PE20091083A1 - Moduladores tieno- y furo- pirimidina del receptor de histamina h4 - Google Patents

Moduladores tieno- y furo- pirimidina del receptor de histamina h4

Info

Publication number
PE20091083A1
PE20091083A1 PE2008001613A PE2008001613A PE20091083A1 PE 20091083 A1 PE20091083 A1 PE 20091083A1 PE 2008001613 A PE2008001613 A PE 2008001613A PE 2008001613 A PE2008001613 A PE 2008001613A PE 20091083 A1 PE20091083 A1 PE 20091083A1
Authority
PE
Peru
Prior art keywords
histamine
receptor
furo
modulators
ilamine
Prior art date
Application number
PE2008001613A
Other languages
English (en)
Inventor
James P Edwards
Danielle K Neff
Deborah M Smith
Jennifer D Venable
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PE20091083A1 publication Critical patent/PE20091083A1/es

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    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
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    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pregnancy & Childbirth (AREA)

Abstract

REFERIDA A UN DERIVADO DE PIRIMIDINA DE FORMULA (I), DONDE X ES O O S; R1 ES H, METILO O BROMO; R2 ES H O ALQUILO C1-C4; R3 Y R4 SON (a), (b), (c), ENTRE OTROS; q ES 0 O 1; Rb Y Rc SON H O ALQUILO C1-C3; R5 ES H O NH2. SON COMPUESTOS PREFERIDOS: 4-(4-METIL-PIPERAZIN-1-IL)-TIENO[3,2-d]PIRIMIDIN-2-ILAMINA, 4-PIPERAZIN-1-IL-6,7,8,9-TETRAHIDRO-BENZO[4,5]TIENO[3,2-d]PIRIMIDIN-2-ILAMINA, 4-[(3aR,6aR)-HEXAHIDROPIRROLO[3,4-b]PIRROL-5-(1H)-IL]-6,7,8,9-TETRAHIDRO[1]BENZOTIENO[3,2-d]PIRIDIN-2-AMINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DEL RECEPTOR DE HISTAMINA H4 Y SON UTILES EN EL TRATAMIENTO DE TRANSTORNOS INFLAMATORIOS
PE2008001613A 2007-09-14 2008-09-15 Moduladores tieno- y furo- pirimidina del receptor de histamina h4 PE20091083A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97258907P 2007-09-14 2007-09-14

Publications (1)

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PE20091083A1 true PE20091083A1 (es) 2009-07-23

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ID=40455164

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PE2008001613A PE20091083A1 (es) 2007-09-14 2008-09-15 Moduladores tieno- y furo- pirimidina del receptor de histamina h4

Country Status (18)

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US (5) US8193178B2 (es)
EP (1) EP2200595B1 (es)
JP (1) JP5439377B2 (es)
KR (1) KR101470933B1 (es)
CN (1) CN101998958B (es)
AR (1) AR068513A1 (es)
AU (1) AU2008301897B2 (es)
BR (1) BRPI0816922A2 (es)
CA (1) CA2705719C (es)
CL (1) CL2008002747A1 (es)
HK (1) HK1143325A1 (es)
MX (1) MX2010002926A (es)
NZ (1) NZ583509A (es)
PA (1) PA8796001A1 (es)
PE (1) PE20091083A1 (es)
TW (1) TW200924781A (es)
UY (1) UY31340A1 (es)
WO (1) WO2009038673A2 (es)

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* Cited by examiner, † Cited by third party
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NZ583509A (en) 2007-09-14 2012-01-12 Janssen Pharmaceutica Nv Thieno-and furo-pyrimidine modulators of the histamine h4 receptor
US8436008B2 (en) 2008-12-22 2013-05-07 Incyte Corporation Substituted heterocyclic compounds
EP2201982A1 (en) 2008-12-24 2010-06-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Histamine H4 receptor antagonists for the treatment of vestibular disorders
AR076052A1 (es) 2009-03-20 2011-05-18 Incyte Corp Derivados de pirimidinas sustituidas, composiciones farmaceuticas que los contienen y uso de los mismos en trastornos asociados con receptores de histamina h4, tales como trastornos inflamatorios, prurito y dolor.
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
BR112013011737A2 (pt) 2010-11-15 2016-08-09 Univ Leuven Kath composto, uso de um composto composição farmacêutica, e, método de tratamento ou prevenção de uma infecção por hiv
AR090037A1 (es) * 2011-11-15 2014-10-15 Xention Ltd Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio
US9688989B2 (en) 2012-06-08 2017-06-27 Sensorion H4 receptor inhibitors for treating tinnitus
AU2013312477B2 (en) * 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
CN104936963B (zh) 2012-11-20 2017-11-28 普罗齐纳斯有限公司 作为蛋白激酶抑制剂的硫醚衍生物
GB201410816D0 (en) * 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven Therapeutic agents

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Also Published As

Publication number Publication date
CN101998958B (zh) 2014-03-12
AU2008301897A1 (en) 2009-03-26
KR20100085913A (ko) 2010-07-29
BRPI0816922A2 (pt) 2015-03-17
CN101998958A (zh) 2011-03-30
US8927555B2 (en) 2015-01-06
UY31340A1 (es) 2009-03-31
US8193178B2 (en) 2012-06-05
JP5439377B2 (ja) 2014-03-12
US20120214792A1 (en) 2012-08-23
NZ583509A (en) 2012-01-12
US8445482B2 (en) 2013-05-21
KR101470933B1 (ko) 2014-12-09
AR068513A1 (es) 2009-11-18
JP2010539169A (ja) 2010-12-16
CA2705719C (en) 2016-10-11
TW200924781A (en) 2009-06-16
US8937075B2 (en) 2015-01-20
US20120208793A1 (en) 2012-08-16
CL2008002747A1 (es) 2009-01-16
US20120270855A1 (en) 2012-10-25
EP2200595B1 (en) 2013-11-20
US20090075970A1 (en) 2009-03-19
EP2200595A2 (en) 2010-06-30
EP2200595A4 (en) 2011-06-01
CA2705719A1 (en) 2009-03-26
AU2008301897B2 (en) 2013-08-01
US20120238544A1 (en) 2012-09-20
US8440654B2 (en) 2013-05-14
HK1143325A1 (en) 2010-12-31
WO2009038673A3 (en) 2009-08-20
PA8796001A1 (es) 2009-04-23
MX2010002926A (es) 2010-03-31
WO2009038673A2 (en) 2009-03-26

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