ECSP066506A - Derivados del 1-`2(1,4´-biperidin-1´-il)-1-(fenil)-etil! ciclohexanol como moduladores de absorción de monoamina parael tratamiento de sintomas visomotores - Google Patents
Derivados del 1-`2(1,4´-biperidin-1´-il)-1-(fenil)-etil! ciclohexanol como moduladores de absorción de monoamina parael tratamiento de sintomas visomotoresInfo
- Publication number
- ECSP066506A ECSP066506A EC2006006506A ECSP066506A ECSP066506A EC SP066506 A ECSP066506 A EC SP066506A EC 2006006506 A EC2006006506 A EC 2006006506A EC SP066506 A ECSP066506 A EC SP066506A EC SP066506 A ECSP066506 A EC SP066506A
- Authority
- EC
- Ecuador
- Prior art keywords
- derivatives
- phenyl
- treatment
- symptoms
- visomotive
- Prior art date
Links
- 238000010521 absorption reaction Methods 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 208000024891 symptom Diseases 0.000 abstract 2
- 230000001457 vasomotor Effects 0.000 abstract 2
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 abstract 1
- 208000001640 Fibromyalgia Diseases 0.000 abstract 1
- 206010021639 Incontinence Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000003406 indolizinyl group Chemical group C=1(C=CN2C=CC=CC12)* 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000001977 isobenzofuranyl group Chemical group C=1(OC=C2C=CC=CC12)* 0.000 abstract 1
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 230000002485 urinary effect Effects 0.000 abstract 1
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
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- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D333/28—Halogen atoms
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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| WO2007067575A2 (en) * | 2005-12-05 | 2007-06-14 | Wyeth | Process for preparing substituted aryl cycloalkanol derivatives |
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| UY32858A (es) | 2009-08-31 | 2011-03-31 | Abbott Healthcare Products Bv | Derivados de (tio)morfolina como moduladores de sip |
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| SG183158A1 (en) | 2010-02-02 | 2012-09-27 | Agency Science Tech & Res | Functionalised antifouling compounds and use thereof |
| TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| TW201206893A (en) * | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
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| PH18686A (en) | 1981-05-26 | 1985-08-29 | Merck & Co Inc | 1-(3 halo-2-pyridinyl) piperazine |
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| DE69105501T2 (de) | 1990-06-01 | 1995-04-13 | Merrell Dow Pharma | (+)-alpha-(2,3 dimethoxyphenyl)-1-[2-(fluorophenyl)ethyl]-4-piperidinmethanol. |
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| AU725556B2 (en) | 1996-03-25 | 2000-10-12 | Eli Lilly And Company | Method for treating pain |
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| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
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| US20040259850A1 (en) | 2001-10-31 | 2004-12-23 | Alves Stephen E. | Method for treating or preventing symptoms of hormonal variation including hot flashes |
| US6602911B2 (en) | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
| SE0103818D0 (sv) * | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
| WO2003066004A2 (en) | 2002-02-08 | 2003-08-14 | President And Fellows Of Harvard College | Therapeutic compounds |
| PL223471B1 (pl) | 2002-03-15 | 2016-10-31 | Cypress Bioscience Inc | Kompozycja farmaceutyczna zawierająca milnacypran do stosowania w leczeniu zespołu nadwrażliwości jelita grubego |
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- 2004-10-13 DE DE602004014955T patent/DE602004014955D1/de not_active Expired - Fee Related
- 2004-10-13 EP EP04794958A patent/EP1673084B1/en not_active Expired - Lifetime
- 2004-10-13 BR BRPI0415294-8A patent/BRPI0415294A/pt not_active IP Right Cessation
- 2004-10-13 CA CA002540191A patent/CA2540191A1/en not_active Abandoned
- 2004-10-13 AU AU2004281746A patent/AU2004281746A1/en not_active Withdrawn
- 2004-10-14 AR ARP040103715A patent/AR046283A1/es unknown
- 2004-10-14 PA PA20048615001A patent/PA8615001A1/es unknown
- 2004-10-14 PE PE2004000995A patent/PE20050440A1/es not_active Application Discontinuation
-
2006
- 2006-03-21 IL IL174472A patent/IL174472A0/en unknown
- 2006-04-12 EC EC2006006506A patent/ECSP066506A/es unknown
-
2009
- 2009-05-18 US US12/467,594 patent/US20090227585A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PE20050440A1 (es) | 2005-07-25 |
| BRPI0415294A (pt) | 2006-12-19 |
| AU2004281746A1 (en) | 2005-04-28 |
| PA8615001A1 (es) | 2005-08-10 |
| US7550485B2 (en) | 2009-06-23 |
| US20090227585A1 (en) | 2009-09-10 |
| CA2540191A1 (en) | 2005-04-28 |
| IL174472A0 (en) | 2006-08-01 |
| MXPA06003880A (es) | 2006-07-03 |
| KR20070026326A (ko) | 2007-03-08 |
| US20050187251A1 (en) | 2005-08-25 |
| JP2007508395A (ja) | 2007-04-05 |
| ATE400273T1 (de) | 2008-07-15 |
| EP1673084B1 (en) | 2008-07-09 |
| EP1673084A1 (en) | 2006-06-28 |
| WO2005037279A1 (en) | 2005-04-28 |
| DE602004014955D1 (de) | 2008-08-21 |
| TW200526619A (en) | 2005-08-16 |
| AR046283A1 (es) | 2005-11-30 |
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