EA201000771A1 - Тетрациклические дипиранокумариновые соединения с активностью против вич и mycobacterium tuberculosis - Google Patents

Тетрациклические дипиранокумариновые соединения с активностью против вич и mycobacterium tuberculosis

Info

Publication number
EA201000771A1
EA201000771A1 EA201000771A EA201000771A EA201000771A1 EA 201000771 A1 EA201000771 A1 EA 201000771A1 EA 201000771 A EA201000771 A EA 201000771A EA 201000771 A EA201000771 A EA 201000771A EA 201000771 A1 EA201000771 A1 EA 201000771A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mycobacterium tuberculosis
activity against
dipiranocumarine
tetracyclic
connections
Prior art date
Application number
EA201000771A
Other languages
English (en)
Inventor
Ган Лю
Хай Сюэ
Тао Ма
Цзивэй Чэнь
Лин Ван
Original Assignee
Инститьют Оф Мэтэрия Медика, Чайниз
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Инститьют Оф Мэтэрия Медика, Чайниз filed Critical Инститьют Оф Мэтэрия Медика, Чайниз
Publication of EA201000771A1 publication Critical patent/EA201000771A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к тетрациклодипиранокумариновым соединениям общей формулы (I), где заместители являются такими, как определено в настоящей заявке. Указанные соединения демонстрируют двойственную биологическую активность против инфекции вируса человеческого иммунодефецита типа 1 (ВИЧ-1) и против Mycobacterium Tuberculosis (ТВ) инфекции.
EA201000771A 2007-11-05 2007-11-05 Тетрациклические дипиранокумариновые соединения с активностью против вич и mycobacterium tuberculosis EA201000771A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2007/003139 WO2009059452A1 (fr) 2007-11-05 2007-11-05 Tétracyclodipyranyl-coumarines et leurs utilisations anti-vih et antituberculose

Publications (1)

Publication Number Publication Date
EA201000771A1 true EA201000771A1 (ru) 2011-02-28

Family

ID=40625346

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201000771A EA201000771A1 (ru) 2007-11-05 2007-11-05 Тетрациклические дипиранокумариновые соединения с активностью против вич и mycobacterium tuberculosis

Country Status (14)

Country Link
US (1) US20100324067A1 (ru)
EP (1) EP2216335B1 (ru)
JP (1) JP2011502176A (ru)
KR (1) KR20100085155A (ru)
CN (1) CN101896492B (ru)
AU (1) AU2007361257A1 (ru)
BR (1) BRPI0722098A2 (ru)
CA (1) CA2704649C (ru)
EA (1) EA201000771A1 (ru)
ES (1) ES2463689T3 (ru)
IL (1) IL205563A0 (ru)
MX (1) MX2010004992A (ru)
WO (1) WO2009059452A1 (ru)
ZA (1) ZA201003177B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103694209B (zh) * 2013-06-07 2015-10-28 中山大学 一类海洋真菌来源的苯乙酮类化合物及其制备方法与应用
WO2017221215A1 (en) * 2016-06-23 2017-12-28 Sun Pharmaceutical Industries Limited Salts of lenvatinib

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892060A (en) * 1994-08-03 1999-04-06 Sarawak Medichem Pharmaceuticals, Inc. Method for the preparation of (+)-calanolide a and analogues thereof
US5489697A (en) * 1994-08-03 1996-02-06 Medichem Research, Inc. Method for the preparation of (+)-calanolide A and intermediates thereof
US6277879B1 (en) * 1994-08-03 2001-08-21 Sarawak Medichem Pharmaceuticals, Inc. Calanolide analogues and methods of their use
CA2346813A1 (en) * 1998-10-15 2000-04-20 Sarawak Medichem Pharmaceuticals Incorporated Method and composition for treating and preventing tuberculosis
AU4491800A (en) * 1999-04-26 2000-11-10 Sarawak Medichem Pharmaceuticals, Inc. Methods for preparing antiviral calanolide compounds
JP2002193971A (ja) * 2000-12-22 2002-07-10 Kuraray Co Ltd カラノリドａおよびその中間体の製造方法
EP1379529A2 (en) * 2001-03-16 2004-01-14 Sarawak Medichem Pharmaceuticals, Inc. Pyranocoumarin compounds as a novel pharmacophore with anti-tb activity
WO2003070159A2 (en) * 2001-11-16 2003-08-28 Sarawak Medichem Pharmaceuticals Novel coumarin and chromene compounds and methods of treating or preventing viral infections
CN1310920C (zh) * 2003-05-09 2007-04-18 中国医学科学院药物研究所 消旋和光活胡桐素a及其类似物的制备方法
CN101100470B (zh) * 2006-07-07 2013-02-13 中国医学科学院药物研究所 四环双吡喃香豆素化合物
JP5479105B2 (ja) * 2007-11-05 2014-04-23 国立大学法人佐賀大学 新規ユビキリン結合性小分子

Also Published As

Publication number Publication date
EP2216335A1 (en) 2010-08-11
CA2704649A1 (en) 2009-05-14
WO2009059452A1 (fr) 2009-05-14
ES2463689T3 (es) 2014-05-28
US20100324067A1 (en) 2010-12-23
AU2007361257A1 (en) 2009-05-14
CN101896492B (zh) 2015-05-06
CA2704649C (en) 2015-02-17
JP2011502176A (ja) 2011-01-20
IL205563A0 (en) 2010-12-30
ZA201003177B (en) 2011-05-25
EP2216335A4 (en) 2011-03-30
EP2216335B1 (en) 2014-03-12
BRPI0722098A2 (pt) 2014-04-08
KR20100085155A (ko) 2010-07-28
MX2010004992A (es) 2010-12-21
CN101896492A (zh) 2010-11-24

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EA201000771A1 (ru) Тетрациклические дипиранокумариновые соединения с активностью против вич и mycobacterium tuberculosis