EA201600436A1 - Кристаллическая солевая форма (s)-(2-(6-хлор-7-метил-1h-бензо[d]имидазол-2-ил)-2-метилпирролидин-1-ил)(5-метокси-2-(2h-1,2,3-триазол-2-ил)фенил)метанона и ее применение в качестве антагонистов орексинового рецептора - Google Patents
Кристаллическая солевая форма (s)-(2-(6-хлор-7-метил-1h-бензо[d]имидазол-2-ил)-2-метилпирролидин-1-ил)(5-метокси-2-(2h-1,2,3-триазол-2-ил)фенил)метанона и ее применение в качестве антагонистов орексинового рецептораInfo
- Publication number
- EA201600436A1 EA201600436A1 EA201600436A EA201600436A EA201600436A1 EA 201600436 A1 EA201600436 A1 EA 201600436A1 EA 201600436 A EA201600436 A EA 201600436A EA 201600436 A EA201600436 A EA 201600436A EA 201600436 A1 EA201600436 A1 EA 201600436A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- triazol
- imidazol
- benzo
- phenyl
- methyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Abstract
Изобретение относится к кристаллической форме гидрохлорида (S)-(2-(6-хлор-7-метил-1Н-бензо[d]имидазол-2-ил)-2-метилпирролидин-1-ил)(5-метокси-2-(2Н-1,2,3-триазол-2-ил)фенил)метанона, способам ее получения, фармацевтическим композициям, содержащим указанную кристаллическую форму, и ее применению в качестве лекарственного средства, в особенности в качестве антагониста орексинового рецептора.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2013060595 | 2013-12-03 | ||
PCT/IB2014/066509 WO2015083071A1 (en) | 2013-12-03 | 2014-12-02 | Crystalline salt form of (s)-(2-(6-chloro-7-methyl-1 h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone as orexin receptor antagonist |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201600436A1 true EA201600436A1 (ru) | 2016-11-30 |
EA030109B1 EA030109B1 (ru) | 2018-06-29 |
Family
ID=52282787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201600436A EA030109B1 (ru) | 2013-12-03 | 2014-12-02 | КРИСТАЛЛИЧЕСКАЯ СОЛЕВАЯ ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ИМИДАЗОЛ-2-ИЛ)-2-МЕТИЛПИРРОЛИДИН-1-ИЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ИЛ)ФЕНИЛ)МЕТАНОНА И ЕЕ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АНТАГОНИСТОВ ОРЕКСИНОВОГО РЕЦЕПТОРА |
Country Status (32)
Country | Link |
---|---|
US (2) | US9790208B2 (ru) |
EP (1) | EP3077390B1 (ru) |
JP (1) | JP6091716B2 (ru) |
KR (1) | KR101839716B1 (ru) |
CN (1) | CN105793258B (ru) |
AU (1) | AU2014358743B2 (ru) |
CA (1) | CA2929720C (ru) |
CL (1) | CL2016001348A1 (ru) |
CY (1) | CY1119687T1 (ru) |
DK (1) | DK3077390T3 (ru) |
EA (1) | EA030109B1 (ru) |
ES (1) | ES2651508T3 (ru) |
HK (1) | HK1225736B (ru) |
HR (1) | HRP20171772T1 (ru) |
HU (1) | HUE034656T2 (ru) |
IL (1) | IL245922B (ru) |
LT (1) | LT3077390T (ru) |
MA (1) | MA39164B1 (ru) |
MX (1) | MX362701B (ru) |
MY (1) | MY176244A (ru) |
NO (1) | NO3077390T3 (ru) |
NZ (1) | NZ721493A (ru) |
PH (1) | PH12016500989B1 (ru) |
PL (1) | PL3077390T3 (ru) |
PT (1) | PT3077390T (ru) |
SA (1) | SA516371248B1 (ru) |
SG (1) | SG11201604541WA (ru) |
SI (1) | SI3077390T1 (ru) |
TW (1) | TWI636982B (ru) |
UA (1) | UA119151C2 (ru) |
WO (1) | WO2015083071A1 (ru) |
ZA (1) | ZA201604501B (ru) |
Families Citing this family (7)
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ES2617863T3 (es) | 2012-06-04 | 2017-06-20 | Actelion Pharmaceuticals Ltd. | Derivados de bencimidazol-prolina |
DK3077389T3 (da) * | 2013-12-03 | 2017-11-13 | Idorsia Pharmaceuticals Ltd | Krystallinsk form af (s)-(2-(6-chlor-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1-yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanon og dens anvendelse som orexinreceptorantagonister |
UA119151C2 (uk) * | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
US9914721B2 (en) | 2013-12-04 | 2018-03-13 | Idorsia Pharmaceuticals Ltd | Use of benzimidazole-proline derivatives |
CN110612291B (zh) | 2017-05-03 | 2024-02-13 | 爱杜西亚药品有限公司 | 2-([1,2,3]三唑-2-基)-苯甲酸衍生物的制备 |
IL297234A (en) | 2020-04-19 | 2022-12-01 | Idorsia Pharmaceuticals Ltd | Medical use of deridorxant |
CN115925699B (zh) * | 2022-02-25 | 2023-10-03 | 南京知和医药科技有限公司 | 具有镇痛活性的稠环化合物及其制备方法与用途 |
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UA119151C2 (uk) * | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
US9914721B2 (en) | 2013-12-04 | 2018-03-13 | Idorsia Pharmaceuticals Ltd | Use of benzimidazole-proline derivatives |
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2014
- 2014-02-12 UA UAA201607115A patent/UA119151C2/uk unknown
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- 2014-12-02 DK DK14824108.6T patent/DK3077390T3/da active
- 2014-12-02 PL PL14824108T patent/PL3077390T3/pl unknown
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- 2014-12-02 KR KR1020167017678A patent/KR101839716B1/ko active IP Right Grant
- 2014-12-02 US US15/101,832 patent/US9790208B2/en active Active
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- 2014-12-02 PT PT148241086T patent/PT3077390T/pt unknown
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- 2014-12-02 CA CA2929720A patent/CA2929720C/en active Active
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- 2014-12-02 TW TW103141830A patent/TWI636982B/zh active
- 2014-12-02 JP JP2016536106A patent/JP6091716B2/ja active Active
- 2014-12-02 CN CN201480065749.2A patent/CN105793258B/zh active Active
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- 2016-05-26 PH PH12016500989A patent/PH12016500989B1/en unknown
- 2016-05-30 IL IL24592216A patent/IL245922B/en active IP Right Grant
- 2016-06-01 SA SA516371248A patent/SA516371248B1/ar unknown
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2017
- 2017-09-12 US US15/702,281 patent/US10023560B2/en active Active
- 2017-11-16 HR HRP20171772TT patent/HRP20171772T1/hr unknown
- 2017-12-12 CY CY20171101302T patent/CY1119687T1/el unknown
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