EA201691502A1 - Мутантные стафилококковые антигены - Google Patents

Мутантные стафилококковые антигены

Info

Publication number
EA201691502A1
EA201691502A1 EA201691502A EA201691502A EA201691502A1 EA 201691502 A1 EA201691502 A1 EA 201691502A1 EA 201691502 A EA201691502 A EA 201691502A EA 201691502 A EA201691502 A EA 201691502A EA 201691502 A1 EA201691502 A1 EA 201691502A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mutant
staphylcoccic
antigens
mutant spa
fhud2
Prior art date
Application number
EA201691502A
Other languages
English (en)
Other versions
EA037818B1 (ru
Inventor
Фабио Баньоли
Луиджи Фьяски
Мария Скарселли
Original Assignee
Глаксосмитклайн Байолоджикалс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксосмитклайн Байолоджикалс С.А. filed Critical Глаксосмитклайн Байолоджикалс С.А.
Publication of EA201691502A1 publication Critical patent/EA201691502A1/ru
Publication of EA037818B1 publication Critical patent/EA037818B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645—Dendrimers; Multiple antigen peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Предложен мутантный SpA со сниженной аффинностью к Fcγ-части человеческого IgG. Иммунизация с использованием EsxA, EsxB, FhuD2, Sta011, Hla и указанного мутантного SpA обеспечивает поразительные результаты в модели абсцесса почки, вызываемого инфекцией S.
EA201691502A 2014-03-26 2015-03-24 Мутантные стафилококковые антигены EA037818B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14161861 2014-03-26
EP14192913 2014-11-12
PCT/EP2015/056175 WO2015144653A1 (en) 2014-03-26 2015-03-24 Mutant staphylococcal antigens

Publications (2)

Publication Number Publication Date
EA201691502A1 true EA201691502A1 (ru) 2017-04-28
EA037818B1 EA037818B1 (ru) 2021-05-25

Family

ID=52706188

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201691502A EA037818B1 (ru) 2014-03-26 2015-03-24 Мутантные стафилококковые антигены

Country Status (24)

Country Link
US (1) US10328140B2 (ru)
EP (2) EP3639850A1 (ru)
JP (2) JP6894237B2 (ru)
KR (3) KR102027429B1 (ru)
CN (2) CN112521464A (ru)
AU (1) AU2015238512B2 (ru)
BE (2) BE1022744B1 (ru)
CA (1) CA2942450A1 (ru)
CY (1) CY1122537T1 (ru)
DK (1) DK3122378T3 (ru)
EA (1) EA037818B1 (ru)
ES (1) ES2769647T3 (ru)
HR (1) HRP20200217T1 (ru)
HU (1) HUE047808T2 (ru)
IL (2) IL247328B (ru)
LT (1) LT3122378T (ru)
MX (1) MX2016012538A (ru)
PL (1) PL3122378T3 (ru)
PT (1) PT3122378T (ru)
RS (1) RS59971B1 (ru)
SG (1) SG11201606887WA (ru)
SI (1) SI3122378T1 (ru)
WO (2) WO2015144655A1 (ru)
ZA (1) ZA201605818B (ru)

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KR20220107166A (ko) 2019-10-02 2022-08-02 얀센 백신스 앤드 프리벤션 비.브이. 스타필로코커스 펩티드 및 사용 방법

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Also Published As

Publication number Publication date
US20180064800A9 (en) 2018-03-08
ES2769647T3 (es) 2020-06-26
US10328140B2 (en) 2019-06-25
HRP20200217T1 (hr) 2020-05-15
CN106103469B (zh) 2020-11-27
BE1022744B1 (fr) 2016-08-29
EP3122378B1 (en) 2019-12-11
ZA201605818B (en) 2022-05-25
PT3122378T (pt) 2020-03-04
IL282104A (en) 2021-05-31
CY1122537T1 (el) 2021-01-27
JP6894237B2 (ja) 2021-06-30
PL3122378T3 (pl) 2020-06-01
BR112016022011A2 (pt) 2017-10-24
KR20160132109A (ko) 2016-11-16
CN106103469A (zh) 2016-11-09
CN112521464A (zh) 2021-03-19
HUE047808T2 (hu) 2020-05-28
IL247328B (en) 2021-04-29
SG11201606887WA (en) 2016-09-29
AU2015238512B2 (en) 2018-02-01
BE1022744A1 (fr) 2016-08-29
RS59971B1 (sr) 2020-03-31
WO2015144653A1 (en) 2015-10-01
MX2016012538A (es) 2016-12-14
JP2017511312A (ja) 2017-04-20
AU2015238512A1 (en) 2016-10-13
EP3639850A1 (en) 2020-04-22
LT3122378T (lt) 2020-02-10
KR20190110655A (ko) 2019-09-30
WO2015144655A1 (en) 2015-10-01
KR102297357B1 (ko) 2021-09-02
KR20190040101A (ko) 2019-04-16
SI3122378T1 (sl) 2020-03-31
JP2021035950A (ja) 2021-03-04
DK3122378T3 (da) 2020-03-02
US20170143816A1 (en) 2017-05-25
EP3122378A1 (en) 2017-02-01
BE1022857A1 (fr) 2016-09-27
KR102027429B1 (ko) 2019-10-01
CA2942450A1 (en) 2015-10-01
EA037818B1 (ru) 2021-05-25
IL247328A0 (en) 2016-09-29

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