UY31264A1 - Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en la terapéutica - Google Patents

Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en la terapéutica

Info

Publication number
UY31264A1
UY31264A1 UY31264A UY31264A UY31264A1 UY 31264 A1 UY31264 A1 UY 31264A1 UY 31264 A UY31264 A UY 31264A UY 31264 A UY31264 A UY 31264A UY 31264 A1 UY31264 A1 UY 31264A1
Authority
UY
Uruguay
Prior art keywords
disorders
therapeutics
derivatives
preparation
application
Prior art date
Application number
UY31264A
Other languages
English (en)
Inventor
Malanda Andre
Yannick Evanno
Laurent Dubois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UY31264A1 publication Critical patent/UY31264A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Derivados de N-heteroaril-carboxamidas tricíclicas de formula general (I), que presentan una actividad antagonista in vitro e in vivo por los receptroes de tipo TRPV1 (o VR1), donde los sustituyentes son tales como se han especificado en la Memoria Descriptiva y en las reivindicaciones correspondientes. Procedimiento de preparacion y aplicacion en terapéutica. Mediacamento destinado a prevenir o tratar el dolor, inflamacion, trastornos metabolicos, trastornos urologicos, trastornos ginecologicos, trastornos gastrointestinales, trastornos respiratorios, psoriasis, pruritos, irritaciones dérmicas, de los ojos o de las mucosas, herpes, zona, depresion, enfermedades del sistema nervioso central.
UY31264A 2007-08-02 2008-08-01 Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en la terapéutica UY31264A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0705677A FR2919610B1 (fr) 2007-08-02 2007-08-02 Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
UY31264A1 true UY31264A1 (es) 2009-03-02

Family

ID=39185736

Family Applications (1)

Application Number Title Priority Date Filing Date
UY31264A UY31264A1 (es) 2007-08-02 2008-08-01 Derivados de n-heteroaril-carboxamidas triciclicas, su preparacion y su aplicacion en la terapéutica

Country Status (24)

Country Link
US (2) US8153796B2 (es)
EP (1) EP2185558B1 (es)
JP (1) JP5259713B2 (es)
KR (1) KR20100041804A (es)
CN (1) CN101772499B (es)
AR (1) AR067754A1 (es)
AU (1) AU2008313601B2 (es)
BR (1) BRPI0814756A2 (es)
CA (1) CA2694994C (es)
CL (1) CL2008002289A1 (es)
CO (1) CO6251362A2 (es)
EA (1) EA017808B1 (es)
FR (1) FR2919610B1 (es)
MA (1) MA31687B1 (es)
MX (1) MX2010001238A (es)
MY (1) MY150428A (es)
NZ (1) NZ582970A (es)
PA (1) PA8790901A1 (es)
PE (1) PE20090565A1 (es)
SG (1) SG183080A1 (es)
TW (1) TWI366566B (es)
UY (1) UY31264A1 (es)
WO (1) WO2009050348A1 (es)
ZA (1) ZA201000745B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA032315B1 (ru) * 2015-03-18 2019-05-31 Бристол-Маерс Сквибб Компани Замещенные трициклические гетероциклические соединения
EP3320241A4 (en) 2015-07-09 2018-07-18 Vistadeltek, LLC Control plate in a valve
DK3340796T3 (da) 2015-08-28 2021-07-26 Chdi Foundation Inc Sonder til afbildning af huntingtin-protein
WO2022111473A1 (en) * 2020-11-26 2022-06-02 Bioardis Llc Compounds as mrgprx2 antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0156327B1 (ko) * 1995-07-12 1998-11-16 김종인 벤즈 또는 피리도이미다졸 유도체
US6313242B1 (en) * 1996-05-20 2001-11-06 Fina Technology, Inc. Stereorigid bis-fluorenyl metallocenes
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
DE602004024375D1 (de) * 2003-02-14 2010-01-14 Glaxo Group Ltd Carboxamidderivate
US20050004133A1 (en) * 2003-06-05 2005-01-06 Makings Lewis R. Modulators of VR1 receptor
GB0319151D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Novel compounds
FR2888847B1 (fr) * 2005-07-22 2007-08-31 Sanofi Aventis Sa Derives de n-(heteriaryl)-1-heteorarylalkyl-1h-indole-2- carboxamides, leur preparation et application en therapeutique
FR2888848B1 (fr) * 2005-07-22 2007-09-28 Sanofi Aventis Sa Derives de n-(arylalkyl)-1h-pyrrrolopyridine-2-carboxamides, leur preparation et leur application en therapeutique
FR2897061B1 (fr) * 2006-02-03 2010-09-03 Sanofi Aventis Derives de n-heteroaryl-carboxamides tricycliques contenant un motif benzimidazole, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
BRPI0814756A2 (pt) 2019-09-24
NZ582970A (en) 2012-03-30
EP2185558A1 (fr) 2010-05-19
JP2010535179A (ja) 2010-11-18
AU2008313601B2 (en) 2013-10-24
CA2694994C (fr) 2015-05-19
CN101772499B (zh) 2013-03-20
AR067754A1 (es) 2009-10-21
ZA201000745B (en) 2011-04-28
PA8790901A1 (es) 2009-03-31
MX2010001238A (es) 2010-03-04
EA017808B1 (ru) 2013-03-29
MA31687B1 (fr) 2010-09-01
AU2008313601A1 (en) 2009-04-23
JP5259713B2 (ja) 2013-08-07
TWI366566B (en) 2012-06-21
TW200922936A (en) 2009-06-01
FR2919610A1 (fr) 2009-02-06
PE20090565A1 (es) 2009-06-01
SG183080A1 (en) 2012-08-30
CN101772499A (zh) 2010-07-07
US8420817B2 (en) 2013-04-16
MY150428A (en) 2014-01-30
CA2694994A1 (fr) 2009-04-23
EA201070217A1 (ru) 2010-08-30
US20120165531A1 (en) 2012-06-28
CL2008002289A1 (es) 2009-10-23
WO2009050348A1 (fr) 2009-04-23
KR20100041804A (ko) 2010-04-22
FR2919610B1 (fr) 2009-10-16
CO6251362A2 (es) 2011-02-21
EP2185558B1 (fr) 2014-06-18
US20100173929A1 (en) 2010-07-08
US8153796B2 (en) 2012-04-10

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Legal Events

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Effective date: 20140729