PE20091350A1 - Derivados de sulfonamidas sustituidas - Google Patents
Derivados de sulfonamidas sustituidasInfo
- Publication number
- PE20091350A1 PE20091350A1 PE2009000059A PE2009000059A PE20091350A1 PE 20091350 A1 PE20091350 A1 PE 20091350A1 PE 2009000059 A PE2009000059 A PE 2009000059A PE 2009000059 A PE2009000059 A PE 2009000059A PE 20091350 A1 PE20091350 A1 PE 20091350A1
- Authority
- PE
- Peru
- Prior art keywords
- metoxy
- piperidin
- pirazin
- dimethylphenylsulfonyl
- ethanone
- Prior art date
Links
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A DERIVADOS DE SULFONAMIDA DE FORMULA (I) DONDE Q ES -O- O -CH2-; X ES N O CR6; Y ES N O CR7; Z ES N O CR8, DONDE R6, R7 Y R8 SON CADA UNO H, HALOGENO, CN, NO2, ALQUILO(C1-C6), ENTRE OTROS; R1 ES ARILO O HETEROARILO; R2, R3, R4a, R4b Y R4c SON CADA UNO H O DOS RADICALES VECINOS DE LOS MISMOS FORMAN UN ANILLO DE 5 O 6 MIEMBROS; R5 ES H, HALOGENO, CN, NO2, ALQUENILO(C2-C6), ENTRE OTROS; a, b Y c SON CADA UNO 0 O 1; m Y n SON CADA UNO DE 0 A 2; p ES 1 O 2. SON COMPUESTOS PREFERIDOS: 1-(5,6-DIHIDRO-[1,2,4]TRIAZOLO[4,3-a]PIRAZIN-7(8H)-IL)-2-((1-(4-METOXI-2,6-DIMETILFENILSULFONIL)PIPERIDIN-2-IL)METOXI)ETANONA,2-((1-(4-METOXI-2,6-DIMETILFENILSULFONIL)PIPERIDIN-2-IL)METOXI)-1-(2-(PIPERIDIN-1-ILMETIL)-5,6-DIHIDROIMIDAZOL[1,2-a]PIRAZIN-7(8H)-IL)ETANONA, 1-(3-CLORO-2-(PIPERIDIN-1-ILMETIL)-5,6-DIHIDROIMIDAZOL[1,2-a]PIRAZIN-7(8H)-IL)-2-((1-(4-METOXI-2,6-DIMETILFENILSULFONIL)PIPERIDIN-2-IL)METOXI)ETANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE BRADIQUININA TIPO 1 (B1R) SIENDO UTILES EN EL TRATAMIENTO DEL DOLOR, MIGRANA, DIABETES, OBESIDAD
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08000839 | 2008-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091350A1 true PE20091350A1 (es) | 2009-09-23 |
Family
ID=39509619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2009000059A PE20091350A1 (es) | 2008-01-17 | 2009-01-16 | Derivados de sulfonamidas sustituidas |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8178535B2 (es) |
| EP (1) | EP2229394A1 (es) |
| JP (1) | JP2011509962A (es) |
| AR (1) | AR070188A1 (es) |
| CA (1) | CA2712266A1 (es) |
| CL (1) | CL2009000084A1 (es) |
| PE (1) | PE20091350A1 (es) |
| WO (1) | WO2009090055A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2066659T1 (sl) * | 2006-09-29 | 2013-10-30 | Grunenthal Gmbh | Substituirani sulfonamidni derivati |
| WO2009090055A1 (en) * | 2008-01-17 | 2009-07-23 | Grünenthal GmbH | Substituted sulfonamide derivatives |
| TW200944530A (en) * | 2008-04-09 | 2009-11-01 | Gruenenthal Chemie | Substituted sulfonamide derivatives |
| US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
| BR112012025101B1 (pt) | 2010-04-02 | 2021-08-31 | Ogeda S.A. | Compostos antagonistas seletivos de receptor nk-3, composição farmacêutica e medicamento compreendendo os mesmos |
| CN102372716A (zh) | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| WO2012172093A1 (en) | 2011-06-17 | 2012-12-20 | Merz Pharma Gmbh & Co. Kgaa | Dihydroindolizine derivate as metabotropic glutamate receptor modulators |
| RS54833B1 (sr) | 2011-10-03 | 2016-10-31 | Euroscreen Sa | Novi hiralni n-acil-5,6,7, (8-supstituisan)-tetrahidro-[1,2,4]triazolo [4,3-a]pirazini kao selektivni antagonisti nk-3 receptora, farmaceutsko jedinjenje, i postupci za upotrebu u nk-3 receptorom posredovanim poremećajima |
| CA2923980C (en) | 2012-09-13 | 2020-03-10 | British Columbia Cancer Agency Branch | Compositions targeting bradykinin receptor b1 for medical imaging of cancer and other disorders |
| EP2989080A1 (en) * | 2013-04-22 | 2016-03-02 | Reuter Chemische Apparatebau KG | Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine |
| PL3197876T3 (pl) | 2014-09-25 | 2019-05-31 | Ogeda Sa | NOWATORSKA SYNTEZA ASYMETRYCZNA N-ACYLO-(3-PODSTAWIENIE)- (8-PODSTAWIENIE)-5,6-DIHYDRO-[1,2,4] TRIAZOLO[4,3-a]PIRAZYN |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05010883A (es) * | 2003-04-10 | 2006-01-23 | Amgen Inc | Derivados de amina ciclica y su uso en el tratamiento de trastornos inflamatorios relacionados mediados por bradiquinina. |
| WO2007101007A2 (en) * | 2006-02-23 | 2007-09-07 | Neurogen Corporation | Aryl sulfonyl heterocycles |
| SI2066659T1 (sl) * | 2006-09-29 | 2013-10-30 | Grunenthal Gmbh | Substituirani sulfonamidni derivati |
| WO2009090055A1 (en) * | 2008-01-17 | 2009-07-23 | Grünenthal GmbH | Substituted sulfonamide derivatives |
-
2009
- 2009-01-15 WO PCT/EP2009/000191 patent/WO2009090055A1/en active Application Filing
- 2009-01-15 EP EP09702213A patent/EP2229394A1/en not_active Withdrawn
- 2009-01-15 JP JP2010542578A patent/JP2011509962A/ja active Pending
- 2009-01-15 CA CA2712266A patent/CA2712266A1/en not_active Abandoned
- 2009-01-16 PE PE2009000059A patent/PE20091350A1/es not_active Application Discontinuation
- 2009-01-16 CL CL2009000084A patent/CL2009000084A1/es unknown
- 2009-01-16 US US12/354,818 patent/US8178535B2/en not_active Expired - Fee Related
- 2009-01-16 AR ARP090100140A patent/AR070188A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009090055A1 (en) | 2009-07-23 |
| CA2712266A1 (en) | 2009-07-23 |
| CL2009000084A1 (es) | 2009-03-20 |
| US8178535B2 (en) | 2012-05-15 |
| US20090203672A1 (en) | 2009-08-13 |
| JP2011509962A (ja) | 2011-03-31 |
| AR070188A1 (es) | 2010-03-17 |
| EP2229394A1 (en) | 2010-09-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |