ECSP066506A - Derivados del 1-`2(1,4´-biperidin-1´-il)-1-(fenil)-etil! ciclohexanol como moduladores de absorción de monoamina parael tratamiento de sintomas visomotores - Google Patents

Derivados del 1-`2(1,4´-biperidin-1´-il)-1-(fenil)-etil! ciclohexanol como moduladores de absorción de monoamina parael tratamiento de sintomas visomotores

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Publication number
ECSP066506A
ECSP066506A EC2006006506A ECSP066506A ECSP066506A EC SP066506 A ECSP066506 A EC SP066506A EC 2006006506 A EC2006006506 A EC 2006006506A EC SP066506 A ECSP066506 A EC SP066506A EC SP066506 A ECSP066506 A EC SP066506A
Authority
EC
Ecuador
Prior art keywords
derivatives
phenyl
treatment
symptoms
visomotive
Prior art date
Application number
EC2006006506A
Other languages
English (en)
Inventor
Lori Danielle Krim
Paige Ering Mahaney
Douglas John Jenkins
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of ECSP066506A publication Critical patent/ECSP066506A/es

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    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract

La presente invención se relaciona a derivados sustituidos de N - heterociclo, composiciones que contienen estos derivados y métodos de su uso para la prevención y tratamiento de condiciones aliviadas por la absorción de monoamina, incluyendo, inter alia, síntomas vasomotores (SVM), disfunción sexual, desórdenes gastrointestinales y genitourinarios, síndrome de fatiga crónica, síndrome de fibromilagia, desórdenes del sistema nervioso y combinaciones de los mismos, particularmente aquellas condiciones seleccionadas del grupo que consiste del mayor desorden depresivo, síntomas vasomotores, stress e incontinencia del impulso urinario, fibromialgia, dolor, neuropatía diabética y combinaciones de las mismas. Donde: A es fenil, naftil, tiofenil, piridinil, furanil, benzofuranil, isobenzofuranil, xantenil, pirrolil, indolizinil, isoindolil, indolil o benzotiofenil, donde 1 a 3 átomos de carbono de dicho A es reemplazado, opcionalmente, con un átomo de nitrógeno. U es N u O; W es H u OR8; los otros sustituyentes son definidos en las reivindicaciones
EC2006006506A 2003-10-14 2006-04-12 Derivados del 1-`2(1,4´-biperidin-1´-il)-1-(fenil)-etil! ciclohexanol como moduladores de absorción de monoamina parael tratamiento de sintomas visomotores ECSP066506A (es)

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