AU2016255573A1 - Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA - Google Patents

Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA Download PDF

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Publication number
AU2016255573A1
AU2016255573A1 AU2016255573A AU2016255573A AU2016255573A1 AU 2016255573 A1 AU2016255573 A1 AU 2016255573A1 AU 2016255573 A AU2016255573 A AU 2016255573A AU 2016255573 A AU2016255573 A AU 2016255573A AU 2016255573 A1 AU2016255573 A1 AU 2016255573A1
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snv
nucleic acids
amount
native nucleic
sample
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Aoy Tomita Mitchell
Michael Mitchell
Karl Stamm
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Medical College of Wisconsin
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Medical College of Wisconsin
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Assigned to THE MEDICAL COLLEGE OF WISCONSIN, INC. reassignment THE MEDICAL COLLEGE OF WISCONSIN, INC. Amend patent request/document other than specification (104) Assignors: MEDICAL COLLEGE OF WISCONSIN, INC.
Priority to AU2022203482A priority Critical patent/AU2022203482A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2016255573A 2015-04-30 2016-04-29 Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA Abandoned AU2016255573A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2022203482A AU2022203482A1 (en) 2015-04-30 2022-05-23 Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562155453P 2015-04-30 2015-04-30
US62/155,453 2015-04-30
PCT/US2016/030313 WO2016176662A1 (en) 2015-04-30 2016-04-29 Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cell-free dna

Related Child Applications (1)

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AU2022203482A Division AU2022203482A1 (en) 2015-04-30 2022-05-23 Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA

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AU2016255573A1 true AU2016255573A1 (en) 2017-12-21

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AU2016255573A Abandoned AU2016255573A1 (en) 2015-04-30 2016-04-29 Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA
AU2022203482A Abandoned AU2022203482A1 (en) 2015-04-30 2022-05-23 Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA

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AU2022203482A Abandoned AU2022203482A1 (en) 2015-04-30 2022-05-23 Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA

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US (1) US20180142296A1 (enExample)
EP (1) EP3289102A1 (enExample)
JP (2) JP2018514219A (enExample)
CN (1) CN107849604A (enExample)
AU (2) AU2016255573A1 (enExample)
BR (1) BR112017023232A2 (enExample)
CA (1) CA2984352A1 (enExample)
EA (1) EA201792389A1 (enExample)
HK (1) HK1252152A1 (enExample)
IL (2) IL255301B (enExample)
MX (1) MX2017013878A (enExample)
WO (1) WO2016176662A1 (enExample)

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US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US12655483B2 (en) 2010-05-18 2026-06-16 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
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US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
AU2011348100B2 (en) 2010-12-22 2016-08-25 Natera, Inc. Methods for non-invasive prenatal paternity testing
JP6153874B2 (ja) 2011-02-09 2017-06-28 ナテラ， インコーポレイテッド 非侵襲的出生前倍数性呼び出しのための方法
US10385396B2 (en) 2012-04-19 2019-08-20 The Medical College Of Wisconsin, Inc. Highly sensitive surveillance using detection of cell free DNA
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
PL3117012T5 (pl) 2014-03-14 2026-03-16 Caredx, Inc. Sposoby monitorowania terapii immunosupresyjnych u biorcy przeszczepu
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
US20180173845A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
AU2016255573A1 (en) * 2015-04-30 2017-12-21 The Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing cell-free DNA
EP4428863A3 (en) 2015-05-11 2024-12-11 Natera, Inc. Methods and compositions for determining ploidy
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CA3022572A1 (en) 2016-04-29 2017-11-02 The Medical College Of Wisconsin, Inc. Multiplexed optimized mismatch amplification (moma)-target number
EA201892491A1 (ru) * 2016-04-29 2019-06-28 Дзе Медикал Колледж Оф Висконсин, Инк. Пцр в реальном времени с мультиплексной оптимизированной амплификацией неправильно спаренных оснований (moma) для анализа злокачественных новообразований
BR112018072197A2 (pt) * 2016-04-29 2019-02-12 Medical College Wisconsin Inc amplificação de emparelhamento optimizado múltiplo (moma) - pcr de tempo real para avaliar o poço fetal
WO2018067517A1 (en) 2016-10-04 2018-04-12 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US20190367972A1 (en) * 2016-11-02 2019-12-05 The Medical College Of Wisconsin, Inc. Methods for assessing risk using total and specific cell-free dna
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AU2017355458A1 (en) * 2016-11-02 2019-06-13 The Medical College Of Wisconsin, Inc. Methods for assessing risk using mismatch amplification and statistical methods
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CN111094593A (zh) * 2017-06-20 2020-05-01 威斯康星州立大学医学院 使用供体特异性无细胞dna来评估移植对象中的病症
US20210139983A1 (en) * 2017-06-20 2021-05-13 The Medical College Of Wisconsin, Inc. Transplant patient monitoring with cell-free dna
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Also Published As

Publication number Publication date
JP2018514219A (ja) 2018-06-07
BR112017023232A2 (pt) 2018-08-07
IL289404A (en) 2022-02-01
JP2022002508A (ja) 2022-01-11
MX2017013878A (es) 2018-06-22
EP3289102A1 (en) 2018-03-07
US20180142296A1 (en) 2018-05-24
CA2984352A1 (en) 2016-11-03
AU2022203482A1 (en) 2022-06-09
IL255301B (en) 2022-02-01
EA201792389A1 (ru) 2018-05-31
CN107849604A (zh) 2018-03-27
WO2016176662A1 (en) 2016-11-03
IL255301A0 (en) 2017-12-31
HK1252152A1 (zh) 2019-05-17

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