EA201171361A1 - Ингибиторы внешнего медуллярного калиевого канала почек - Google Patents

Ингибиторы внешнего медуллярного калиевого канала почек

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Publication number
EA201171361A1
EA201171361A1 EA201171361A EA201171361A EA201171361A1 EA 201171361 A1 EA201171361 A1 EA 201171361A1 EA 201171361 A EA201171361 A EA 201171361A EA 201171361 A EA201171361 A EA 201171361A EA 201171361 A1 EA201171361 A1 EA 201171361A1
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Eurasian Patent Office
Prior art keywords
external
meddullary
kalieva
kid
inhibitors
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EA201171361A
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English (en)
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EA021008B1 (ru
Inventor
Александер Пастернак
Аураш Шахрипур
Хайфын Тан
Нардос Х. Тумелсан
Лиху Ян
Юйпин Чжу
Шон П. Уолш
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Мерк Шарп Энд Домэ Корп.
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Application filed by Мерк Шарп Энд Домэ Корп. filed Critical Мерк Шарп Энд Домэ Корп.
Publication of EA201171361A1 publication Critical patent/EA201171361A1/ru
Publication of EA021008B1 publication Critical patent/EA021008B1/ru

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Abstract

Настоящее изобретение относится к соединениям структурной формулы I и их фармацевтически приемлемым солям, которые ингибируют внешний медуллярный калиевый канал почек (ROMK) (Kirl.1). Соединения формулы I могут применяться в качестве диуретических и натрийуретических лекарственных средств и, следовательно, могут применяться для терапии и профилактики расстройств, которые являются результатом избыточного содержания соли и удержания воды, включая сердечно-сосудистые заболевания, такие как гипертензия и хроническая и острая сердечная недостаточность.
EA201171361A 2009-05-06 2010-04-29 Ингибиторы внешнего медуллярного калиевого канала почек EA021008B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17584709P 2009-05-06 2009-05-06
PCT/US2010/032872 WO2010129379A1 (en) 2009-05-06 2010-04-29 Inhibitors of the renal outer medullary potassium channel

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EA201171361A1 true EA201171361A1 (ru) 2012-05-30
EA021008B1 EA021008B1 (ru) 2015-03-31

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US (2) US8673920B2 (ru)
EP (1) EP2427444B1 (ru)
JP (2) JP5092068B2 (ru)
KR (1) KR101373902B1 (ru)
CN (1) CN102459216B (ru)
AR (1) AR076836A1 (ru)
AU (1) AU2010246269C1 (ru)
BR (1) BRPI1014050A2 (ru)
CA (1) CA2759399C (ru)
CL (1) CL2011002761A1 (ru)
CO (1) CO6460758A2 (ru)
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EC (1) ECSP11011444A (ru)
ES (1) ES2561654T3 (ru)
GE (1) GEP20146055B (ru)
GT (1) GT201100278A (ru)
HN (1) HN2011002933A (ru)
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PE (1) PE20120346A1 (ru)
SG (1) SG175841A1 (ru)
TN (1) TN2011000540A1 (ru)
TW (1) TWI408135B (ru)
UA (1) UA106611C2 (ru)
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CN105693706B (zh) * 2014-12-10 2019-11-22 江苏恒瑞医药股份有限公司 异苯并呋喃酮类衍生物、其制备方法及其在医药上的应用
EP3250204B1 (en) 2015-01-29 2019-10-30 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
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EP2427444A1 (en) 2012-03-14
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US8673920B2 (en) 2014-03-18
AR076836A1 (es) 2011-07-13
KR20120011069A (ko) 2012-02-06
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CN102459216A (zh) 2012-05-16
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