EA201201414A8 - КОМБИНАЦИИ, СОДЕРЖАЩИЕ ЗАМЕЩЕННЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИНЫ - Google Patents
КОМБИНАЦИИ, СОДЕРЖАЩИЕ ЗАМЕЩЕННЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИНЫInfo
- Publication number
- EA201201414A8 EA201201414A8 EA201201414A EA201201414A EA201201414A8 EA 201201414 A8 EA201201414 A8 EA 201201414A8 EA 201201414 A EA201201414 A EA 201201414A EA 201201414 A EA201201414 A EA 201201414A EA 201201414 A8 EA201201414 A8 EA 201201414A8
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- component
- dihydroimidazo
- combinations
- solvates
- stereoisomers
- Prior art date
Links
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- NTTQCLSBWRKUIJ-UHFFFAOYSA-N 2,3-dihydroimidazo[1,2-c]quinazoline Chemical class C1=CC=C2C3=NCCN3C=NC2=C1 NTTQCLSBWRKUIJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002136 L01XE07 - Lapatinib Substances 0.000 abstract 1
- XNRVGTHNYCNCFF-UHFFFAOYSA-N Lapatinib ditosylate monohydrate Chemical compound O.CC1=CC=C(S(O)(=O)=O)C=C1.CC1=CC=C(S(O)(=O)=O)C=C1.O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 XNRVGTHNYCNCFF-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 125000004421 aryl sulphonamide group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000009434 installation Methods 0.000 abstract 1
- 238000007912 intraperitoneal administration Methods 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 229960004891 lapatinib Drugs 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10160109 | 2010-04-16 | ||
| PCT/EP2011/055917 WO2011128407A2 (en) | 2010-04-16 | 2011-04-14 | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline-containing combinations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201201414A1 EA201201414A1 (ru) | 2013-04-30 |
| EA201201414A8 true EA201201414A8 (ru) | 2013-12-30 |
Family
ID=44144895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201201414A EA201201414A8 (ru) | 2010-04-16 | 2011-04-14 | КОМБИНАЦИИ, СОДЕРЖАЩИЕ ЗАМЕЩЕННЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИНЫ |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20130184270A1 (enExample) |
| EP (1) | EP2558126A2 (enExample) |
| JP (1) | JP5886271B2 (enExample) |
| KR (1) | KR20130098155A (enExample) |
| CN (1) | CN102958540B (enExample) |
| AU (1) | AU2011240003A1 (enExample) |
| BR (1) | BR112012026480A2 (enExample) |
| CA (1) | CA2796253A1 (enExample) |
| CL (1) | CL2012002887A1 (enExample) |
| CO (1) | CO6620036A2 (enExample) |
| CR (1) | CR20120524A (enExample) |
| CU (1) | CU20120150A7 (enExample) |
| DO (1) | DOP2012000269A (enExample) |
| EA (1) | EA201201414A8 (enExample) |
| EC (1) | ECSP12012261A (enExample) |
| IL (1) | IL222356A0 (enExample) |
| MA (1) | MA34158B1 (enExample) |
| MX (1) | MX2012012064A (enExample) |
| PE (1) | PE20130191A1 (enExample) |
| PH (1) | PH12012502069A1 (enExample) |
| SG (1) | SG184550A1 (enExample) |
| TN (1) | TN2012000493A1 (enExample) |
| WO (1) | WO2011128407A2 (enExample) |
| ZA (1) | ZA201208616B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2168583A1 (en) | 2008-09-24 | 2010-03-31 | Bayer Schering Pharma Aktiengesellschaft | Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma |
| UA113280C2 (xx) | 2010-11-11 | 2017-01-10 | АМІНОСПИРТЗАМІЩЕНІ ПОХІДНІ 2,3-ДИГІДРОІМІДАЗО$1,2-c]ХІНАЗОЛІНУ, ПРИДАТНІ ДЛЯ ЛІКУВАННЯ ГІПЕРПРОЛІФЕРАТИВНИХ ПОРУШЕНЬ І ЗАХВОРЮВАНЬ, ПОВ'ЯЗАНИХ З АНГІОГЕНЕЗОМ | |
| JO3733B1 (ar) * | 2011-04-05 | 2021-01-31 | Bayer Ip Gmbh | استخدام 3,2-دايهيدروايميدازو[1, 2 -c]كوينازولينات مستبدلة |
| EP2508525A1 (en) | 2011-04-05 | 2012-10-10 | Bayer Pharma Aktiengesellschaft | Substituted 2,3-dihydroimidazo[1,2-c]quinazoline salts |
| WO2014160034A1 (en) * | 2013-03-14 | 2014-10-02 | The Board Of Trustees Of The Leland Stanford Junior University | Aldehyde dehydrogenase-1 modulators and methods of use thereof |
| AP2015008750A0 (en) | 2013-04-08 | 2015-09-30 | Bayer Pharma AG | Use of substituted 2,3-dihydroimidazo[1,2-c] quinazolines for treating lymphomas |
| WO2015082376A2 (en) * | 2013-12-03 | 2015-06-11 | Bayer Pharma Aktiengesellschaft | Use of pi3k-inhibitors |
| EA201791974A1 (ru) * | 2015-03-09 | 2018-05-31 | Байер Фарма Акциенгезельшафт | Комбинации, содержащие замещенный 2,3-дигидроимидазо[1,2-с]хиназолин |
| WO2016142313A1 (en) * | 2015-03-09 | 2016-09-15 | Bayer Pharma Aktiengesellschaft | Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines |
| WO2017153220A1 (en) * | 2016-03-08 | 2017-09-14 | Bayer Pharma Aktiengesellschaft | 2—amino—n— [7—methoxy—2, 3-dihydroimidazo-[1, 2-c] quinazolin-5-yl] pyrimidine—5—carboxamides |
| CA3068324A1 (en) | 2017-06-28 | 2019-01-03 | Bayer Consumer Care Ag | Combination of a pi3k-inhibitor with an androgen receptor antagonist |
| US11498923B2 (en) | 2017-12-13 | 2022-11-15 | Merck Sharp & Dohme Llc | Substituted imidazo[1,2-c]quinazolines as A2A antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| WO2004029055A1 (en) * | 2002-09-30 | 2004-04-08 | Bayer Pharmaceuticals Corporation | Fused azole-pyrimidine derivatives |
| JP4323793B2 (ja) | 2002-12-16 | 2009-09-02 | キヤノン株式会社 | ズームレンズ及びそれを有する光学機器 |
| DE102004064002B4 (de) | 2004-08-04 | 2019-05-09 | Continental Automotive Gmbh | System zum Überwachen einer Sensorvorrichtung |
| US8101799B2 (en) * | 2005-07-21 | 2012-01-24 | Ardea Biosciences | Derivatives of N-(arylamino) sulfonamides as inhibitors of MEK |
| MX2008002114A (es) * | 2005-07-21 | 2008-04-17 | Ardea Biosciences Inc | Inhibidores de n-(arilamino)-sulfonamida de mek. |
| AR064106A1 (es) * | 2006-12-05 | 2009-03-11 | Bayer Schering Pharma Ag | Derivados de 2,3-dihidroimidazo [1,2-c] quinazolina sustituida utiles para el tratamiento de enfermedades y trastornos hiper-proliferativos asociados con la angiogenesis |
| CN102131771A (zh) * | 2008-04-14 | 2011-07-20 | 阿迪生物科学公司 | 组合物及其制备和使用方法 |
| EP2168583A1 (en) * | 2008-09-24 | 2010-03-31 | Bayer Schering Pharma Aktiengesellschaft | Use of substituted 2,3-dihydroimidazo[1,2-c]quinazolines for the treatment of myeloma |
-
2011
- 2011-04-14 EA EA201201414A patent/EA201201414A8/ru unknown
- 2011-04-14 SG SG2012075511A patent/SG184550A1/en unknown
- 2011-04-14 BR BR112012026480A patent/BR112012026480A2/pt not_active IP Right Cessation
- 2011-04-14 KR KR1020127029890A patent/KR20130098155A/ko not_active Withdrawn
- 2011-04-14 MX MX2012012064A patent/MX2012012064A/es unknown
- 2011-04-14 US US13/640,994 patent/US20130184270A1/en not_active Abandoned
- 2011-04-14 AU AU2011240003A patent/AU2011240003A1/en not_active Abandoned
- 2011-04-14 CN CN201180029827.XA patent/CN102958540B/zh not_active Expired - Fee Related
- 2011-04-14 JP JP2013504278A patent/JP5886271B2/ja not_active Expired - Fee Related
- 2011-04-14 PH PH1/2012/502069A patent/PH12012502069A1/en unknown
- 2011-04-14 WO PCT/EP2011/055917 patent/WO2011128407A2/en not_active Ceased
- 2011-04-14 MA MA35308A patent/MA34158B1/fr unknown
- 2011-04-14 PE PE2012002028A patent/PE20130191A1/es not_active Application Discontinuation
- 2011-04-14 EP EP11714553A patent/EP2558126A2/en not_active Withdrawn
- 2011-04-14 CA CA2796253A patent/CA2796253A1/en not_active Abandoned
-
2012
- 2012-10-11 IL IL222356A patent/IL222356A0/en unknown
- 2012-10-12 TN TNP2012000493A patent/TN2012000493A1/en unknown
- 2012-10-15 EC ECSP12012261 patent/ECSP12012261A/es unknown
- 2012-10-16 CO CO12182241A patent/CO6620036A2/es not_active Application Discontinuation
- 2012-10-16 CR CR20120524A patent/CR20120524A/es unknown
- 2012-10-16 CL CL2012002887A patent/CL2012002887A1/es unknown
- 2012-10-16 CU CU2012000150A patent/CU20120150A7/es unknown
- 2012-10-16 DO DO2012000269A patent/DOP2012000269A/es unknown
- 2012-11-15 ZA ZA2012/08616A patent/ZA201208616B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG184550A1 (en) | 2012-11-29 |
| MX2012012064A (es) | 2012-12-17 |
| JP5886271B2 (ja) | 2016-03-16 |
| IL222356A0 (en) | 2012-12-31 |
| JP2013525293A (ja) | 2013-06-20 |
| EP2558126A2 (en) | 2013-02-20 |
| US20130184270A1 (en) | 2013-07-18 |
| DOP2012000269A (es) | 2012-12-15 |
| CO6620036A2 (es) | 2013-02-15 |
| CU20120150A7 (es) | 2013-02-26 |
| CR20120524A (es) | 2013-01-09 |
| CL2012002887A1 (es) | 2013-01-18 |
| CN102958540B (zh) | 2015-09-02 |
| AU2011240003A1 (en) | 2012-11-08 |
| WO2011128407A3 (en) | 2012-02-23 |
| ZA201208616B (en) | 2015-08-26 |
| CA2796253A1 (en) | 2011-10-20 |
| CN102958540A (zh) | 2013-03-06 |
| PE20130191A1 (es) | 2013-02-21 |
| HK1182937A1 (en) | 2013-12-13 |
| WO2011128407A9 (en) | 2011-12-22 |
| BR112012026480A2 (pt) | 2016-08-16 |
| KR20130098155A (ko) | 2013-09-04 |
| WO2011128407A2 (en) | 2011-10-20 |
| ECSP12012261A (es) | 2012-11-30 |
| MA34158B1 (fr) | 2013-04-03 |
| TN2012000493A1 (en) | 2014-04-01 |
| EA201201414A1 (ru) | 2013-04-30 |
| PH12012502069A1 (en) | 2013-02-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201201414A1 (ru) | КОМБИНАЦИИ, СОДЕРЖАЩИЕ ЗАМЕЩЕННЫЕ 2,3-ДИГИДРОИМИДАЗО[1,2-c]ХИНАЗОЛИНЫ | |
| MX2013003695A (es) | Combinaciones que contienen n-(2-arilamino) arilsulfonamida sustituida. | |
| EA200970928A1 (ru) | Антагонисты рецептора гонадотропин-рилизин-фактора и способы их применения | |
| EA201390908A1 (ru) | Производные бицикло[3.2.1]октиламида и их применение | |
| PH12021551256A1 (en) | Pantetheine derivatives and uses thereof | |
| EA200971115A1 (ru) | Новые ингибиторы обратной транскриптазы вич | |
| EA201170922A1 (ru) | Производные сульфонамида | |
| EA201400358A1 (ru) | Замещенные n-[1-циано-2-(фенил)этил]-2-азабицикло[2.2.1]гептан-3-карбоксамидные ингибиторы катепсина с | |
| EA200970913A1 (ru) | 2-пиридинкарбоксамидные производные в качестве модуляторов натриевых каналов | |
| EA200700099A1 (ru) | Производные пиридина | |
| EA201071317A1 (ru) | ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛЬНЫЕ МОДУЛЯТОРЫ РЕЦЕПТОРОВ АНДРОГЕНОВ | |
| EA201070597A1 (ru) | Антибактериальные аналоги аминогликозида | |
| UY38625A (es) | Compuestos y su uso en el tratamiento del cáncer | |
| RU2014141362A (ru) | Комбинированная терапия пролиферативных нарушений | |
| BRPI0611705A2 (pt) | composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto | |
| EA200801997A1 (ru) | Новые соединения | |
| BR112022020933A2 (pt) | Inibidores de replicação do vírus da imunodeficiência humana | |
| RU2010138650A (ru) | Комбинация, включающая паклитаксел, для лечения рака яичников | |
| BR112012020377A8 (pt) | utilização de um ou mais selecionado do grupo constituído por um composto da fórmula (i), uma mistura racêmica-diastereomérica e um isômero óptico do referido composto, e um sal farmaceuticamente aceitável e uma pródroga do mesmo, método, composição farmacêutica e kit para tratamento de caquexia e embalagem comercial | |
| EA201390488A1 (ru) | Новые агонисты gpr 119 | |
| ZA202206436B (en) | Macrocyclic pantetheine derivatives and uses thereof | |
| MX2021004471A (es) | Derivados de pirrolo-pididazina como moduladores alostéricos positivos del receptor muscarínico m1. | |
| TN2013000141A1 (en) | Substituted n-(2-arylamino) aryl sulfonamide-containing combinations | |
| RU2013107451A (ru) | Комбинация силоксана и активного ингредиента для лечения стоматологических заболеваний | |
| TH155317A (th) | สารรวมที่ประกอบด้วย n-(2-แอริลอะมิโน)แอริลซัลโฟนาไมด์ซึ่งถูกแทนที่ซัลโฟนาไมด์ (substituted n-(2-arylamino)aryl sulfonamide-containing combinations) |