EA201992801A1 - Способ получения соединения гетероциклического производного, композиции, содержащей указанное соединение, и гидрата указанного соединения - Google Patents
Способ получения соединения гетероциклического производного, композиции, содержащей указанное соединение, и гидрата указанного соединенияInfo
- Publication number
- EA201992801A1 EA201992801A1 EA201992801A EA201992801A EA201992801A1 EA 201992801 A1 EA201992801 A1 EA 201992801A1 EA 201992801 A EA201992801 A EA 201992801A EA 201992801 A EA201992801 A EA 201992801A EA 201992801 A1 EA201992801 A1 EA 201992801A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- hydrate
- producing
- heterocyclic derivative
- specified compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 208000037157 Azotemia Diseases 0.000 abstract 1
- 206010007027 Calculus urinary Diseases 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 201000001431 Hyperuricemia Diseases 0.000 abstract 1
- 206010029148 Nephrolithiasis Diseases 0.000 abstract 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 abstract 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 abstract 1
- 208000020832 chronic kidney disease Diseases 0.000 abstract 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 201000008383 nephritis Diseases 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- DBODNPMIIRVQGW-UHFFFAOYSA-N trihydrate;dihydrochloride Chemical compound O.O.O.Cl.Cl DBODNPMIIRVQGW-UHFFFAOYSA-N 0.000 abstract 1
- 208000009852 uremia Diseases 0.000 abstract 1
- 229940116269 uric acid Drugs 0.000 abstract 1
- 208000008281 urolithiasis Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/04—Monocyclic monocarboxylic acids
- C07C63/06—Benzoic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
- C07C63/04—Monocyclic monocarboxylic acids
- C07C63/06—Benzoic acid
- C07C63/10—Halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Настоящее изобретение относится к новому способу получения соединения гетероциклического производного химической формулы I; к новому промежуточному соединению, используемому в способе получения; к композиции для лечения или предупреждения гиперурикемии, подагры, нефрита, хронической почечной недостаточности, нефролитиаза, уремии, уролитиаза или заболевания, ассоциированного с мочевой кислотой, которая содержит соединение формулы I в дозе от более чем 2 до 10 мг или менее и вводится перорально один раз в сутки; и к 1,5-гидрату (сесквигидрату) гидрохлорида нового соединения химической формулы I.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170064914 | 2017-05-25 | ||
| PCT/KR2018/005932 WO2018217050A1 (ko) | 2017-05-25 | 2018-05-24 | 헤테로사이클 유도체 화합물의 제조방법, 상기 화합물을 포함하는 조성물 및 상기 화합물의 수화물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201992801A1 true EA201992801A1 (ru) | 2020-03-19 |
Family
ID=64396846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201992801A EA201992801A1 (ru) | 2017-05-25 | 2018-05-24 | Способ получения соединения гетероциклического производного, композиции, содержащей указанное соединение, и гидрата указанного соединения |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US20200207784A1 (ru) |
| EP (3) | EP3632917B1 (ru) |
| JP (2) | JP2020521007A (ru) |
| KR (1) | KR102307504B1 (ru) |
| CN (2) | CN110691783A (ru) |
| AU (1) | AU2018273020B2 (ru) |
| BR (1) | BR112019024253A2 (ru) |
| CA (2) | CA3061301C (ru) |
| EA (1) | EA201992801A1 (ru) |
| ES (1) | ES2907590T3 (ru) |
| IL (2) | IL294127B1 (ru) |
| MX (2) | MX2019013937A (ru) |
| NZ (1) | NZ758513A (ru) |
| PH (1) | PH12019502418A1 (ru) |
| PL (1) | PL3632917T3 (ru) |
| TW (1) | TW202411234A (ru) |
| WO (1) | WO2018217050A1 (ru) |
| ZA (1) | ZA201908433B (ru) |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6197291A (ja) * | 1984-10-17 | 1986-05-15 | Yamanouchi Pharmaceut Co Ltd | ７−〔α−（２−アミノ−４−チアゾリル）−α−（低級アルコキシイミノ）アセトアミド〕−３−〔６−（２Ｈ−ピリド〔４，３−ｂ〕−１，４−オキサジニオ）メチル〕−Δ３−セフエム−４−カルボキシレ−トおよびその製造法 |
| IL119466A (en) * | 1995-11-03 | 2001-08-26 | Akzo Nobel Nv | Thrombin inhibitors, their preparation and pharmaceutical compositions containing them |
| JP3988832B2 (ja) * | 2004-11-29 | 2007-10-10 | 日本たばこ産業株式会社 | 窒素含有縮合環化合物及びその用途 |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| JP4646068B2 (ja) * | 2005-09-30 | 2011-03-09 | 国立大学法人東京工業大学 | ポジ型感光性樹脂組成物、その製造方法、及びレリーフパターンの形成方法 |
| US20080305169A1 (en) * | 2006-05-26 | 2008-12-11 | Japan Tobacco Inc. | Pharmaceutical Compositions Comprising Nitrogen-Containing Fused Ring Coumpounds |
| US20080064871A1 (en) * | 2006-05-26 | 2008-03-13 | Japan Tobacco Inc. | Production Method of Nitrogen-Containing Fused Ring Compounds |
| WO2008062740A1 (fr) * | 2006-11-20 | 2008-05-29 | Japan Tobacco Inc. | Composé azoté à anneaux fusionnés et son utilisation |
| CA2718709C (en) * | 2008-03-31 | 2016-08-09 | C & C Research Laboratories | Heterocyclic derivatives |
| EP2281128B1 (en) * | 2008-04-28 | 2019-08-28 | Robert Bosch GmbH | Drive belt ring component and manufacturing method and maraging steel base material therefor |
-
2018
- 2018-05-24 MX MX2019013937A patent/MX2019013937A/es unknown
- 2018-05-24 EA EA201992801A patent/EA201992801A1/ru unknown
- 2018-05-24 PL PL18806513T patent/PL3632917T3/pl unknown
- 2018-05-24 CA CA3061301A patent/CA3061301C/en active Active
- 2018-05-24 JP JP2020516362A patent/JP2020521007A/ja not_active Withdrawn
- 2018-05-24 AU AU2018273020A patent/AU2018273020B2/en active Active
- 2018-05-24 CN CN201880034458.5A patent/CN110691783A/zh active Pending
- 2018-05-24 EP EP18806513.0A patent/EP3632917B1/en active Active
- 2018-05-24 NZ NZ758513A patent/NZ758513A/en unknown
- 2018-05-24 ES ES18806513T patent/ES2907590T3/es active Active
- 2018-05-24 KR KR1020197032941A patent/KR102307504B1/ko active IP Right Grant
- 2018-05-24 CN CN202111329839.6A patent/CN114085235A/zh active Pending
- 2018-05-24 CA CA3150710A patent/CA3150710C/en active Active
- 2018-05-24 WO PCT/KR2018/005932 patent/WO2018217050A1/ko unknown
- 2018-05-24 IL IL294127A patent/IL294127B1/en unknown
- 2018-05-24 TW TW112144614A patent/TW202411234A/zh unknown
- 2018-05-24 US US16/615,566 patent/US20200207784A1/en not_active Abandoned
- 2018-05-24 EP EP21180716.9A patent/EP3909955A1/en active Pending
- 2018-05-24 EP EP21180717.7A patent/EP3909956A1/en active Pending
- 2018-05-24 BR BR112019024253-8A patent/BR112019024253A2/pt active Search and Examination
- 2018-05-24 IL IL270789A patent/IL270789B2/en unknown
-
2019
- 2019-10-25 PH PH12019502418A patent/PH12019502418A1/en unknown
- 2019-11-21 MX MX2022005722A patent/MX2022005722A/es unknown
- 2019-12-18 ZA ZA2019/08433A patent/ZA201908433B/en unknown
-
2022
- 2022-06-14 JP JP2022095779A patent/JP2022126729A/ja active Pending
- 2022-07-07 US US17/859,566 patent/US11866448B2/en active Active
- 2022-07-07 US US17/859,603 patent/US20220363691A1/en active Pending
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2023
- 2023-09-26 US US18/372,856 patent/US20240067659A1/en active Pending
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