EA201400965A1 - 6-алкилпиридины в качестве миметиков smac - Google Patents
6-алкилпиридины в качестве миметиков smacInfo
- Publication number
- EA201400965A1 EA201400965A1 EA201400965A EA201400965A EA201400965A1 EA 201400965 A1 EA201400965 A1 EA 201400965A1 EA 201400965 A EA201400965 A EA 201400965A EA 201400965 A EA201400965 A EA 201400965A EA 201400965 A1 EA201400965 A1 EA 201400965A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkylpiridin
- smac mimetic
- alkynylpyridines
- pharmaceuticals
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
В заявке описаны 6-алкинилпиридины общей формулы (I)их применение в качестве миметиков SMAC, содержащие их фармацевтические композиции и их применение в качестве лекарственных средств, предназначенных для лечения и/или предупреждения заболеваний, характеризующихся чрезмерной или аномальной пролиферацией клеток, и родственных патологических состояний, таких как рак. Группы R-Rобладают значениями, приведенными в формуле изобретения и в описании.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12157199 | 2012-02-27 | ||
PCT/EP2013/053689 WO2013127729A1 (en) | 2012-02-27 | 2013-02-25 | 6 - alkynyl pyridines as smac mimetics |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201400965A1 true EA201400965A1 (ru) | 2015-01-30 |
EA026497B1 EA026497B1 (ru) | 2017-04-28 |
Family
ID=47748636
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201400965A EA026497B1 (ru) | 2012-02-27 | 2013-02-25 | 6-алкинилпиридины в качестве миметиков smac |
Country Status (40)
Country | Link |
---|---|
US (1) | US8859541B2 (ru) |
EP (1) | EP2819996B1 (ru) |
JP (1) | JP5969054B2 (ru) |
KR (1) | KR102038585B1 (ru) |
CN (1) | CN104169257B (ru) |
AP (1) | AP3999A (ru) |
AR (1) | AR090159A1 (ru) |
AU (1) | AU2013225173B2 (ru) |
BR (1) | BR112014021027B1 (ru) |
CA (1) | CA2865467C (ru) |
CL (1) | CL2014002257A1 (ru) |
CO (1) | CO7061075A2 (ru) |
CY (1) | CY1118859T1 (ru) |
DK (1) | DK2819996T3 (ru) |
EA (1) | EA026497B1 (ru) |
EC (1) | ECSP14018375A (ru) |
ES (1) | ES2619958T3 (ru) |
GE (1) | GEP20186899B (ru) |
HK (1) | HK1201267A1 (ru) |
HR (1) | HRP20170536T1 (ru) |
HU (1) | HUE031992T2 (ru) |
IL (1) | IL234106A (ru) |
IN (1) | IN2014DN06896A (ru) |
LT (1) | LT2819996T (ru) |
ME (1) | ME02627B (ru) |
MX (1) | MX345493B (ru) |
MY (1) | MY170938A (ru) |
NZ (1) | NZ628583A (ru) |
PE (1) | PE20141828A1 (ru) |
PH (1) | PH12014501913B1 (ru) |
PL (1) | PL2819996T3 (ru) |
PT (1) | PT2819996T (ru) |
RS (1) | RS55793B1 (ru) |
SG (1) | SG11201405230XA (ru) |
SI (1) | SI2819996T1 (ru) |
TN (1) | TN2014000361A1 (ru) |
TW (1) | TWI586649B (ru) |
UA (1) | UA113077C2 (ru) |
UY (1) | UY34643A (ru) |
WO (1) | WO2013127729A1 (ru) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9278978B2 (en) * | 2013-08-23 | 2016-03-08 | Boehringer Ingelheim International Gmbh | 6-Alkynyl Pyridine |
WO2015130922A2 (en) * | 2014-02-26 | 2015-09-03 | The Trustees Of The University Of Pennsylvania | Small molecule hsp70 inhibitors |
AR101479A1 (es) * | 2014-08-11 | 2016-12-21 | Boehringer Ingelheim Int | Derivados de 6-alquinil-piridina |
WO2016079527A1 (en) | 2014-11-19 | 2016-05-26 | Tetralogic Birinapant Uk Ltd | Combination therapy |
WO2016097773A1 (en) | 2014-12-19 | 2016-06-23 | Children's Cancer Institute | Therapeutic iap antagonists for treating proliferative disorders |
JP6533997B2 (ja) * | 2014-12-26 | 2019-06-26 | 株式会社ヤクルト本社 | Znf143阻害活性を有する化合物およびその利用 |
CA2985161A1 (en) * | 2015-05-18 | 2016-11-24 | Sun Pharma Advanced Research Company Limited | Novel amidoheteroaryl aroyl hydrazide ethynes |
JP2019516681A (ja) * | 2016-05-04 | 2019-06-20 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | インドールアミン2,3−ジオキシゲナーゼ阻害剤およびその使用方法 |
BR112018071289A2 (pt) * | 2016-05-19 | 2019-02-05 | Boehringer Ingelheim Int | processo para a fabricação de derivados de 6-alquinil-piridina |
WO2018167803A1 (en) * | 2017-03-15 | 2018-09-20 | Sun Pharma Advanced Research Company Limited | Novel amorphous dispersion of cyclopropanecarboxylic acid (5-{5-[ n'-(2-chloro-6-methylbenzoyl) hydrazinocarbonyl] -2-methyl-phenylethynyl}-pyridin-2-yl) amide |
CN110475567A (zh) * | 2017-03-31 | 2019-11-19 | 勃林格殷格翰国际有限公司 | 抗癌组合疗法 |
KR20200094734A (ko) | 2017-09-22 | 2020-08-07 | 주빌런트 에피파드 엘엘씨 | Pad 억제제로서의 헤테로사이클릭 화합물 |
DK3697785T3 (da) | 2017-10-18 | 2023-04-03 | Jubilant Epipad LLC | Imidazo-pyridine forbindelser som pad-inhibitorer |
AU2018362046B2 (en) | 2017-11-06 | 2023-04-13 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation |
CA3083374A1 (en) | 2017-11-24 | 2019-05-31 | Jubilant Episcribe Llc | Heterocyclic compounds as prmt5 inhibitors |
AU2019234185A1 (en) | 2018-03-13 | 2020-10-01 | Jubilant Prodel LLC. | Bicyclic compounds as inhibitors of PD1/PD-L1 interaction/activation |
CN113453678A (zh) | 2018-11-26 | 2021-09-28 | 德彪药业国际股份公司 | Hiv感染的联合治疗 |
TW202043466A (zh) | 2019-01-25 | 2020-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 編碼ccl21之重組棒狀病毒 |
AU2020356356A1 (en) | 2019-09-25 | 2022-05-12 | Debiopharm International S.A. | Dosing regimens for treatment of patients with locally advanced squamous cell carcinoma |
JP2023527577A (ja) | 2020-06-03 | 2023-06-29 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | CD80細胞外ドメインFc融合タンパク質をコードするリコンビナントラブドウイルス |
AU2022297082B2 (en) * | 2021-06-22 | 2024-04-18 | Alchemedicine, Inc. | Compound, endothelin A receptor antagonist and pharmaceutical composition |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0312408A (pt) * | 2002-07-02 | 2005-04-19 | Novartis Ag | Inibidores de peptìdeo de ligação de proteìna smac a inibidor de apoptose de proteìnas (iap) |
US20060205740A1 (en) * | 2003-08-14 | 2006-09-14 | Reno Michael J | Chemical compounds |
BRPI0611922A2 (pt) * | 2005-06-08 | 2010-10-05 | Novartis Ag | compostos orgánicos |
WO2007101347A1 (en) | 2006-03-07 | 2007-09-13 | Aegera Therapeutics Inc. | Bir domain binding compounds |
PE20110218A1 (es) * | 2006-08-02 | 2011-04-01 | Novartis Ag | DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS |
CN101595093A (zh) * | 2006-12-07 | 2009-12-02 | 诺瓦提斯公司 | 有机化合物 |
EP2318401A4 (en) * | 2008-08-16 | 2013-10-30 | Genentech Inc | AZAINDOLI INHIBITORS OF IPA |
-
2013
- 2013-02-19 US US13/769,934 patent/US8859541B2/en active Active
- 2013-02-25 SI SI201330585A patent/SI2819996T1/sl unknown
- 2013-02-25 CA CA2865467A patent/CA2865467C/en active Active
- 2013-02-25 PT PT137057998T patent/PT2819996T/pt unknown
- 2013-02-25 PL PL13705799T patent/PL2819996T3/pl unknown
- 2013-02-25 MY MYPI2014002481A patent/MY170938A/en unknown
- 2013-02-25 EA EA201400965A patent/EA026497B1/ru not_active IP Right Cessation
- 2013-02-25 CN CN201380011072.XA patent/CN104169257B/zh active Active
- 2013-02-25 IN IN6896DEN2014 patent/IN2014DN06896A/en unknown
- 2013-02-25 HU HUE13705799A patent/HUE031992T2/en unknown
- 2013-02-25 NZ NZ628583A patent/NZ628583A/en unknown
- 2013-02-25 ME MEP-2017-53A patent/ME02627B/me unknown
- 2013-02-25 PE PE2014001306A patent/PE20141828A1/es not_active Application Discontinuation
- 2013-02-25 WO PCT/EP2013/053689 patent/WO2013127729A1/en active Application Filing
- 2013-02-25 ES ES13705799.8T patent/ES2619958T3/es active Active
- 2013-02-25 BR BR112014021027-6A patent/BR112014021027B1/pt active IP Right Grant
- 2013-02-25 MX MX2014010249A patent/MX345493B/es active IP Right Grant
- 2013-02-25 GE GEAP201313584A patent/GEP20186899B/en unknown
- 2013-02-25 AU AU2013225173A patent/AU2013225173B2/en active Active
- 2013-02-25 SG SG11201405230XA patent/SG11201405230XA/en unknown
- 2013-02-25 JP JP2014558141A patent/JP5969054B2/ja active Active
- 2013-02-25 LT LTEP13705799.8T patent/LT2819996T/lt unknown
- 2013-02-25 KR KR1020147026641A patent/KR102038585B1/ko active IP Right Grant
- 2013-02-25 UA UAA201410431A patent/UA113077C2/uk unknown
- 2013-02-25 RS RS20170250A patent/RS55793B1/sr unknown
- 2013-02-25 EP EP13705799.8A patent/EP2819996B1/en active Active
- 2013-02-25 AP AP2014007873A patent/AP3999A/en active
- 2013-02-25 DK DK13705799.8T patent/DK2819996T3/en active
- 2013-02-26 TW TW102106769A patent/TWI586649B/zh not_active IP Right Cessation
- 2013-02-26 AR ARP130100586A patent/AR090159A1/es unknown
- 2013-02-27 UY UY0001034643A patent/UY34643A/es unknown
-
2014
- 2014-08-13 IL IL234106A patent/IL234106A/en active IP Right Grant
- 2014-08-25 CL CL2014002257A patent/CL2014002257A1/es unknown
- 2014-08-26 TN TNP2014000361A patent/TN2014000361A1/fr unknown
- 2014-08-26 PH PH12014501913A patent/PH12014501913B1/en unknown
- 2014-08-27 CO CO14188599A patent/CO7061075A2/es unknown
- 2014-09-11 EC ECIEPI201418375A patent/ECSP14018375A/es unknown
-
2015
- 2015-02-18 HK HK15101804.7A patent/HK1201267A1/xx not_active IP Right Cessation
-
2017
- 2017-03-16 CY CY20171100329T patent/CY1118859T1/el unknown
- 2017-03-31 HR HRP20170536TT patent/HRP20170536T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201400965A1 (ru) | 6-алкилпиридины в качестве миметиков smac | |
EA201500536A1 (ru) | Триазолопиразин | |
EA201201661A1 (ru) | Новые аминопиразолохиназолины | |
PH12015501385A1 (en) | Autotaxin inhibitors | |
EA201101330A1 (ru) | Замещенные пиримидины, предназначенные для лечения рака | |
MD20150043A2 (ru) | Ингибиторы гистон деметилаз | |
EA201591753A1 (ru) | 3-пиримидин-4-илоксазолидин-2-оны в качестве ингибиторов мутантного idh | |
EA201590005A1 (ru) | Замещенные трициклические соединения как ингибиторы fgfr | |
MX2013001970A (es) | Compuestos de pirrolopirimidina y usos de los mismos. | |
UA111305C2 (uk) | Конденсовані лактами арилу та гетероарилу | |
EA201790349A1 (ru) | Производные 6-алкинил-пиридина в качестве миметиков белка smac | |
EA201590962A1 (ru) | Новые соединения | |
UY35711A (es) | Bis-amidopiridinas como moduladores de la actividad de iap y sus usos como miméticos de smac | |
UY35710A (es) | 6-alquinilpiridinas como moduladores de la actividad de iap y sus usos como miméticos de smac | |
MX2017007377A (es) | Compuestos organicos. | |
WO2015059463A3 (en) | Treatment of beta-catenin related diseases8 | |
WO2013169631A3 (en) | Wnt protein signalling inhibitors | |
EA201590339A1 (ru) | Новые антибактериальные соединения | |
EA201590331A1 (ru) | Новые антибактериальные соединения | |
IN2015DN02109A (ru) | ||
MX371158B (es) | Compuestos inhibidores de pde2. | |
TN2013000012A1 (en) | New aminopyrazoloquinazolines |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KG TJ TM |
|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY KZ |