MX357061B - Diseño de inmunogenos a base de linaje de celulas b con animales humanizados. - Google Patents

Diseño de inmunogenos a base de linaje de celulas b con animales humanizados.

Info

Publication number
MX357061B
MX357061B MX2015010110A MX2015010110A MX357061B MX 357061 B MX357061 B MX 357061B MX 2015010110 A MX2015010110 A MX 2015010110A MX 2015010110 A MX2015010110 A MX 2015010110A MX 357061 B MX357061 B MX 357061B
Authority
MX
Mexico
Prior art keywords
design
cell lineage
methods
immunogen design
humanized animals
Prior art date
Application number
MX2015010110A
Other languages
English (en)
Other versions
MX2015010110A (es
Inventor
J Murphy Andrew
D Yancopoulos George
Macdonald Lynn
Mcwhirter John
Gurer Cagan
A Meagher Karolina
Lowy Israel
Haynes Barton
Kelsoe Garnett
I Baras Aris
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of MX2015010110A publication Critical patent/MX2015010110A/es
Publication of MX357061B publication Critical patent/MX357061B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1018—Orthomyxoviridae, e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)

Abstract

La presente invención se refiere a animales no humanos con loci de inmunoglobulina humanizados y métodos para usarlos en el diseño de vacunas, y también se proporcionan métodos para hacer anticuerpos de amplia neutralización contra agentes infecciosos y patógenos. Se proporcionan animales no humanos con loci de inmunoglobulina humanizados usados en el diseño de inmunógenos de linaje de células B en el desarrollo de vacunas, así como métodos para llevar a cabo tal diseño.
MX2015010110A 2013-02-06 2014-02-06 Diseño de inmunogenos a base de linaje de celulas b con animales humanizados. MX357061B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361761419P 2013-02-06 2013-02-06
PCT/US2014/015133 WO2014124156A1 (en) 2013-02-06 2014-02-06 B cell lineage based immunogen design with humanized animals

Publications (2)

Publication Number Publication Date
MX2015010110A MX2015010110A (es) 2016-06-21
MX357061B true MX357061B (es) 2018-06-25

Family

ID=50150835

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015010110A MX357061B (es) 2013-02-06 2014-02-06 Diseño de inmunogenos a base de linaje de celulas b con animales humanizados.

Country Status (12)

Country Link
US (2) US9963501B2 (es)
EP (1) EP2953452A1 (es)
KR (1) KR20150115775A (es)
AU (2) AU2014214863B2 (es)
CA (1) CA2899740A1 (es)
HK (1) HK1218866A1 (es)
IL (1) IL240114B (es)
MX (1) MX357061B (es)
RU (1) RU2664187C2 (es)
SG (2) SG11201505713YA (es)
WO (1) WO2014124156A1 (es)
ZA (1) ZA201505307B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012279018B2 (en) 2011-07-05 2017-06-08 Children's Medical Center Corporation N-terminal deleted GP120 immunogens
WO2013052095A2 (en) 2011-10-03 2013-04-11 Duke University Vaccine
EP2953452A1 (en) 2013-02-06 2015-12-16 Regeneron Pharmaceuticals, Inc. B cell lineage based immunogen design with humanized animals
AU2017221425A1 (en) * 2016-02-16 2018-08-23 Regeneron Pharmaceuticals, Inc. Non-human animals having a mutant kynureninase gene
CA3125380A1 (en) 2019-02-18 2020-08-27 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animals with humanized immunoglobulin locus
EP4158034A4 (en) 2020-06-02 2024-07-03 Biocytogen Pharmaceuticals Beijing Co Ltd GENETICALLY MODIFIED NON-HUMAN ANIMALS HAVING A LIGHT-CHAIN IMMUNOGLOBULIN LOCUS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2322108A (en) 1939-04-21 1943-06-15 Molins Machine Co Ltd Weighing apparatus
US5770429A (en) * 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JP4720065B2 (ja) 2001-09-04 2011-07-13 日本電気株式会社 フィルム外装電池及び組電池
CN102638971B (zh) 2009-07-08 2015-10-07 科马布有限公司 动物模型及治疗分子
PL2578688T5 (pl) 2011-02-25 2023-05-29 Regeneron Pharmaceuticals, Inc. Myszy adam6
WO2013052095A2 (en) 2011-10-03 2013-04-11 Duke University Vaccine
EP2953452A1 (en) 2013-02-06 2015-12-16 Regeneron Pharmaceuticals, Inc. B cell lineage based immunogen design with humanized animals

Also Published As

Publication number Publication date
CA2899740A1 (en) 2014-08-14
AU2014214863B2 (en) 2019-03-21
MX2015010110A (es) 2016-06-21
US20180298082A1 (en) 2018-10-18
SG10201706190PA (en) 2017-09-28
KR20150115775A (ko) 2015-10-14
US9963501B2 (en) 2018-05-08
US10626168B2 (en) 2020-04-21
SG11201505713YA (en) 2015-08-28
AU2014214863A1 (en) 2015-09-24
EP2953452A1 (en) 2015-12-16
AU2019204329A1 (en) 2019-07-11
ZA201505307B (en) 2016-07-27
RU2015137173A (ru) 2017-03-13
HK1218866A1 (zh) 2017-03-17
US20140221625A1 (en) 2014-08-07
IL240114A0 (en) 2015-09-24
IL240114B (en) 2019-08-29
WO2014124156A1 (en) 2014-08-14
RU2664187C2 (ru) 2018-08-15

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