EA202091871A1 - Поливалентное антитело - Google Patents
Поливалентное антителоInfo
- Publication number
- EA202091871A1 EA202091871A1 EA202091871A EA202091871A EA202091871A1 EA 202091871 A1 EA202091871 A1 EA 202091871A1 EA 202091871 A EA202091871 A EA 202091871A EA 202091871 A EA202091871 A EA 202091871A EA 202091871 A1 EA202091871 A1 EA 202091871A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- antibody
- region
- binding domain
- additional binding
- linker
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Изобретение относится к поливалентному антителу, которое содержит основной участок антитела, который содержит два связывающих домена; и по меньшей мере один дополнительный связывающий домен, причем основной участок антитела присоединен к по меньшей мере одному дополнительному связывающему домену посредством линкера, при этом каждый связывающий домен основного участка антитела и каждый из по меньшей мере одного дополнительного связывающего домена имеет общую вариабельную область, и при этом линкер содержит шарнирную последовательность или последовательность, полученную из шарнирной последовательности. Изобретение также относится к поливалентному антителу, которое содержит основной участок антитела, который содержит два связывающих домена; и по меньшей мере один дополнительный связывающий домен, причем по меньшей мере один дополнительный связывающий домен содержит область CH1 и присоединен к основному участку антитела посредством указанного линкера, связывая вариабельную область основного участка антитела с областью CH1, и при этом поливалентное антитело связывается с по меньшей мере тремя разными эпитопами.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862650467P | 2018-03-30 | 2018-03-30 | |
PCT/NL2019/050199 WO2019190327A2 (en) | 2018-03-30 | 2019-03-29 | Multivalent antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202091871A1 true EA202091871A1 (ru) | 2021-06-22 |
Family
ID=66349617
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091871A EA202091871A1 (ru) | 2018-03-30 | 2019-03-29 | Поливалентное антитело |
Country Status (17)
Country | Link |
---|---|
US (1) | US11952424B2 (ru) |
EP (1) | EP3774885A2 (ru) |
JP (1) | JP2021519610A (ru) |
KR (1) | KR20200139189A (ru) |
CN (1) | CN111936514A (ru) |
AR (1) | AR115320A1 (ru) |
AU (2) | AU2019243665B2 (ru) |
BR (1) | BR112020019795A2 (ru) |
CA (1) | CA3094318A1 (ru) |
EA (1) | EA202091871A1 (ru) |
IL (1) | IL277672A (ru) |
MA (1) | MA52212A (ru) |
MX (1) | MX2020010267A (ru) |
PH (1) | PH12020551504A1 (ru) |
SG (1) | SG11202009036YA (ru) |
TW (1) | TW202003569A (ru) |
WO (1) | WO2019190327A2 (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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EA202091871A1 (ru) | 2018-03-30 | 2021-06-22 | Мерус Н.В. | Поливалентное антитело |
CN114249823A (zh) | 2018-12-31 | 2022-03-29 | 美勒斯公司 | 混合的结合域 |
SG11202105926QA (en) | 2018-12-31 | 2021-07-29 | Merus Nv | Truncated multivalent multimers |
TW202039578A (zh) | 2019-03-29 | 2020-11-01 | 荷蘭商美勒斯公司 | Cd3結合分子 |
BR112021022405A2 (pt) | 2019-05-09 | 2022-04-19 | Merus Nv | Domínios variantes para multimerização de proteínas e separação das mesmas |
EP4081306A1 (en) | 2019-12-24 | 2022-11-02 | Merus N.V. | Tgf-beta-rii binding proteins |
EP4097131A1 (en) | 2020-01-29 | 2022-12-07 | Merus N.V. | Means and method for modulating immune cell engaging effects |
CN113563473A (zh) * | 2020-04-29 | 2021-10-29 | 三生国健药业(上海)股份有限公司 | 四价双特异性抗体、其制备方法和用途 |
IL298394A (en) | 2020-05-21 | 2023-01-01 | Merus Nv | Methods and means for producing ig-like molecules |
WO2023166418A2 (en) * | 2022-03-03 | 2023-09-07 | Pfizer Inc. | Multispecific antibodies and uses thereof |
WO2023201309A1 (en) * | 2022-04-13 | 2023-10-19 | Xencor, Inc. | Antibodies that bind pd-l1, pd-l2 and/or cd28 |
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EA202091871A1 (ru) | 2018-03-30 | 2021-06-22 | Мерус Н.В. | Поливалентное антитело |
CN114249823A (zh) * | 2018-12-31 | 2022-03-29 | 美勒斯公司 | 混合的结合域 |
BR112021022405A2 (pt) * | 2019-05-09 | 2022-04-19 | Merus Nv | Domínios variantes para multimerização de proteínas e separação das mesmas |
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2019
- 2019-03-29 EA EA202091871A patent/EA202091871A1/ru unknown
- 2019-03-29 WO PCT/NL2019/050199 patent/WO2019190327A2/en active Application Filing
- 2019-03-29 MX MX2020010267A patent/MX2020010267A/es unknown
- 2019-03-29 BR BR112020019795-5A patent/BR112020019795A2/pt unknown
- 2019-03-29 JP JP2021502692A patent/JP2021519610A/ja active Pending
- 2019-03-29 CA CA3094318A patent/CA3094318A1/en active Pending
- 2019-03-29 MA MA052212A patent/MA52212A/fr unknown
- 2019-03-29 SG SG11202009036YA patent/SG11202009036YA/en unknown
- 2019-03-29 KR KR1020207030642A patent/KR20200139189A/ko active Search and Examination
- 2019-03-29 CN CN201980023259.9A patent/CN111936514A/zh active Pending
- 2019-03-29 EP EP19721163.4A patent/EP3774885A2/en active Pending
- 2019-03-29 TW TW108111354A patent/TW202003569A/zh unknown
- 2019-03-29 AU AU2019243665A patent/AU2019243665B2/en active Active
- 2019-03-29 AR ARP190100836A patent/AR115320A1/es unknown
- 2019-03-29 US US16/370,346 patent/US11952424B2/en active Active
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2020
- 2020-09-16 PH PH12020551504A patent/PH12020551504A1/en unknown
- 2020-09-29 IL IL277672A patent/IL277672A/en unknown
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2023
- 2023-09-01 AU AU2023222983A patent/AU2023222983A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3094318A1 (en) | 2019-10-03 |
US20190352401A1 (en) | 2019-11-21 |
WO2019190327A3 (en) | 2019-11-14 |
MX2020010267A (es) | 2020-11-06 |
AU2019243665A1 (en) | 2020-10-08 |
US11952424B2 (en) | 2024-04-09 |
EP3774885A2 (en) | 2021-02-17 |
AU2019243665B2 (en) | 2023-06-01 |
AU2023222983A1 (en) | 2023-09-21 |
PH12020551504A1 (en) | 2021-09-13 |
WO2019190327A2 (en) | 2019-10-03 |
WO2019190327A8 (en) | 2021-06-17 |
SG11202009036YA (en) | 2020-10-29 |
JP2021519610A (ja) | 2021-08-12 |
CN111936514A (zh) | 2020-11-13 |
BR112020019795A2 (pt) | 2021-01-05 |
TW202003569A (zh) | 2020-01-16 |
IL277672A (en) | 2020-11-30 |
KR20200139189A (ko) | 2020-12-11 |
MA52212A (fr) | 2021-02-17 |
AR115320A1 (es) | 2020-12-23 |
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