CL2014000350A1 - Compuestos 1-oxo-1h-(ftalazin o isoquinolin)-2-il sustituidos, inhibidores de la tirosina-quinasa de bruton (btk); composicion farmaceutica; metodo para el tratamiento de un estado patologico inflamatorio y/o autoinmune, artritis resumatoide o asma; y uso para tratar un estado patologico inflamatorio y/o autoinmune. - Google Patents
Compuestos 1-oxo-1h-(ftalazin o isoquinolin)-2-il sustituidos, inhibidores de la tirosina-quinasa de bruton (btk); composicion farmaceutica; metodo para el tratamiento de un estado patologico inflamatorio y/o autoinmune, artritis resumatoide o asma; y uso para tratar un estado patologico inflamatorio y/o autoinmune.Info
- Publication number
- CL2014000350A1 CL2014000350A1 CL2014000350A CL2014000350A CL2014000350A1 CL 2014000350 A1 CL2014000350 A1 CL 2014000350A1 CL 2014000350 A CL2014000350 A CL 2014000350A CL 2014000350 A CL2014000350 A CL 2014000350A CL 2014000350 A1 CL2014000350 A1 CL 2014000350A1
- Authority
- CL
- Chile
- Prior art keywords
- inflammatory
- pathological state
- autoimmune pathological
- btk
- isoquinolin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161524374P | 2011-08-17 | 2011-08-17 | |
US201261649991P | 2012-05-22 | 2012-05-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2014000350A1 true CL2014000350A1 (es) | 2014-08-22 |
Family
ID=46690498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2014000350A CL2014000350A1 (es) | 2011-08-17 | 2014-02-12 | Compuestos 1-oxo-1h-(ftalazin o isoquinolin)-2-il sustituidos, inhibidores de la tirosina-quinasa de bruton (btk); composicion farmaceutica; metodo para el tratamiento de un estado patologico inflamatorio y/o autoinmune, artritis resumatoide o asma; y uso para tratar un estado patologico inflamatorio y/o autoinmune. |
Country Status (22)
Country | Link |
---|---|
US (1) | US8889682B2 (es) |
EP (1) | EP2744804B1 (es) |
JP (1) | JP5823616B2 (es) |
KR (1) | KR20140052032A (es) |
CN (1) | CN103748088A (es) |
AR (1) | AR087543A1 (es) |
AU (1) | AU2012296888A1 (es) |
BR (1) | BR112014003582A2 (es) |
CA (1) | CA2841801A1 (es) |
CL (1) | CL2014000350A1 (es) |
CO (1) | CO6842020A2 (es) |
CR (1) | CR20140027A (es) |
EA (1) | EA024689B1 (es) |
EC (1) | ECSP14013212A (es) |
HK (1) | HK1197060A1 (es) |
IL (1) | IL230561A0 (es) |
MA (1) | MA35419B1 (es) |
MX (1) | MX349372B (es) |
PE (1) | PE20140865A1 (es) |
TW (1) | TW201311669A (es) |
WO (1) | WO2013024078A1 (es) |
ZA (1) | ZA201400739B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2552514T3 (es) | 2011-11-03 | 2015-11-30 | Hoffmann-La Roche Ag | Compuestos bicíclicos de piperazina |
WO2013067264A1 (en) | 2011-11-03 | 2013-05-10 | Genentech, Inc. | 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity |
UA111756C2 (uk) | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
BR112014010439A2 (pt) | 2011-11-03 | 2017-04-18 | F Hoffmann - La Roche Ag | compostos, composição farmacêutica, processo de produção, método de tratamento de uma doença ou distúrbio, métodos, kit e uso de uma composição farmacêutica |
CN104662018B (zh) | 2012-04-20 | 2017-10-24 | 阿迪维纳斯治疗有限公司 | 取代的杂双环化合物、组合物及其医疗应用 |
WO2013157021A1 (en) | 2012-04-20 | 2013-10-24 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
CN104704129A (zh) | 2012-07-24 | 2015-06-10 | 药品循环公司 | 与对布鲁顿酪氨酸激酶(btk)抑制剂的抗性相关的突变 |
WO2014025976A1 (en) | 2012-08-10 | 2014-02-13 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
JP6088063B2 (ja) * | 2012-11-16 | 2017-03-01 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトン型チロシンキナーゼの阻害剤 |
MX2015006457A (es) * | 2012-11-30 | 2015-08-14 | Hoffmann La Roche | Inhibidores de la tirosina cinasa de bruton. |
EP2964627B1 (en) | 2013-03-05 | 2017-03-01 | F. Hoffmann-La Roche AG | Inhibitors of bruton's tyrosine kinase |
CN104177338B (zh) * | 2013-05-22 | 2018-04-03 | 南京勇山生物科技有限公司 | 一类布鲁顿激酶抑制剂 |
CA2912359A1 (en) * | 2013-07-03 | 2015-01-08 | F. Hoffmann-La Roche Ag | Heteroaryl pyridone and aza-pyridone amide compounds |
CA2919068C (en) | 2013-07-26 | 2018-03-20 | Carna Biosciences, Inc. | Triazine derivative |
EP3048102A1 (en) * | 2013-09-20 | 2016-07-27 | Carna Biosciences Inc. | Novel triazine derivative |
KR101813830B1 (ko) | 2013-12-05 | 2017-12-29 | 에프. 호프만-라 로슈 아게 | 친전자성 작용기를 갖는 헤테로아릴 피리돈 및 아자-피리돈 화합물 |
EP3042903B1 (en) | 2015-01-06 | 2019-08-14 | Impetis Biosciences Ltd. | Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof |
DK3247699T3 (da) | 2015-01-22 | 2019-08-12 | Sanofi Aventis Deutschland | Proces til produktion of 2-[4-(cyclopropancarbonyl)phenyl]-2-methyl-propannitril |
US10208024B2 (en) | 2015-10-23 | 2019-02-19 | Array Biopharma Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases |
AU2021267373A1 (en) | 2020-05-06 | 2022-12-08 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
WO2023009709A1 (en) * | 2021-07-29 | 2023-02-02 | Ajax Therapeutics, Inc. | Pyrazolo piperazines as jak2 inhibitors |
WO2023086319A1 (en) | 2021-11-09 | 2023-05-19 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
CN115073299A (zh) * | 2022-06-14 | 2022-09-20 | 爱斯特(成都)生物制药股份有限公司 | 一种制备2-氟-3-三氟甲基苯胺的方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7683064B2 (en) * | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
WO2009098144A1 (en) * | 2008-02-05 | 2009-08-13 | F. Hoffmann-La Roche Ag | Novel pyridinones and pyridazinones |
EP2297142B1 (en) | 2008-06-24 | 2015-10-14 | F. Hoffmann-La Roche AG | Novel substituted pyridin-2-ones and pyridazin-3-ones |
US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
AR082590A1 (es) * | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
WO2013067264A1 (en) * | 2011-11-03 | 2013-05-10 | Genentech, Inc. | 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity |
CA2853138A1 (en) * | 2011-12-05 | 2013-06-13 | Immunomedics, Inc. | Therapeutic use of anti-cd22 antibodies for inducing trogocytosis |
-
2012
- 2012-08-14 WO PCT/EP2012/065844 patent/WO2013024078A1/en active Application Filing
- 2012-08-14 EP EP12748200.8A patent/EP2744804B1/en not_active Not-in-force
- 2012-08-14 JP JP2014525423A patent/JP5823616B2/ja not_active Expired - Fee Related
- 2012-08-14 KR KR1020147006816A patent/KR20140052032A/ko not_active Application Discontinuation
- 2012-08-14 BR BR112014003582A patent/BR112014003582A2/pt not_active IP Right Cessation
- 2012-08-14 CA CA2841801A patent/CA2841801A1/en active Pending
- 2012-08-14 AU AU2012296888A patent/AU2012296888A1/en not_active Abandoned
- 2012-08-14 PE PE2014000220A patent/PE20140865A1/es not_active Application Discontinuation
- 2012-08-14 EA EA201490452A patent/EA024689B1/ru not_active IP Right Cessation
- 2012-08-14 TW TW101129401A patent/TW201311669A/zh unknown
- 2012-08-14 CN CN201280038959.3A patent/CN103748088A/zh active Pending
- 2012-08-14 MX MX2014001653A patent/MX349372B/es active IP Right Grant
- 2012-08-15 AR ARP120102984A patent/AR087543A1/es unknown
- 2012-08-16 US US13/586,958 patent/US8889682B2/en not_active Expired - Fee Related
-
2013
- 2013-12-30 CO CO13303019A patent/CO6842020A2/es not_active Application Discontinuation
-
2014
- 2014-01-20 CR CR20140027A patent/CR20140027A/es unknown
- 2014-01-20 IL IL230561A patent/IL230561A0/en unknown
- 2014-01-30 ZA ZA2014/00739A patent/ZA201400739B/en unknown
- 2014-02-12 CL CL2014000350A patent/CL2014000350A1/es unknown
- 2014-02-17 EC ECSP14013212 patent/ECSP14013212A/es unknown
- 2014-02-26 MA MA36783A patent/MA35419B1/fr unknown
- 2014-10-20 HK HK14110443A patent/HK1197060A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP14013212A (es) | 2014-03-31 |
CA2841801A1 (en) | 2013-02-21 |
EP2744804A1 (en) | 2014-06-25 |
CN103748088A (zh) | 2014-04-23 |
CO6842020A2 (es) | 2014-01-20 |
AU2012296888A1 (en) | 2014-01-23 |
JP5823616B2 (ja) | 2015-11-25 |
AR087543A1 (es) | 2014-04-03 |
US8889682B2 (en) | 2014-11-18 |
HK1197060A1 (en) | 2015-01-02 |
ZA201400739B (en) | 2016-01-27 |
IL230561A0 (en) | 2014-03-31 |
EA024689B1 (ru) | 2016-10-31 |
PE20140865A1 (es) | 2014-07-19 |
WO2013024078A1 (en) | 2013-02-21 |
US20130045965A1 (en) | 2013-02-21 |
JP2014521734A (ja) | 2014-08-28 |
BR112014003582A2 (pt) | 2017-03-14 |
KR20140052032A (ko) | 2014-05-02 |
MX2014001653A (es) | 2014-03-21 |
EA201490452A1 (ru) | 2014-05-30 |
CR20140027A (es) | 2014-03-13 |
TW201311669A (zh) | 2013-03-16 |
MA35419B1 (fr) | 2014-09-01 |
MX349372B (es) | 2017-07-26 |
EP2744804B1 (en) | 2017-05-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2014000350A1 (es) | Compuestos 1-oxo-1h-(ftalazin o isoquinolin)-2-il sustituidos, inhibidores de la tirosina-quinasa de bruton (btk); composicion farmaceutica; metodo para el tratamiento de un estado patologico inflamatorio y/o autoinmune, artritis resumatoide o asma; y uso para tratar un estado patologico inflamatorio y/o autoinmune. | |
CL2013000391A1 (es) | Compuestos derivados de 6-(2-hidroximetil-fenil)-2-metil-2h-piridazin-3-ona, inhibidores de la tirosina-quinasa de bruton (btk); composicion farmaceutica; metodo para tratar una condicion inflamatoria y/o autoinmune, artritis reumatoidea o asma; y su uso para tratar una condicion inflamatoria y/o autoinmune. | |
CL2015000094A1 (es) | Compuestos derivados de imidazotriazincarbonitrilos, inhibidores de la proteina cinasa; composicion farmaceutica que los comprende; y su uso para tratar el cancer, psoriasis y artritis reumatoide. | |
BR112014004569A2 (pt) | composto da fórmula i, métodos para tratar condição inflamatória, artrite reumatoide, asma e distúrbio imune, composição farmacêutica e uso do composto | |
CL2015001268A1 (es) | Compuestos derivados de pirrolopirimidina, como inhibidores de quinasas; composicion farmaceutica que los comprende, util para el tratamiento de una enfermedad o condicion autoinmune tal como artritis reumatoide o lupus, y para el tratamiento de una enfermedad o condicion heteroinmune o inflamatoria. | |
CO6950482A2 (es) | Composiciones para el tratamiento de la artritis reumatoide y métodos para su utilización | |
CL2018000685A1 (es) | Nuevos compuestos bicíclicos como inhibidores duales de atx/ca | |
CL2014000543A1 (es) | Compuestos derivados de imidazopiridazinas sustituidas con amino, inhibidores de la quinasa ,mknk2; metodo de preparacion; compuestos intermediarios y su uso; composicion farmaceutica; combinacion farmaceutica; y su uso para el tratamiento del cancer. | |
CL2012003722A1 (es) | Compuestos derivados del acido naf-2-ilacetico; composicion farmaceutica; y uso para el tratamiento del sida. | |
CL2014002873A1 (es) | Compuestos derivados de pirimidin-amina o triazin-amina, inhibidores de adn-pk; composicion farmaceutica; y su uso para el tratamiento del cancer. | |
BR112014001279A2 (pt) | composto, uso do composto, composição farmacêutica, e, método para tratar um indivíduo que sofre com um distùrbio mediado pela tirosina cinase de bruton (btk) | |
CR20140034A (es) | Métodos para tratar el cáncer por el uso de antagonistas de unión al eje pd-1e inhibidores de mek | |
CO6930363A2 (es) | Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas | |
CL2015000256A1 (es) | Compuestos heteroaromáticos, inhibidores de btk, composicion farmaceutica que los comprende y uso en enfermedades tales como artritis reumatoide, lupus, entre otras. | |
EA201590721A1 (ru) | Фармацевтические композиции, содержащие ингибитор pde4 и ингибитор pi3-дельта или двойной ингибитор pi3-дельта-гамма киназы | |
CL2014001103A1 (es) | Compuestos derivados de heteroaril piridona y aza-piridona sustituidas, inhibidores de btk quinasa; composicion farmaceutica que los comprende; proceso de preparacion de la composicion farmaceutica; kit farmaceutico; y uso para el tratamiento de trastornos inmunes, cancer, inflamacion, trastornos neurologicos, entre otros. | |
CL2014000299A1 (es) | Compuestos derivados de n-[1-ciano-2-(fenil)etil]-2-azabiciclo[2.2.1]heptan-3-carboxamidas sustituidas, inhibidores de catepsina c; composicion farmaceutica; metodo de tratamiento o prevencion; y uso para el tratamiento de enfermedades tales como asma, enfermedades alergicas, artritis reumatoidea y aterosclerosis, entre otras. | |
CL2008003119A1 (es) | Compuestos derivados de piridina o piridazina sustituidos, inhibidores de quinasa; composicion farmaceutica; y uso para el tratamiento de un estado inflamatorio y/o autoinmune tal como artritis reumatoide. | |
BR112013029967A2 (pt) | método para a integração simultânea de duas ou mais cópias de um polinucleotídeo de interesse no cromossomo de uma célula hospedeira fúngica | |
BR112014000653A2 (pt) | inibidores de tirosina quinase de bruton | |
BR112013029620A2 (pt) | inibidores de tirosina quinase de bruton | |
CL2013002446A1 (es) | Compuestos derivados de quinolin-triazolopiridin-etilpirrolidina, como inihibidores de cinasa pim; proceso para su preparacion; compuestos intermediarios; composicion que los comprende, util para el tratamiento de una enfermedad inflamatoria o autoinmunitaria tal como esclerosis multiple y lupus, y para el tratamiento del cancer. | |
CO6791602A2 (es) | Métodos y sistemas para el tratamiento de pozos | |
SMT201500201B (it) | Nuovi mutanti di prongf e loro usi per la produzione di beta-ngf | |
CL2014000113A1 (es) | Compuestos derivados de quinolinas sustituidas; formulacion farmaceutica que los contiene; y su uso para el tratamiento de una enfermedad que se puede tratar mediante la inhibicion de la enzima syk, tales como rinitis alergica, asma, epoc, bronquitis, lupus eritematoso, esclerosis multiple, osteoporosis, osteopenia y arterioesclerosis. |