EA201070217A1 - Производные трициклических n-гетероарилкарбоксамидов, их получение и их применение в терапии - Google Patents

Производные трициклических n-гетероарилкарбоксамидов, их получение и их применение в терапии

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Publication number
EA201070217A1
EA201070217A1 EA201070217A EA201070217A EA201070217A1 EA 201070217 A1 EA201070217 A1 EA 201070217A1 EA 201070217 A EA201070217 A EA 201070217A EA 201070217 A EA201070217 A EA 201070217A EA 201070217 A1 EA201070217 A1 EA 201070217A1
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EA
Eurasian Patent Office
Prior art keywords
pyrrolo
pyridinyl
nitrogen atom
therapy
atom
Prior art date
Application number
EA201070217A
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English (en)
Other versions
EA017808B1 (ru
Inventor
Лоран Дюбуа
Янник Эванно
Андре Маланда
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Санофи-Авентис
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Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA201070217A1 publication Critical patent/EA201070217A1/ru
Publication of EA017808B1 publication Critical patent/EA017808B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к производным трициклических N-гетероарилкарбоксамидов общей формулы (I), в которой А вместе со связью Z-Zбицикла, с которым он объединен, означает (С-С)-циклоалкил, 4-7-членный моноциклический гетероарил или моногетероцикл, включающий от одного до трех гетероатомов, выбираемых среди О, S и N, включая туда атомы Zи Z; Z, Z, Z, Zи Zнезависимо друг от друга означают атом азота, атом углерода или группу C-R; Z, Z, Zи Zнезависимо друг от друга означают атом азота или атом углерода и Z, Z, Z, Z, Z, Z, Z, Zи Zвместе образуют бициклический гетероарил, связанный с атомом азота амида или тиоамида формулы (I) в положениях Z, Z, Zили Z, когда эти положения соответствуют атому углерода, причем по меньшей мере один из Z, Z, Z, Z, Zи Zсоответствует атому азота; W означает атом кислорода или серы; Р означает индолил, пирроло[2,3-с]пиридинил, пирроло[2,3-b]пиридинил, пирроло[3,2-b]пиридинил или пирроло[3,2-с]пиридинил, причем эта группа замещена. Оно также относится к способу их получения и применения в терапии.
EA201070217A 2007-08-02 2008-07-31 Производные трициклических n-гетероарилкарбоксамидов, их получение и их применение в терапии EA017808B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0705677A FR2919610B1 (fr) 2007-08-02 2007-08-02 Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique
PCT/FR2008/001141 WO2009050348A1 (fr) 2007-08-02 2008-07-31 Dérivés de λ/-hétéroaryl-carboxamides tricycliques, leur préparation et leur application en thérapeutique

Publications (2)

Publication Number Publication Date
EA201070217A1 true EA201070217A1 (ru) 2010-08-30
EA017808B1 EA017808B1 (ru) 2013-03-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070217A EA017808B1 (ru) 2007-08-02 2008-07-31 Производные трициклических n-гетероарилкарбоксамидов, их получение и их применение в терапии

Country Status (24)

Country Link
US (2) US8153796B2 (ru)
EP (1) EP2185558B1 (ru)
JP (1) JP5259713B2 (ru)
KR (1) KR20100041804A (ru)
CN (1) CN101772499B (ru)
AR (1) AR067754A1 (ru)
AU (1) AU2008313601B2 (ru)
BR (1) BRPI0814756A2 (ru)
CA (1) CA2694994C (ru)
CL (1) CL2008002289A1 (ru)
CO (1) CO6251362A2 (ru)
EA (1) EA017808B1 (ru)
FR (1) FR2919610B1 (ru)
MA (1) MA31687B1 (ru)
MX (1) MX2010001238A (ru)
MY (1) MY150428A (ru)
NZ (1) NZ582970A (ru)
PA (1) PA8790901A1 (ru)
PE (1) PE20090565A1 (ru)
SG (1) SG183080A1 (ru)
TW (1) TWI366566B (ru)
UY (1) UY31264A1 (ru)
WO (1) WO2009050348A1 (ru)
ZA (1) ZA201000745B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2017011434A (es) * 2015-03-18 2018-01-25 Squibb Bristol Myers Co Compuestos heterociclicos triciclicos sustituidos.
MY188606A (en) 2015-07-09 2021-12-22 Vistadeltek Llc Control plate in a valve
RU2721419C2 (ru) * 2015-08-28 2020-05-19 СиЭйчДиАй ФАУНДЕЙШН, ИНК. Зонды визуализации белка гентингтина
WO2022111473A1 (en) * 2020-11-26 2022-06-02 Bioardis Llc Compounds as mrgprx2 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0156327B1 (ko) * 1995-07-12 1998-11-16 김종인 벤즈 또는 피리도이미다졸 유도체
US6313242B1 (en) * 1996-05-20 2001-11-06 Fina Technology, Inc. Stereorigid bis-fluorenyl metallocenes
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
ATE450533T1 (de) * 2003-02-14 2009-12-15 Glaxo Group Ltd Carboxamidderivate
US20050004133A1 (en) * 2003-06-05 2005-01-06 Makings Lewis R. Modulators of VR1 receptor
GB0319151D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
FR2888848B1 (fr) * 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
FR2897061B1 (fr) * 2006-02-03 2010-09-03 Sanofi Aventis Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
CA2694994C (fr) 2015-05-19
SG183080A1 (en) 2012-08-30
NZ582970A (en) 2012-03-30
EP2185558A1 (fr) 2010-05-19
AU2008313601A1 (en) 2009-04-23
CN101772499B (zh) 2013-03-20
JP5259713B2 (ja) 2013-08-07
US8153796B2 (en) 2012-04-10
FR2919610B1 (fr) 2009-10-16
PA8790901A1 (es) 2009-03-31
AU2008313601B2 (en) 2013-10-24
MA31687B1 (fr) 2010-09-01
MX2010001238A (es) 2010-03-04
EA017808B1 (ru) 2013-03-29
US20120165531A1 (en) 2012-06-28
KR20100041804A (ko) 2010-04-22
WO2009050348A1 (fr) 2009-04-23
JP2010535179A (ja) 2010-11-18
TW200922936A (en) 2009-06-01
FR2919610A1 (fr) 2009-02-06
EP2185558B1 (fr) 2014-06-18
BRPI0814756A2 (pt) 2019-09-24
PE20090565A1 (es) 2009-06-01
CA2694994A1 (fr) 2009-04-23
TWI366566B (en) 2012-06-21
MY150428A (en) 2014-01-30
CN101772499A (zh) 2010-07-07
US20100173929A1 (en) 2010-07-08
CO6251362A2 (es) 2011-02-21
UY31264A1 (es) 2009-03-02
CL2008002289A1 (es) 2009-10-23
AR067754A1 (es) 2009-10-21
ZA201000745B (en) 2011-04-28
US8420817B2 (en) 2013-04-16

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