BR112017024747A2 - composições e métodos para enriquecer populações de ácidos nucleicos - Google Patents
composições e métodos para enriquecer populações de ácidos nucleicosInfo
- Publication number
- BR112017024747A2 BR112017024747A2 BR112017024747A BR112017024747A BR112017024747A2 BR 112017024747 A2 BR112017024747 A2 BR 112017024747A2 BR 112017024747 A BR112017024747 A BR 112017024747A BR 112017024747 A BR112017024747 A BR 112017024747A BR 112017024747 A2 BR112017024747 A2 BR 112017024747A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- nucleic acid
- acid populations
- enriching nucleic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/155—Modifications characterised by incorporating/generating a new priming site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/159—Reduction of complexity, e.g. amplification of subsets, removing duplicated genomic regions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163273P | 2015-05-18 | 2015-05-18 | |
| US201662334348P | 2016-05-10 | 2016-05-10 | |
| PCT/US2016/032936 WO2016187234A1 (en) | 2015-05-18 | 2016-05-17 | Compositions and methods for enriching populations of nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017024747A2 true BR112017024747A2 (pt) | 2018-11-13 |
Family
ID=57320699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017024747A BR112017024747A2 (pt) | 2015-05-18 | 2016-05-17 | composições e métodos para enriquecer populações de ácidos nucleicos |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US11111520B2 (pt) |
| EP (1) | EP3298169A4 (pt) |
| JP (3) | JP6873921B2 (pt) |
| CN (1) | CN107922971A (pt) |
| AU (1) | AU2016264102A1 (pt) |
| BR (1) | BR112017024747A2 (pt) |
| CA (1) | CA2986036C (pt) |
| HK (1) | HK1251946A1 (pt) |
| IL (1) | IL255647B (pt) |
| WO (1) | WO2016187234A1 (pt) |
| ZA (1) | ZA201708264B (pt) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10774365B2 (en) | 2014-12-20 | 2020-09-15 | Arc Bio, Llc | Compositions and methods for targeted depletion, enrichment, and partitioning of nucleic acids using CRISPR/Cas system proteins |
| WO2016187234A1 (en) | 2015-05-18 | 2016-11-24 | Karius, Inc. | Compositions and methods for enriching populations of nucleic acids |
| US10538758B2 (en) | 2015-08-19 | 2020-01-21 | Arc Bio, Llc | Capture of nucleic acids using a nucleic acid-guided nuclease-based system |
| AU2016357723A1 (en) | 2015-11-16 | 2018-06-14 | Revere Biosensors, Llc | Systems and methods for identifying and distinguishing genetic samples |
| US9976181B2 (en) | 2016-03-25 | 2018-05-22 | Karius, Inc. | Synthetic nucleic acid spike-ins |
| GB2559319B (en) * | 2016-12-23 | 2019-01-16 | Cs Genetics Ltd | Reagents and methods for the analysis of linked nucleic acids |
| US10982351B2 (en) | 2016-12-23 | 2021-04-20 | Grail, Inc. | Methods for high efficiency library preparation using double-stranded adapters |
| WO2018140452A1 (en) * | 2017-01-30 | 2018-08-02 | Counsyl, Inc. | Enrichment of cell-free dna from a biological sample |
| US11155805B2 (en) | 2017-03-27 | 2021-10-26 | Sekisui Medical Co., Ltd. | Target nucleic acid concentration and recovery method using antibody |
| WO2018183918A1 (en) | 2017-03-30 | 2018-10-04 | Grail, Inc. | Enhanced ligation in sequencing library preparation |
| WO2018183897A1 (en) * | 2017-03-31 | 2018-10-04 | Grail, Inc. | Higher target capture efficiency using probe extension |
| US10697008B2 (en) | 2017-04-12 | 2020-06-30 | Karius, Inc. | Sample preparation methods, systems and compositions |
| WO2018195951A1 (en) * | 2017-04-28 | 2018-11-01 | Coyote Diagnostics Lab (Beijing) Co., Ltd. | Integrated sample collection, processing and analysis systems |
| CA3063106A1 (en) | 2017-05-09 | 2018-11-15 | Revere Biosensors, Llc | Systems and methods for identifying and distinguishing genetic samples |
| CA3079687A1 (en) * | 2017-10-18 | 2019-04-25 | Chiahao TSUI | Selective enrichment of a population of dna in a mixed dna sample through targeted suppression of dna amplification |
| CN108220479B (zh) * | 2018-01-05 | 2021-08-13 | 浙江农林大学 | 能检测多种猪猝死症病原的多重连接探针扩增鉴别试剂盒 |
| CN110272984A (zh) * | 2018-03-13 | 2019-09-24 | 深圳华大生命科学研究院 | 测序获取寄生虫核酸信息及对寄生虫分类的方法和系统 |
| US20200087709A1 (en) * | 2018-03-13 | 2020-03-19 | Microinvestigate, Llc | Direct-to-consumer genomic diagnostic device |
| WO2019178157A1 (en) | 2018-03-16 | 2019-09-19 | Karius, Inc. | Sample series to differentiate target nucleic acids from contaminant nucleic acids |
| CN111065746A (zh) | 2018-03-19 | 2020-04-24 | 伊鲁米纳公司 | 用于用重组核酸酶选择性切割核酸的方法和组合物 |
| GB201810571D0 (en) * | 2018-06-27 | 2018-08-15 | Cs Genetics Ltd | Reagents and methods for the analysis of circulating microparticles |
| EP3815092A2 (en) | 2018-06-29 | 2021-05-05 | F. Hoffmann-La Roche AG | Detection of microsatellite instability |
| CA3117218A1 (en) * | 2018-10-25 | 2020-04-30 | Quadrant Biosciences Inc. | Methods and machine learning for disease diagnosis |
| JP7132100B2 (ja) * | 2018-11-21 | 2022-09-06 | 株式会社日立製作所 | 生体分子分析装置及び生体分子分析方法 |
| WO2020106893A1 (en) | 2018-11-21 | 2020-05-28 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
| WO2020106987A1 (en) * | 2018-11-21 | 2020-05-28 | Karius, Inc. | Detection and prediction of infectious disease |
| CN109355365A (zh) * | 2018-11-25 | 2019-02-19 | 中国农业科学院兰州兽医研究所 | 一种小rna高通量测序检测微生物的方法 |
| CN113039283B (zh) * | 2018-12-12 | 2023-12-26 | 深圳华大生命科学研究院 | 分离和/或富集宿主源核酸和病原核酸的方法和试剂及其制备方法 |
| CN113454218A (zh) * | 2018-12-20 | 2021-09-28 | 夸登特健康公司 | 用于改进核酸分子的回收的方法、组合物和系统 |
| GB201902887D0 (en) * | 2019-03-04 | 2019-04-17 | St Georges Hospital Medical School | Detection and antibiotic resistance profiling of microorganisms |
| WO2020198664A1 (en) * | 2019-03-28 | 2020-10-01 | The Regents Of The University Of California | Methods and systems for sequencing cell-free microbiome dna |
| EP3963087A1 (en) * | 2019-04-29 | 2022-03-09 | Illumina Inc | Identification and analysis of microbial samples by rapid incubation and nucleic acid enrichment |
| US11396679B2 (en) | 2019-05-31 | 2022-07-26 | Universal Diagnostics, S.L. | Detection of colorectal cancer |
| US11898199B2 (en) | 2019-11-11 | 2024-02-13 | Universal Diagnostics, S.A. | Detection of colorectal cancer and/or advanced adenomas |
| CA3131632A1 (en) * | 2019-12-04 | 2021-06-10 | Tong Liu | Preparation of dna sequencing libraries for detection of dna pathogens in plasma |
| US20230028205A1 (en) * | 2019-12-16 | 2023-01-26 | Qiagen Gmbh | Enrichment method |
| CN111254190B (zh) * | 2020-01-20 | 2021-02-23 | 中国医学科学院病原生物学研究所 | 一种血浆病毒组学的纳米孔三代测序检测方法 |
| CN111239392B (zh) * | 2020-02-26 | 2023-04-21 | 浙江诺迦生物科技有限公司 | 一种新型冠状病毒肺炎(covid-19)血清学诊断试剂盒 |
| US11530453B2 (en) * | 2020-06-30 | 2022-12-20 | Universal Diagnostics, S.L. | Systems and methods for detection of multiple cancer types |
| US20220315986A1 (en) * | 2021-04-01 | 2022-10-06 | Diversity Arrays Technology Pty Limited | Processes for enriching desirable elements and uses therefor |
| CN113201599B (zh) * | 2021-06-03 | 2023-03-31 | 北京大学人民医院 | 一种基于PCR和nanopore测序检测脑脊液感染哪些病原体的方法 |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9220773D0 (en) | 1992-10-02 | 1992-11-18 | Mini Agriculture & Fisheries | Detection of antigens and nucleic acids |
| US6759217B2 (en) | 1996-03-26 | 2004-07-06 | Oncomedx, Inc. | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer |
| USRE39920E1 (en) | 1997-05-30 | 2007-11-13 | Xenomics, Inc. | Methods for detection of nucleic acid sequences in urine |
| US6753137B2 (en) | 2001-01-31 | 2004-06-22 | The Chinese University Of Hong Kong | Circulating epstein-barr virus DNA in the serum of patients with gastric carcinoma |
| US20050202414A1 (en) | 2001-11-15 | 2005-09-15 | The Regents Of The University Of California | Apparatus and methods for detecting a microbe in a sample |
| US7727720B2 (en) * | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20040209299A1 (en) | 2003-03-07 | 2004-10-21 | Rubicon Genomics, Inc. | In vitro DNA immortalization and whole genome amplification using libraries generated from randomly fragmented DNA |
| EP1647600A3 (en) | 2004-09-17 | 2006-06-28 | Affymetrix, Inc. (A US Entity) | Methods for identifying biological samples by addition of nucleic acid bar-code tags |
| ITRM20050068A1 (it) | 2005-02-17 | 2006-08-18 | Istituto Naz Per Le Malattie I | Metodo per la rivelazione di acidi nucleici di agenti patogeni batterici o di parassiti nelle urine. |
| WO2006088895A2 (en) | 2005-02-17 | 2006-08-24 | Istituto Nazionale Per Le Malattie Infettive Irccs Lazzaro Spallanzani | Compositions and methods for detecting pathogen specific nucleic acids in urine |
| EP1856295B1 (en) | 2005-02-17 | 2013-04-03 | TrovaGene, Inc. | Compositions and methods for detecting viral specific nucleic acids in urine |
| ITRM20050067A1 (it) | 2005-02-17 | 2006-08-18 | Istituto Naz Per Le Malattie I | Metodo per la rivelazione di acidi nucleici virali o di origine virale nelle urine. |
| US7914982B2 (en) | 2005-02-17 | 2011-03-29 | Trovagene, Inc. | Methods for detecting pathogen specific nucleic acids in urine |
| US20060292585A1 (en) * | 2005-06-24 | 2006-12-28 | Affymetrix, Inc. | Analysis of methylation using nucleic acid arrays |
| US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
| US8679741B2 (en) * | 2006-05-31 | 2014-03-25 | Sequenom, Inc. | Methods and compositions for the extraction and amplification of nucleic acid from a sample |
| TR201802758T4 (tr) | 2007-08-22 | 2018-03-21 | Trovagene Inc | In vivo hücre ölümünün saptanmasına yönelik miRNA kullanmanın yöntemleri. |
| DE102007041864B4 (de) | 2007-09-04 | 2012-05-03 | Sirs-Lab Gmbh | Verfahren zum Nachweis von Bakterien und Pilzen |
| WO2009036525A2 (en) | 2007-09-21 | 2009-03-26 | Katholieke Universiteit Leuven | Tools and methods for genetic tests using next generation sequencing |
| CA2715385A1 (en) | 2008-02-12 | 2009-08-20 | Pacific Biosciences Of California, Inc. | Compositions and methods for use in analytical reactions |
| ES2532153T3 (es) * | 2008-07-18 | 2015-03-24 | Trovagene, Inc. | Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR |
| WO2011015944A2 (en) | 2009-08-06 | 2011-02-10 | Cedars-Sinai Medical Center | Use of free dna as an early predictor of severity in acute pancreatitis |
| CN102770558B (zh) * | 2009-11-05 | 2016-04-06 | 香港中文大学 | 由母本生物样品进行胎儿基因组的分析 |
| HUE052213T2 (hu) | 2009-11-06 | 2021-04-28 | Univ Leland Stanford Junior | Grafitkilökõdés nem invazív diagnosztizálása szervátültetett betegekben |
| WO2011100617A2 (en) | 2010-02-12 | 2011-08-18 | Life Technologies Corporation | Nucleic acid, biomolecule and polymer identifier codes |
| WO2011143659A2 (en) | 2010-05-14 | 2011-11-17 | Fluidigm Corporation | Nucleic acid isolation methods |
| US20120077185A1 (en) | 2010-08-06 | 2012-03-29 | Tandem Diagnostics, Inc. | Detection of genetic abnormalities and infectious disease |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| US20120100549A1 (en) * | 2010-10-01 | 2012-04-26 | Ibis Biosciences, Inc. | Targeted genome amplification methods |
| US20120184449A1 (en) | 2010-12-23 | 2012-07-19 | Sequenom, Inc. | Fetal genetic variation detection |
| AU2012236109A1 (en) | 2011-04-01 | 2013-11-21 | Occam Biolabs, Inc. | Methods and kits for detecting cell-free pathogen-specific nucleic acids |
| US20140179726A1 (en) | 2011-05-19 | 2014-06-26 | Virginia Commonwealth University | Gut microflora as biomarkers for the prognosis of cirrhosis and brain dysfunction |
| WO2012168815A2 (en) | 2011-06-06 | 2012-12-13 | Koninklijke Philips Electronics N.V. | Method for assembly of nucleic acid sequence data |
| US20130024127A1 (en) | 2011-07-19 | 2013-01-24 | John Stuelpnagel | Determination of source contributions using binomial probability calculations |
| GB201115095D0 (en) | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| CA3069089A1 (en) | 2011-09-22 | 2013-03-28 | Lineage Biosciences, Inc. | Compositions and methods for analyzing heterogeneous samples |
| CA2850785C (en) | 2011-10-06 | 2022-12-13 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2013109981A1 (en) | 2012-01-20 | 2013-07-25 | Sequenom, Inc. | Diagnostic processes that factor experimental conditions |
| SG10201906331TA (en) | 2012-01-27 | 2019-08-27 | Univ Leland Stanford Junior | Methods for profiling and quantitating cell-free rna |
| WO2013134261A1 (en) * | 2012-03-05 | 2013-09-12 | President And Fellows Of Harvard College | Systems and methods for epigenetic sequencing |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| CA2866324C (en) | 2012-03-13 | 2019-01-15 | The Chinese University Of Hong Kong | Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis |
| EP3741871A3 (en) | 2012-04-19 | 2021-02-17 | The Medical College of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| EP2653562A1 (en) | 2012-04-20 | 2013-10-23 | Institut Pasteur | Anellovirus genome quantification as a biomarker of immune suppression |
| US9487828B2 (en) * | 2012-05-10 | 2016-11-08 | The General Hospital Corporation | Methods for determining a nucleotide sequence contiguous to a known target nucleotide sequence |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| MX2014015425A (es) | 2012-06-15 | 2015-07-14 | Harry Stylli | Metodos para detectar enfermedades o condiciones. |
| CN104619858B (zh) | 2012-07-31 | 2017-06-06 | 深圳华大基因股份有限公司 | 胎儿健康状态的无创性检测 |
| EP2888354B1 (en) * | 2012-08-21 | 2020-04-01 | Qiagen GmbH | Virus particle stabilisation and method for isolating viral nucleic acids |
| US9316802B2 (en) | 2012-08-24 | 2016-04-19 | Commscope Technologies Llc | Optical fiber cable having reinforcing layer of tape heat-bonded to jacket |
| CN110872617A (zh) | 2012-09-04 | 2020-03-10 | 夸登特健康公司 | 检测稀有突变和拷贝数变异的系统和方法 |
| US20140066317A1 (en) | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| EP3026124A1 (en) | 2012-10-31 | 2016-06-01 | Genesupport SA | Non-invasive method for detecting a fetal chromosomal aneuploidy |
| GB201302900D0 (en) | 2013-02-19 | 2013-04-03 | Genome Res Ltd | Nucleic acid marker molecules for identifying and detecting cross contaminationof nucleic acid samples |
| US20140242582A1 (en) | 2013-02-28 | 2014-08-28 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities using ligation-based detection and digital pcr |
| AU2014233373B2 (en) | 2013-03-15 | 2019-10-24 | Verinata Health, Inc. | Generating cell-free DNA libraries directly from blood |
| GB2528205B (en) | 2013-03-15 | 2020-06-03 | Guardant Health Inc | Systems and methods to detect rare mutations and copy number variation |
| EP4253558A1 (en) | 2013-03-15 | 2023-10-04 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| WO2014179805A1 (en) | 2013-05-03 | 2014-11-06 | Webroot Inc. | Method and apparatus for providing forensic visibility into systems and networks |
| WO2015048535A1 (en) * | 2013-09-27 | 2015-04-02 | Natera, Inc. | Prenatal diagnostic resting standards |
| US20150119260A1 (en) | 2013-10-18 | 2015-04-30 | National Taiwan University | Circulating cancer biomarker and its use |
| CA2929557C (en) * | 2013-11-07 | 2023-09-26 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-free nucleic acids for the analysis of the human microbiome and components thereof |
| WO2015085105A1 (en) * | 2013-12-04 | 2015-06-11 | University Of Alaska Fairbanks | Methods and compositions for enriching non-host sequences in host samples |
| WO2016187234A1 (en) | 2015-05-18 | 2016-11-24 | Karius, Inc. | Compositions and methods for enriching populations of nucleic acids |
-
2016
- 2016-05-17 WO PCT/US2016/032936 patent/WO2016187234A1/en active Application Filing
- 2016-05-17 CN CN201680042387.4A patent/CN107922971A/zh active Pending
- 2016-05-17 BR BR112017024747A patent/BR112017024747A2/pt not_active IP Right Cessation
- 2016-05-17 EP EP16797172.0A patent/EP3298169A4/en active Pending
- 2016-05-17 CA CA2986036A patent/CA2986036C/en active Active
- 2016-05-17 US US15/157,374 patent/US11111520B2/en active Active
- 2016-05-17 AU AU2016264102A patent/AU2016264102A1/en not_active Abandoned
- 2016-05-17 JP JP2017560813A patent/JP6873921B2/ja active Active
-
2017
- 2017-11-14 IL IL255647A patent/IL255647B/en unknown
- 2017-12-05 ZA ZA2017/08264A patent/ZA201708264B/en unknown
-
2018
- 2018-09-03 HK HK18111278.0A patent/HK1251946A1/zh unknown
-
2021
- 2021-04-21 JP JP2021071794A patent/JP2021112200A/ja active Pending
- 2021-07-30 US US17/390,550 patent/US20220154246A1/en active Pending
-
2023
- 2023-05-31 JP JP2023090282A patent/JP2023110928A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018520652A (ja) | 2018-08-02 |
| CN107922971A (zh) | 2018-04-17 |
| JP2023110928A (ja) | 2023-08-09 |
| AU2016264102A1 (en) | 2017-12-21 |
| JP6873921B2 (ja) | 2021-05-19 |
| WO2016187234A1 (en) | 2016-11-24 |
| JP2021112200A (ja) | 2021-08-05 |
| ZA201708264B (en) | 2022-03-30 |
| IL255647B (en) | 2022-04-01 |
| US20170016048A1 (en) | 2017-01-19 |
| EP3298169A4 (en) | 2018-10-24 |
| US20220154246A1 (en) | 2022-05-19 |
| EP3298169A1 (en) | 2018-03-28 |
| CA2986036A1 (en) | 2016-11-24 |
| IL255647A (en) | 2018-01-31 |
| US11111520B2 (en) | 2021-09-07 |
| CA2986036C (en) | 2022-07-26 |
| HK1251946A1 (zh) | 2019-05-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112017024747A2 (pt) | composições e métodos para enriquecer populações de ácidos nucleicos | |
| SG10202108763UA (en) | Methods and compositions for nucleic acid analysis | |
| BR112017008877A2 (pt) | métodos e composições para sequenciamento de ácido nucleico-alvo | |
| DK3341482T3 (da) | Kunstige nukleinsyremolekyler | |
| PT3325669T (pt) | Composições e métodos de análise de rna | |
| HK1219503A1 (zh) | 用於核酸測序的方法和組合物 | |
| EP3352795A4 (en) | COMPOSITIONS AND METHODS FOR MODIFICATION OF TARGET NUCLEIC ACIDS | |
| BR112017013838A2 (pt) | composições de nanopartícula e métodos para imunoterapia | |
| KR20180084891A (ko) | 구조 조성물 및 방법 | |
| DK3394248T3 (da) | Dendritisk cellesammensætning | |
| DK3351633T3 (da) | Antisense-nukleinsyre | |
| ZA201801947B (en) | Compounds as dna probes, methods and applications thereof | |
| DK3253485T3 (da) | No-holdige sammensætninger | |
| IL260122A (en) | Methods and compositions for assembly of nucleic acids | |
| MA42692A (fr) | Compositions biopharmaceutiques | |
| GB201403216D0 (en) | Nucleic acid sample preparation | |
| GB201413318D0 (en) | Nucleic acid sample preparation | |
| GB201418621D0 (en) | Improved nucleic acid sample preparation using concatenation | |
| DK3307878T3 (da) | Fremgangsmåder til fremstilling og oprensning af nukleinsyreholdige sammensætninger | |
| DK3331498T3 (da) | Nasalsammensætning | |
| GB201506669D0 (en) | Nucleic acid sample enrichment | |
| DK3316856T3 (da) | Blandede formuleringer | |
| GB201415674D0 (en) | Nucleic acid analysis | |
| DK3357520T3 (da) | Viskoelastisk sammensætning | |
| DK3288536T3 (da) | Sammensætninger omfattende anakinra |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2723 DE 14/03/2023. |