PE20090565A1 - Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en terapeutica

Info

Publication number
PE20090565A1
PE20090565A1 PE2008001286A PE2008001286A PE20090565A1 PE 20090565 A1 PE20090565 A1 PE 20090565A1 PE 2008001286 A PE2008001286 A PE 2008001286A PE 2008001286 A PE2008001286 A PE 2008001286A PE 20090565 A1 PE20090565 A1 PE 20090565A1
Authority
PE
Peru
Prior art keywords
pirrolo
heteroaryl
monociclic
fluorobenzyl
imidazo
Prior art date
Application number
PE2008001286A
Other languages
English (en)
Inventor
Laurent Dubois
Yannick Evanno
Andre Malanda
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20090565A1 publication Critical patent/PE20090565A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

REFERIDA A COMPUESTOS DERIVADOS DE N-HETEROARIL-CARBOXAMIDAS TRICICLICAS DE FORMULA (I) DONDE A CON EL ENLACE Z2-Z3 DEL BICICLO ES CICLOALQUILO(C4-C7), HETEROARILO MONOCICLICO O HETEROCICLO MONOCICLICO DE 4 A 7 MIEMBROS, INCLUIDOS LOS ATOMOS Z2 Y Z3; Z2, Z3, Z4 Y Z9 SON CADA UNO N O C; Z1, Z5, Z6, Z7 Y Z8 SON CADA UNO N, C O C-R2, DONDE R2 ES H, HALOGENO, ALQUILO(C1-C6), FLUOROALCOXI(C1-C6), ENTRE OTROS; W ES O O S; P ES INDOLILO, PIRROLO[2,3-c]PIRIDINILO, PIRROLO[3,2-b]PIRIDINILO, ENTRE OTROS; R3 Y R3' SON CADA UNO H, HALOGENO, ALQUILO(C1-C6), CICLOALQUILO(C3-C7), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-(2.3-DIHIDRO-1H-PIRROLO[1'.2':1.2]IMIDAZO[5.4-b]PIRIDIN-6-IL)-5-FLUORO-1-(3-FLUOROBENCIL)-1H-INDOL-2-CARBOXAMIDA, N-(3-ACETOXI-2.3-DIHIDRO-1H-PIRROLO[1'.2':1.2]IMIDAZO[5.4-b]PIRIDIN-6-IL)-5-FLUORO-1-(3-FLUOROBENCIL)-1H-INDOL-2-CARBOXAMIDA, N-(2.3-DIHIDRO-3-OXO-1H-PIRROLO[1'.2':1.2]IMIDAZO[5.4-b]PIRIDIN-6-IL)-5-FLUORO-1-(3-FLUOROBENCIL)-1H-INDOL-2-CARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DE LOS RECEPTORES DE TIPO TRPV1 SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR OSTEOARTRITICO, NEUROPATICO, DIABETES, HIPERREFLEXIA VESICAL, CISTITIS, COLICO NEFRITICO, ULCERA DE ESTOMAGO, ENFERMEDAD DE CROHN, ASMA
PE2008001286A 2007-08-02 2008-07-31 Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en terapeutica PE20090565A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705677A FR2919610B1 (fr) 2007-08-02 2007-08-02 Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
PE20090565A1 true PE20090565A1 (es) 2009-06-01

Family

ID=39185736

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001286A PE20090565A1 (es) 2007-08-02 2008-07-31 Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en terapeutica

Country Status (24)

Country Link
US (2) US8153796B2 (es)
EP (1) EP2185558B1 (es)
JP (1) JP5259713B2 (es)
KR (1) KR20100041804A (es)
CN (1) CN101772499B (es)
AR (1) AR067754A1 (es)
AU (1) AU2008313601B2 (es)
BR (1) BRPI0814756A2 (es)
CA (1) CA2694994C (es)
CL (1) CL2008002289A1 (es)
CO (1) CO6251362A2 (es)
EA (1) EA017808B1 (es)
FR (1) FR2919610B1 (es)
MA (1) MA31687B1 (es)
MX (1) MX2010001238A (es)
MY (1) MY150428A (es)
NZ (1) NZ582970A (es)
PA (1) PA8790901A1 (es)
PE (1) PE20090565A1 (es)
SG (1) SG183080A1 (es)
TW (1) TWI366566B (es)
UY (1) UY31264A1 (es)
WO (1) WO2009050348A1 (es)
ZA (1) ZA201000745B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA032315B1 (ru) * 2015-03-18 2019-05-31 Бристол-Маерс Сквибб Компани Замещенные трициклические гетероциклические соединения
EP3320241A4 (en) 2015-07-09 2018-07-18 Vistadeltek, LLC Control plate in a valve
US10137211B2 (en) 2015-08-28 2018-11-27 Chdi Foundation, Inc. Probes for imaging Huntingtin protein
WO2022111473A1 (en) * 2020-11-26 2022-06-02 Bioardis Llc Compounds as mrgprx2 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0156327B1 (ko) * 1995-07-12 1998-11-16 김종인 벤즈 또는 피리도이미다졸 유도체
US6313242B1 (en) * 1996-05-20 2001-11-06 Fina Technology, Inc. Stereorigid bis-fluorenyl metallocenes
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
ATE450533T1 (de) * 2003-02-14 2009-12-15 Glaxo Group Ltd Carboxamidderivate
WO2004108133A2 (en) * 2003-06-05 2004-12-16 Vertex Pharmaceuticals Incorporated Modulators of vr1 receptor
GB0319151D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
FR2888848B1 (fr) * 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2897061B1 (fr) * 2006-02-03 2010-09-03 Sanofi Aventis Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
ZA201000745B (en) 2011-04-28
JP5259713B2 (ja) 2013-08-07
MA31687B1 (fr) 2010-09-01
AU2008313601B2 (en) 2013-10-24
CN101772499B (zh) 2013-03-20
AR067754A1 (es) 2009-10-21
BRPI0814756A2 (pt) 2019-09-24
JP2010535179A (ja) 2010-11-18
FR2919610A1 (fr) 2009-02-06
TWI366566B (en) 2012-06-21
AU2008313601A1 (en) 2009-04-23
PA8790901A1 (es) 2009-03-31
KR20100041804A (ko) 2010-04-22
UY31264A1 (es) 2009-03-02
MY150428A (en) 2014-01-30
SG183080A1 (en) 2012-08-30
CO6251362A2 (es) 2011-02-21
MX2010001238A (es) 2010-03-04
US8153796B2 (en) 2012-04-10
FR2919610B1 (fr) 2009-10-16
CA2694994A1 (fr) 2009-04-23
CN101772499A (zh) 2010-07-07
EA201070217A1 (ru) 2010-08-30
CA2694994C (fr) 2015-05-19
EP2185558A1 (fr) 2010-05-19
CL2008002289A1 (es) 2009-10-23
WO2009050348A1 (fr) 2009-04-23
US8420817B2 (en) 2013-04-16
US20120165531A1 (en) 2012-06-28
EA017808B1 (ru) 2013-03-29
EP2185558B1 (fr) 2014-06-18
US20100173929A1 (en) 2010-07-08
NZ582970A (en) 2012-03-30
TW200922936A (en) 2009-06-01

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