EA202091597A1 - Способы и композиции для лечения апноэ сна - Google Patents
Способы и композиции для лечения апноэ снаInfo
- Publication number
- EA202091597A1 EA202091597A1 EA202091597A EA202091597A EA202091597A1 EA 202091597 A1 EA202091597 A1 EA 202091597A1 EA 202091597 A EA202091597 A EA 202091597A EA 202091597 A EA202091597 A EA 202091597A EA 202091597 A1 EA202091597 A1 EA 202091597A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- sleep apnea
- compositions
- treatment
- nri
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
В общем, изобретение относится к фармацевтическим композициям, включающим (R)-оксибутинин и ингибитор обратного захвата норадреналина (NRI), и к способам лечения апноэ сна, включающим введение (R)-оксибутинина и ингибитора обратного захвата норадреналина (NRI). В некоторых вариантах осуществления NRI представляет собой атомоксетин.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862623892P | 2018-01-30 | 2018-01-30 | |
PCT/US2019/015781 WO2019152475A1 (en) | 2018-01-30 | 2019-01-30 | Methods and compositions for treating sleep apnea |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202091597A1 true EA202091597A1 (ru) | 2020-10-22 |
Family
ID=65441079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091597A EA202091597A1 (ru) | 2018-01-30 | 2019-01-30 | Способы и композиции для лечения апноэ сна |
Country Status (14)
Country | Link |
---|---|
US (2) | US11911351B2 (ru) |
EP (1) | EP3746126A1 (ru) |
JP (2) | JP7422666B2 (ru) |
KR (1) | KR20200115598A (ru) |
CN (1) | CN111670050A (ru) |
AU (1) | AU2019214891A1 (ru) |
BR (1) | BR112020015316A2 (ru) |
CA (1) | CA3089712A1 (ru) |
EA (1) | EA202091597A1 (ru) |
IL (1) | IL276247A (ru) |
MA (1) | MA52861A (ru) |
MX (1) | MX2020008086A (ru) |
SG (1) | SG11202007226UA (ru) |
WO (1) | WO2019152475A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20240042261A (ko) * | 2017-04-28 | 2024-04-01 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 수면 무호흡을 치료하기 위한 방법 및 조성물 |
US20220362221A1 (en) * | 2019-11-04 | 2022-11-17 | Apnimed, Inc. (Delaware) | Combination pharmacological interventions for multiple mechanisms of obstructive sleep apnea |
JP2024508498A (ja) * | 2021-03-04 | 2024-02-27 | アプニメッド,インコーポレイテッド(デラウェア) | 睡眠時無呼吸の治療における使用のためのレボキセチン及びムスカリン受容体拮抗薬(mra)の組み合わせ |
WO2022204228A1 (en) * | 2021-03-24 | 2022-09-29 | Apnimed, Inc. (Delaware) | Methods and compositions for treating sleep apnea |
KR20240004600A (ko) | 2021-05-04 | 2024-01-11 | 애프니메드, 인코포레이티드 (델라웨어) | (r)-옥시부티닌 d-말레이트의 고체 형태 |
BR112023026158A2 (pt) * | 2021-06-17 | 2024-03-05 | Apnimed Inc Delaware | Inibidores da recaptação de norepinefrina para tratamento da apneia do sono |
TW202342033A (zh) | 2021-12-22 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α2-腎上腺素受體亞型C(α-2C)拮抗劑與正腎上腺素再吸收抑制劑之組合 |
TW202342011A (zh) | 2021-12-22 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於治療睡眠呼吸中止之α2-腎上腺素受體亞型C(α-2C)拮抗劑與蕈毒鹼受體拮抗劑之組合 |
WO2023219991A1 (en) * | 2022-05-13 | 2023-11-16 | Apnimed, Inc. (Delaware) | Methods and compositions for treating sleep apnea |
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NL267508A (ru) | 1960-07-26 | |||
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
AU714270B2 (en) | 1995-10-24 | 1999-12-23 | Gruenenthal Gmbh | Method of inhibiting sleep apnea |
CN1396829A (zh) * | 2000-02-24 | 2003-02-12 | 法玛西雅厄普约翰美国公司 | 新的药物联合形式 |
WO2002089843A1 (en) | 2001-03-13 | 2002-11-14 | Millenium Pharmaceuticals, Inc. | Methods for treating or preventing cardiovascular disorders by modulating metalloprotease function |
US20030060513A1 (en) | 2001-09-27 | 2003-03-27 | Arneric Stephen P. | Pharmaceutical composition |
US20030185882A1 (en) * | 2001-11-06 | 2003-10-02 | Vergez Juan A. | Pharmaceutical compositions containing oxybutynin |
US20040235925A1 (en) | 2002-12-17 | 2004-11-25 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of duloxetine, venlafaxine or atomoxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
US20050009862A1 (en) | 2003-04-25 | 2005-01-13 | Sabounjian Luann | Method for promoting uninterrupted sleep by administration of trospium chloride |
ATE426405T1 (de) | 2003-12-22 | 2009-04-15 | Acadia Pharm Inc | Amino-substituierte diarylaa,ducyclohepten- analoga als muscarinische agonisten und verfahren zur behandlung von neuropsychiatrischen erkrankungen |
US20060039866A1 (en) | 2004-08-20 | 2006-02-23 | Cypress Bioscience, Inc. | Method for treating sleep-related breathing disorders |
US8252321B2 (en) | 2004-09-13 | 2012-08-28 | Chrono Therapeutics, Inc. | Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like |
WO2006055854A2 (en) | 2004-11-17 | 2006-05-26 | Cypress Bioscience, Inc. | Methods for reducing the side effects associated with mirtazapine treatment |
EP1833467B1 (en) | 2004-12-20 | 2016-08-03 | Collegium Pharmaceutical, Inc. | Pharmaceutical compositions for sleep disorders |
CA2646729A1 (en) | 2005-03-21 | 2006-09-28 | Dov Pharmaceutical, Inc. | Methods and compositions for the treatment of urinary incontinence |
EP1868602A1 (en) | 2005-04-15 | 2007-12-26 | The Board Of Trustees Of The University Of Illinois | Pharmacological treatment for sleep apnea |
US8364407B2 (en) | 2005-07-21 | 2013-01-29 | The Invention Science Fund I, Llc | Selective resonance of chemical structures |
FR2889811B1 (fr) | 2005-08-19 | 2009-10-09 | Sanofi Aventis Sa | Association d'un agent hypnotique a duree d'action longue et d'un agent hypnotique a duree d'action courte, composition pharmaceutique la contenant et son application en therapeutique. |
WO2008066750A1 (en) | 2006-11-22 | 2008-06-05 | Seaside Therapeutics, Llc | Methods of treating mental retardation, down's syndrome, fragile x syndrome and autism |
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NZ580250A (en) | 2007-04-09 | 2012-05-25 | Sunovion Pharmaceuticals Inc | Methods and compositions comprising desmethylvenlafaxine or duloxetine for treating sleep-related breathing disorders |
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BRPI0821761A2 (pt) | 2007-12-21 | 2015-06-16 | Eurand Inc | Composições de comprimidos de desintegração oral de temazepam |
US20100204058A1 (en) | 2009-01-28 | 2010-08-12 | Howard Yuan-Hao Chang | Profiling for Determination of Response to Treatment for Inflammatory Disease |
MX2012011395A (es) | 2010-04-01 | 2013-02-26 | Theravida Inc | Metodos de mejoramiento de la calidad del sueño. |
EP2672972B1 (en) | 2011-01-28 | 2020-11-04 | Pfantastic Medical Research Institute, LLC | Methods for treating obstructive sleep apnea |
JP2012176958A (ja) | 2012-04-20 | 2012-09-13 | Watson Pharmaceuticals Inc | (r)−オキシブチニンおよび(r)−デスエチルオキシブチニンによる平滑筋機能亢進の処置 |
CA2904310C (en) | 2013-03-05 | 2022-07-12 | Requis Pharmaceuticals Inc. | Preparations for the treatment of sleep-related respiratory disorders |
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HUE047169T2 (hu) | 2015-04-27 | 2020-04-28 | Arena Pharm Inc | 5-HT2C receptor agonisták és készítmények és felhasználási eljárások |
WO2017015309A1 (en) | 2015-07-22 | 2017-01-26 | John Hsu | Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof |
US20180235934A1 (en) | 2015-08-18 | 2018-08-23 | Massachusetts Institute Of Technology | Noradrenergic drug treatment of obstructive sleep apnea |
KR20240042261A (ko) * | 2017-04-28 | 2024-04-01 | 더 브리검 앤드 우먼즈 하스피털, 인크. | 수면 무호흡을 치료하기 위한 방법 및 조성물 |
CN111818946A (zh) | 2018-01-31 | 2020-10-23 | 国家儿童医院研究所 | 2c型肢带型肌营养不良的基因疗法 |
SG11202108225QA (en) | 2019-02-08 | 2021-08-30 | Brigham & Womens Hospital Inc | Methods and compositions for treating sleep apnea |
-
2019
- 2019-01-30 BR BR112020015316-8A patent/BR112020015316A2/pt unknown
- 2019-01-30 EP EP19705634.4A patent/EP3746126A1/en active Pending
- 2019-01-30 WO PCT/US2019/015781 patent/WO2019152475A1/en unknown
- 2019-01-30 EA EA202091597A patent/EA202091597A1/ru unknown
- 2019-01-30 AU AU2019214891A patent/AU2019214891A1/en active Pending
- 2019-01-30 KR KR1020207024790A patent/KR20200115598A/ko unknown
- 2019-01-30 MA MA052861A patent/MA52861A/fr unknown
- 2019-01-30 MX MX2020008086A patent/MX2020008086A/es unknown
- 2019-01-30 US US16/965,960 patent/US11911351B2/en active Active
- 2019-01-30 CN CN201980010884.XA patent/CN111670050A/zh active Pending
- 2019-01-30 JP JP2020542075A patent/JP7422666B2/ja active Active
- 2019-01-30 CA CA3089712A patent/CA3089712A1/en active Pending
- 2019-01-30 SG SG11202007226UA patent/SG11202007226UA/en unknown
-
2020
- 2020-07-23 IL IL276247A patent/IL276247A/en unknown
-
2022
- 2022-08-05 US US17/882,318 patent/US20220378724A1/en not_active Abandoned
-
2023
- 2023-10-25 JP JP2023183525A patent/JP2023181322A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US11911351B2 (en) | 2024-02-27 |
US20210038541A1 (en) | 2021-02-11 |
US20220378724A1 (en) | 2022-12-01 |
JP2021516218A (ja) | 2021-07-01 |
IL276247A (en) | 2020-09-30 |
CA3089712A1 (en) | 2019-08-08 |
MX2020008086A (es) | 2021-02-15 |
MA52861A (fr) | 2021-05-05 |
KR20200115598A (ko) | 2020-10-07 |
SG11202007226UA (en) | 2020-08-28 |
WO2019152475A1 (en) | 2019-08-08 |
JP2023181322A (ja) | 2023-12-21 |
JP7422666B2 (ja) | 2024-01-26 |
CN111670050A (zh) | 2020-09-15 |
EP3746126A1 (en) | 2020-12-09 |
BR112020015316A2 (pt) | 2020-12-08 |
AU2019214891A1 (en) | 2020-08-20 |
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