EA200970347A1 - Соединения и композиции в качестве ингибиторов протеинкиназ - Google Patents
Соединения и композиции в качестве ингибиторов протеинкиназInfo
- Publication number
- EA200970347A1 EA200970347A1 EA200970347A EA200970347A EA200970347A1 EA 200970347 A1 EA200970347 A1 EA 200970347A1 EA 200970347 A EA200970347 A EA 200970347A EA 200970347 A EA200970347 A EA 200970347A EA 200970347 A1 EA200970347 A1 EA 200970347A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- proteinkinaz
- inhibitors
- compositions
- raf
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
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Abstract
Данное изобретение предлагает новый класс соединений, фармацевтические композиции, содержащие указанные соединения, и способы применения указанных соединений для лечения или профилактики заболеваний или расстройств, связанных с аномальной или нарушенной киназной активностью, в частности, заболеваний или расстройств, которые включают аномальную активацию киназ Abl, ARG, BCR-Abl, BRK, EphB, Fms, Fyn, KDR, c-Kit, LCK, PDGF-R, b-Raf, c-Raf, SAPK2, Src, Tie2 и TrkB.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US82787306P | 2006-10-02 | 2006-10-02 | |
PCT/US2007/079340 WO2008042639A1 (en) | 2006-10-02 | 2007-09-24 | Compounds and compositions as protein kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200970347A1 true EA200970347A1 (ru) | 2009-10-30 |
EA015751B1 EA015751B1 (ru) | 2011-12-30 |
Family
ID=38955203
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200970347A EA015751B1 (ru) | 2006-10-02 | 2007-09-24 | Соединения и композиции в качестве ингибиторов протеинкиназ |
Country Status (22)
Country | Link |
---|---|
US (1) | US8202876B2 (ru) |
EP (1) | EP2057146A1 (ru) |
JP (1) | JP5153777B2 (ru) |
KR (1) | KR101101675B1 (ru) |
CN (2) | CN101522661A (ru) |
AR (1) | AR063099A1 (ru) |
AU (1) | AU2007305016B2 (ru) |
BR (1) | BRPI0719797A8 (ru) |
CA (1) | CA2663366C (ru) |
CL (1) | CL2007002836A1 (ru) |
CO (1) | CO6180440A2 (ru) |
CR (1) | CR10670A (ru) |
EA (1) | EA015751B1 (ru) |
IL (1) | IL197724A0 (ru) |
MA (1) | MA30772B1 (ru) |
MX (1) | MX2009003456A (ru) |
NO (1) | NO20091759L (ru) |
PE (1) | PE20080828A1 (ru) |
SM (1) | SMAP200900020A (ru) |
TN (1) | TN2009000105A1 (ru) |
TW (1) | TW200823200A (ru) |
WO (1) | WO2008042639A1 (ru) |
Families Citing this family (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2493155C2 (ru) | 2006-12-08 | 2013-09-20 | Ф.Хоффманн-Ля Рош Аг | Замещенные пиримидины и их применение в качестве модуляторов jnk |
CN101801187B (zh) * | 2007-07-13 | 2014-07-23 | 得克萨斯系统大学评议会 | 大麻素受体的杂环调节剂 |
KR101559597B1 (ko) * | 2007-09-28 | 2015-10-12 | 다케다 야쿠힌 고교 가부시키가이샤 | 5―원 헤테로시클릭 화합물 |
JP2011513330A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | Raf阻害化合物およびその使用方法 |
BRPI0908268A2 (pt) * | 2008-02-29 | 2018-10-30 | Array Biopharma Inc | compostos do inibidor de raf e seus métodos de uso |
EP2265574A1 (en) * | 2008-02-29 | 2010-12-29 | Array Biopharma, Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
JP2011513329A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | RAF阻害化合物として使用されるイミダゾ[4,5−b]ピリジン誘導体 |
WO2009158432A2 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
EP2324008B1 (en) * | 2008-07-24 | 2012-05-09 | Nerviano Medical Sciences S.R.L. | 3,4-diarylpyrazoles as protein kinase inhibitors |
US20120190666A1 (en) * | 2009-05-13 | 2012-07-26 | Amgen Inc. | Heteroaryl Compounds as PIKK Inhibitors |
AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
CN108542906A (zh) | 2011-11-11 | 2018-09-18 | 诺华股份有限公司 | 治疗增生性疾病的方法 |
SG11201401260QA (en) | 2011-11-23 | 2014-07-30 | Novartis Ag | Pharmaceutical formulations |
RS61664B1 (sr) * | 2012-04-24 | 2021-04-29 | Vertex Pharma | Inhibitori dna-pk |
CN107383009B (zh) | 2012-06-13 | 2020-06-09 | 因塞特控股公司 | 作为fgfr抑制剂的取代的三环化合物 |
WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
RS58374B1 (sr) | 2013-03-12 | 2019-03-29 | Vertex Pharma | Inhibitori dnk-pk |
SG11201508328PA (en) | 2013-04-19 | 2015-11-27 | Incyte Corp | Bicyclic heterocycles as fgfr inhibitors |
WO2015013581A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
EP3057953B1 (en) | 2013-10-17 | 2018-08-15 | Vertex Pharmaceuticals Incorporated | Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors |
PL3057959T3 (pl) * | 2013-10-17 | 2018-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitory DNA-PK |
US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
WO2016134294A1 (en) | 2015-02-20 | 2016-08-25 | Incyte Corporation | Bicyclic heterocycles as fgfr4 inhibitors |
CN107438607B (zh) | 2015-02-20 | 2021-02-05 | 因赛特公司 | 作为fgfr抑制剂的双环杂环 |
MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
WO2016164754A1 (en) * | 2015-04-09 | 2016-10-13 | Eisai R&D Management Co., Ltd. | Fgfr4 inhibitors |
US10738035B2 (en) | 2015-05-13 | 2020-08-11 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
US10179131B2 (en) | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
US10301255B2 (en) * | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
WO2017066193A1 (en) | 2015-10-15 | 2017-04-20 | Princeton Drug Discovery, Llc | Novel inhibitors of protein kinases |
US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
PL3426245T3 (pl) | 2016-03-07 | 2023-05-22 | Enanta Pharmaceuticals, Inc. | Środki przeciwwirusowe zapalenia wątroby typu b |
CN109843296A (zh) | 2016-06-10 | 2019-06-04 | 英安塔制药有限公司 | 乙型肝炎抗病毒药剂 |
TW201815418A (zh) | 2016-09-27 | 2018-05-01 | Vertex Pharma | 使用dna破壞劑及dna-pk抑制劑之組合治療癌症的方法 |
EP3553056B1 (en) | 2017-01-20 | 2021-02-17 | Shenzhen TargetRx, Inc. | (hetero)arylamide compound for inhibiting protein kinase activity |
US10875853B2 (en) | 2017-01-20 | 2020-12-29 | Shenzhen Targetrx, Inc. | (Hetero)arylamide compound for inhibiting protein kinase activity |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
SG11202001685TA (en) | 2017-08-28 | 2020-03-30 | Enanta Pharm Inc | Hepatitis b antiviral agents |
TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
WO2019113175A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
WO2019141957A1 (en) | 2018-01-19 | 2019-07-25 | Cado Biotechnology Ivs | N-pyrimidinyl hydroxy pyrazole derivatives and uses thereof |
WO2019143902A2 (en) | 2018-01-22 | 2019-07-25 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
CA3099116A1 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Salts of an fgfr inhibitor |
AU2019262195B2 (en) | 2018-05-04 | 2024-09-12 | Incyte Corporation | Solid forms of an FGFR inhibitor and processes for preparing the same |
CA3113235A1 (en) | 2018-09-21 | 2020-03-26 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
WO2020106816A1 (en) | 2018-11-21 | 2020-05-28 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
US11472808B2 (en) | 2019-06-04 | 2022-10-18 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents |
US11760755B2 (en) | 2019-06-04 | 2023-09-19 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
WO2021007269A1 (en) | 2019-07-09 | 2021-01-14 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
US11738019B2 (en) | 2019-07-11 | 2023-08-29 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
JP2022552324A (ja) | 2019-10-14 | 2022-12-15 | インサイト・コーポレイション | Fgfr阻害剤としての二環式複素環 |
US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
KR20220131900A (ko) | 2019-12-04 | 2022-09-29 | 인사이트 코포레이션 | Fgfr 억제제의 유도체 |
CA3163875A1 (en) | 2019-12-04 | 2021-06-10 | Incyte Corporation | Tricyclic heterocycles as fgfr inhibitors |
WO2021146424A1 (en) | 2020-01-15 | 2021-07-22 | Incyte Corporation | Bicyclic heterocycles as fgfr inhibitors |
US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
US12065494B2 (en) | 2021-04-12 | 2024-08-20 | Incyte Corporation | Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent |
WO2022255778A1 (ko) | 2021-06-01 | 2022-12-08 | 주식회사 에즈큐리스 | Il-33 단백질 저해용 화합물의 스크리닝 방법 및 상기 화합물을 포함하는 알러지성 질환 치료용 약학조성물 |
JP2024522189A (ja) | 2021-06-09 | 2024-06-11 | インサイト・コーポレイション | Fgfr阻害剤としての三環式ヘテロ環 |
WO2023158795A1 (en) * | 2022-02-18 | 2023-08-24 | Accent Therapeutics, Inc. | Inhibitors of rna helicase dhx9 and uses thereof |
WO2024159094A1 (en) * | 2023-01-27 | 2024-08-02 | Enliven Inc. | Pyrimidinyl (hetero)aromatic aminopyridine compounds for inhibition of raf kinases |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3575130D1 (de) * | 1984-05-12 | 1990-02-08 | Fisons Plc | Antiinflammatorische 1,n-diarylpyrazol-3-amine, deren zusammensetzungen und verfahren zu deren herstellung. |
US6087381A (en) | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
US6979686B1 (en) * | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
WO2001030154A2 (de) | 1999-10-25 | 2001-05-03 | Basf Aktiengesellschaft | Pyrazole enthaltende agrochemische zusammensetzungen und ihre verwendung als fungizide flanzenschutzmittel |
GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
AR042067A1 (es) | 2002-11-27 | 2005-06-08 | Bayer Pharmaceuticals Corp | Derivados de anilinopirazol utiles en el tratamiento de la diabetes |
US20050014753A1 (en) * | 2003-04-04 | 2005-01-20 | Irm Llc | Novel compounds and compositions as protein kinase inhibitors |
JP4889489B2 (ja) * | 2003-08-06 | 2012-03-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | プロテインキナーゼのインヒビターとして有用なアミノトリアゾール化合物 |
MXPA06007820A (es) | 2004-01-09 | 2006-09-01 | Novartis Ag | Derivados de fenil-[4-(3-fenil-1h-pirazol-4-il)-pirimidin-2-il]-amina como inhibidores de igf-ir. |
CA2567569A1 (en) * | 2004-05-21 | 2006-01-26 | Banyu Pharmaceutical Co., Ltd. | Selective inhibitors against cdk4 and cdk6 having aminothiazole skeleton |
JP4688876B2 (ja) * | 2004-06-10 | 2011-05-25 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
EP1791830B1 (en) * | 2004-09-17 | 2010-12-29 | Vertex Pharmaceuticals Incorporated | Diaminotriazole compounds useful as protein kinase inhibitors |
TW200639163A (en) | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
AU2006247118A1 (en) | 2005-05-20 | 2006-11-23 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
DE102005036126A1 (de) | 2005-07-26 | 2007-02-01 | Carl Zeiss Industrielle Messtechnik Gmbh | Sensormodul für einen Tastkopf eines taktilen Koordinatenmessgerätes |
EP1928455A1 (en) * | 2005-08-31 | 2008-06-11 | Bayer Healthcare, LLC | Anilinopyrazole derivatives useful for the treatment of diabetes |
KR20080052630A (ko) | 2005-09-01 | 2008-06-11 | 어레이 바이오파마 인크. | Raf 억제제 화합물 및 그의 사용 방법 |
WO2007105058A2 (en) | 2006-03-16 | 2007-09-20 | Pfizer Products Inc. | Pyrazole compounds |
WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
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AU2007305016A1 (en) | 2008-04-10 |
CL2007002836A1 (es) | 2008-05-23 |
JP5153777B2 (ja) | 2013-02-27 |
IL197724A0 (en) | 2009-12-24 |
KR101101675B1 (ko) | 2011-12-30 |
NO20091759L (no) | 2009-07-01 |
SMAP200900020A (it) | 2009-05-11 |
CR10670A (es) | 2009-05-13 |
AR063099A1 (es) | 2008-12-30 |
CA2663366A1 (en) | 2008-04-10 |
EA015751B1 (ru) | 2011-12-30 |
JP2010505862A (ja) | 2010-02-25 |
KR20090060322A (ko) | 2009-06-11 |
WO2008042639A1 (en) | 2008-04-10 |
BRPI0719797A2 (pt) | 2017-10-24 |
CO6180440A2 (es) | 2010-07-19 |
US20100029605A1 (en) | 2010-02-04 |
PE20080828A1 (es) | 2008-08-12 |
TN2009000105A1 (en) | 2010-08-19 |
EP2057146A1 (en) | 2009-05-13 |
CN101522661A (zh) | 2009-09-02 |
TW200823200A (en) | 2008-06-01 |
CN103739595A (zh) | 2014-04-23 |
MX2009003456A (es) | 2009-04-14 |
US8202876B2 (en) | 2012-06-19 |
CA2663366C (en) | 2012-02-07 |
AU2007305016B2 (en) | 2011-11-03 |
MA30772B1 (fr) | 2009-10-01 |
BRPI0719797A8 (pt) | 2017-12-26 |
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