EA201491655A1 - Новый слитый fgfr3 - Google Patents

Новый слитый fgfr3

Info

Publication number
EA201491655A1
EA201491655A1 EA201491655A EA201491655A EA201491655A1 EA 201491655 A1 EA201491655 A1 EA 201491655A1 EA 201491655 A EA201491655 A EA 201491655A EA 201491655 A EA201491655 A EA 201491655A EA 201491655 A1 EA201491655 A1 EA 201491655A1
Authority
EA
Eurasian Patent Office
Prior art keywords
gene
probes
polynucleotide
primer
fgfr3
Prior art date
Application number
EA201491655A
Other languages
English (en)
Other versions
EA029140B1 (ru
Inventor
Ацуси Сузуки
Макото Асауми
Казухиса Цунояма
Коуити Нисимура
Акифуми Моринака
Томохиро Ямаути
Масаясу Йосино
Хироаки Йосизаки
Original Assignee
Астеллас Фарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49116820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201491655(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астеллас Фарма Инк. filed Critical Астеллас Фарма Инк.
Publication of EA201491655A1 publication Critical patent/EA201491655A1/ru
Publication of EA029140B1 publication Critical patent/EA029140B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/50—Fibroblast growth factors [FGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

Настоящее изобретение имеет целью выявить полинуклеотид в качестве нового гена, ответственного за рак, и, соответственно, предоставить способ детектирования полинуклеотида и полипептида, кодируемого полинуклеотидом, и набор для детектирования, набор зондов и набор праймеров для детектирования. Целью настоящего изобретения также является предоставление фармацевтической композиции для лечения рака. Способ детектирует слитый ген, составленный из части гена FGFR3 и части гена ТАСС3, или слитый белок, кодируемый слитым геном. Набор праймеров, набор зондов или набор для детектирования содержит смысловой праймер и набор зондов, спроектированных по части, кодирующей FGFR3, и антисмысловой праймер и набор зондов, спроектированных по части, кодирующей ТАСС3. Поскольку ингибитор полипептида демонстрирует противоопухолевый эффект, предоставляется фармацевтическая композиция для лечения рака, который является положительным либо по слитому гену, либо по полипептиду.
EA201491655A 2012-03-08 2013-03-07 Новый слитый fgfr3 EA029140B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012052147 2012-03-08
JP2012195451 2012-09-05
JP2012280325 2012-12-21
PCT/JP2013/056225 WO2013133351A1 (ja) 2012-03-08 2013-03-07 新規ｆｇｆｒ３融合体

Publications (2)

Publication Number Publication Date
EA201491655A1 true EA201491655A1 (ru) 2015-01-30
EA029140B1 EA029140B1 (ru) 2018-02-28

Family

ID=49116820

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491655A EA029140B1 (ru) 2012-03-08 2013-03-07 Новый слитый fgfr3

Country Status (17)

Country Link
US (2) US9481911B2 (ru)
EP (1) EP2824181B1 (ru)
JP (1) JP6107812B2 (ru)
KR (4) KR102106962B1 (ru)
CN (1) CN104379740B (ru)
AU (1) AU2013228389A1 (ru)
BR (1) BR112014021897B1 (ru)
CA (1) CA2865388C (ru)
EA (1) EA029140B1 (ru)
ES (1) ES2702305T3 (ru)
HK (1) HK1205528A1 (ru)
MX (1) MX365214B (ru)
PH (1) PH12014501918A1 (ru)
PL (1) PL2824181T3 (ru)
PT (1) PT2824181T (ru)
WO (1) WO2013133351A1 (ru)
ZA (1) ZA201406570B (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
WO2014018673A2 (en) 2012-07-24 2014-01-30 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
US20150203589A1 (en) 2012-07-24 2015-07-23 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
EA031631B1 (ru) 2012-09-27 2019-01-31 Чугаи Сеияку Кабушики Каиша Способ лечения или предупреждения злокачественного новообразования, способ отбора пациента, способ тестирования предрасположенности к злокачественному новообразованию у субъекта, гибридный полипептид и его применения
AU2013337264B2 (en) * 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel fusion molecules and uses thereof
WO2014139145A1 (en) 2013-03-15 2014-09-18 Hutchison Medipharma Limited Novel pyrimidine and pyridine compounds and usage thereof
WO2014165710A2 (en) * 2013-04-05 2014-10-09 Life Technologies Corporation Gene fusions
AR097455A1 (es) * 2013-08-28 2016-03-16 Astellas Pharma Inc Composición farmacéutica que contiene compuesto de pirimidina como un ingrediente activo
WO2015093557A1 (ja) * 2013-12-19 2015-06-25 独立行政法人国立がん研究センター 胃がんの責任因子としての新規融合遺伝子
EP3098312B1 (en) * 2014-01-24 2023-07-19 Japanese Foundation For Cancer Research Novel fusant and method for detecting same
WO2015120094A2 (en) * 2014-02-04 2015-08-13 Mayo Foundation For Medical Education And Research Method of identifying tyrosine kinase receptor rearrangements in patients
LT3122359T (lt) 2014-03-26 2021-03-25 Astex Therapeutics Ltd. Fgfr inhibitoriaus ir igf1r inhibitoriaus deriniai
SI3122358T1 (sl) 2014-03-26 2021-04-30 Astex Therapeutics Ltd. Kombinacije FGFR- in CMET-inhibitorjev za zdravljenje raka
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en) * 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
JP6524833B2 (ja) * 2015-07-17 2019-06-05 コニカミノルタ株式会社 蛍光体集積ナノ粒子を用いたｆｉｓｈまたは免疫染色スライドの封入方法
EP3353177B1 (en) 2015-09-23 2020-06-03 Janssen Pharmaceutica NV Tricyclic heterocycles for the treatment of cancer
RU2747644C2 (ru) 2015-09-23 2021-05-11 Янссен Фармацевтика Нв Бигетероарил-замещенные 1,4-бензодиазепины и пути их применения для лечения рака
CN111424081B (zh) * 2020-04-13 2023-04-25 广东省妇幼保健院 基于多重荧光定量pcr技术检测软骨发育不全fgfr3基因突变的引物、探针和试剂盒
US11505611B2 (en) 2020-08-21 2022-11-22 Genzyme Corporation FGFR3 antibodies and methods of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1692085A4 (en) 2003-11-07 2010-10-13 Novartis Vaccines & Diagnostic INHIBITION OF FGFR3 AND TREATMENT OF MULTIPLE MYELOMA
CN1976706B (zh) * 2003-11-07 2012-01-18 诺华疫苗和诊断公司 抑制fgfr3及治疗多发性骨髓瘤
US7737149B2 (en) 2006-12-21 2010-06-15 Astrazeneca Ab N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof
AR078411A1 (es) 2009-05-07 2011-11-09 Lilly Co Eli Compuesto de vinil imidazolilo y composicion farmaceutica que lo comprende
EP2761300A4 (en) 2011-09-27 2015-12-02 Univ Michigan FUSIONS OF RECURRENT GENES IN BREAST CANCER
KR102032007B1 (ko) * 2012-02-28 2019-10-14 아스텔라스세이야쿠 가부시키가이샤 질소 함유 방향족 헤테로환 화합물
WO2014018673A2 (en) * 2012-07-24 2014-01-30 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
EA031631B1 (ru) 2012-09-27 2019-01-31 Чугаи Сеияку Кабушики Каиша Способ лечения или предупреждения злокачественного новообразования, способ отбора пациента, способ тестирования предрасположенности к злокачественному новообразованию у субъекта, гибридный полипептид и его применения
AU2013337264B2 (en) 2012-11-05 2018-03-08 Foundation Medicine, Inc. Novel fusion molecules and uses thereof

Also Published As

Publication number Publication date
EA029140B1 (ru) 2018-02-28
BR112014021897B1 (pt) 2022-06-14
MX2014010823A (es) 2015-03-19
ZA201406570B (en) 2015-12-23
ES2702305T3 (es) 2019-02-28
WO2013133351A1 (ja) 2013-09-12
AU2013228389A1 (en) 2014-09-25
MX365214B (es) 2019-05-27
US20150031703A1 (en) 2015-01-29
PL2824181T3 (pl) 2019-02-28
HK1205528A1 (en) 2015-12-18
CN104379740A (zh) 2015-02-25
US9481911B2 (en) 2016-11-01
US10004739B2 (en) 2018-06-26
KR102106962B1 (ko) 2020-05-07
PH12014501918A1 (en) 2014-11-24
CN104379740B (zh) 2019-05-14
EP2824181B1 (en) 2018-11-14
CA2865388A1 (en) 2013-09-12
KR20140140070A (ko) 2014-12-08
BR112014021897A2 (pt) 2017-07-11
EP2824181A1 (en) 2015-01-14
CA2865388C (en) 2022-01-04
JPWO2013133351A1 (ja) 2015-07-30
KR20230111270A (ko) 2023-07-25
KR20200046135A (ko) 2020-05-06
EP2824181A4 (en) 2015-07-15
KR20220017512A (ko) 2022-02-11
US20160375023A1 (en) 2016-12-29
JP6107812B2 (ja) 2017-04-05
PT2824181T (pt) 2018-12-20

Similar Documents

Publication Publication Date Title
EA201491655A1 (ru) Новый слитый fgfr3
EA201591785A1 (ru) Трициклические гетероциклы как ингибиторы белков бэт
EA201790876A1 (ru) Способ контроля, предотвращения или лечения кровотечения
WO2014160499A3 (en) Methods and compositions for detecting pancreatic cancer
EA201592143A1 (ru) Новые бициклические ингибиторы бромодомена
EA201690734A1 (ru) Ингибиторы бромодомена
NZ730763A (en) Methods of treating a tauopathy
EA201690007A1 (ru) Соединения, ингибирующие металлоферменты
WO2014150751A3 (en) Biomarkers associated with brm inhibition
EA201891539A1 (ru) Соединения, ингибирующие металлоферменты
EP4276200A3 (en) Fgfr-tacc fusion proteins and methods thereof
MX2016002423A (es) Composiciones y metodos de diagnostico para el tratamiento de glioblastoma.
UA117096C2 (uk) Поліпептид, що зв'язується з c5 комплементу людини
TW201613935A (en) Tricyclic heterocycles as BET protein inhibitors
EA201590162A1 (ru) МУТАНТНЫЕ ФРАГМЕНТЫ OspA И СВЯЗАННЫЕ С НИМИ СПОСОБЫ И ПРИМЕНЕНИЕ
EA201690269A1 (ru) Способы контроля уровней фукозилирования в белках
MX2015016472A (es) Anticuerpo anti-vegf y composicion farmaceutica que comprende los mismos para prevenir, diagnosticar o tratar enfermedades relacionadas con cáncer o angiogénesis.
PH12018501070A1 (en) Anti-pcsk9 antibody and use thereof
WO2014124339A3 (en) Use of translational profiling to identify target molecules for therapeutic treatment
EA201690559A1 (ru) Способы определения ответа на терапию
FI20115328A (fi) Uusia kutinaaseja, niiden tuottaminen ja käytöt
BR112015020054A2 (pt) Método de detectar resistência aos efeitos terapêuticos de um inibidor de akt em uma célula cancerosa
CL2012000938A1 (es) Aptamero que se une al virus de la septicemia viral hemorrágica (vhsn); adn que codifica el aptamero, vector de expresión; transformante que se obtiene al introducir dicho vector; método para extraer el vhsv; composicion farmaceutica para tratar o prevenir la vhs; estuche de detección del vhsv.
EA201501137A1 (ru) Биомаркеры генной экспрессии и их использование для диагностического и прогностического применения у пациентов, потенциально нуждающихся в лечении ингибитором hdac
MX2017000831A (es) Cuantificacion de tnfr2 : fc plegada erroneamente.

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM