EA201792389A1 - Пцр в реальном времени для мультиплексной оптимизированной амплификации с несоответствиями (moma) и для оценки неклеточной днк - Google Patents
Пцр в реальном времени для мультиплексной оптимизированной амплификации с несоответствиями (moma) и для оценки неклеточной днкInfo
- Publication number
- EA201792389A1 EA201792389A1 EA201792389A EA201792389A EA201792389A1 EA 201792389 A1 EA201792389 A1 EA 201792389A1 EA 201792389 A EA201792389 A EA 201792389A EA 201792389 A EA201792389 A EA 201792389A EA 201792389 A1 EA201792389 A1 EA 201792389A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- moma
- multiplex
- assessment
- correspondence
- real
- Prior art date
Links
- 108091093105 Nuclear DNA Proteins 0.000 title 1
- 230000003321 amplification Effects 0.000 title 1
- 238000003199 nucleic acid amplification method Methods 0.000 title 1
- 238000003753 real-time PCR Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562155453P | 2015-04-30 | 2015-04-30 | |
| PCT/US2016/030313 WO2016176662A1 (en) | 2015-04-30 | 2016-04-29 | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201792389A1 true EA201792389A1 (ru) | 2018-05-31 |
Family
ID=56027193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201792389A EA201792389A1 (ru) | 2015-04-30 | 2016-04-29 | Пцр в реальном времени для мультиплексной оптимизированной амплификации с несоответствиями (moma) и для оценки неклеточной днк |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20180142296A1 (enExample) |
| EP (1) | EP3289102A1 (enExample) |
| JP (2) | JP2018514219A (enExample) |
| CN (1) | CN107849604A (enExample) |
| AU (2) | AU2016255573A1 (enExample) |
| BR (1) | BR112017023232A2 (enExample) |
| CA (1) | CA2984352A1 (enExample) |
| EA (1) | EA201792389A1 (enExample) |
| HK (1) | HK1252152A1 (enExample) |
| IL (2) | IL255301B (enExample) |
| MX (1) | MX2017013878A (enExample) |
| WO (1) | WO2016176662A1 (enExample) |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11773434B2 (en) | 2017-06-20 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11946101B2 (en) | 2015-05-11 | 2024-04-02 | Natera, Inc. | Methods and compositions for determining ploidy |
| US12020778B2 (en) | 2010-05-18 | 2024-06-25 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| US12100478B2 (en) | 2012-08-17 | 2024-09-24 | Natera, Inc. | Method for non-invasive prenatal testing using parental mosaicism data |
| US12110552B2 (en) | 2010-05-18 | 2024-10-08 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12146195B2 (en) | 2016-04-15 | 2024-11-19 | Natera, Inc. | Methods for lung cancer detection |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| US12260934B2 (en) | 2014-06-05 | 2025-03-25 | Natera, Inc. | Systems and methods for detection of aneuploidy |
| US12270073B2 (en) | 2010-05-18 | 2025-04-08 | Natera, Inc. | Methods for preparing a biological sample obtained from an individual for use in a genetic testing assay |
| US12305229B2 (en) | 2014-04-21 | 2025-05-20 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12410476B2 (en) | 2010-05-18 | 2025-09-09 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12460264B2 (en) | 2016-11-02 | 2025-11-04 | Natera, Inc. | Method of detecting tumour recurrence |
| US12509728B2 (en) | 2005-07-29 | 2025-12-30 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US12571043B2 (en) | 2005-11-26 | 2026-03-10 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US8825412B2 (en) | 2010-05-18 | 2014-09-02 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| EP2656263B1 (en) | 2010-12-22 | 2019-11-06 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| AU2013249012B2 (en) | 2012-04-19 | 2019-03-28 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free DNA |
| CN113774132A (zh) | 2014-04-21 | 2021-12-10 | 纳特拉公司 | 检测染色体片段中的突变和倍性 |
| CN107849604A (zh) * | 2015-04-30 | 2018-03-27 | 威斯康星州立大学医学院 | 用于评估无细胞dna的多重优化错配扩增(moma)实时pcr |
| EA201892491A1 (ru) * | 2016-04-29 | 2019-06-28 | Дзе Медикал Колледж Оф Висконсин, Инк. | Пцр в реальном времени с мультиплексной оптимизированной амплификацией неправильно спаренных оснований (moma) для анализа злокачественных новообразований |
| BR112018072196A2 (pt) | 2016-04-29 | 2019-02-12 | Medical College Wisconsin Inc | amplificação de incompatibilidade otimizada multiplexadas (moma) - número do alvo |
| AU2017258800A1 (en) * | 2016-04-29 | 2018-12-20 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing fetal well being |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| JP2019534016A (ja) * | 2016-11-02 | 2019-11-28 | ザ メディカル カレッジ オブ ウィスコンシン，インコーポレイテッドＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | 全および特異的な無細胞ｄｎａを使用しリスクを評価するための方法 |
| CA3042722A1 (en) * | 2016-11-02 | 2018-05-11 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using mismatch amplification and statistical methods |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| JP2020529193A (ja) * | 2017-06-20 | 2020-10-08 | ザ メディカル カレッジ オブ ウィスコンシン，インコーポレイテッドＴｈｅ Ｍｅｄｉｃａｌ Ｃｏｌｌｅｇｅ ｏｆ Ｗｉｓｃｏｎｓｉｎ， Ｉｎｃ． | ドナー特異的セルフリーｄｎａを用いる移植対象における状態の評価 |
| AU2018288838A1 (en) * | 2017-06-20 | 2020-01-16 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free DNA |
| AU2018317875A1 (en) * | 2017-08-17 | 2020-03-05 | Tai Diagnostics, Inc. | Methods of determining donor cell-free DNA without donor genotype |
| SG11202005474RA (en) | 2017-12-15 | 2020-07-29 | Acrannolife Genomics Pvt Ltd | A non-invasive method for monitoring transplanted organ status in organ-transplant recipients |
| WO2020131955A1 (en) * | 2018-12-17 | 2020-06-25 | The Medical College Of Wisconsin, Inc. | Assessing risk with total cell-free dna |
| WO2020206290A1 (en) * | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using total cell-free dna |
| EP3980559A1 (en) | 2019-06-06 | 2022-04-13 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| WO2021236962A1 (en) | 2020-05-20 | 2021-11-25 | The Medical College Of Wisconsin, Inc. | Compositions and methods for inhibiting cytokine-release syndrome |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2274861T3 (es) * | 2001-12-24 | 2007-06-01 | Wolfgang Prof. Holzgreve | Metodo para el diagnostico no-invasivo de transplantes y transfusiones. |
| HUE052213T2 (hu) * | 2009-11-06 | 2021-04-28 | Univ Leland Stanford Junior | Grafitkilökõdés nem invazív diagnosztizálása szervátültetett betegekben |
| US20130143219A1 (en) * | 2010-01-28 | 2013-06-06 | Medical College of Wisconsin Inc. | Methods and compositions for high yield, specific amplification |
| CN102892901B (zh) * | 2010-03-24 | 2015-11-25 | 凸版印刷株式会社 | 利用竞争性引物的目标碱基序列的检测方法 |
| AU2013249012B2 (en) * | 2012-04-19 | 2019-03-28 | The Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free DNA |
| EP2959016A4 (en) * | 2013-02-21 | 2016-10-12 | Toma Biosciences Inc | METHOD, COMPOSITIONS AND NUCLEIC ACID ANALYSIS KITS |
| US20160115541A1 (en) * | 2013-05-29 | 2016-04-28 | Chronix Biomedical | Detection and quantification of donor cell-free dna in the circulation of organ transplant recipients |
| CN107849604A (zh) * | 2015-04-30 | 2018-03-27 | 威斯康星州立大学医学院 | 用于评估无细胞dna的多重优化错配扩增(moma)实时pcr |
-
2016
- 2016-04-29 CN CN201680039018.XA patent/CN107849604A/zh active Pending
- 2016-04-29 HK HK18111543.9A patent/HK1252152A1/zh unknown
- 2016-04-29 JP JP2017557142A patent/JP2018514219A/ja active Pending
- 2016-04-29 US US15/570,560 patent/US20180142296A1/en not_active Abandoned
- 2016-04-29 AU AU2016255573A patent/AU2016255573A1/en not_active Abandoned
- 2016-04-29 MX MX2017013878A patent/MX2017013878A/es unknown
- 2016-04-29 BR BR112017023232A patent/BR112017023232A2/pt not_active IP Right Cessation
- 2016-04-29 EP EP16724189.2A patent/EP3289102A1/en active Pending
- 2016-04-29 WO PCT/US2016/030313 patent/WO2016176662A1/en not_active Ceased
- 2016-04-29 EA EA201792389A patent/EA201792389A1/ru unknown
- 2016-04-29 CA CA2984352A patent/CA2984352A1/en active Pending
-
2017
- 2017-10-29 IL IL255301A patent/IL255301B/en unknown
-
2021
- 2021-08-03 JP JP2021127555A patent/JP2022002508A/ja active Pending
- 2021-12-26 IL IL289404A patent/IL289404A/en unknown
-
2022
- 2022-05-23 AU AU2022203482A patent/AU2022203482A1/en not_active Abandoned
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12509728B2 (en) | 2005-07-29 | 2025-12-30 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US12571043B2 (en) | 2005-11-26 | 2026-03-10 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12020778B2 (en) | 2010-05-18 | 2024-06-25 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12410476B2 (en) | 2010-05-18 | 2025-09-09 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12270073B2 (en) | 2010-05-18 | 2025-04-08 | Natera, Inc. | Methods for preparing a biological sample obtained from an individual for use in a genetic testing assay |
| US12110552B2 (en) | 2010-05-18 | 2024-10-08 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12100478B2 (en) | 2012-08-17 | 2024-09-24 | Natera, Inc. | Method for non-invasive prenatal testing using parental mosaicism data |
| US12305229B2 (en) | 2014-04-21 | 2025-05-20 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12260934B2 (en) | 2014-06-05 | 2025-03-25 | Natera, Inc. | Systems and methods for detection of aneuploidy |
| US11946101B2 (en) | 2015-05-11 | 2024-04-02 | Natera, Inc. | Methods and compositions for determining ploidy |
| US12146195B2 (en) | 2016-04-15 | 2024-11-19 | Natera, Inc. | Methods for lung cancer detection |
| US12460264B2 (en) | 2016-11-02 | 2025-11-04 | Natera, Inc. | Method of detecting tumour recurrence |
| US11773434B2 (en) | 2017-06-20 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free DNA |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| US12385096B2 (en) | 2018-04-14 | 2025-08-12 | Natera, Inc. | Methods for cancer detection and monitoring |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2022203482A1 (en) | 2022-06-09 |
| CN107849604A (zh) | 2018-03-27 |
| CA2984352A1 (en) | 2016-11-03 |
| MX2017013878A (es) | 2018-06-22 |
| EP3289102A1 (en) | 2018-03-07 |
| IL289404A (en) | 2022-02-01 |
| BR112017023232A2 (pt) | 2018-08-07 |
| IL255301B (en) | 2022-02-01 |
| JP2018514219A (ja) | 2018-06-07 |
| IL255301A0 (en) | 2017-12-31 |
| WO2016176662A1 (en) | 2016-11-03 |
| AU2016255573A1 (en) | 2017-12-21 |
| US20180142296A1 (en) | 2018-05-24 |
| JP2022002508A (ja) | 2022-01-11 |
| HK1252152A1 (zh) | 2019-05-17 |
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