EA201790206A1 - Новые 2,5-замещенные пиримидины в качестве ингибиторов pde4 - Google Patents

Новые 2,5-замещенные пиримидины в качестве ингибиторов pde4

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Publication number
EA201790206A1
EA201790206A1 EA201790206A EA201790206A EA201790206A1 EA 201790206 A1 EA201790206 A1 EA 201790206A1 EA 201790206 A EA201790206 A EA 201790206A EA 201790206 A EA201790206 A EA 201790206A EA 201790206 A1 EA201790206 A1 EA 201790206A1
Authority
EA
Eurasian Patent Office
Prior art keywords
new
pde4 inhibitors
substituted pyrimidines
medicines
pde4
Prior art date
Application number
EA201790206A
Other languages
English (en)
Russian (ru)
Inventor
Антонио Нарди
Флориан Якоб
Инго Конетцки
Тобиас Кран
Кристиан Хесслингер
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of EA201790206A1 publication Critical patent/EA201790206A1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
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EA201790206A 2014-07-16 2015-07-16 Новые 2,5-замещенные пиримидины в качестве ингибиторов pde4 EA201790206A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14002450 2014-07-16
PCT/EP2015/001473 WO2016008590A1 (en) 2014-07-16 2015-07-16 Novel 2,5-substituted pyrimidines as pde4 inhibitors

Publications (1)

Publication Number Publication Date
EA201790206A1 true EA201790206A1 (ru) 2017-07-31

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EA201790206A EA201790206A1 (ru) 2014-07-16 2015-07-16 Новые 2,5-замещенные пиримидины в качестве ингибиторов pde4

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Country Link
US (2) US9546158B2 (enExample)
EP (2) EP3415510A1 (enExample)
JP (1) JP6723217B2 (enExample)
KR (1) KR20170032421A (enExample)
CN (1) CN106660996B (enExample)
AR (1) AR101198A1 (enExample)
AU (1) AU2015291475B2 (enExample)
BR (1) BR112017000830A2 (enExample)
CA (1) CA2955053A1 (enExample)
CL (1) CL2017000106A1 (enExample)
CO (1) CO2017001506A2 (enExample)
EA (1) EA201790206A1 (enExample)
EC (1) ECSP17010481A (enExample)
IL (1) IL250026A0 (enExample)
MX (1) MX366839B (enExample)
PE (1) PE20170251A1 (enExample)
TW (1) TW201613896A (enExample)
WO (1) WO2016008590A1 (enExample)
ZA (1) ZA201701131B (enExample)

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AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
AR101196A1 (es) * 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
WO2018065849A1 (en) 2016-10-03 2018-04-12 Koninklijke Philips N.V. Radiopaque arrangement of electronic components in intra-cardiac echocardiography (ice) catheter
CN108570052A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用
WO2018234353A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE
WO2018234354A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH NOVEL SUBSTITUTED 3-INDOLE AND 3-INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS
KR20210083287A (ko) * 2018-10-25 2021-07-06 메르크 파텐트 게엠베하 아데노신 수용체 안타고니스트로서의 5-아자인다졸 유도체
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
US20240066027A1 (en) * 2020-12-03 2024-02-29 Domain Therapeutics Novel par-2 inhibitors
CN115108992B (zh) * 2022-06-29 2024-05-31 浙江手心制药有限公司 6-氯-2-甲基-2h-吲唑-5-胺的制备方法
CN116836162B (zh) * 2023-05-24 2025-09-05 南方医科大学 吡唑[4,3-c]吡啶类化合物或其药学上可接受的盐及其应用

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