true CO6382159A2 (es) 2012-02-15

Family

ID=41037668

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11072131A CO6382159A2 (es) 2008-12-11 2011-06-10 Derivados bicíclicos de morfina-6-glucurónido, su preparación y su aplicación en terapéuticaqq

Country Status (33)

Country Link
US (1) US8440634B2 (es)
EP (1) EP2376511B1 (es)
JP (1) JP5616355B2 (es)
KR (1) KR20110091536A (es)
CN (1) CN102317302B (es)
AR (1) AR074578A1 (es)
AU (1) AU2009326907B2 (es)
BR (1) BRPI0923368A2 (es)
CA (1) CA2746701A1 (es)
CL (1) CL2011001401A1 (es)
CO (1) CO6382159A2 (es)
CR (1) CR20110317A (es)
EA (1) EA201170791A1 (es)
EC (1) ECSP11011107A (es)
ES (1) ES2470684T3 (es)
FR (1) FR2939796B1 (es)
HK (1) HK1163109A1 (es)
HN (1) HN2011001614A (es)
IL (1) IL213380A (es)
MA (1) MA32954B1 (es)
ME (1) ME01147B (es)
MX (1) MX2011006251A (es)
MY (1) MY153779A (es)
NI (1) NI201100113A (es)
NZ (1) NZ593340A (es)
PE (1) PE20120231A1 (es)
SG (1) SG172070A1 (es)
SV (1) SV2011003937A (es)
TN (1) TN2011000277A1 (es)
TW (1) TW201026313A (es)
UA (1) UA104445C2 (es)
WO (1) WO2010067008A2 (es)
ZA (1) ZA201104389B (es)

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766188A (en) 1971-06-28 1973-10-16 Yamanouchi Pharma Co Ltd Carbonyldioxymorphinan derivatives
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
GB2282758A (en) 1993-08-23 1995-04-19 Euro Celtique Sa Oral morphine-6-glucuronide compositions
ES2201482T3 (es) * 1997-04-14 2004-03-16 Ufc Limited Derivados de la morfina.
ATE252593T1 (de) * 1998-02-02 2003-11-15 Finetech Ltd Glykosidierung von 4,5-epoxymorphinan-6-olen
ATE225363T1 (de) 1998-06-06 2002-10-15 Cenes Ltd Synthese von morphin-6-glucuronid
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
DE10229842A1 (de) * 2002-07-03 2004-02-05 Helmut Prof. Dr. Schmidhammer Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung
GB0218811D0 (en) * 2002-08-14 2002-09-18 Cenes Ltd Salts of morphine-6-glucuronide
FR2864082B1 (fr) * 2003-12-22 2006-03-10 Synt Em Nouveau derive de la morphine-6-glucuronide, composition pharmaceutique le contenant et son utilisation pour le traitement de la douleur
AU2005249508A1 (en) * 2004-05-28 2005-12-15 Human Biomolecular Research Institute Synthesis of metabolically stable analgesics, pain medications and other agents
FR2907121B1 (fr) * 2006-10-12 2012-05-04 Neorphys Nouveaux derives morphiniques

Also Published As

Publication number Publication date
CN102317302A (zh) 2012-01-11
ME01147B (me) 2012-12-20
FR2939796A1 (fr) 2010-06-18
NI201100113A (es) 2011-12-15
US8440634B2 (en) 2013-05-14
PE20120231A1 (es) 2012-04-04
KR20110091536A (ko) 2011-08-11
AU2009326907B2 (en) 2016-05-26
ZA201104389B (en) 2012-09-26
TW201026313A (en) 2010-07-16
MA32954B1 (fr) 2012-01-02
MY153779A (en) 2015-03-13
UA104445C2 (uk) 2014-02-10
EA201170791A1 (ru) 2012-01-30
MX2011006251A (es) 2011-11-18
US20110275580A1 (en) 2011-11-10
JP2012511552A (ja) 2012-05-24
EP2376511A2 (fr) 2011-10-19
WO2010067008A3 (fr) 2011-07-07
FR2939796B1 (fr) 2010-12-17
WO2010067008A2 (fr) 2010-06-17
HN2011001614A (es) 2014-03-03
CR20110317A (es) 2011-10-18
CA2746701A1 (fr) 2010-06-17
NZ593340A (en) 2012-12-21
CL2011001401A1 (es) 2011-10-28
AR074578A1 (es) 2011-01-26
EP2376511B1 (fr) 2014-03-12
BRPI0923368A2 (pt) 2019-09-24
SV2011003937A (es) 2012-01-20
IL213380A0 (en) 2011-07-31
AU2009326907A1 (en) 2011-06-30
CN102317302B (zh) 2014-02-12
IL213380A (en) 2014-02-27
ECSP11011107A (es) 2011-07-29
HK1163109A1 (en) 2012-09-07
SG172070A1 (en) 2011-07-28
TN2011000277A1 (fr) 2012-12-17
JP5616355B2 (ja) 2014-10-29
ES2470684T3 (es) 2014-06-24

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