KR20170032421A - Pde4 억제제로서의 신규한 2,5-치환된 피리미딘 - Google Patents

Pde4 억제제로서의 신규한 2,5-치환된 피리미딘 Download PDF

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KR20170032421A
KR20170032421A KR1020177004412A KR20177004412A KR20170032421A KR 20170032421 A KR20170032421 A KR 20170032421A KR 1020177004412 A KR1020177004412 A KR 1020177004412A KR 20177004412 A KR20177004412 A KR 20177004412A KR 20170032421 A KR20170032421 A KR 20170032421A
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alkyl
alkylene
mmol
compound
alkoxy
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Korean (ko)
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안토니오 나르디
플로리안 야콥
잉고 코네츠키
토비아스 크란
크리스티안 헤쓸링거
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그뤼넨탈 게엠베하
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Heart & Thoracic Surgery (AREA)
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KR1020177004412A 2014-07-16 2015-07-16 Pde4 억제제로서의 신규한 2,5-치환된 피리미딘 Withdrawn KR20170032421A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14002450 2014-07-16
EP14002450.6 2014-07-16
PCT/EP2015/001473 WO2016008590A1 (en) 2014-07-16 2015-07-16 Novel 2,5-substituted pyrimidines as pde4 inhibitors

Publications (1)

Publication Number Publication Date
KR20170032421A true KR20170032421A (ko) 2017-03-22

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KR1020177004412A Withdrawn KR20170032421A (ko) 2014-07-16 2015-07-16 Pde4 억제제로서의 신규한 2,5-치환된 피리미딘

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US (2) US9546158B2 (enExample)
EP (2) EP3169679A1 (enExample)
JP (1) JP6723217B2 (enExample)
KR (1) KR20170032421A (enExample)
CN (1) CN106660996B (enExample)
AR (1) AR101198A1 (enExample)
AU (1) AU2015291475B2 (enExample)
BR (1) BR112017000830A2 (enExample)
CA (1) CA2955053A1 (enExample)
CL (1) CL2017000106A1 (enExample)
CO (1) CO2017001506A2 (enExample)
EA (1) EA201790206A1 (enExample)
EC (1) ECSP17010481A (enExample)
IL (1) IL250026A0 (enExample)
MX (1) MX366839B (enExample)
PE (1) PE20170251A1 (enExample)
TW (1) TW201613896A (enExample)
WO (1) WO2016008590A1 (enExample)
ZA (1) ZA201701131B (enExample)

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AR101196A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Compuestos de pirimidina sustituidos
AR101198A1 (es) 2014-07-16 2016-11-30 Gruenenthal Gmbh Pirimidinas 2,5-sustituidas como inhibidores de pde4b
WO2018065849A1 (en) 2016-10-03 2018-04-12 Koninklijke Philips N.V. Radiopaque arrangement of electronic components in intra-cardiac echocardiography (ice) catheter
CN108570052A (zh) * 2017-03-13 2018-09-25 中国科学院上海药物研究所 五元杂环并吡嗪化合物、制备方法、中间体、组合和应用
WO2018234354A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH Novel substituted 3-indole and 3-indazole compounds as phosphodiesterase inhibitors
WO2018234353A1 (en) 2017-06-20 2018-12-27 Grünenthal GmbH Novel substituted indole and indazole compounds as phosphodiesterase inhibitors
BR112021007435A2 (pt) * 2018-10-25 2021-08-03 Merck Patent Gmbh derivados de 5-azaindazol como antagonistas de receptor de adenosina
CN110156785B (zh) * 2019-04-15 2020-08-28 浙江大学 吲唑类化合物及其制备方法和应用
US20240066027A1 (en) * 2020-12-03 2024-02-29 Domain Therapeutics Novel par-2 inhibitors
CN115108992B (zh) * 2022-06-29 2024-05-31 浙江手心制药有限公司 6-氯-2-甲基-2h-吲唑-5-胺的制备方法
CN116836162B (zh) * 2023-05-24 2025-09-05 南方医科大学 吡唑[4,3-c]吡啶类化合物或其药学上可接受的盐及其应用

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