EA201991497A1 - Производные бензодиазепина, композиции и способы лечения когнитивного нарушения - Google Patents
Производные бензодиазепина, композиции и способы лечения когнитивного нарушенияInfo
- Publication number
- EA201991497A1 EA201991497A1 EA201991497A EA201991497A EA201991497A1 EA 201991497 A1 EA201991497 A1 EA 201991497A1 EA 201991497 A EA201991497 A EA 201991497A EA 201991497 A EA201991497 A EA 201991497A EA 201991497 A1 EA201991497 A1 EA 201991497A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cognitive impairment
- treatment
- gaba receptor
- age
- compositions
- Prior art date
Links
- 208000028698 Cognitive impairment Diseases 0.000 title abstract 7
- 208000010877 cognitive disease Diseases 0.000 title abstract 7
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 3
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 4
- 208000024827 Alzheimer disease Diseases 0.000 abstract 3
- 239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 abstract 2
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 2
- 102000005915 GABA Receptors Human genes 0.000 abstract 2
- 108010005551 GABA Receptors Proteins 0.000 abstract 2
- 229940121909 GABA receptor agonist Drugs 0.000 abstract 2
- 208000018737 Parkinson disease Diseases 0.000 abstract 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 229940126027 positive allosteric modulator Drugs 0.000 abstract 2
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 2
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000001914 Fragile X syndrome Diseases 0.000 abstract 1
- 208000000172 Medulloblastoma Diseases 0.000 abstract 1
- 208000036626 Mental retardation Diseases 0.000 abstract 1
- 230000007000 age related cognitive decline Effects 0.000 abstract 1
- 208000029560 autism spectrum disease Diseases 0.000 abstract 1
- 231100000867 compulsive behavior Toxicity 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 206010027175 memory impairment Diseases 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662436272P | 2016-12-19 | 2016-12-19 | |
| PCT/IB2017/001763 WO2018130869A1 (en) | 2016-12-19 | 2017-12-20 | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| PCT/IB2017/001762 WO2018130868A1 (en) | 2016-12-19 | 2017-12-20 | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201991497A1 true EA201991497A1 (ru) | 2020-01-20 |
Family
ID=62557208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201991497A EA201991497A1 (ru) | 2016-12-19 | 2017-12-20 | Производные бензодиазепина, композиции и способы лечения когнитивного нарушения |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20180170941A1 (https=) |
| EP (1) | EP3555100B1 (https=) |
| JP (1) | JP7153938B2 (https=) |
| CN (2) | CN110382501A (https=) |
| AU (1) | AU2017393082B2 (https=) |
| CA (1) | CA3047684A1 (https=) |
| EA (1) | EA201991497A1 (https=) |
| IL (1) | IL267451B2 (https=) |
| MX (1) | MX388726B (https=) |
| WO (2) | WO2018130869A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ760341A (en) | 2013-12-20 | 2021-12-24 | Agenebio Inc | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| MX392119B (es) | 2015-06-19 | 2025-03-11 | Agenebio Inc | Derivados de benzodiazepina, composiciones y metodos para tratar deterioro cognitivo |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| CN112601749B (zh) * | 2018-06-19 | 2024-03-26 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法 |
| WO2020072675A1 (en) | 2018-10-02 | 2020-04-09 | Northwestern University | Beta-carbolines as positive allosteric modulators of the human serotonin receptor 2c (5-ht2c) |
| JP7737721B2 (ja) * | 2019-12-19 | 2025-09-11 | エージンバイオ， インコーポレイテッド | 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法 |
| CN116075302A (zh) * | 2020-07-10 | 2023-05-05 | 艾吉因生物股份有限公司 | GABAAα5激动剂和SV2A抑制剂的组合以及在认知损害的治疗中的使用方法 |
| WO2022011314A1 (en) * | 2020-07-10 | 2022-01-13 | Agenebio, Inc. | POLYMORPHS OF A GABAA α5 AGONIST AND METHODS OF USING IN THE TREATMENT OF COGNITIVE IMPAIRMENT |
| CN113413532B (zh) * | 2021-07-01 | 2022-03-01 | 曾迎春 | 基于虚拟现实的癌症相关认知障碍评估与康复训练系统 |
| CN120584115A (zh) | 2022-08-19 | 2025-09-02 | 艾吉因生物股份有限公司 | 苯并氮杂䓬衍生物、组合物和用于治疗认知损害的方法 |
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| US20180170941A1 (en) | 2016-12-19 | 2018-06-21 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| CN108567786A (zh) | 2017-03-10 | 2018-09-25 | 陈洪国 | 一种治疗溃疡性结肠炎的药物组合物 |
| CN108567787A (zh) | 2017-03-10 | 2018-09-25 | 辛衍雪 | 一种治疗慢性阻塞性肺病的药物组合物 |
| CN112601749B (zh) | 2018-06-19 | 2024-03-26 | 艾吉因生物股份有限公司 | 用于治疗认知损害的苯并二氮杂环庚三烯衍生物，组合物和方法 |
| JP7737721B2 (ja) * | 2019-12-19 | 2025-09-11 | エージンバイオ， インコーポレイテッド | 認知障害を処置するためのベンゾジアゼピン誘導体、組成物および方法 |
-
2017
- 2017-12-19 US US15/847,906 patent/US20180170941A1/en not_active Abandoned
- 2017-12-20 CN CN201780086584.0A patent/CN110382501A/zh active Pending
- 2017-12-20 AU AU2017393082A patent/AU2017393082B2/en active Active
- 2017-12-20 EA EA201991497A patent/EA201991497A1/ru unknown
- 2017-12-20 CN CN202310213936.1A patent/CN116640143A/zh active Pending
- 2017-12-20 MX MX2019007338A patent/MX388726B/es unknown
- 2017-12-20 WO PCT/IB2017/001763 patent/WO2018130869A1/en not_active Ceased
- 2017-12-20 WO PCT/IB2017/001762 patent/WO2018130868A1/en not_active Ceased
- 2017-12-20 CA CA3047684A patent/CA3047684A1/en active Pending
- 2017-12-20 IL IL267451A patent/IL267451B2/en unknown
- 2017-12-20 EP EP17891696.1A patent/EP3555100B1/en active Active
- 2017-12-20 JP JP2019554038A patent/JP7153938B2/ja active Active
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2022
- 2022-09-02 US US17/902,374 patent/US12528819B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| NZ755287A (en) | 2025-06-27 |
| IL267451A (en) | 2019-08-29 |
| US20180170941A1 (en) | 2018-06-21 |
| WO2018130868A1 (en) | 2018-07-19 |
| JP2020512389A (ja) | 2020-04-23 |
| IL267451B1 (en) | 2023-06-01 |
| EP3555100A4 (en) | 2020-06-10 |
| MX388726B (es) | 2025-03-20 |
| WO2018130868A8 (en) | 2019-08-08 |
| CN116640143A (zh) | 2023-08-25 |
| AU2017393082B2 (en) | 2022-04-21 |
| JP7153938B2 (ja) | 2022-10-17 |
| US20230134844A1 (en) | 2023-05-04 |
| AU2017393082A1 (en) | 2019-07-25 |
| WO2018130869A1 (en) | 2018-07-19 |
| IL267451B2 (en) | 2023-10-01 |
| MX2019007338A (es) | 2019-09-19 |
| EP3555100B1 (en) | 2023-05-10 |
| US12528819B2 (en) | 2026-01-20 |
| CN110382501A (zh) | 2019-10-25 |
| CA3047684A1 (en) | 2018-07-19 |
| EP3555100A1 (en) | 2019-10-23 |
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