EA201490452A1 - Ингибиторы тирозинкиназы брутона - Google Patents

Ингибиторы тирозинкиназы брутона

Info

Publication number
EA201490452A1
EA201490452A1 EA201490452A EA201490452A EA201490452A1 EA 201490452 A1 EA201490452 A1 EA 201490452A1 EA 201490452 A EA201490452 A EA 201490452A EA 201490452 A EA201490452 A EA 201490452A EA 201490452 A1 EA201490452 A1 EA 201490452A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
bluton
useful
proposed
diseases associated
Prior art date
Application number
EA201490452A
Other languages
English (en)
Other versions
EA024689B1 (ru
Inventor
Кристин Бразертон-Плейсс
Саул Хайме-Фигейра
Франсиско Хавьер Лопез-Тапиа
Ян Лоу
Тимоти Д. Оуэнс
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46690498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201490452(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA201490452A1 publication Critical patent/EA201490452A1/ru
Publication of EA024689B1 publication Critical patent/EA024689B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

В настоящей заявке предложены соединения общей формулы Iгде переменные раскрыты в данном тексте, которые ингибируют Btk. Предложенные соединения полезны для модуляции активности Btk и лечения заболеваний, связанных с избыточной активностью Btk. Кроме того, эти соединения полезны для лечения воспалительных и аутоиммунных заболеваний, связанных с аномальной пролиферацией В-клеток, таких как ревматоидный артрит. Предложены также композиции, содержащие соединения формулы I и по меньшей мере один носитель, разбавитель или эксципиент.
EA201490452A 2011-08-17 2012-08-14 Ингибиторы тирозинкиназы брутона EA024689B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161524374P 2011-08-17 2011-08-17
US201261649991P 2012-05-22 2012-05-22
PCT/EP2012/065844 WO2013024078A1 (en) 2011-08-17 2012-08-14 Inhibitors of bruton's tyrosine kinase

Publications (2)

Publication Number Publication Date
EA201490452A1 true EA201490452A1 (ru) 2014-05-30
EA024689B1 EA024689B1 (ru) 2016-10-31

Family

ID=46690498

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490452A EA024689B1 (ru) 2011-08-17 2012-08-14 Ингибиторы тирозинкиназы брутона

Country Status (22)

Country Link
US (1) US8889682B2 (ru)
EP (1) EP2744804B1 (ru)
JP (1) JP5823616B2 (ru)
KR (1) KR20140052032A (ru)
CN (1) CN103748088A (ru)
AR (1) AR087543A1 (ru)
AU (1) AU2012296888A1 (ru)
BR (1) BR112014003582A2 (ru)
CA (1) CA2841801A1 (ru)
CL (1) CL2014000350A1 (ru)
CO (1) CO6842020A2 (ru)
CR (1) CR20140027A (ru)
EA (1) EA024689B1 (ru)
EC (1) ECSP14013212A (ru)
HK (1) HK1197060A1 (ru)
IL (1) IL230561A0 (ru)
MA (1) MA35419B1 (ru)
MX (1) MX349372B (ru)
PE (1) PE20140865A1 (ru)
TW (1) TW201311669A (ru)
WO (1) WO2013024078A1 (ru)
ZA (1) ZA201400739B (ru)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2552514T3 (es) 2011-11-03 2015-11-30 Hoffmann-La Roche Ag Compuestos bicíclicos de piperazina
WO2013067264A1 (en) 2011-11-03 2013-05-10 Genentech, Inc. 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
BR112014010439A2 (pt) 2011-11-03 2017-04-18 F Hoffmann - La Roche Ag compostos, composição farmacêutica, processo de produção, método de tratamento de uma doença ou distúrbio, métodos, kit e uso de uma composição farmacêutica
CN104662018B (zh) 2012-04-20 2017-10-24 阿迪维纳斯治疗有限公司 取代的杂双环化合物、组合物及其医疗应用
WO2013157021A1 (en) 2012-04-20 2013-10-24 Advinus Therapeutics Limited Bicyclic compounds, compositions and medicinal applications thereof
CN104704129A (zh) 2012-07-24 2015-06-10 药品循环公司 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变
WO2014025976A1 (en) 2012-08-10 2014-02-13 Boehringer Ingelheim International Gmbh Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors
JP6088063B2 (ja) * 2012-11-16 2017-03-01 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトン型チロシンキナーゼの阻害剤
MX2015006457A (es) * 2012-11-30 2015-08-14 Hoffmann La Roche Inhibidores de la tirosina cinasa de bruton.
EP2964627B1 (en) 2013-03-05 2017-03-01 F. Hoffmann-La Roche AG Inhibitors of bruton's tyrosine kinase
CN104177338B (zh) * 2013-05-22 2018-04-03 南京勇山生物科技有限公司 一类布鲁顿激酶抑制剂
CA2912359A1 (en) * 2013-07-03 2015-01-08 F. Hoffmann-La Roche Ag Heteroaryl pyridone and aza-pyridone amide compounds
CA2919068C (en) 2013-07-26 2018-03-20 Carna Biosciences, Inc. Triazine derivative
EP3048102A1 (en) * 2013-09-20 2016-07-27 Carna Biosciences Inc. Novel triazine derivative
KR101813830B1 (ko) 2013-12-05 2017-12-29 에프. 호프만-라 로슈 아게 친전자성 작용기를 갖는 헤테로아릴 피리돈 및 아자-피리돈 화합물
EP3042903B1 (en) 2015-01-06 2019-08-14 Impetis Biosciences Ltd. Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
DK3247699T3 (da) 2015-01-22 2019-08-12 Sanofi Aventis Deutschland Proces til produktion of 2-[4-(cyclopropancarbonyl)phenyl]-2-methyl-propannitril
US10208024B2 (en) 2015-10-23 2019-02-19 Array Biopharma Inc. 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
AU2021267373A1 (en) 2020-05-06 2022-12-08 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
WO2023009709A1 (en) * 2021-07-29 2023-02-02 Ajax Therapeutics, Inc. Pyrazolo piperazines as jak2 inhibitors
WO2023086319A1 (en) 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
CN115073299A (zh) * 2022-06-14 2022-09-20 爱斯特（成都）生物制药股份有限公司 一种制备2-氟-3-三氟甲基苯胺的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7683064B2 (en) * 2008-02-05 2010-03-23 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
WO2009098144A1 (en) * 2008-02-05 2009-08-13 F. Hoffmann-La Roche Ag Novel pyridinones and pyridazinones
EP2297142B1 (en) 2008-06-24 2015-10-14 F. Hoffmann-La Roche AG Novel substituted pyridin-2-ones and pyridazin-3-ones
US8299077B2 (en) * 2009-03-02 2012-10-30 Roche Palo Alto Llc Inhibitors of Bruton's tyrosine kinase
AR082590A1 (es) * 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
WO2013067264A1 (en) * 2011-11-03 2013-05-10 Genentech, Inc. 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity
CA2853138A1 (en) * 2011-12-05 2013-06-13 Immunomedics, Inc. Therapeutic use of anti-cd22 antibodies for inducing trogocytosis

Also Published As

Publication number Publication date
ECSP14013212A (es) 2014-03-31
CA2841801A1 (en) 2013-02-21
EP2744804A1 (en) 2014-06-25
CN103748088A (zh) 2014-04-23
CO6842020A2 (es) 2014-01-20
AU2012296888A1 (en) 2014-01-23
JP5823616B2 (ja) 2015-11-25
AR087543A1 (es) 2014-04-03
US8889682B2 (en) 2014-11-18
HK1197060A1 (en) 2015-01-02
ZA201400739B (en) 2016-01-27
IL230561A0 (en) 2014-03-31
EA024689B1 (ru) 2016-10-31
PE20140865A1 (es) 2014-07-19
WO2013024078A1 (en) 2013-02-21
US20130045965A1 (en) 2013-02-21
JP2014521734A (ja) 2014-08-28
CL2014000350A1 (es) 2014-08-22
BR112014003582A2 (pt) 2017-03-14
KR20140052032A (ko) 2014-05-02
MX2014001653A (es) 2014-03-21
CR20140027A (es) 2014-03-13
TW201311669A (zh) 2013-03-16
MA35419B1 (fr) 2014-09-01
MX349372B (es) 2017-07-26
EP2744804B1 (en) 2017-05-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU