ECSP045465A - Formas de dosis y composiciones para la administración osmótica de dos variables de oxicodona - Google Patents

Formas de dosis y composiciones para la administración osmótica de dos variables de oxicodona

Info

Publication number
ECSP045465A
ECSP045465A EC2004005465A ECSP045465A ECSP045465A EC SP045465 A ECSP045465 A EC SP045465A EC 2004005465 A EC2004005465 A EC 2004005465A EC SP045465 A ECSP045465 A EC SP045465A EC SP045465 A ECSP045465 A EC SP045465A
Authority
EC
Ecuador
Prior art keywords
drug
oxycodone
compositions
dosage forms
oxicodona
Prior art date
Application number
EC2004005465A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ECSP045465A publication Critical patent/ECSP045465A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describen formas de dosis, composiciones y métodos para liberación controlada de oxicodona durante un periodo de tiempo prolongado; la presente invención describe métodos novedosos para administrar dosis variables de oxicodona utilizando una composición del fármaco que solamente tiene oxicodona, un vehículo polímero y cantidades variables de la sal para proveer una viscosidad particular del núcleo hidratado del fármaco para la administración del fármaco a la velocidad de liberación deseada; la presente invención funciona mediante la modulación de la viscosidad de la capa hidratada del fármaco en operación mediante la adición o reducción de sales en la composición del fármaco; el sistema es independiente de los potenciadores de solubilidad o de los modificadores de pH; las formas de liberación sostenida proveen concentraciones promedio de oxicodona terapéuticamente efectivas en plasma en un estado constante cuando se administran una vez por día.
EC2004005465A 2002-05-31 2004-11-30 Formas de dosis y composiciones para la administración osmótica de dos variables de oxicodona ECSP045465A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38444202P 2002-05-31 2002-05-31

Publications (1)

Publication Number Publication Date
ECSP045465A true ECSP045465A (es) 2005-01-28

Family

ID=29712032

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2004005465A ECSP045465A (es) 2002-05-31 2004-11-30 Formas de dosis y composiciones para la administración osmótica de dos variables de oxicodona

Country Status (21)

Country Link
US (1) US20030224051A1 (es)
EP (1) EP1513497A2 (es)
JP (1) JP2005528423A (es)
KR (1) KR20050034645A (es)
CN (1) CN1671358A (es)
AR (1) AR040245A1 (es)
AU (1) AU2003245345A1 (es)
BR (1) BR0304960A (es)
CA (1) CA2487786A1 (es)
EC (1) ECSP045465A (es)
IL (1) IL165361A0 (es)
MX (1) MXPA04012021A (es)
MY (1) MY151013A (es)
NO (1) NO20040421L (es)
NZ (1) NZ536693A (es)
PL (1) PL372797A1 (es)
RU (1) RU2004134728A (es)
TW (1) TW200406206A (es)
UY (1) UY27832A1 (es)
WO (1) WO2003101384A2 (es)
ZA (1) ZA200410398B (es)

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Also Published As

Publication number Publication date
EP1513497A2 (en) 2005-03-16
UY27832A1 (es) 2003-09-30
PL372797A1 (en) 2005-08-08
WO2003101384A2 (en) 2003-12-11
AU2003245345A1 (en) 2003-12-19
CA2487786A1 (en) 2003-12-11
ZA200410398B (en) 2006-02-22
JP2005528423A (ja) 2005-09-22
RU2004134728A (ru) 2005-06-10
AR040245A1 (es) 2005-03-23
TW200406206A (en) 2004-05-01
US20030224051A1 (en) 2003-12-04
WO2003101384A3 (en) 2004-04-08
MY151013A (en) 2014-03-31
KR20050034645A (ko) 2005-04-14
BR0304960A (pt) 2005-01-04
NO20040421L (no) 2004-03-26
IL165361A0 (en) 2006-01-15
MXPA04012021A (es) 2005-08-16
NZ536693A (en) 2007-01-26
CN1671358A (zh) 2005-09-21

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