EA201891562A3 - Трифторметиловые спирты как модуляторы roryt - Google Patents

Трифторметиловые спирты как модуляторы roryt

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Publication number
EA201891562A3
EA201891562A3 EA201891562A EA201891562A EA201891562A3 EA 201891562 A3 EA201891562 A3 EA 201891562A3 EA 201891562 A EA201891562 A EA 201891562A EA 201891562 A EA201891562 A EA 201891562A EA 201891562 A3 EA201891562 A3 EA 201891562A3
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EA
Eurasian Patent Office
Prior art keywords
triftoromethyl
alcohols
present
roryt modulators
syndrome
Prior art date
Application number
EA201891562A
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English (en)
Other versions
EA035998B1 (ru
EA201891562A2 (ru
Inventor
Харихаран Венкатесан
Вирджиния Танис
Олаф Кинцель
Кристиан Геге
Кристоф Штенек
Геральд Клейман
Томас Хоффманн
Стивен Голдберг
Сяохуа Сюэ
Анн М. Фурье
Original Assignee
Янссен Фармацевтика Нв
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Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of EA201891562A2 publication Critical patent/EA201891562A2/ru
Publication of EA201891562A3 publication Critical patent/EA201891562A3/ru
Publication of EA035998B1 publication Critical patent/EA035998B1/ru

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Настоящее изобретение содержит соединения формулы Iгде X, A, A, A, A, R, Rи Rопределены в спецификации. Настоящее изобретение также содержит способ лечения или облегчения синдрома, расстройства или заболевания, причем указанный синдром, расстройство или заболевание представляет собой ревматоидный артрит или псориаз. Настоящее изобретение также содержит способ модулирования активности RORγt у млекопитающего путем введения терапевтически эффективного количества по меньшей мере одного соединения по п.1 формулы изобретения.
EA201891562A 2014-10-30 2015-10-30 Способ получения замещенных производных тиазола EA035998B1 (ru)

Applications Claiming Priority (1)

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US201462072563P 2014-10-30 2014-10-30

Publications (3)

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EA201891562A2 EA201891562A2 (ru) 2018-12-28
EA201891562A3 true EA201891562A3 (ru) 2019-04-30
EA035998B1 EA035998B1 (ru) 2020-09-10

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ID=54754732

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EA201891562A EA035998B1 (ru) 2014-10-30 2015-10-30 Способ получения замещенных производных тиазола
EA201790942A EA033699B1 (ru) 2014-10-30 2015-10-30 ТРИФТОРМЕТИЛОВЫЕ СПИРТЫ КАК МОДУЛЯТОРЫ RORγt

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US (2) US9850236B2 (ru)
EP (2) EP3212643B1 (ru)
JP (3) JP6998204B2 (ru)
KR (2) KR20170127580A (ru)
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CN112292124A (zh) * 2018-03-12 2021-01-29 爱思凯利尔生物科学私人有限责任公司 双环ROR-γ调节剂
KR20210060367A (ko) 2018-03-12 2021-05-26 에스칼리에 바이오사이언시스, 비브이 스피로사이클릭 ror-감마 조절제
CN112566901A (zh) 2018-06-18 2021-03-26 詹森药业有限公司 作为RORγt的调节剂的苯基取代的吡唑类
EP3807261B1 (en) 2018-06-18 2022-07-13 Janssen Pharmaceutica NV Pyridinyl pyrazoles as modulators of roryt
ES2929140T3 (es) 2018-06-18 2022-11-25 Janssen Pharmaceutica Nv Imidazoles sustituidos con fenilo y piridinilo como moduladores de RORgammat
WO2019244001A1 (en) 2018-06-18 2019-12-26 Janssen Pharmaceutica Nv 6-aminopyridin-3-yl pyrazoles as modulators of roryt
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19
WO2024089216A1 (en) 2022-10-27 2024-05-02 Syngenta Crop Protection Ag Novel sulfur-containing heteroaryl carboxamide compounds

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