EA201190134A1 - Трансдермальные фармацевтические препараты - Google Patents

Трансдермальные фармацевтические препараты

Info

Publication number
EA201190134A1
EA201190134A1 EA201190134A EA201190134A EA201190134A1 EA 201190134 A1 EA201190134 A1 EA 201190134A1 EA 201190134 A EA201190134 A EA 201190134A EA 201190134 A EA201190134 A EA 201190134A EA 201190134 A1 EA201190134 A1 EA 201190134A1
Authority
EA
Eurasian Patent Office
Prior art keywords
transdermal
pharmaceuticals
transdermal pharmaceuticals
bioavailability
dispersed
Prior art date
Application number
EA201190134A
Other languages
English (en)
Other versions
EA023502B1 (ru
Inventor
Эндре Микулашик
Патрик Фазекаш
Original Assignee
Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг filed Critical Эгиш Дьёдьсердьяр Ньильваношан Мюкеде Ресвеньтаршашаг
Publication of EA201190134A1 publication Critical patent/EA201190134A1/ru
Publication of EA023502B1 publication Critical patent/EA023502B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)

Abstract

Настоящее изобретение относится к полутвердому трансдермальному фармацевтическому препарату, обладающему улучшенной стабильностью и биодоступностью, где частицы покрыты компонентом, представляющим собой летучее силиконовое масло, и получаемая таким образом суспензия диспергирована в гелевой или кремовой основе.
EA201190134A 2009-02-06 2010-02-05 Трансдермальная фармацевтическая композиция (варианты) EA023502B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0900072A HUP0900072A2 (hu) 2009-02-06 2009-02-06 Transzdermális gyógyszerkészítmények
PCT/HU2010/000015 WO2010089617A2 (en) 2009-02-06 2010-02-05 Transdermal pharmaceutical preparations

Publications (2)

Publication Number Publication Date
EA201190134A1 true EA201190134A1 (ru) 2012-02-28
EA023502B1 EA023502B1 (ru) 2016-06-30

Family

ID=89988766

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201190134A EA023502B1 (ru) 2009-02-06 2010-02-05 Трансдермальная фармацевтическая композиция (варианты)

Country Status (18)

Country Link
US (1) US20120024743A1 (ru)
EP (1) EP2393479A2 (ru)
JP (1) JP2012517414A (ru)
KR (1) KR20110120304A (ru)
CN (2) CN103349643A (ru)
AU (1) AU2010212158A1 (ru)
BR (1) BRPI1005433A2 (ru)
CA (1) CA2751633A1 (ru)
CL (1) CL2011001875A1 (ru)
EA (1) EA023502B1 (ru)
HU (1) HUP0900072A2 (ru)
IL (1) IL214402A0 (ru)
MX (1) MX2011008213A (ru)
NZ (1) NZ594618A (ru)
PE (1) PE20120584A1 (ru)
UA (1) UA107563C2 (ru)
WO (1) WO2010089617A2 (ru)
ZA (1) ZA201105662B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170065533A1 (en) * 2011-01-24 2017-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nanoparticles for dermal and systemic delivery of drugs
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US10045935B2 (en) * 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
JP5630679B1 (ja) * 2013-09-08 2014-11-26 株式会社Ｅ・テック 揮発性消毒剤、揮発性消毒剤の製造方法
US20170189443A1 (en) * 2014-02-24 2017-07-06 C. Lowell Parsons Compositions and methods for treatment of diseases and conditions employing oral administration of sodium pentosan polysulfate and other pentosan polysulfate salts
KR102559743B1 (ko) 2016-08-31 2023-07-25 오지 홀딩스 가부시키가이샤 산성 자일로올리고당의 제조 방법 및 산성 자일로올리고당
JP6225321B1 (ja) 2016-08-31 2017-11-08 王子ホールディングス株式会社 ポリ硫酸ペントサンの製造方法
JP6281659B1 (ja) 2017-02-28 2018-02-21 王子ホールディングス株式会社 ポリ硫酸ペントサン、医薬組成物及び抗凝固剤
BR112019025030A2 (pt) 2017-05-31 2020-06-16 Oji Holdings Corporation Preparação umidificante tópica.
MX2020002726A (es) 2017-09-12 2020-07-20 Oji Holdings Corp Polisulfato de pentosan y metodo para producir polisulfato de pentosan.
EP3730521B1 (en) 2017-12-20 2023-05-17 Oji Holdings Corporation Pentosan polysulfate and medicine containing pentosan polysulfate
RU2704623C1 (ru) * 2018-12-07 2019-10-30 Общество с ограниченной ответственностью "Научно-производственное объединение "Ликом" Перевязочное средство на биополимерной основе
TW202202129A (zh) * 2020-07-10 2022-01-16 大陸商江蘇恒瑞醫藥股份有限公司 含麻醉藥物活性成分的透皮製劑及其製備方法
CN115475224B (zh) * 2022-08-31 2023-11-28 中国人民解放军空军特色医学中心 一种用于治疗冻疮的药膏及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1141094B (it) 1979-12-03 1986-10-01 Gen Electric Emulsioni di siliconi volantili e acqua e loro metodo di preparazione ed uso
DE3010572C2 (de) 1980-03-19 1982-05-06 Süess, Hans R., Dr., Starrkirch Hautpflege- und Hautschutzpräparate
US4720353A (en) * 1987-04-14 1988-01-19 Richardson-Vicks Inc. Stable pharmaceutical w/o emulsion composition
US5122519A (en) 1989-06-27 1992-06-16 American Cyanamid Company Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
US5336692A (en) 1990-06-28 1994-08-09 Medicis Pharmaceutical Corporation Ointment base and method of use
FR2709131B1 (fr) 1993-08-18 1995-11-10 Cilag Laboratoire Dispositif de distribution d'une substance thérapeutique ou cosmétique dont le véhicule inerte est un polydiorganosiloxane volatil, et composition destinée à être utilisée dans le dispositif.
DE19837850C1 (de) 1998-08-20 2000-01-05 Wacker Chemie Gmbh Mischungen flüchtiger linearer Siloxane, Verfahren zu ihrer Herstellung sowie diese enthaltenden kosmetischen Formulierungen
IT1302275B1 (it) 1998-09-25 2000-09-05 Giorgio Panin Formulazione di gel idrofobo a base di vitamina e acetato perapplicazione topica.
CN100413871C (zh) 2001-11-13 2008-08-27 Ge拜尔硅股份有限公司 硅氧烷作为可汽化载体的应用
PL1686972T3 (pl) 2003-11-21 2008-09-30 Galderma Res & Dev Kompozycja możliwa do rozpylania dla podawania pochodnych witaminy D
GB0506139D0 (en) 2005-03-24 2005-05-04 Transphase Ltd A transdermal topical composition and its uses
WO2006138035A1 (en) * 2005-06-13 2006-12-28 Dow Corning Corporation Vehicle for the delivery of topical lipid soluble pharmaceutical agents
CA2618993A1 (en) * 2005-08-13 2007-02-22 Collegium Pharmaceutical, Inc. Topical delivery with a carrier fluid
HU227970B1 (en) * 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility

Also Published As

Publication number Publication date
KR20110120304A (ko) 2011-11-03
US20120024743A1 (en) 2012-02-02
HU0900072D0 (en) 2009-03-30
CN103349643A (zh) 2013-10-16
HUP0900072A2 (hu) 2010-09-28
WO2010089617A3 (en) 2011-06-16
MX2011008213A (es) 2011-09-28
EA023502B1 (ru) 2016-06-30
AU2010212158A1 (en) 2011-09-08
EP2393479A2 (en) 2011-12-14
NZ594618A (en) 2014-01-31
JP2012517414A (ja) 2012-08-02
CN102573793A (zh) 2012-07-11
UA107563C2 (ru) 2015-01-26
PE20120584A1 (es) 2012-05-23
CA2751633A1 (en) 2010-08-12
CL2011001875A1 (es) 2012-07-13
ZA201105662B (en) 2012-10-31
WO2010089617A2 (en) 2010-08-12
IL214402A0 (en) 2011-09-27
BRPI1005433A2 (pt) 2019-09-24

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Designated state(s): AM AZ BY KZ KG MD TJ TM RU