ATE434617T1 - 5-amino-4-hydroxy-7-(imidazo ä1,2-aü pyridin-6- ylmethyl)-8-methylnonamidderivate und verwandte verbindungen als renininhibitoren zur behandlung von bluthochdruck - Google Patents

5-amino-4-hydroxy-7-(imidazo ä1,2-aü pyridin-6- ylmethyl)-8-methylnonamidderivate und verwandte verbindungen als renininhibitoren zur behandlung von bluthochdruck

Info

Publication number
ATE434617T1
ATE434617T1 AT06793521T AT06793521T ATE434617T1 AT E434617 T1 ATE434617 T1 AT E434617T1 AT 06793521 T AT06793521 T AT 06793521T AT 06793521 T AT06793521 T AT 06793521T AT E434617 T1 ATE434617 T1 AT E434617T1
Authority
AT
Austria
Prior art keywords
methylnonamide
imidazo
ylmethyl
hypertension
pyridine
Prior art date
Application number
AT06793521T
Other languages
English (en)
Inventor
Peter Herold
Robert Mah
Vincenzo Tschinke
Stefan Stutz
Aleksandar Stojanovic
Christiane Marti
Dirk Behnke
Stjepan Jelakovic
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE434617T1 publication Critical patent/ATE434617T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
AT06793521T 2005-09-17 2006-09-14 5-amino-4-hydroxy-7-(imidazo ä1,2-aü pyridin-6- ylmethyl)-8-methylnonamidderivate und verwandte verbindungen als renininhibitoren zur behandlung von bluthochdruck ATE434617T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH15262005 2005-09-17
PCT/EP2006/066369 WO2007031558A1 (en) 2005-09-17 2006-09-14 5-amino-4-hydroxy-7- (imidazo [1,2-a] pyridin-6- ylmethyl)-8-methyl-nonamide derivatives and related compounds as renin inhibitors for the treatment of hypertension

Publications (1)

Publication Number Publication Date
ATE434617T1 true ATE434617T1 (de) 2009-07-15

Family

ID=37686018

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06793521T ATE434617T1 (de) 2005-09-17 2006-09-14 5-amino-4-hydroxy-7-(imidazo ä1,2-aü pyridin-6- ylmethyl)-8-methylnonamidderivate und verwandte verbindungen als renininhibitoren zur behandlung von bluthochdruck

Country Status (15)

Country Link
US (1) US8071651B2 (de)
EP (1) EP1948654B1 (de)
JP (1) JP2009507900A (de)
CN (1) CN101268074B (de)
AR (1) AR056197A1 (de)
AT (1) ATE434617T1 (de)
BR (1) BRPI0617166A2 (de)
CA (1) CA2622082A1 (de)
DE (1) DE602006007481D1 (de)
ES (1) ES2328630T3 (de)
IL (1) IL190061A0 (de)
PL (1) PL1948654T3 (de)
PT (1) PT1948654E (de)
TW (1) TW200804371A (de)
WO (1) WO2007031558A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0420722D0 (en) 2004-09-17 2004-10-20 Addex Pharmaceuticals Sa Novel allosteric modulators
PE20071177A1 (es) 2005-12-30 2008-01-18 Novartis Ag Derivados de 3,5-piridina como inhibidores de renina
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
US8084485B2 (en) 2006-03-31 2011-12-27 Vitae Pharmaceuticals, Inc. 6-(aminoalkyl)indazoles
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
WO2009000811A1 (en) 2007-06-25 2008-12-31 Novartis Ag N5-(2-ethoxyethyl)-n3-(2-pyridinyl)-3,5-piperidinedicarboxamide derivatives for use as renin inhibitors
JP5133416B2 (ja) 2007-09-14 2013-01-30 オルソー−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド． １’，３’−二置換−４−フェニル−３，４，５，６−テトラヒドロ−２ｈ，１’ｈ−［１，４’］ビピリジニル−２’−オン
TW200922566A (en) 2007-09-14 2009-06-01 Ortho Mcneil Janssen Pharm 1,3 disubstituted 4-(aryl-X-phenyl)-1H-pyridin-2-ones
US8722894B2 (en) 2007-09-14 2014-05-13 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones
WO2009062676A2 (en) 2007-11-14 2009-05-22 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US8691849B2 (en) 2008-09-02 2014-04-08 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
EP2163245A1 (de) 2008-09-10 2010-03-17 Novartis Ag Renin-Inhibitoren zur Behandlung von Psoriasis
EP2346505B1 (de) 2008-10-16 2014-04-23 Janssen Pharmaceuticals, Inc. Indol- und benzomorpholinderivate als modulatoren von metabotropen glutamatrezeptoren
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
US8937060B2 (en) 2009-05-12 2015-01-20 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
EP2430031B1 (de) 2009-05-12 2013-04-17 Janssen Pharmaceuticals, Inc. 1,2,4-triazol[4,3-a]-pyridin-derivate und ihre verwendung als positive allosterische modulatoren von mglur2-rezeptoren
AU2011328195B2 (en) 2010-11-08 2015-04-02 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
WO2012062750A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
IL279202B2 (en) 2014-01-21 2023-09-01 Janssen Pharmaceutica Nv Combinations containing positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic subtype 2 receptor and their use
PL3431106T3 (pl) 2014-01-21 2021-06-28 Janssen Pharmaceutica Nv Kombinacje zawierające pozytywne modulatory allosteryczne metabotropowego receptora glutaminergicznego podtypu 2 i ich zastosowanie

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
CA2560199A1 (en) 2004-03-19 2005-09-29 Speedel Experimenta Ag 5-amino-4-hydroxy-7-(1h-indolmethyl)-8-methylnonamide derivatives as renin inhibitors for the treatment of hypertension

Also Published As

Publication number Publication date
CA2622082A1 (en) 2007-03-22
ES2328630T3 (es) 2009-11-16
EP1948654B1 (de) 2009-06-24
CN101268074B (zh) 2011-09-21
DE602006007481D1 (de) 2009-08-06
PT1948654E (pt) 2009-09-28
CN101268074A (zh) 2008-09-17
BRPI0617166A2 (pt) 2011-07-12
US8071651B2 (en) 2011-12-06
AR056197A1 (es) 2007-09-26
EP1948654A1 (de) 2008-07-30
PL1948654T3 (pl) 2009-12-31
WO2007031558A1 (en) 2007-03-22
JP2009507900A (ja) 2009-02-26
TW200804371A (en) 2008-01-16
IL190061A0 (en) 2008-08-07
US20100063087A1 (en) 2010-03-11

Similar Documents

Publication Publication Date Title
ATE434617T1 (de) 5-amino-4-hydroxy-7-(imidazo ä1,2-aü pyridin-6- ylmethyl)-8-methylnonamidderivate und verwandte verbindungen als renininhibitoren zur behandlung von bluthochdruck
ATE421501T1 (de) 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck
ATE483705T1 (de) (lh-ind0l-7-yl)-(pyrimidin-2 -yl-amino) methanon derivate und verwandte verbindungen als igf-rl inhibitoren zur behandlung von krebs
ATE472327T1 (de) Ä4-(heteroaryl)piperazin-1-ylü-(2,5-substituier e phenyl)methanon-derivate als glycin-transporter 1 (glyt-1) hemmer zur behandlung von neurologischen und neuropsychiatrischen erkrankungen
ATE428424T1 (de) 1-benzoyl-piperazin-derivate als glycin- aufnahmehemmer zur behandlung von psychosen
NO20082476L (no) Bicykliske forbindelser med kinaseinhiberende aktivitet
ATE499370T1 (de) 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3- aminderivate und verwandte verbindungen als p2y1- rezeptor-hemmer zur behandlung thromboembolischer erkrankungen
ATE451363T1 (de) 3-(indazol-5-yl)-(1,2,4)triazinderivate und verwandte verbindungen als proteinkinaseinhibitoren zur behandlung von krebs
EA200900798A1 (ru) Производные индол-4-илпиримидинил-2-иламина и их применение в качестве ингибиторов циклинзависимой киназы
EA200900779A1 (ru) Производные дигидропиридина, полезные как ингибиторы протеинкиназы
ATE492545T1 (de) Verbindungen und zusammensetzungen als proteinkinase-hemmer
DE602005007717D1 (de) Imidazolverbindungen zur behandlung von neurodegenerativen erkrankungen
ATE527241T1 (de) Pyridiazinonderivate zur behandlung von tumoren
EA200970738A1 (ru) Ингибиторы активности akt
ATE542823T1 (de) 4,5-dihydro-ä1,2,4ütriazoloä4,3-füpteridine als plk1-proteinkinasehemmer zur behandlung proliferativer erkrankungen
EA201000100A1 (ru) Гетероциклические соединения, полезные в качестве ингибиторов mk2
EA201001774A1 (ru) Конденсированные азотсодержащие гетероциклы и содержащие их композиции в качестве ингибиторов киназы
ATE374610T1 (de) 1-(2-amino-benzoyl)-piperazin-derivate als glycin-aufnahmehemmer zur behandlung von psychosen
EA201170052A1 (ru) Производные тиофена или тиазола и их применение как ингибиторов pi3k
DE602005027388D1 (de) Malonsäureamidderivate als inhibitoren von g-sekretase zur behandlung von alzheimer-krankheit
WO2009073153A3 (en) Small molecule myristate inhibitors of bcr-abl and methods of use
WO2008078100A3 (en) Tricyclic amine derivatives as protein tyrosine kinase inhibitors
ATE384061T1 (de) Imidazo- und thiazolopyridine als jak3-kinase- inhibitoren
ATE543795T1 (de) Kondensierte bicyclische carbonsäureamidderivate zur verwendung als cxcr2-inhibitoren bei der behandlung von entzündungen
CY1112253T1 (el) Ενωσεις διαμινοτριαζολιου χρησιμες ως αναστολεις κινασης πρωτεϊνης

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1948654

Country of ref document: EP