EA202091134A1 - Экзосомы для иммуноонкологической и противовоспалительной терапии - Google Patents
Экзосомы для иммуноонкологической и противовоспалительной терапииInfo
- Publication number
- EA202091134A1 EA202091134A1 EA202091134A EA202091134A EA202091134A1 EA 202091134 A1 EA202091134 A1 EA 202091134A1 EA 202091134 A EA202091134 A EA 202091134A EA 202091134 A EA202091134 A EA 202091134A EA 202091134 A1 EA202091134 A1 EA 202091134A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- oncological
- exosomes
- immuno
- inflammatory therapy
- extracellular vesicles
- Prior art date
Links
- 238000011861 anti-inflammatory therapy Methods 0.000 title 1
- 210000001808 exosome Anatomy 0.000 title 1
- 238000011275 oncology therapy Methods 0.000 title 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000002519 immonomodulatory effect Effects 0.000 abstract 1
Classifications
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07—ORGANIC CHEMISTRY
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
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- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/00—Fusion polypeptide
- C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
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Abstract
В изобретении раскрыты внеклеточные везикулы, содержащие иммуномодулирующий компонент. Также представлены способы получения внеклеточных везикул, а также способы применения указанных внеклеточных везикул для лечения рака, GvHD и аутоиммунных заболеваний.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201762611140P | 2017-12-28 | 2017-12-28 | |
US201862723267P | 2018-08-27 | 2018-08-27 | |
PCT/US2018/068062 WO2019133934A2 (en) | 2017-12-28 | 2018-12-28 | Exosomes for immuno-oncology and anti-inflammatory therapy |
Publications (1)
Publication Number | Publication Date |
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EA202091134A1 true EA202091134A1 (ru) | 2020-11-20 |
Family
ID=67058801
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA202091134A EA202091134A1 (ru) | 2017-12-28 | 2018-12-28 | Экзосомы для иммуноонкологической и противовоспалительной терапии |
Country Status (16)
Country | Link |
---|---|
US (3) | US10723782B2 (ru) |
EP (1) | EP3731849A4 (ru) |
JP (2) | JP7507090B2 (ru) |
KR (1) | KR20200108275A (ru) |
CN (1) | CN111655271A (ru) |
AU (1) | AU2018394238A1 (ru) |
BR (1) | BR112020013131A2 (ru) |
CA (1) | CA3085471A1 (ru) |
CL (1) | CL2020001691A1 (ru) |
CO (1) | CO2020009091A2 (ru) |
EA (1) | EA202091134A1 (ru) |
IL (1) | IL275600A (ru) |
MX (1) | MX2020006672A (ru) |
PH (1) | PH12020550805A1 (ru) |
SG (1) | SG11202005049QA (ru) |
WO (1) | WO2019133934A2 (ru) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111491655A (zh) | 2017-08-07 | 2020-08-04 | 加利福尼亚大学董事会 | 用于生成安全细胞治疗剂的平台 |
BR112020013131A2 (pt) | 2017-12-28 | 2020-12-08 | Codiak Biosciences, Inc. | Exossomos para imuno-oncologia e terapia anti-inflamatória |
CA3093856A1 (en) * | 2018-03-12 | 2019-09-19 | Board Of Regents, The University Of Texas System | Immuno-exosomes and methods of use thereof |
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