EA201591767A8 - Композиции, обеспечивающие пропускание экзонов, для лечения мышечной дистрофии - Google Patents

Композиции, обеспечивающие пропускание экзонов, для лечения мышечной дистрофии

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Publication number
EA201591767A8
EA201591767A8 EA201591767A EA201591767A EA201591767A8 EA 201591767 A8 EA201591767 A8 EA 201591767A8 EA 201591767 A EA201591767 A EA 201591767A EA 201591767 A EA201591767 A EA 201591767A EA 201591767 A8 EA201591767 A8 EA 201591767A8
Authority
EA
Eurasian Patent Office
Prior art keywords
treating muscle
compositions providing
missing exons
providing missing
distrophy
Prior art date
Application number
EA201591767A
Other languages
English (en)
Other versions
EA201591767A1 (ru
EA035882B1 (ru
Inventor
Ричард К. Бестуик
Дайан Элизабет Франк
Фред Джозеф Шнелль
Original Assignee
Сарепта Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сарепта Терапьютикс, Инк. filed Critical Сарепта Терапьютикс, Инк.
Publication of EA201591767A1 publication Critical patent/EA201591767A1/ru
Publication of EA201591767A8 publication Critical patent/EA201591767A8/ru
Publication of EA035882B1 publication Critical patent/EA035882B1/ru

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

Описаны антисмысловые молекулы, способные связываться с выбранным участком-мишенью в гене дистрофина человека, для индукции пропускания экзона 44.
EA201591767A 2013-03-14 2014-03-14 Антисмысловые олигонуклеотиды, обеспечивающие пропуск экзонов, для лечения мышечной дистрофии EA035882B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361784547P 2013-03-14 2013-03-14
PCT/US2014/029689 WO2014153220A2 (en) 2013-03-14 2014-03-14 Exon skipping compositions for treating muscular dystrophy

Publications (3)

Publication Number Publication Date
EA201591767A1 EA201591767A1 (ru) 2016-02-29
EA201591767A8 true EA201591767A8 (ru) 2018-04-30
EA035882B1 EA035882B1 (ru) 2020-08-27

Family

ID=50694004

Family Applications (2)

Application Number Title Priority Date Filing Date
EA202090946A EA202090946A3 (ru) 2013-03-14 2014-03-14 Композиции, обеспечивающие пропускание экзонов, для лечения мышечной дистрофии
EA201591767A EA035882B1 (ru) 2013-03-14 2014-03-14 Антисмысловые олигонуклеотиды, обеспечивающие пропуск экзонов, для лечения мышечной дистрофии

Family Applications Before (1)

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EA202090946A EA202090946A3 (ru) 2013-03-14 2014-03-14 Композиции, обеспечивающие пропускание экзонов, для лечения мышечной дистрофии

Country Status (16)

Country Link
US (9) US20140329881A1 (ru)
EP (3) EP3633035A1 (ru)
JP (5) JP6449231B2 (ru)
KR (6) KR102258326B1 (ru)
CN (3) CN110218727A (ru)
AU (3) AU2014236140B2 (ru)
BR (2) BR122020016865B1 (ru)
CA (1) CA2906209A1 (ru)
EA (2) EA202090946A3 (ru)
ES (1) ES2762881T3 (ru)
HK (1) HK1219755A1 (ru)
IL (3) IL280443B (ru)
MX (2) MX366485B (ru)
NZ (4) NZ790263A (ru)
SA (1) SA515361125B1 (ru)
WO (1) WO2014153220A2 (ru)

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JP7022079B2 (ja) * 2016-06-30 2022-02-17 サレプタ セラピューティクス， インコーポレイテッド ホスホロジアミダートモルホリノオリゴマーを調製するためのプロセス
KR20190024977A (ko) 2016-06-30 2019-03-08 사렙타 쎄러퓨틱스 인코퍼레이티드 근육 이상증에 대한 엑손 스킵핑 올리고머
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